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Shroomers420


Registered: 01/09/24
Posts: 130
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Re: If you could design the perfect psychedelic? [Re: elasticaltiger]
#28619246 - 01/12/24 09:56 PM (15 days, 10 hours ago) |
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elasticaltiger said: Yeah this is a neat thread. It's interesting to see that the perspectives of what's desirable really range all over the spectrum from people who wouldn't change a thing to people who desire something completely fantastical. Just goes to show you how hard it is to study these compounds when everyone's personal experiences are so unique.
RIght! This tingles my brain so much to know that my perspective is just one- among billions, but by the way I act and talk sometimes you might thing I am the only person on earth who knows how to slice bread.
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  Shroomers with the 420
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tregar
Stranger


Registered: 08/30/04
Posts: 1,049
Last seen: 2 hours, 45 seconds
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Re: If you could design the perfect psychedelic? [Re: Shroomers420]
#28619314 - 01/13/24 01:36 AM (15 days, 7 hours ago) |
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Nillion, I'm not a vendor nor ever been, you might be thinking of 69ron, I am not 69ron. Lifelong chemist and researcher. Anyways, I cracked the code on how to make THH at home in only 1.5 hour, no exotic chemicals needed like in TIHKAL, more on this below.
--> To those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by an hour +, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I love that it lasts incredibly long allready.
Sabnock said:
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There may be some confusion surrounding THH for people. From my understanding, the form of THH found in the B. Caapi vine is purely a Serotonin reuptake inhibitor and ime it certainly feels that way, it doesn't have or at least isn't supposed to have MAOI properties, which that comes from the Harmine and Harmaline.
Sabnock is a legend, read countless posts from him and he is indeed correct.
Bardy said:
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DMT-nexus says: Like other harmala alkaloids it is a RIMA reversible inhibitor of monoamine oxidase A. However, unlike harmine and harmaline, THH also inhibits reuptake of serotonin. https://wiki.dmt-nexus.me/Tetrahydroharmine Are you claiming these folks are wrong?
Yes, that information is incredibly vague or unclear. The sentence is very vague in that it does not tell you it would take a severe overdose of THH to inhibit MAO-A and MAO-B.
From Interprise chemical:
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THH is a fluorescent indole alkaloid extracted from B. caapi that inhibits MAO-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 μM, respectively) compared to its companion harmala alkaloids: harmaline (IC50s = 2.5 nM and 25 μM, respectively) and harmine (IC50s = 2 nM and 20 μM, respectively)
https://interpriseusa.com/product/tetrahydro-harmine-10-mg/
Keep in mind, the lower the nM, the higher or stronger the activity. Reading those numbers, you would have to take 30 times the normal dosage of 100mg THH, or 30 x 100 = 3,000mg THH just to equal rima activity of 100mg of harmaline, and it takes at least 100mg of harmaline to activate DMT. That much THH would be an overdose and most likely kill a person. My max is 300mg of THH.
It takes around 150mg of harmine to activate DMT, that would require 5500 mg of THH to do the same.
--> If you remember 69ron, I was not around when he used to post, as I was at the mescaline king forum thenook.org for at least a decade (now extinct) he claimed that THH alone would activate DMT, this is completely un-true, this earned him or her a very bad reputation as people found out after his writing of this, that no such thing was possible.
Bardy said:
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So contrary to what you claim, THH is found in Syrian Rue, but in smaller amounts than Caapi.
When you compare 4.3% harmine and 5.6% harmaline to 0.1% THH, you end up with next to nothing in the seeds as THH.
There is absolutely no significant amount of THH in rue seeds, period...but you can make THH from harmaline in 1.5 hour. Even as a chemist, I spent months trying to make THH from harmaline without using exotic chemicals like TIHKAL, after months of failure, I went into a trance and was given a vision of how to complete the process I was stuck at using an over the counter chemical and explain how to make it simply in link below, I wanted humanity to know how to do this, as I feel it is extremely important.
Hallucinogenic Plants in the Mediterranean Countries, Ioannis D. Passos, Maria Mironidou-Tzouveleki, in Neuropathology of Drug Addictions and Substance Misuse, 2016:
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The content of dried seeds of the plant in harmine is about 4.3% w/w, 5.6% in harmaline, 0.6% in harmalol, and 0.1% in tetrahydroharmine.
https://www.sciencedirect.com/topics/neuroscience/tetrahydroharmine
Older Caapi is becoming close to extinct as harvesters have to go further and deeper into the Jungle...hence the over hundred spiritual centers in South America are having to harvest younger cappi with much less tetrahydroharmine, here in link below is an alternative to help conserve while it grows over many years:
Traditional true Ayahuasca has always been (1) Caapi by itself or (2) Caapi with psychotria viridis or Diplopterys cabrerana.
12 reasons THH rocks and how to make her here: https://www.shroomery.org/forums/showflat.php/Number/28423951/fpart/all
Nillion, I'm not a vendor nor ever been, you might be thinking of 69ron, I am not 69ron. Lifelong chemist and researcher. Anyways, I cracked the code on how to make THH at home in only 1.5 hour, no exotic chemicals needed like in TIHKAL, more on this below.
Bardy said:
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We get it Tregar. THH makes shrooms better for you. You’ll find that it is a RIMA as well as being an SRI I think.
I'm a life long chemist, and know my chemistry, THH is 100% SRI and not a significant RIMA at all. Harmine is a RIMA, so is harmaline. THH is the 2nd highest alkaloid in caapi, in same family as ibogaine with a 10.5 hour half life with peak at 5.25 hours.
Be careful if you buy THH from china (liftmode) as there have been reports of it not staining blue under UV (like real THH) but green, indicating harmaline is still in it. Dab a cue tip in vinegar, then take up a bit of your THH, smear on a paper plate, hold under uv light, if it glows blue you got pure thh, if any yellow or green it's contaminated with harmaline.
Freedom said:
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Its kind of odd that no one else seems to have any reports of THH combos, not on erowid or blue light as far as i can tell
Freedom, You will find no reports of THH + mushrooms or THH + LSD cause this is brand new cutting edge, but I've been doing it for many years, gorgeous experience, it's like taking a low dose of mescaline with you shrooms or acid.
THH or tetrahydroharmine is the best kept secret in the psychedlic world:
THH and how to make her (along with many trip reports of 300mg THH by itself):
https://www.shroomery.org/forums/showflat.php/Number/28423951/fpart/1/vc/1
More of my research (10 topics), on the cutting edge, and why dmt should always be taken with thh as found in true Ayahuasca:
https://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/
2 minute formed HPBCD DMT liquid very bioavailable sublingually under tongue & outperforms DMT salts orally by many factors in personal trials, combo with tetrahydroharmine, Ayahuasca. Part 0: 12 reasons pure THH or tetrahydroharmine rocks (this post #1 in middle) Part 1: HPBCD complexed DMT experimental dosage, effects & duration, over 44 sublingual DMT experiences over a year's time (this post #1 at bottom). Many times stronger than oral DMT. Updated 1-1-2022. Part 2: Receptorome chart & explanation Part 3: Tetrahydroharmine (THH) effects --> Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note Part 5: Chemist Patrick Arnold's HPBCD prohormones & bloodwork studies part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal, absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. part 7: a little bit on my 70 Ayahuasca experiences, doses & visions part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water part 9: 20 minute visionary visit from a dead Aztec Shaman part 10: One way to make pure tetrahydroharmine part 11: From the archives of DMT world: How to easily extract 2.3g DMT from 170g bark using a 2 liter Erlenmeyer flask part 12: Out of print writings on the Divine Plant of the Incas, coca leaf visions...and writings on strong euphoria from coca leaf tea bags soaked in wine, forming orally active cocaethylene in the liver, discovered in 1994. Explains the popularity of Vin Mariani (coca leaf soaked wine) with both popes, Thomas Edison and countless celebrities. part 13: THH + mushrooms report from JKW. part 14: Multiple encounters with death & depression.
Northerner said:
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It's popular enough if you go and read on dmtnexus. Used with DMT orally though rather than shrooms, but it's very much a thing.
Thank you Northerner. I've been taking dmt with THH for many, many years, here is a compilation of my 50 + trip reports with many pics of the 150mg harmine + 70-300mg THH + 90mg dmt true Ayahuasca capsules:
https://www.shroomery.org/forums/showflat.php/Number/28189371/fpart/all
Since harmine has a half life of from 1 to 3 hours, I redose at the 1.5 hour to 2 hour point using only 75mg harmine + 90mg dmt in a single capsule again for a +4 moderately strong experience, as 1/2 the harmine dose is still active from the first dose. You don't have to add anymore THH since THH has a half life of 10.5 hours, peaking at around 5 hours. You can re dose as many times as you want, continues to work strongly.
This gives me a total 4 hour strong trip that is easy to handle, with hours of afterglow. Going beyond 120mg DMT is not recommended, see my trip reports on page 2. I recommend crushing the dmt freebase into fresh aloe vera gel from fresh leaf (*almart carries fresh leaf in grocery section or buy on line, store excess gel in freezer as it only lasts 1 week in fridge, defrost more when needed) only as the polysaccharides in the fresh leaf increase the penetration of the dmt into the intestines by many factors, for an experience that can easily reach +4 to +5 and is all encompassing and super colorful just like real Jungle Ayahuasca, I've noticed no difference in strength between these zero nausea Ayahuasca capsules and real Ayahuasca brew I've prepared from caapi and Hawaiian psychotria.
THH + mushrooms report from JKW:
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Tregar, just wanted to let you know that I finally tried 3 grams of cubensis with 180 mg of THH, and all I can say is WOW! Intense and beautiful like I've never had before, with a definite DMT edge to it. I've always been a hard-head, needing 4.5+ grams to get anywhere interesting. I've done up to 9 grams, and never got near this intensity. Just wanted to thank you for the tip. This is the way for me to go form now on. I look forward to combining THH with DMT. All the best, and take care.
Edited by tregar (01/21/24 09:46 AM)
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Shroomers420


Registered: 01/09/24
Posts: 130
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Re: If you could design the perfect psychedelic? [Re: tregar]
#28619324 - 01/13/24 02:13 AM (15 days, 6 hours ago) |
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tregar said: For those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by hours, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I loQuote:
tregar said: For those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by hours, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I love that it lasts incredibly long allready.
WHEN i DID SHROOMS IT WWAS LLIKE i AND WE JUST
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  Shroomers with the 420
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Shroomers420


Registered: 01/09/24
Posts: 130
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Re: If you could design the perfect psychedelic? [Re: Shroomers420] 1
#28619327 - 01/13/24 02:19 AM (15 days, 6 hours ago) |
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i WRITE THIS FROM THE BLANK FACE i WRITE FROM TTHE i WRITE FROM TTEH i WRIE FROM HTE THE i WRITE FROM THE
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tree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 34 minutes, 24 seconds
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Re: If you cold design the perfect psychedelic? [Re: CHUCK.HNTR]
#28619389 - 01/13/24 05:31 AM (15 days, 3 hours ago) |
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CHUCK.HNTR said:
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dovedescent7 said:
I've done a TON of MDMA, was a Coke/Heroin (technically speedball) addict for over a decade and nothing messed me up long-term like Acid. 25 years later it still affects me.
I would tell the young-ins try not to trip on LSD more than 5-10 times depending on strength. Like no more than 5-10 separate trips or your playing with losing touch with reality in some sense, for years.
Oh and the wrong dose of MDMA can wipe the brain like a bad hard drive, saw it happen to a good buddy, from 1 dose.
Curious why LSD has fucked you up so bad especially 25 years later?
Not the person you asked but I had a bad acid trip in my twenties that fucked me up for about ten years.
DMT and actually, more LSD, helped me sort it out. Along with good social supports.
What fucked me up wasn't the drugs, but the social context I took them in along with discovering vulnerable parts of myself I felt ashamed of integrating at the time.
Also, tripped well over 100 times on LSD and 100 more on shrooms. I'd tell the youngins to eat until you're full. But wait until you're an adult and take them in safe spaces.
-------------------- Listen to the silence behind the engines' noise. Jesus, Sweets, listen. Hear it? It's a love song. For whom? You are loved. ~ David Foster Wallace, Westward the Course of Empire Takes Its Way
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Nillion
Nobody

Registered: 04/14/22
Posts: 1,000
Loc: Terra Firma
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Re: If you cold design the perfect psychedelic? [Re: tree frog]
#28619442 - 01/13/24 07:04 AM (15 days, 1 hour ago) |
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Interesting. I had a bad experience with LSD once and wasn't comfortable with taking it again for about 8 years. Also in my 20s.
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CHUCK.HNTR
feral urbanite



Registered: 09/30/19
Posts: 2,254
Loc: SF, CA, USA
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Re: If you cold design the perfect psychedelic? [Re: Nillion]
#28619498 - 01/13/24 08:30 AM (15 days, 7 minutes ago) |
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Tree frog, I feel you, the way I read dovedescent7’s comments were that it fucked him up physically health wise more like brain damage not a “bad trip” type of fucked up, but that’s why I wanted to hear more.
Like you, I took nearly a decade break from psychedelics after a bad trip in Amsterdam in 2007. It was during the short window that fresh shrooms were legal there. I’m glad I found my way back to them with more maturity and respect.
-------------------- "What is the practical application of a million universes?" -Alan Watts
   
Edited by CHUCK.HNTR (01/13/24 08:31 AM)
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PancyanterA
Stranger
Registered: 12/17/22
Posts: 75
Last seen: 23 hours, 26 minutes
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Re: If you cold design the perfect psychedelic? [Re: Nillion]
#28619502 - 01/13/24 08:33 AM (15 days, 5 minutes ago) |
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tree frog said:What fucked me up wasn't the drugs, but the social context I took them in along with discovering vulnerable parts of myself I felt ashamed of integrating at the time.
That makes perfect sense. In my opinion people should be older and already on the path of personal development/healing before touching a psychedelic.
Explains why so many people have zero interest or get turned off as well.
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Bardy


Registered: 04/02/14
Posts: 2,184
Last seen: 8 hours, 38 minutes
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Re: If you cold design the perfect psychedelic? [Re: PancyanterA]
#28622420 - 01/15/24 05:18 PM (12 days, 15 hours ago) |
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I’m gonna sound like a real stoner here… Maybe not the perfect psychedelic, but I think it’d be cool if there was a synthetic cannabinoid on the market which: - lasted only one to two hours - cleared your system quickly (no next day grogginess) - was less toxic than THC - was non addictive.
That’d be cool too I think. Obviously wouldn’t be as enlightening as others people have mentioned here.
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