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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: gopher]
    #28643806 - 02/02/24 10:28 AM (3 months, 12 days ago)

@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...


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OfflinegopherS
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow] * 1
    #28643808 - 02/02/24 10:32 AM (3 months, 12 days ago)

Oof I feel bad about your gums, I am afraid of going to a dentist because my teeth are horrible shape, I probably have a zillion cavities, last time I went to a dentist I was 8, I'm now 35


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow] * 1
    #28643848 - 02/02/24 11:23 AM (3 months, 12 days ago)

Quote:

gopher said:
What's a zombie cell?




A cell which should have died, but by malfunction, didnt. D+Q makes that type of senescent cell, die.


5 hours in, light headache.

it seems it will be a nonevent, like for most people.


Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...




you shouldnmt have exposed bone, it can get infected. What quack dentist left you with exposed bone?


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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643888 - 02/02/24 11:56 AM (3 months, 12 days ago)

Quote:

Asante said:
Quote:

gopher said:
What's a zombie cell?




A cell which should have died, but by malfunction, didnt. D+Q makes that type of senescent cell, die.


5 hours in, light headache.

it seems it will be a nonevent, like for most people.


Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...




you shouldnmt have exposed bone, it can get infected. What quack dentist left you with exposed bone?



The only one in the entire state that accepted my insurance...I went back and he re cut it to try to get it to heal but it is still exposed. He put dental putty stuff to cover it and said it was supposed to stay but my body dissolved it in like 10 min into driving back home...


Edit: I saw the new x ray when I went back and there is no tooth left, it's just the bone to the side that kinda holds the tooth in is the bone that is exposed. It's like my teeth were so big and long that it just left that bone exposed when extracted :/


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Edited by spirit_shadow (02/02/24 12:01 PM)

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OfflineBaby_Hitler
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643897 - 02/02/24 11:59 AM (3 months, 12 days ago)

Relevant:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891180/

Dasatinib is apparently a tyrosine kinase inhibitor


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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28643900 - 02/02/24 12:03 PM (3 months, 12 days ago)

Oh and the cherry on top is I'm almost positive the area around one of the extractions caused fractures or hairline fractures, and it's a non opiod place so all I got was ibuprofen and a "good luck soldier" after I was told there is now a hole in my sinus cavity 💀


Edit: the pain is much more manageable today but up until a day or so ago it was still hurting bad which is why I would put money on that there was a fracture as I've had extractions before and none of them hurt like that for that long.


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Edited by spirit_shadow (02/02/24 12:05 PM)

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Offlinelifeiswhatyoumake
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643901 - 02/02/24 12:05 PM (3 months, 12 days ago)

Only one doctor in your entire state accepts your insurance?  What kind of insurance do you have?! 
It might be worth it to go to an out-of-network dentist that knows what they're doing... your health is everything.

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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: lifeiswhatyoumake]
    #28643904 - 02/02/24 12:06 PM (3 months, 12 days ago)

Quote:

lifeiswhatyoumake said:
Only one doctor in your entire state accepts your insurance?  What kind of insurance do you have?! 
It might be worth it to go to an out-of-network dentist that knows what they're doing... your health is everything.



Yeah, unfortunately my options have been very limited. Have you ever read a series of unfortunate events? That title is my fucking life for real 💀


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OnlineIce9
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643945 - 02/02/24 12:43 PM (3 months, 12 days ago)

Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...



You got dry socket.  Usually it will heal on its own, but it is painful and can lead to infections.


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The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable man. -- George Bernard Shaw

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OfflineMickalopagus
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643959 - 02/02/24 01:05 PM (3 months, 12 days ago)

This thread is intriguing. I underwent chemo before and it was not what I would call a fun time. Massive cellular death feels like somewhat of a freakshow, but I guess you gotta weigh it against a greater good.

I am wondering how this would compare to something like fasting, which to my understanding triggers a type of cellular death response as well.

Will continue to monitor these studies and if plenty of good evidence continues to pile up might head to Mexico and pick some of this dasatnib stuff up.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28643963 - 02/02/24 01:11 PM (3 months, 12 days ago)

Quote:

Baby_Hitler said:
Relevant:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891180/

Dasatinib is apparently a tyrosine kinase inhibitor





yup,

Quote:

Dasatinib has been shown to induce apoptosis in senescent cells by inhibiting Src kinase, whereas quercetin inhibits the anti-apoptotic protein Bcl-xL.[23] Administration of dasatinib along with quercetin to mice improved cardiovascular function and eliminated senescent cells.[24] Aged mice given dasatinib with quercetin showed improved health and survival.[24]




so on one end it induces apoptosis (cell death) on the other end it inhibits a protective mechanism against cell death, like giving someone blood thinners before stabbing them :shocked:

Hardcore killing, attacking while disabling defenses.

In the coming days my dead zombies will be removed and replaced with healthy cells. I hope there will be marked benefit noticable.


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OnlineIce9
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643973 - 02/02/24 01:17 PM (3 months, 12 days ago)

How are you planning to measure any benefit of this?


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Ice9]
    #28643988 - 02/02/24 01:32 PM (3 months, 12 days ago)

Quote:

Ice9 said:
How are you planning to measure any benefit of this?





subjectively. its not to further science but to see if this hit-and-run attack on my senescent cells will improve my blood test outcomes, whether i feel better, function better. I got diabetes going on, in mice diabetes was correlated with larger improvement.

If i can improve and extend my healthspan, even a bit, its a nobrainer. Should it extend lifespan too i hit the jackpot.

Its not a placebo, its a killing agent for senescent cells combined with a substance that inhibits the ability of a senescent cell to dodge the kill.

It was hard to source as its an oncology drug. A connection to a brick-and-mortar Turkish pharmacy helped out.
Leukemia drugs have zero recreational value :crazy:

7 hours in, couldve easily taken the 200mg most take.

The list of side effects is a house of horrors but most of those effects that only form during repeat dosing, just like one dose of testosterone won't clog your arteries.

But its scary, it kills cancer!


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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Ice9]
    #28644063 - 02/02/24 02:19 PM (3 months, 12 days ago)

Quote:

Ice9 said:
Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...



You got dry socket.  Usually it will heal on its own, but it is painful and can lead to infections.



I've heard and read a little about dry socket but it's just that when my two teeth that were next to each other were ripped out it took most of the gum tissue around that bone which is why it is showing. Those teeth and roots were massive, is it a dry socket if it isn't even in the socket?  I can feel the tissue around and beside it healing but the bone protrudes past the gum damage....will the gum evenentually grow around the bone? Also I know it was fractured as I can feel an insanely sharp spot on the edge of it like where it is cracked 😞

Edit: it was like getting hit in the face with a baseball bat and recovering from that. It was a crazy radiating pain that lasted over a week and a half and I JUST started feeling better yesterday and today even more.


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Edited by spirit_shadow (02/02/24 02:20 PM)

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28644071 - 02/02/24 02:24 PM (3 months, 12 days ago)

(No calcium chloride.)

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008] * 1
    #28644099 - 02/02/24 02:37 PM (3 months, 12 days ago)

8 hours in. i'm coming down with a typical mild flu feeling, which is also a mass die-off event.

People sometimes sleep 10 hours on the day after the D+Q.

I dont mind

Anything i can do right now to help my system clear the rubble.

Gonna make a big glass of "immunity tea" featuring echinacea, chamomile etc.

I'm feeling the cell death.


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Offlinespirit_shadow
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28644103 - 02/02/24 02:37 PM (3 months, 12 days ago)

Don't forget water. Without water we will die :shroomeryhead:


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Invisibledurian_2008
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644201 - 02/02/24 03:54 PM (3 months, 12 days ago)

People who believe in 'terrain theory' think that such a cleanup is happening, when we get sick.

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008]
    #28644210 - 02/02/24 04:02 PM (3 months, 12 days ago)

Virii grab a lot of healthy cells. They need a healthy cell to procreate in

D+Q like a lion, picks off the sickest ones.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644220 - 02/02/24 04:15 PM (3 months, 12 days ago)

Oh, to be complete:





20mg Sprycel inscriptions:  BMS  527


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