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veggie said:
....“These results provide evidence against the hypothesis that CBD attenuates THC effects, highlight the potential for drug interactions even at low doses of CBD, and add to the understanding of THC analgesia,” authors wrote in the report.

One author, Geert van Groeneveld, a professor at Leiden University Medical Center and the CEO of the Centre for Human Drug Research, was emphatic that the team’s findings refute the idea that CBD might lessen anxiety or otherwise ease the adverse effects of THC.

“CBD does not in any way alleviate psychomimetic effects of THC or reduce anxiety,” Groeneveld told PsyPost. “If anything, in higher dose levels it will enhance the effects of THC because the breakdown of THC in the liver is inhibited by CBD.”

The study’s conclusion adds to past findings that combinations of cannabinoids and other chemicals in cannabis may produce a stronger high than THC on its own.

Separate research published last year, for example, found that cannabis products with a more diverse array of natural cannabinoids produced a stronger psychoactive experience that lasts longer than the high generated by pure THC alone.

Another scientific review, published this past spring, found that the “complex interaction between phytocannabinoids and biological systems offers hope for novel treatment approaches,” laying the groundwork for a new era of innovation in cannabis-based medicines.

While results of the new study suggest CBD may not do much to reduce the side-effects of THC consumption, another study published earlier this year found that a terpene produced by marijuana, D-limonene, reduced anxiety and paranoia in people who took THC.

Although the terpene modulated the anxiety-like effects, however, it seemed to have minimal effect otherwise on participants’ experiences.

The addition of D-limonene, which is found in many citrus fruits in addition to cannabis and smells like oranges, “had little impact on other common acute subjective, cognitive, or physiological effects of THC,” researchers found. Inhaling the vaporized terpene by itself, meanwhile, “did not produce any acute effects that differ from placebo.”

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Interesting stuff, totally contrary to the common view point of what CBD does. Surprised that such a relatively low dose of THC @ 9mg was potentiated by the CBD (tho a pretty large dose of it).

I was thinking as I started to read the article, how I knew CBD inhibits the metabolism of THC so that could be playing a role and I see they ended up mentioning that too.

IME I find CBD seems to "modulate" the high/effects into a longer lasting and much more focused/clear head-space, a bit less sedating or muddled and more sharp & "engaged" feeling. With CBD in the mix I often find myself up later at night and much more focused/stuck on something versus with out it my mind eventually becomes much more muddled and sleepy/less focused.

I've been curious about taking a large dose of CBD and now after reading this I'm even more interested. I can't recall but the largest amount of CBD I've taken is prob around 100mg (both via vaporized/dabbing and tincture).



I used to hype terpenes and I still do feel they're playing a role and have some synergy to some extent, but I feel there's a lot of complex stuff going on among the cannabinoids and different ratios of such and perhaps some of the other aromatic components (there's way more than just terps that contribute to the overall aroma/essence).






-OM

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The results of the study, published Feb. 13 in JAMA Network Open, found that the maximum amount of THC measured in participants’ blood samples was almost twice as high after consuming a brownie containing THC with CBD than after eating a brownie with only THC, even though the dose of THC in each brownie (20 mg) was the same. In addition, the maximum amount of 11-OH-THC (a metabolic byproduct of THC that produces drug effects similar to THC) was 10-fold greater after eating the brownie with the high CBD extract compared with the one containing high THC extract

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