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InvisibleAsante
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i'm going to apply Dasatinib + Quercetin to kill senescent cells.
    #28626937 - 01/19/24 09:38 AM (3 months, 27 days ago)

Senescent cells aka. zombie cells are cells that increasingly clutter up your tissues as you age, and add significantly to the adverse effects of aging.

Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.

this is the beginning of anti aging drug technology, dozens of pharma companies are trying to create a blockbuster drug in this exciting new field.

I'm getting on board with the tried and true granddaddy of the technology - once, beause within a few years there will be a second generation that is better.

I'm willing though to spend a few hundred bucks to be sick for a day so i can be healthier thereafter.

If you're an old fart like me, you may want to look into this.

Of course do nothing medical without a doctor's supervision.


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Invisibledurian_2008
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28626957 - 01/19/24 09:55 AM (3 months, 27 days ago)

Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28626964 - 01/19/24 10:00 AM (3 months, 27 days ago)

Let us know your results

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008] * 1
    #28626996 - 01/19/24 10:18 AM (3 months, 27 days ago)

Quote:

durian_2008 said:
Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?




rhabdomyolysis is a possibility, particularly with prolonged use.

All the high medical dose needs to do is not kill me. In 2024, unlike 1824, the odds for surviving it are good.

I'm fine with puking bile or an ER visit. odds are great it will be a relative nonevent. It's not "chemotherapy" in the sense of swallowing a derivative of nitrogen mustard gas that harms the whole organism almost equally. It's a very specific attack targeting mostly senescent cells, and certain strains of leukemia.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627006 - 01/19/24 10:29 AM (3 months, 27 days ago)

Quote:

Asante said:
Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.






Let's see the research.

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OfflineBaby_Hitler
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28627134 - 01/19/24 12:03 PM (3 months, 27 days ago)

Quote:

Asante said:

Of course do nothing medical without a doctor's supervision.




I hope you're following your own advice.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28627167 - 01/19/24 12:28 PM (3 months, 27 days ago)

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease


Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice


A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish


Price of these pills are nothing to sneeze at.

For a person of fairly normal weight, a 100mg pill Dasatinib is typially combined with two 500mg Quercetin capsules. This costs about 100 bucks. There are only 2 days though, 1 week apart.

I'll take more to get my mg/kg up but within the medically acceptable range. i'll likely spice the pot with quercetin first, getting it distributed through my system before popping the kill drug, lowering senescent cell defenses before the wallop comes.

D+Q uses the senescent cell's dysfunctionality to kill it, ie zombies shuffle off the cliff but humans halt.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler] * 1
    #28627178 - 01/19/24 12:38 PM (3 months, 27 days ago)

Quote:

Baby_Hitler said:
Quote:

Asante said:

Of course do nothing medical without a doctor's supervision.




I hope you're following your own advice.





My doc was taken aback that i could obtain something as far fetched as a niche oncology drug, he asked to stick to official protocols and to call it in on the days i will be doing it, just in case. I asked him whether i should take it in the waiting room of the ER, he told he'd give me a hard no if he saw that much of a risk.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627188 - 01/19/24 12:48 PM (3 months, 27 days ago)

I'd be lying if I said I wasn't intrigued.


I mean, I almost bought horse paste that one time because of your recommendation.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28627273 - 01/19/24 01:49 PM (3 months, 27 days ago)

Think about it, when you're aging you accumulate more and more dysfuntional cells that were programmed for cell death but didn't. They stick around obstructing the function of the tissues they're in. They are basically, non-spreading cancer cells that indeed later might not just stick around but multiply.

If you visualize it like that, taking a highly selective cancer killing substance and team it up with a supplement that renders such rogue cells extra vulnerable to the selective poison.. its basically like spraying your garden vs aphids.

i aumulated mine over 51 years and after one or two applications most are largely gone.

That's worth some discomfort.

Where do you have most of these zombie cells?  If you smoked, think of your lungs. If you ate crap foods, your intestines. If you had way too much sun exposure, surely your skin.

your brain! liver! kidneys! eyes!

its an approved leukemia drug for more than a decade and you take it in a strong normal dose, with a supplement, but oly once or twice, not months on end.

I need to expand my healthspan. now. More thsn most of you.

D+Q does that. A supermarket supplement and a cancer pill, only once.


i quote this redditor:


Quote:

Not at all elderly. 49 Days since I dosed. Only one dose at 200/2000 D/Q mg (176lb male). Late 50's. Very healthy. I've been on Rapamycin and Metformin for 29 months.

Objective: About a 10% increase in HRV. About 4-6% increase in power (Cycling power meter). A dramatic increase in balance, at least 5X longer time on balance board and I can hula hoop at least 10x longer. ( I don't HH much but I thought I'd try it again after my balance board results) Quick recovery from hard efforts during rides and dramatically lower fatigue after workouts. 8% increase in grip strength. All that within days of dosing. Steady since then.

Subjective: General feeling of more energy and optimism. My mind feels quicker at work and home but especially at work. I make fewer mistakes and a general feeling of less brain fog for lack of a better term. Scrapped any ideas of early retirement. I don't want to run out of money and I'm more skeptical than ever that current retirement plans are ready for what's coming. Worse (Oura ring) sleep but I can't figure out if it's related.

I seem to have better results then anyone I've heard from and I don't know why. I tried very high dose Fisetin in January and felt nothing so I doubt placebo is having much bearing but you never know with N=1. Doing more detailed testing with BP and reaction time before I dose again.




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InvisibleTexas Honey BadgerM
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627386 - 01/19/24 03:26 PM (3 months, 27 days ago)

You go first :leocheers:


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InvisiblePatrickKn
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Texas Honey Badger]
    #28627394 - 01/19/24 03:37 PM (3 months, 27 days ago)

Without knowing too much (anything) about it, my first concern would be that while it can kill dysfunctional cells, that it might damage existing ones. Similar to how chemo treatments tend to cause secondary cancers. While it might be good to take it if you have leukemia, I'm not sure you'd want to take it if there is no active cancer going on.

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008]
    #28627647 - 01/19/24 06:57 PM (3 months, 26 days ago)

Quote:

durian_2008 said:
Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?




What is this quote from and what is its relevance?

Certainly would be a concern that someone with chronic inflammation could have a lot of these cells and killing them all off at one time could have serious consequences.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627841 - 01/19/24 09:36 PM (3 months, 26 days ago)

Quote:

Asante said:


Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.








Never heard of this, but it doesn't surprise me.

This might get left in the dust by lab grown organs, though.

By the time what you're talking about goes through medical testing and approval and studies, we'll probably be able to just buy lab grown organs and have them "installed" in our bodies.

For instance, Bad stomach with acid ulcers? No problem, just order up a $40,000 stomach grown in a lab, and do a $90,000 surgery to have it installed.

I think in combination of what you are talking about, and what I am talking about, in less than 100 years people may be living to 200, 300+ years even, like in the Bible.

Why did the people in the bible live so long? Because God removed the senescent cells- duh!:fairy:

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Shroomers420]
    #28643661 - 02/02/24 07:25 AM (3 months, 13 days ago)




Fresh from Türkiye:  BMS 527


Down the hatch: (14:18h)

Dasatinib 140mg
Quercetin 1400mg


an hour later, so far so good.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643674 - 02/02/24 07:42 AM (3 months, 13 days ago)

1:30h feeling a bit nauseous, but dizzy, indeed a kinda mild flu feeling.


Meanwhile among my senescent zombie cells..



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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643735 - 02/02/24 09:01 AM (3 months, 13 days ago)

Quote:

Dasatinib is rapidly absorbed, with the time for maximal serum concentration varying between 0.25 and 1.5 h. Oral absorption is not affected by food. Dasatinib is eliminated through cytochrome P450 (CYP) 3A4-mediated metabolism, with a terminal half-life of 3–4 h. Dasatinib pharmacokinetics are not influenced by age (children, and adults up to 86 years of age), race and renal insufficiency.




At almost 3 hours in, in already nearing the first halving.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643748 - 02/02/24 09:26 AM (3 months, 13 days ago)

:africaface:

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Shroomers420] * 1
    #28643766 - 02/02/24 09:39 AM (3 months, 13 days ago)

You are starting to sound like my mother. She is in the medical field and hacks her health like a computer as well.....that shit seems dangerous but you guys do you. I always said real scientists test on themselves anyway :lol:


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643778 - 02/02/24 09:47 AM (3 months, 13 days ago)

What's a zombie cell?


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: gopher]
    #28643806 - 02/02/24 10:28 AM (3 months, 13 days ago)

@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow] * 1
    #28643808 - 02/02/24 10:32 AM (3 months, 13 days ago)

Oof I feel bad about your gums, I am afraid of going to a dentist because my teeth are horrible shape, I probably have a zillion cavities, last time I went to a dentist I was 8, I'm now 35


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow] * 1
    #28643848 - 02/02/24 11:23 AM (3 months, 13 days ago)

Quote:

gopher said:
What's a zombie cell?




A cell which should have died, but by malfunction, didnt. D+Q makes that type of senescent cell, die.


5 hours in, light headache.

it seems it will be a nonevent, like for most people.


Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...




you shouldnmt have exposed bone, it can get infected. What quack dentist left you with exposed bone?


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643888 - 02/02/24 11:56 AM (3 months, 13 days ago)

Quote:

Asante said:
Quote:

gopher said:
What's a zombie cell?




A cell which should have died, but by malfunction, didnt. D+Q makes that type of senescent cell, die.


5 hours in, light headache.

it seems it will be a nonevent, like for most people.


Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...




you shouldnmt have exposed bone, it can get infected. What quack dentist left you with exposed bone?



The only one in the entire state that accepted my insurance...I went back and he re cut it to try to get it to heal but it is still exposed. He put dental putty stuff to cover it and said it was supposed to stay but my body dissolved it in like 10 min into driving back home...


Edit: I saw the new x ray when I went back and there is no tooth left, it's just the bone to the side that kinda holds the tooth in is the bone that is exposed. It's like my teeth were so big and long that it just left that bone exposed when extracted :/


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Edited by spirit_shadow (02/02/24 12:01 PM)

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643897 - 02/02/24 11:59 AM (3 months, 13 days ago)

Relevant:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891180/

Dasatinib is apparently a tyrosine kinase inhibitor


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28643900 - 02/02/24 12:03 PM (3 months, 13 days ago)

Oh and the cherry on top is I'm almost positive the area around one of the extractions caused fractures or hairline fractures, and it's a non opiod place so all I got was ibuprofen and a "good luck soldier" after I was told there is now a hole in my sinus cavity 💀


Edit: the pain is much more manageable today but up until a day or so ago it was still hurting bad which is why I would put money on that there was a fracture as I've had extractions before and none of them hurt like that for that long.


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Edited by spirit_shadow (02/02/24 12:05 PM)

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643901 - 02/02/24 12:05 PM (3 months, 13 days ago)

Only one doctor in your entire state accepts your insurance?  What kind of insurance do you have?! 
It might be worth it to go to an out-of-network dentist that knows what they're doing... your health is everything.

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: lifeiswhatyoumake]
    #28643904 - 02/02/24 12:06 PM (3 months, 13 days ago)

Quote:

lifeiswhatyoumake said:
Only one doctor in your entire state accepts your insurance?  What kind of insurance do you have?! 
It might be worth it to go to an out-of-network dentist that knows what they're doing... your health is everything.



Yeah, unfortunately my options have been very limited. Have you ever read a series of unfortunate events? That title is my fucking life for real 💀


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643945 - 02/02/24 12:43 PM (3 months, 13 days ago)

Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...



You got dry socket.  Usually it will heal on its own, but it is painful and can lead to infections.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643959 - 02/02/24 01:05 PM (3 months, 13 days ago)

This thread is intriguing. I underwent chemo before and it was not what I would call a fun time. Massive cellular death feels like somewhat of a freakshow, but I guess you gotta weigh it against a greater good.

I am wondering how this would compare to something like fasting, which to my understanding triggers a type of cellular death response as well.

Will continue to monitor these studies and if plenty of good evidence continues to pile up might head to Mexico and pick some of this dasatnib stuff up.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28643963 - 02/02/24 01:11 PM (3 months, 13 days ago)

Quote:

Baby_Hitler said:
Relevant:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891180/

Dasatinib is apparently a tyrosine kinase inhibitor





yup,

Quote:

Dasatinib has been shown to induce apoptosis in senescent cells by inhibiting Src kinase, whereas quercetin inhibits the anti-apoptotic protein Bcl-xL.[23] Administration of dasatinib along with quercetin to mice improved cardiovascular function and eliminated senescent cells.[24] Aged mice given dasatinib with quercetin showed improved health and survival.[24]




so on one end it induces apoptosis (cell death) on the other end it inhibits a protective mechanism against cell death, like giving someone blood thinners before stabbing them :shocked:

Hardcore killing, attacking while disabling defenses.

In the coming days my dead zombies will be removed and replaced with healthy cells. I hope there will be marked benefit noticable.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643973 - 02/02/24 01:17 PM (3 months, 13 days ago)

How are you planning to measure any benefit of this?


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Ice9]
    #28643988 - 02/02/24 01:32 PM (3 months, 13 days ago)

Quote:

Ice9 said:
How are you planning to measure any benefit of this?





subjectively. its not to further science but to see if this hit-and-run attack on my senescent cells will improve my blood test outcomes, whether i feel better, function better. I got diabetes going on, in mice diabetes was correlated with larger improvement.

If i can improve and extend my healthspan, even a bit, its a nobrainer. Should it extend lifespan too i hit the jackpot.

Its not a placebo, its a killing agent for senescent cells combined with a substance that inhibits the ability of a senescent cell to dodge the kill.

It was hard to source as its an oncology drug. A connection to a brick-and-mortar Turkish pharmacy helped out.
Leukemia drugs have zero recreational value :crazy:

7 hours in, couldve easily taken the 200mg most take.

The list of side effects is a house of horrors but most of those effects that only form during repeat dosing, just like one dose of testosterone won't clog your arteries.

But its scary, it kills cancer!


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Ice9]
    #28644063 - 02/02/24 02:19 PM (3 months, 13 days ago)

Quote:

Ice9 said:
Quote:

spirit_shadow said:
@asante, speaking of health hacks. Do you know of any magic chemical that promotes gum tissue growth? I still can't find a surgeon and I need my gums to grow over my facebone that is showing from my tooth extractions...



You got dry socket.  Usually it will heal on its own, but it is painful and can lead to infections.



I've heard and read a little about dry socket but it's just that when my two teeth that were next to each other were ripped out it took most of the gum tissue around that bone which is why it is showing. Those teeth and roots were massive, is it a dry socket if it isn't even in the socket?  I can feel the tissue around and beside it healing but the bone protrudes past the gum damage....will the gum evenentually grow around the bone? Also I know it was fractured as I can feel an insanely sharp spot on the edge of it like where it is cracked 😞

Edit: it was like getting hit in the face with a baseball bat and recovering from that. It was a crazy radiating pain that lasted over a week and a half and I JUST started feeling better yesterday and today even more.


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Edited by spirit_shadow (02/02/24 02:20 PM)

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28644071 - 02/02/24 02:24 PM (3 months, 13 days ago)

(No calcium chloride.)

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008] * 1
    #28644099 - 02/02/24 02:37 PM (3 months, 13 days ago)

8 hours in. i'm coming down with a typical mild flu feeling, which is also a mass die-off event.

People sometimes sleep 10 hours on the day after the D+Q.

I dont mind

Anything i can do right now to help my system clear the rubble.

Gonna make a big glass of "immunity tea" featuring echinacea, chamomile etc.

I'm feeling the cell death.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28644103 - 02/02/24 02:37 PM (3 months, 13 days ago)

Don't forget water. Without water we will die :shroomeryhead:


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644201 - 02/02/24 03:54 PM (3 months, 13 days ago)

People who believe in 'terrain theory' think that such a cleanup is happening, when we get sick.

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008]
    #28644210 - 02/02/24 04:02 PM (3 months, 13 days ago)

Virii grab a lot of healthy cells. They need a healthy cell to procreate in

D+Q like a lion, picks off the sickest ones.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644220 - 02/02/24 04:15 PM (3 months, 13 days ago)

Oh, to be complete:





20mg Sprycel inscriptions:  BMS  527


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644363 - 02/02/24 06:06 PM (3 months, 12 days ago)

I got my finasteride from a Turkish pharmacy too before my insurance covered it and I got a legit prescription


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28644451 - 02/02/24 07:18 PM (3 months, 12 days ago)

Quote:

Asante said:
8 hours in. i'm coming down with a typical mild flu feeling, which is also a mass die-off event.

People sometimes sleep 10 hours on the day after the D+Q.

I dont mind

Anything i can do right now to help my system clear the rubble.

Gonna make a big glass of "immunity tea" featuring echinacea, chamomile etc.

I'm feeling the cell death.




All chemo is different I suppose, but am pretty surprised with the fast response. 8 hours in, I would imagine this process would last for a few days at minimum, with a peak into a day two, or maybe 3-4, should you be taking a second dose tomorrow.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Mickalopagus]
    #28645961 - 02/04/24 04:27 AM (3 months, 11 days ago)

Its different from classical chemo, it is a receptor activator, not an aggressive chemical.


Its too early to call the results, also because i'm on a cocktail of fentanyl valium and memantine to deal with the current flareup of my chronic pain.

I think i notice some benefits already but, first need to get off my pain cocktail


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28646005 - 02/04/24 06:17 AM (3 months, 11 days ago)

Quote:

Asante said:
Quote:

Ice9 said:
How are you planning to measure any benefit of this?





subjectively. its not to further science but to see if this hit-and-run attack on my senescent cells will improve my blood test outcomes, whether i feel better, function better. I got diabetes going on, in mice diabetes was correlated with larger improvement.

If i can improve and extend my healthspan, even a bit, its a nobrainer. Should it extend lifespan too i hit the jackpot.

Its not a placebo, its a killing agent for senescent cells combined with a substance that inhibits the ability of a senescent cell to dodge the kill.

It was hard to source as its an oncology drug. A connection to a brick-and-mortar Turkish pharmacy helped out.
Leukemia drugs have zero recreational value :crazy:

7 hours in, couldve easily taken the 200mg most take.

The list of side effects is a house of horrors but most of those effects that only form during repeat dosing, just like one dose of testosterone won't clog your arteries.

But its scary, it kills cancer!



I think that would be a way to measure outcome.  I understand this wasn't done with scientific rigor, but still curious about the outcomes.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Ice9]
    #28680514 - 02/28/24 11:23 PM (2 months, 17 days ago)

Just checking in on this thread.

How do you think it all went Asante?


--------------------
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Mickalopagus]
    #28680760 - 02/29/24 07:38 AM (2 months, 17 days ago)

I feel better off for having done it. My mind and body feel a bit more crisp. Not as much as I hoped for but yes, will repeat.


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28682511 - 03/01/24 12:05 PM (2 months, 16 days ago)

Will you be pairing telomerase treatments with your senolytics?

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28682516 - 03/01/24 12:08 PM (2 months, 16 days ago)

Quote:

Asante said:
I feel better off for having done it. My mind and body feel a bit more crisp. Not as much as I hoped for but yes, will repeat.



That's great. Have you been eating well and drinking plenty of water? Don't forget stretching as that is seriously super important and nobody does it on a daily basis except me lol


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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28682631 - 03/01/24 01:48 PM (2 months, 16 days ago)

Your drugs are purporting to do the same thing regularly fasting is medically proven to do.

Maybe just fast for 24-48 hours once a month? This other thing seems far more dangerous.

Well im super tardy to the party arent I


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