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InvisibleAsante
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i'm going to apply Dasatinib + Quercetin to kill senescent cells.
    #28626937 - 01/19/24 09:38 AM (3 months, 27 days ago)

Senescent cells aka. zombie cells are cells that increasingly clutter up your tissues as you age, and add significantly to the adverse effects of aging.

Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.

this is the beginning of anti aging drug technology, dozens of pharma companies are trying to create a blockbuster drug in this exciting new field.

I'm getting on board with the tried and true granddaddy of the technology - once, beause within a few years there will be a second generation that is better.

I'm willing though to spend a few hundred bucks to be sick for a day so i can be healthier thereafter.

If you're an old fart like me, you may want to look into this.

Of course do nothing medical without a doctor's supervision.


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Invisibledurian_2008
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28626957 - 01/19/24 09:55 AM (3 months, 27 days ago)

Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?

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Invisibleloladoreen
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28626964 - 01/19/24 10:00 AM (3 months, 27 days ago)

Let us know your results

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008] * 1
    #28626996 - 01/19/24 10:18 AM (3 months, 27 days ago)

Quote:

durian_2008 said:
Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?




rhabdomyolysis is a possibility, particularly with prolonged use.

All the high medical dose needs to do is not kill me. In 2024, unlike 1824, the odds for surviving it are good.

I'm fine with puking bile or an ER visit. odds are great it will be a relative nonevent. It's not "chemotherapy" in the sense of swallowing a derivative of nitrogen mustard gas that harms the whole organism almost equally. It's a very specific attack targeting mostly senescent cells, and certain strains of leukemia.


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Offlinelifeiswhatyoumake
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627006 - 01/19/24 10:29 AM (3 months, 27 days ago)

Quote:

Asante said:
Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.






Let's see the research.

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OfflineBaby_Hitler
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante] * 1
    #28627134 - 01/19/24 12:03 PM (3 months, 27 days ago)

Quote:

Asante said:

Of course do nothing medical without a doctor's supervision.




I hope you're following your own advice.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28627167 - 01/19/24 12:28 PM (3 months, 27 days ago)

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease


Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice


A short dasatinib and quercetin treatment is sufficient to reinstate potent adult neuroregenesis in the aged killifish


Price of these pills are nothing to sneeze at.

For a person of fairly normal weight, a 100mg pill Dasatinib is typially combined with two 500mg Quercetin capsules. This costs about 100 bucks. There are only 2 days though, 1 week apart.

I'll take more to get my mg/kg up but within the medically acceptable range. i'll likely spice the pot with quercetin first, getting it distributed through my system before popping the kill drug, lowering senescent cell defenses before the wallop comes.

D+Q uses the senescent cell's dysfunctionality to kill it, ie zombies shuffle off the cliff but humans halt.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler] * 1
    #28627178 - 01/19/24 12:38 PM (3 months, 27 days ago)

Quote:

Baby_Hitler said:
Quote:

Asante said:

Of course do nothing medical without a doctor's supervision.




I hope you're following your own advice.





My doc was taken aback that i could obtain something as far fetched as a niche oncology drug, he asked to stick to official protocols and to call it in on the days i will be doing it, just in case. I asked him whether i should take it in the waiting room of the ER, he told he'd give me a hard no if he saw that much of a risk.


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OfflineBaby_Hitler
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627188 - 01/19/24 12:48 PM (3 months, 27 days ago)

I'd be lying if I said I wasn't intrigued.


I mean, I almost bought horse paste that one time because of your recommendation.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Baby_Hitler]
    #28627273 - 01/19/24 01:49 PM (3 months, 27 days ago)

Think about it, when you're aging you accumulate more and more dysfuntional cells that were programmed for cell death but didn't. They stick around obstructing the function of the tissues they're in. They are basically, non-spreading cancer cells that indeed later might not just stick around but multiply.

If you visualize it like that, taking a highly selective cancer killing substance and team it up with a supplement that renders such rogue cells extra vulnerable to the selective poison.. its basically like spraying your garden vs aphids.

i aumulated mine over 51 years and after one or two applications most are largely gone.

That's worth some discomfort.

Where do you have most of these zombie cells?  If you smoked, think of your lungs. If you ate crap foods, your intestines. If you had way too much sun exposure, surely your skin.

your brain! liver! kidneys! eyes!

its an approved leukemia drug for more than a decade and you take it in a strong normal dose, with a supplement, but oly once or twice, not months on end.

I need to expand my healthspan. now. More thsn most of you.

D+Q does that. A supermarket supplement and a cancer pill, only once.


i quote this redditor:


Quote:

Not at all elderly. 49 Days since I dosed. Only one dose at 200/2000 D/Q mg (176lb male). Late 50's. Very healthy. I've been on Rapamycin and Metformin for 29 months.

Objective: About a 10% increase in HRV. About 4-6% increase in power (Cycling power meter). A dramatic increase in balance, at least 5X longer time on balance board and I can hula hoop at least 10x longer. ( I don't HH much but I thought I'd try it again after my balance board results) Quick recovery from hard efforts during rides and dramatically lower fatigue after workouts. 8% increase in grip strength. All that within days of dosing. Steady since then.

Subjective: General feeling of more energy and optimism. My mind feels quicker at work and home but especially at work. I make fewer mistakes and a general feeling of less brain fog for lack of a better term. Scrapped any ideas of early retirement. I don't want to run out of money and I'm more skeptical than ever that current retirement plans are ready for what's coming. Worse (Oura ring) sleep but I can't figure out if it's related.

I seem to have better results then anyone I've heard from and I don't know why. I tried very high dose Fisetin in January and felt nothing so I doubt placebo is having much bearing but you never know with N=1. Doing more detailed testing with BP and reaction time before I dose again.




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InvisibleTexas Honey BadgerM
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Registered: 07/12/18
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627386 - 01/19/24 03:26 PM (3 months, 27 days ago)

You go first :leocheers:


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InvisiblePatrickKn
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Registered: 07/10/11
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Texas Honey Badger]
    #28627394 - 01/19/24 03:37 PM (3 months, 27 days ago)

Without knowing too much (anything) about it, my first concern would be that while it can kill dysfunctional cells, that it might damage existing ones. Similar to how chemo treatments tend to cause secondary cancers. While it might be good to take it if you have leukemia, I'm not sure you'd want to take it if there is no active cancer going on.

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Offlinekoods
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: durian_2008]
    #28627647 - 01/19/24 06:57 PM (3 months, 26 days ago)

Quote:

durian_2008 said:
Quote:

When muscle breaks down, it releases a protein (myoglobin) into the blood. Myoglobin is filtered by the kidneys, causing a tea- or “Coca-Cola”-colored urine...





So, does senolytics stress the organs of elimination?




What is this quote from and what is its relevance?

Certainly would be a concern that someone with chronic inflammation could have a lot of these cells and killing them all off at one time could have serious consequences.


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InvisibleShroomers420
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28627841 - 01/19/24 09:36 PM (3 months, 26 days ago)

Quote:

Asante said:


Research has it that if you take a high medical dose of the highly selective antileukemia drug Dasatinib combined with a high dose of the OTC supplement Quercetin, a single combination dose, then a week later repeating it once, like in deworming, you will massacre your senescent cells causing your general health to permanently improve due to some aging effects reversing - lastingly! - if you are middle aged or older.








Never heard of this, but it doesn't surprise me.

This might get left in the dust by lab grown organs, though.

By the time what you're talking about goes through medical testing and approval and studies, we'll probably be able to just buy lab grown organs and have them "installed" in our bodies.

For instance, Bad stomach with acid ulcers? No problem, just order up a $40,000 stomach grown in a lab, and do a $90,000 surgery to have it installed.

I think in combination of what you are talking about, and what I am talking about, in less than 100 years people may be living to 200, 300+ years even, like in the Bible.

Why did the people in the bible live so long? Because God removed the senescent cells- duh!:fairy:

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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Shroomers420]
    #28643661 - 02/02/24 07:25 AM (3 months, 13 days ago)




Fresh from Türkiye:  BMS 527


Down the hatch: (14:18h)

Dasatinib 140mg
Quercetin 1400mg


an hour later, so far so good.


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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643674 - 02/02/24 07:42 AM (3 months, 13 days ago)

1:30h feeling a bit nauseous, but dizzy, indeed a kinda mild flu feeling.


Meanwhile among my senescent zombie cells..



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InvisibleAsante
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643735 - 02/02/24 09:01 AM (3 months, 13 days ago)

Quote:

Dasatinib is rapidly absorbed, with the time for maximal serum concentration varying between 0.25 and 1.5 h. Oral absorption is not affected by food. Dasatinib is eliminated through cytochrome P450 (CYP) 3A4-mediated metabolism, with a terminal half-life of 3–4 h. Dasatinib pharmacokinetics are not influenced by age (children, and adults up to 86 years of age), race and renal insufficiency.




At almost 3 hours in, in already nearing the first halving.


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OfflineMystikal
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Asante]
    #28643748 - 02/02/24 09:26 AM (3 months, 13 days ago)

:africaface:

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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: Shroomers420] * 1
    #28643766 - 02/02/24 09:39 AM (3 months, 13 days ago)

You are starting to sound like my mother. She is in the medical field and hacks her health like a computer as well.....that shit seems dangerous but you guys do you. I always said real scientists test on themselves anyway :lol:


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OfflinegopherS
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Re: i'm going to apply Dasatinib + Quercetin to kill senescent cells. [Re: spirit_shadow]
    #28643778 - 02/02/24 09:47 AM (3 months, 13 days ago)

What's a zombie cell?


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