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OfflineNorthernerM
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If you could design the perfect psychedelic? * 2
    #28610319 - 01/05/24 10:22 AM (22 days, 22 hours ago)

Imagine for a moment you have the power of the universe and you could create the perfect psychedelic. What would it be like?


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The nearest we ever come to knowing truth is when we are witness to paradox.


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OfflinePluviophile
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Re: If you cold design the perfect psychedelic? [Re: Northerner] * 3
    #28610326 - 01/05/24 10:30 AM (22 days, 22 hours ago)

Lsd that only lasts for 5-6 hours would be nice.

It’s hard for me to find time to use lsd nowadays because it’s such a long experience.


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OfflineWomble
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Re: If you cold design the perfect psychedelic? [Re: Pluviophile] * 1
    #28610364 - 01/05/24 11:13 AM (22 days, 21 hours ago)

Quote:

Pluviophile said:
Lsd that only lasts for 5-6 hours would be nice.

It’s hard for me to find time to use lsd nowadays because it’s such a long experience.




This, but with zero tolerance build up.

and it grew on trees :grin::grin::grin:


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OfflineWomble
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Re: If you cold design the perfect psychedelic? [Re: Womble] * 1
    #28610367 - 01/05/24 11:14 AM (22 days, 21 hours ago)

and with some kind of instant trip killer - like eat a banana or something and the trip instantly stops


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Invisibleredgreenvines
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Re: If you cold design the perfect psychedelic? [Re: Womble]
    #28610373 - 01/05/24 11:17 AM (22 days, 21 hours ago)

instant tripping after insufflating small line, no tolerance, no ld-50, legal.


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InvisibleCHUCK.HNTR
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Re: If you cold design the perfect psychedelic? [Re: Pluviophile] * 2
    #28610395 - 01/05/24 11:29 AM (22 days, 21 hours ago)

I’d want to say any of them without the mindfuck and scary parts, also without the hard bodily sensations and nausea, and rough transition as the egoic self is taken over.
However I’ve learned so much from all of it. I don’t get to to be in charge, I don’t fully get to say how it’s going to go down, and that has been so humbling that it makes me approach consensus reality with more space and openness. So actually I wouldn’t change a thing I’m so grateful the psychedelic space is there for us with all of its challenges.

Sorry I failed your excellent thought experiment question.

(Also no fake or dangerous drugs to mistake, it’s comforting to know on aya and shrooms that you can’t OD)


--------------------
"What is the practical application of a million universes?" -Alan Watts
:mushroom2::mushroom2::mushroom2::mushroom2::mushroom2:


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Offlinetree frog
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Re: If you cold design the perfect psychedelic? [Re: redgreenvines]
    #28610398 - 01/05/24 11:32 AM (22 days, 21 hours ago)

I think sclerotia are pretty close for me honestly.

Clear headed, very visual, minimal body load.  Short enough duration I can take it without it dominating my whole day.  Clear headed enough I can have morphing 3-D open and closed eye visuals but still carry on a conversation.

Redosing without ever getting a headache would be nice.  But taking to much of any tryptamine gives me headaches on the comedown.

Just getting into Pan Bisporus and they seem pretty nice too.  The body load is more intense but pleasurable (body buzz more than load).  Similar to a good DMT body buzz that can disolve you into everything.  But I've only taken a quarter gram so far.  I suspect a half gram would be about 1/8th of non-PE cubes only more clear headed and a better body high.  Looking forward to testing the water at that dose in the coming week or two.

@chuck, check out stones if you haven't yet.  Fresh if you can.  They sound like they might be what you're looking for.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (01/05/24 11:33 AM)


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Offlinetaskamil
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Re: If you cold design the perfect psychedelic? [Re: tree frog] * 1
    #28610514 - 01/05/24 01:16 PM (22 days, 19 hours ago)

I would design a beatiful flower with great smell, once you smell you will go to tryptamine realm instantly for 4 hours and back to reality with afterglow. This plant would be so agressive and reproductive that it grows everywhere in every climate in summer or winter. so aggressive that cannot be controlled by goverments, or bad organizations or bad people.


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Invisibleelasticaltiger
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Re: If you cold design the perfect psychedelic? [Re: taskamil]
    #28610565 - 01/05/24 02:05 PM (22 days, 18 hours ago)

ET-69 - the perfect psychedelic.

No nausea
Easily weighed dosage amounts in half gram increments per trip level (level 5 trips guaranteed at 2.6 grams)
Last 3 to 6 hours.
No tolerance developed.
Easily produceable using common household ingredients without any chemistry know how yet people always willing to pay full price.
All the visual effects of lsd and shrooms with a great body high but still allows for perfect hand eye coordination.
Mild serotonin effects similar to mdma
Trip can be ended quickly by ingesting something bubbly.


--------------------
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No Pouring. No Syringes. No Cutting. No flaming. No Contamination. No Bullshit.

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Van Gogh would’ve sold more than one painting if he’d put tigers in them.―Bill Watterson

EZEKIEL 23:20


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Invisiblethe_chosen_one
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Re: If you cold design the perfect psychedelic? [Re: elasticaltiger] * 1
    #28610571 - 01/05/24 02:13 PM (22 days, 18 hours ago)

Subtropicalis with an off/pause switch.. or even a glaucine mode.. and a cattle prod for when the octostumps get too personal. Shadow dude can screw himself. The peanuts are for them.
:crankeyclaus:


--------------------
"Luck favors the observant." - Workman



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OfflineskOsH
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Re: If you cold design the perfect psychedelic? [Re: the_chosen_one] * 1
    #28610667 - 01/05/24 03:16 PM (22 days, 17 hours ago)

The perfect psychedelic for me would have the combined visual effects of lsd, psilocybin, ketamine, mescaline, and dmt.

The compound takes an hour to peak, you plateau for three hours and then the come down is 1-2 hours. There is no nausea or discomfort.

The psychedelic does not really build tolerance that fast, so you could redose an hour before the peak ends, and have a solid 8 hour trip if you wanted to

That would be what I would invent


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OfflineWhoManBeing
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Re: If you cold design the perfect psychedelic? [Re: skOsH]
    #28610672 - 01/05/24 03:21 PM (22 days, 17 hours ago)

A shorter tail end ketamine like one. I like the heavy deep far out trips. Just always forgets lasts so long and tend to make difficult coming out of.


--------------------
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Eye was thinking the other day...  ahh, thinking never done me no good.



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InvisibleThe Blind Ass
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Re: If you cold design the perfect psychedelic? [Re: Northerner] * 2
    #28610686 - 01/05/24 03:32 PM (22 days, 17 hours ago)

Question @ Notherner?

Are we self limiting to modern day limits or can we go bonkers with the Trek/Force of how 'it' is?  :rules:

I'd take many of what's already been shared and distill the best shared aspects into an elixir and be done with it .
 

Ha, jk.

Its kind of odd to answer this Q. 

Psychedelia fungi, LSD, Mescaline, Salvia d, Cannabis, and other similar psychedelic substances are already so absurdly mind-blowingly amazing its marvelous.  Sure, subtracting undsireable side efx would be cool for many who suffer them, but dang. 

You've already inflamed desire with wishes with this thread, self included.


Hahaha!...:cookiemonster:




*pulls up to the Northerner's drive through window to place  an order*


*long pause*


Ughhhh....

I'll take an abundantly available, 100% legal, 0% stigmatized throughout the entirety of the world -  no matter which nation or what location one finds themselves.

"uhhhhm, hnnn.. alrighty.  I'd like one 'perfect psychedelic', plz, the one WITH the combo meal, cool? thanx!"  :cool::thumbup:.

:toohightothink::highdog::highfive:



Let's see here...


I'd prefer:

No requisite RX, no limits upon quantities. 
Controlled for safety reasons, yet regulated by Ythan because I said so.

Additionally, No tolerance, No harmful effects upon the body related to its usage - despite frequency, dosages, or duration used.

Depending on prefered ROA: Kicks in @ 1 second.  The second most preferred ROA @ 10 seconds, the third most @ 60 seconds, or maybe having some time to gear up, so speak, and prep, allowing a route which withholds all efx until @ 1 hour.

Note: whichever is chosen, when it hits?
It does so straight from the peak efx.  :yesnod:

... but, as for the duration? I don't know?
How about as long as it takes or can it stop on cue via some action or other non harmful, unhindering substance?  :stroke beard:

  I may have to give the whole notion of 'my' & 'perfect psychedelic' a bit more more thought.

However, my dearest psychonauts...

It, umm...it does have 3 major side effects.

1) Near as to infinitely scalable efx as possible wrt dosage and roa.

2) Actualizable siddhis, and other siddhi-like tricks and treats potentially available on cue (*optional) at any given time during the experience from the perfect psychedelic.  :geordinod:

3) Upon Mastery of # 2 ~ a previously unknown-unknown yet novel biochemical reaction , IDK - say, a genetic anomaly occurs from it after so and so related to the substance.  Whatever does the trick is it ~ something to somehow enable a mode of being allowing an available option for turning on or off a partial or full sharing in another's mind via one's own psychedelic trip thanks to the 'perfect substabce'. 

Experiential POV, mind wrt the senses & perception with another for true....justimagine it.

of say....Logical Chaos, Northerner, Asante, RGV, SBC, Ythan, SS, or anyone else for that matter.

Whoever the potential candidate - if mutually agreed upon - with the tripper actually tripping able to transmit it in all its features as simulated to you while they're tripping on the 'perfect psychedelic', or anyone else for that matter. 

Ie.  Shared sensory perception of some variety.
Maybe Vulcan-esque mind melding of a sort. 
Some variation of the theme only while retaining the option for privacy at any instant, sounds as sweet as could be, imho.

In addition to trips, it extends the same stipulations as mentioned for tripping as just mentioned, plus, the experience of sharing in of that of dream-mode/dream/dreaming in general, too. 

Basically:  Star Trek Holo Deck without the Star Trek or the Holo Deck.  Just psychedelic expeirence and or dream plus easter egg Siddhis and then some with one's knowledge at hand/hand, and, all our experiences still neural-based memory, too.


:mitebecool: 

a so-called genuine meeting of the Minds via Brain:Brain synchrony  harmonizing appropriately so as to enable the phenomenologically holographic-like dreamy yet however one, or, many - might wish.

Non harmful to one's actual creature, imho, it seems like there'd be next to an infinitely infinitive infinity worth of infinities of  near endless extents of pure creativity, play, experimentation, examination, fulfillment....

Essentially? (w)hol(l)y fun. :snowman:

:manofapproval:


--------------------
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OfflineNorthernerM
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Re: If you cold design the perfect psychedelic? [Re: The Blind Ass]
    #28610716 - 01/05/24 03:52 PM (22 days, 16 hours ago)

Quote:

The Blind Ass said:
Question @ Notherner?

Are we self limiting to modern day limits or can we go bonkers with the Trek/Force of how 'it' is?  :rules:




You're literally given the power of the universe to create your perfect psychedelic substance, so that includes every god and science, known and unknown. 

Seems like you came up with some fire gear!

Loving the responses so far. :heart:


--------------------
The nearest we ever come to knowing truth is when we are witness to paradox.


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Offlinetree frog
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Re: If you cold design the perfect psychedelic? [Re: The Blind Ass]
    #28610718 - 01/05/24 03:53 PM (22 days, 16 hours ago)

I feel like the odd man out in that I like having some tolerance curve on my drugs.  Otherwise I'd just trip everyday.

Literally gave away 3/4 gram of 2c-b once upon a time because I was finding myself dosing and watching TV with it like it was weed.

I can't say I never regretted that decision though lol


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


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InvisibleThe Blind Ass
Bodhi
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Registered: 08/16/16
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Re: If you cold design the perfect psychedelic? [Re: Northerner]
    #28610759 - 01/05/24 04:31 PM (22 days, 16 hours ago)

Quote:

Northerner said:
Quote:

The Blind Ass said:
Question @ Notherner?

Are we self limiting to modern day limits or can we go bonkers with the Trek/Force of how 'it' is?  :rules:




You're literally given the power of the universe to create your perfect psychedelic substance, so that includes every god and science, known and unknown. 

Seems like you came up with some fire gear!

Loving the responses so far. :heart:




Hopefully you'll love them even more so once I find an optometrist.

I'm smashing keys in the dark, at the moment literally, and, wrt vision, ever since my blind ass broke my glasses. 
Fell asleep reading, woke up, and then rolled over.
...Right onto the suckers without realizing it until hearing that wallet piercing, heart breaking 'crackling pop'. :nonono:

With that said: :rules:

Regardless of who's undertaking the perfecting of said "perfect psychedelic",

A vivid & lengthy lingering afterglow which grants perfect vision ought' to be part of it anyways.  :oldman:

I bet the perfect psychedelic is cheaper than another pair of the same glasses.
:cryaboutit:

Ty.  :goodmorning:

Carry on with the perfecting, lads.  My less fun than making a perfect psychedelic substance job beckons.  :leaving:


--------------------
Give me Liberty caps -or- give me Death caps


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Onlineepilectric
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Re: If you cold design the perfect psychedelic? [Re: The Blind Ass]
    #28610785 - 01/05/24 05:06 PM (22 days, 15 hours ago)

hmm i'm already happy with what we have

but apart from that i agree to the ketamine notions before... something more healthy and beneficial like shrooms with the duration and usability of ketamine and maybe a clear lysergic edge :smile:

ketamine has been dubbed god somewhere in the 90s spiral tribe soundsystem rave scene. but it is too hard physically. something with that round god factor, just healthier.

with intricate fractals forming from the center but always in shape and control. clearheaded like lucy but with the flesh of shrooms and the reliability of ketamine :smile:


--------------------
i :heartpump: shroomery

https://soundcloud.com/cyberhops/tracks


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: epilectric]
    #28610837 - 01/05/24 05:51 PM (22 days, 14 hours ago)

I think 25i/25c nBome or something similar without any of the health risks or burnout associated with them. They’re wonderfully psychedelic, feel very warm, they’re moderately stimulating and they last about 8 hours which I think is the perfect duration.

-Fully entactogenic like MDMA
-Rainbow tracers, fractal open eye visuals

They felt to me as though it would be difficult to have a bad trip on them when taken in the right dosages.

I would probably add some more DMT/psilocybin type visuals to the trip.

Maybe the visuals of the trip could change all the way throughout so you could get a taste of what all the different psychedelics have to offer.

The trip starts off 25i nBome visuals and gradually proceeds through lsd visuals, mushroom visuals, DMT visuals and the lands you in Salvia visuals or something, returning to 25i on the way out, but with only the same amount of head fuck as an average dose of 25i nBome.


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OfflineGenesisCorruptedS
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Re: If you cold design the perfect psychedelic? [Re: Northerner]
    #28610964 - 01/05/24 08:11 PM (22 days, 12 hours ago)

Quote:

Northerner said:
You're literally given the power of the universe to create your perfect psychedelic substance, so that includes every god and science, known and unknown. 




Based off of this.
I want the psychedelic to allow you to communicate with spirits. Learn information. To be able to have an afterglow that last for weeks.
It would last for hours. while not having it affect any of my locomotion or thought processing abilities.
Completely without influence hallucinations.
Being able to be teleported to completely different universes. It also tones your muscles.
It’s also great for your hair. It boosts your immune system. It makes you more sexually potent.
It promotes stamina. It reduces blood pressure.
Powerful and spiritual.

When can it be ready?
:lol:


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InvisibleCreonAntigone
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Re: If you cold design the perfect psychedelic? [Re: CHUCK.HNTR] * 2
    #28611133 - 01/06/24 01:44 AM (22 days, 6 hours ago)

Quote:

CHUCK.HNTR said:
I’d want to say any of them without the mindfuck and scary parts, also without the hard bodily sensations and nausea, and rough transition as the egoic self is taken over.
However I’ve learned so much from all of it. I don’t get to to be in charge, I don’t fully get to say how it’s going to go down, and that has been so humbling that it makes me approach consensus reality with more space and openness. So actually I wouldn’t change a thing I’m so grateful the psychedelic space is there for us with all of its challenges.





In an ideal world we could imagine just the euphoria or afterglow in a drug.

Yet we realize that the euphoria and afterglow are essentially causally related to the hard chills, sweats, fear and 'activation' that comes with psychedelics. The comeup is required for the subsequent glow.

If, though, I could tip the scales and just plant myself right in the most pleasurable part of the experience - right after the ordeal, into the part where I rest in the infinite, followed by a cool glow - I'd probably dose that pill.

But since the world is not ideal, the harsh parts of psychedelics may serve instructive or moral value, as they frequently bring up precisely the things we don't want to think about, and force a confrontation. So we might conclude like CHUCK.HNTR that it is better that these drugs are the way they are.


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: CreonAntigone] * 1
    #28611170 - 01/06/24 03:12 AM (22 days, 5 hours ago)

Good point. If they were just good times they wouldn’t be as good as they are


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InvisibleCreonAntigone
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Re: If you cold design the perfect psychedelic? [Re: Bardy] * 1
    #28611177 - 01/06/24 03:31 AM (22 days, 5 hours ago)

Quote:

Bardy said:
Good point. If they were just good times they wouldn’t be as good as they are




I am in some sense unsure if a 'good times only' psychedelic is possible - or would it cease to be a psychedelic at that point? 'Good times only' would be closer to heroin or some other sedative, that just wipes out one's sharpness entirely and is prone to becoming addictive.

If something made you feel really good and not worry about anything, would you ever not use it? Hence drugs like opiates are addicting.

Psychedelics are characterized by - for the most part - maintaining at least some semblance of one's alertness - one's ability to fear, but also really to plan and organize. Even on the most impairing psychs, there's at least some kind of awareness of what's going on, even if that's awareness of a hyper-reality.

So would a psych that eliminated all the painful aspects of the experience, all the anxiety, be useful or possible?


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: CreonAntigone]
    #28611180 - 01/06/24 03:45 AM (22 days, 4 hours ago)

This is the old “you can’t know the good without the bad” problem

Well it’s not so much a problem as it is a fact I think… maybe there’s someone that disagrees


Edited by Bardy (01/06/24 03:47 AM)


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Offlinetree frog
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Re: If you cold design the perfect psychedelic? [Re: epilectric]
    #28611300 - 01/06/24 06:30 AM (22 days, 2 hours ago)

Quote:

epilectric said:
hmm i'm already happy with what we have

but apart from that i agree to the ketamine notions before... something more healthy and beneficial like shrooms with the duration and usability of ketamine and maybe a clear lysergic edge :smile:

ketamine has been dubbed god somewhere in the 90s spiral tribe soundsystem rave scene. but it is too hard physically. something with that round god factor, just healthier.

with intricate fractals forming from the center but always in shape and control. clearheaded like lucy but with the flesh of shrooms and the reliability of ketamine :smile:




If you don't mind a long trip, Ibogaine is a psychedelic tryptamine with disassociative action like K.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (01/06/24 07:21 AM)


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InvisibleNillion
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Re: If you cold design the perfect psychedelic? [Re: Northerner]
    #28611333 - 01/06/24 07:07 AM (22 days, 1 hour ago)

Quote:

Northerner said:
Imagine for a moment you have the power of the universe and you could create the perfect psychedelic. What would it be like?




A drug that never requires a sitter for the user.


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: tree frog]
    #28611335 - 01/06/24 07:08 AM (22 days, 1 hour ago)

How dangerous is it? Because I’ve kinda been scared off of that one


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Offlinetree frog
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Re: If you cold design the perfect psychedelic? [Re: Bardy] * 1
    #28611348 - 01/06/24 07:27 AM (22 days, 1 hour ago)

Quote:

Bardy said:
How dangerous is it? Because I’ve kinda been scared off of that one




It's relatively safe for people that don't have heart conditions and aren't on other psychiatric medications.  Grapefruit juice should be avoided as it interferes with the livers ability to process ibogaine.

It's not as safe as mushrooms or LSD and should be used with as much caution as ketamine as far as dose.  Which can be difficult when using plants vs pure chemicals.

I haven't personally taken it but I know people in the harm reduction community who have used it to help with opiod addiction and have never heard of anyone dying or needing to be hospitalized.

So, I guess I'm saying it's safe if you trust the person giving it to you to know how potent their plants are and to give you an appropriate dose.  And, as I said before, if you don't have a heart condition and aren't on other medications that could interact with it.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


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Invisibleredgreenvines
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Re: If you cold design the perfect psychedelic? [Re: Nillion]
    #28611580 - 01/06/24 10:51 AM (21 days, 21 hours ago)

Quote:

Nillion said:
Quote:

Northerner said:
Imagine for a moment you have the power of the universe and you could create the perfect psychedelic. What would it be like?




A drug that never requires a sitter for the user.



this would imply that the drug lacked the "break through" qualities that do frequently require a sitter


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InvisibleNillion
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Re: If you cold design the perfect psychedelic? [Re: Northerner] * 1
    #28611626 - 01/06/24 11:26 AM (21 days, 21 hours ago)

Right?

It was actually the last line in the following:

I’d want a drug that is absolutely safe, never terrifying or overwhelming or able to facilitate a sense of panic or discomfort, that has no negative side effects in anyone. 

I’d want the substance to elicit empathy, to increase tactile and sensory awareness and perceptive ability, to allow synaesthesia so that music can be seen and other senses mixed as well, able to instill a cosmic sense of oneness at even relatively low doses and the ability to allow individuals to explore the infinite kaleidoscopic playground where limits are set by imagination alone, at higher doses.  All in a way where people explore such worlds safely as they sit or lie and breathe, rather than wandering into traffic or falling into water. And the line I posted as a comment went right here where this line is.

I think the idea is to maximize benefit and reward while minimizing risk and adversity. My ideal psychedelic is safe and useful, though most psychedelics are safe and useful, in my opinion, when their use is approached responsibly.


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Re: If you cold design the perfect psychedelic? [Re: Nillion] * 1
    #28611882 - 01/06/24 03:44 PM (21 days, 16 hours ago)

IMHO, mescaline is perfect, if only it grew like mushrooms :smile: Over a lifetime, have consumed cactus tea at least 150 times plus, love, love.


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OfflineNorthernerM
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Re: If you cold design the perfect psychedelic? [Re: tregar] * 3
    #28612490 - 01/07/24 01:15 AM (21 days, 7 hours ago)

For me the ultimate psychedelic would be something akin to DMT, but without the fear and derealization. A perfect symphony of psychedelic landscapes and scenarios, with simple reintegration.


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Re: If you cold design the perfect psychedelic? [Re: Northerner] * 3
    #28612578 - 01/07/24 04:39 AM (21 days, 3 hours ago)

Mushrooms without anxiety


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Re: If you cold design the perfect psychedelic? [Re: Northerner]
    #28613528 - 01/08/24 12:31 AM (20 days, 8 hours ago)

LSD but with the emotions and depth of mushrooms, and zero anxiety and other bad unwanted effects even at high doses. Plus it would reliably cause that incredible inspiration and insight that only rarely occurs in normal psychedelics.



However, there is one other idea I want to bring up:

This is something I have seriously thought about ever since the first time I tried lysergamides:

I want the lysergic part of LSD, without the psychedelic part. A pure lysergic that is not a psychedelic.

I don't know if it's possible to separate the two, but to me it has always felt like lysergamides have a totally separate action that is different from their psychedelic effects. Like there are uniquely lysergic hallucinations, uniquely lysergic feelings, and uniquely lysergic ideas. It's always felt like two drugs in one to me: one a psychedelic and one something else. I honestly wish there was serious medical research into this subject, because I would bet money that you could separate the two effects.


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Re: If you cold design the perfect psychedelic? [Re: nooneman] * 2
    #28613674 - 01/08/24 05:59 AM (20 days, 2 hours ago)

There has been some pretty serious research on LSD receptor binding.

Here's a list of the receptor sites it hits in decreasing order of selectivity.

LSD: 4.00 5ht1b, 3.77 5ht7, 3.75 5ht6, 3.73 5ht1a, 3.70 5ht1d, 3.64 5ht5a, 3.54 5ht2a, 3.16 D3, 3.11 5ht2b, 3.11 5ht2c, 2.93 Alpha2A, 2.62 5ht1e, 2.55 D2, 2.39 D4, 2.34 D1, 2.05 D5, 1.54 Alpha1A, 1.40 H1, 1.39 Beta1, 1.05 Beta2, 0.65 Alpha1B

And this is a similar, non-psychedelic drug used to treat parkinson's ran in the same paper.

lisuride: 4.00 5ht1a, 3.88 Alpha2C, 3.78 Alpha2B, 3.22 Alpha2A, 3.01 5ht2b, 2.99 5ht5a, 2.90 D4, 2.74 5ht2a, 2.65 D2, 2.64 5ht7, 2.61 5ht6, 2.56 Beta1, 2.27 5ht1b, 2.09 Alpha1A, 1.93 Beta2, 1.83 5ht1e, 1.59 D5, 1.42 H2, 1.34 D3, 1.08 Alpha1B

LSD has a much stronger action on a lot of 5ht receptors (serotonin).  Both actually have action at 5ht2a (thought of as the classical psychedelic receptor) thought lisurides binding here is quite a bit lower (meaning it will mostly bind to other receptors, and with it's strong action on adrenaline receptors and little affinity for other serotonin receptors, you're likely to be having a really bad time before you start tripping).

Both bind to a lot of other receptors.  D is dopamine.  Alpha and Beta are adrenal receptors.  The numbers are specific receptor subtypes.

Here's DMT and Psilocybin just for fun.

DMT: 4.00 5ht7, 3.97 5ht1d, 3.91 5ht2b, 3.53 Alpha2B, 3.53 Alpha2C, 3.51 D1, 3.42 5ht2c, 3.28 5ht1e, 3.25 5ht6, 3.16 5ht5a, 3.13 Imidazoline1, 2.95 Alpha1B, 2.75 Alpha2A, 2.70 Alpha1A, 2.58 5ht2a, 2.37 SERT, 2.23 Sigma1

Not sure about Imidazoline, but SERT is the serotonin reuptake transporter.  SSRIs target this.  Sigma we're still trying to understand.  But it shows up in a few types of disassociatives and I think might be responsible for the out of body experiences people have on DMT and PCP etc.

Psilocin: 4.00 5ht2b, 3.40 5ht1d, 3.37 D1, 3.03 5ht1e, 2.88 5ht1a, 2.83 5ht5a, 2.82 5ht7, 2.82 5ht6, 2.67 D3, 2.52 5ht2c, 2.19 5ht1b, 2.14 5ht2a, 1.77 Imidazoline1, 1.74 SERT, 1.57 Alpha2B, 1.36 Alpha2A, 1.03 Alpha2C

Primarily serotonin.  SERT and Imidazoline show up again.  Adrenal A but not B. Dopamine action at fewer sites than LSD.

Original paper.  And it is pretty outdated but still very useful.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814854/

edit:  the tldr version is LSD has a lot of action at dopamine sites other psychedelics don't.  Dopamine is stimulating but it's primarily the reward circuit for learning.  It gives you the sense of having epiphinies.  The novel nature of having the serotonin system triggered in such a way means you probably are having some actual epiphinies too.

The first time I smoked crystal meth I felt I was having a lot of epiphenies, they turned out to be bullshit.  My point here is that dopamine is that 'sense' of aha!  It's not the aha (or novel thing) itself.


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Edited by tree frog (01/08/24 06:32 AM)


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Re: If you cold design the perfect psychedelic? [Re: tree frog]
    #28613680 - 01/08/24 06:02 AM (20 days, 2 hours ago)

2CB is perfect :awedance:

Duration - effects - can be snorted - museum dose is perfect etc..


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Re: If you cold design the perfect psychedelic? [Re: connectedcosmos]
    #28613703 - 01/08/24 06:34 AM (20 days, 2 hours ago)

Quote:

connectedcosmos said:
2CB is perfect :awedance:

Duration - effects - can be snorted - museum dose is perfect etc..




It's to perfect for me lol

Only psychedelic my ego fell in love with and I gave away due to excessive use.

I'd love to take it again sometime with my current gf though.  I think it would be a blast.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
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Edited by tree frog (01/08/24 06:35 AM)


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Re: If you cold design the perfect psychedelic? [Re: tree frog]
    #28613734 - 01/08/24 07:03 AM (20 days, 1 hour ago)

I never found 2cb, came around to RC's too late.


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Re: If you cold design the perfect psychedelic? [Re: redgreenvines]
    #28613770 - 01/08/24 07:47 AM (20 days, 50 minutes ago)

you're not missing out on anything i think! i always found it inferior to other psychs, with more physical side effects (nausea, phenethylamine heartrate)

but as i said before, ketamine would really suit your mind.. it has this primordial empty space...


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Edited by epilectric (01/08/24 07:51 AM)


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Re: If you cold design the perfect psychedelic? [Re: redgreenvines]
    #28614825 - 01/09/24 05:44 AM (19 days, 2 hours ago)

Quote:

redgreenvines said:
I never found 2cb, came around to RC's too late.




I snagged some off the original silk road when it was a thing otherwise I would have missed it too.  Got a lot out of 2c-e around that same time though the body load was like, btw, you're dying every second of every day.


--------------------
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Re: If you cold design the perfect psychedelic? *DELETED* [Re: tree frog]
    #28615301 - 01/09/24 01:54 PM (18 days, 18 hours ago)

Post deleted by Typerwritermonky

Reason for deletion: friend deleting his recent posts for safety


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Re: If you cold design the perfect psychedelic? [Re: Typerwritermonky]
    #28615434 - 01/09/24 04:00 PM (18 days, 16 hours ago)

Quote:

Typerwritermonky said:
I got some 2CB but I tried it when I was on an awesome acid trip and it ruined it, so I got turned off from it and gave it all away.  The people I gave it to were so confused because they loved it and couldn't ever find it.


The perfect psychedelic for me is LSD-25 as it is with a shorter time frame akin to mushrooms.  Peaking in 1 hr, 3 hr peak, and 2h of coming down.  At around hour 7, your fairly sober and can easily smoke weed and fall asleep.

LSD-25 is the perfect psychedelic, but it takes me almost 2.5 hours to peak on it, and that come up every time is a challenge for me, no matter how clean the LSD is, yet every time around 2.5 hours in I feel fantastic and once I'm peaking and the come up is over it's smooth sailing.  It's not that the come up is so bad, it just lasts so damn long that there are some hard moments to traverse sometimes that can easily set the tone for a bad experience if not handled correctly, and in 2 and a half hours a lot more can go wrong then just one hour of a come up.


Lorenzo from the Psychedelic Salon once spoke of a substance he took that Nick Sands gave him that was LSD that lasted 4 hrs just like I described and you could take it back to back days without issue like DMT.  I tried to get him to talk about it more, but he never will - I respect the hell out of the dude and have been supporting him on patreon for years - but I kinda think he was making that one up or misremembered it being maybe something like 2C-B or another RC that Shulgin had developed and just calls it a LSD lysergamide type drug.

If anyone knows him better I'd love to speak with him about this supposed magical LSD that lasts 4 hrs.



If your a patron doesn't that already give you and in?

If you don't feel comfortable just asking you could write up 8 interview questions and tell them you want to do an interview and include that as one of the questions?


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Invisibleconnectedcosmos
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Re: If you cold design the perfect psychedelic? [Re: elasticaltiger]
    #28615442 - 01/09/24 04:05 PM (18 days, 16 hours ago)

2CB is like mescaline , without the legs IMO


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54. The true nature of things is to be known personally , through the eyes of clear illumination and not through a sage : what the moon exactly is , is to be known with one's own eyes ; can another make him know it?


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Re: If you cold design the perfect psychedelic? [Re: connectedcosmos]
    #28615445 - 01/09/24 04:08 PM (18 days, 16 hours ago)

Does it have any characteristics that mescaline does not? Or is it just as you say, lacking the legs?


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Re: If you cold design the perfect psychedelic? [Re: Bardy] * 1
    #28615470 - 01/09/24 04:34 PM (18 days, 16 hours ago)

Well you can easily snort it , as it's much more potent by weight , as far as effects go - it seems to share the qualities of mescaline visuals opposed to LSD or mushrooms

It just doesn't last too long  at all especially insufflated , tripping within 10-20m and by 2 hours if not increasing dosage with small bumps you come down - and the tolerance is super forgiving :awesomenod:


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54. The true nature of things is to be known personally , through the eyes of clear illumination and not through a sage : what the moon exactly is , is to be known with one's own eyes ; can another make him know it?


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Re: If you cold design the perfect psychedelic? [Re: connectedcosmos] * 1
    #28615495 - 01/09/24 04:56 PM (18 days, 15 hours ago)

Sounds pretty good to me


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Re: If you cold design the perfect psychedelic? [Re: Bardy] * 1
    #28615522 - 01/09/24 05:16 PM (18 days, 15 hours ago)

If you ever have the chance , definitely scoop some up :awesomenod:  I think I used 600mg or so within a year or two

Such a versatile drug I combined it with shrooms, LSD , nitrous , 5mapb and 6apb


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54. The true nature of things is to be known personally , through the eyes of clear illumination and not through a sage : what the moon exactly is , is to be known with one's own eyes ; can another make him know it?


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Re: If you cold design the perfect psychedelic? [Re: connectedcosmos]
    #28616082 - 01/10/24 07:51 AM (18 days, 46 minutes ago)

2cb hits my heart and stomach in an uncomfortable way. the headspace is okay, authentic, humorous, erotic, ... it reminds me of shrooms with an easier head


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Re: If you cold design the perfect psychedelic? [Re: epilectric]
    #28616207 - 01/10/24 10:25 AM (17 days, 22 hours ago)

LSD with a shorter duration, euphoria tantamount to MDMA and no come down?

Wouldn't get rid of the tolerance though as it already sounds unhealthy/dangerous enough!


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Re: If you cold design the perfect psychedelic? [Re: wolf8312] * 1
    #28617803 - 01/11/24 04:22 PM (16 days, 16 hours ago)

Quote:

wolf8312 said:
LSD with a shorter duration, euphoria tantamount to MDMA and no come down?

Wouldn't get rid of the tolerance though as it already sounds unhealthy/dangerous enough!






I'm with this guy, except if you could CONTROL the duration somehow during the trip + MDMA
+++ XANAX


I've shroomed lately. Just makes me miss blotters

Also, no long term effects.


I used to put a notch with a knife on my headboard for every trip i did. i was a little over 150 separate lsd trips when i got busy on other stuff.

I've done a TON of MDMA, was a Coke/Heroin (technically speedball) addict for over a decade and nothing messed me up long-term like Acid. 25 years later it still affects me.

I would tell the young-ins try not to trip on LSD more than 5-10 times depending on strength. Like no more than 5-10 separate trips or your playing with losing touch with reality in some sense, for years.

Oh and the wrong dose of MDMA can wipe the brain like a bad hard drive, saw it happen to a good buddy, from 1 dose.


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Edited by dovedescent7 (01/11/24 04:30 PM)


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: dovedescent7]
    #28617819 - 01/11/24 04:36 PM (16 days, 16 hours ago)

Yeah I feel like I had one of those brain wiping MDMA trips once… wasn’t completely wiped lol, but that combined with some really rough and intense shroom trips at the time plus one bad acid trip made me feel like more of an outcast than I already did.

Then the way I dealt with that was to smoke heaps of weed… not a good way of trying to integrate back into society.


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Re: If you cold design the perfect psychedelic? [Re: dovedescent7] * 1
    #28617977 - 01/11/24 06:50 PM (16 days, 13 hours ago)

Quote:

dovedescent7 said:
Quote:

wolf8312 said:
LSD with a shorter duration, euphoria tantamount to MDMA and no come down?

Wouldn't get rid of the tolerance though as it already sounds unhealthy/dangerous enough!






I'm with this guy, except if you could CONTROL the duration somehow during the trip + MDMA
+++ XANAX


I've shroomed lately. Just makes me miss blotters

Also, no long term effects.


I used to put a notch with a knife on my headboard for every trip i did. i was a little over 150 separate lsd trips when i got busy on other stuff.

I've done a TON of MDMA, was a Coke/Heroin (technically speedball) addict for over a decade and nothing messed me up long-term like Acid. 25 years later it still affects me.

I would tell the young-ins try not to trip on LSD more than 5-10 times depending on strength. Like no more than 5-10 separate trips or your playing with losing touch with reality in some sense, for years.

Oh and the wrong dose of MDMA can wipe the brain like a bad hard drive, saw it happen to a good buddy, from 1 dose.




If I notched my headboard every time I tripped in my life, I would be sleeping in a pile of sawdust.

I feel like all of the other drugs I did hurt my brain and body WAY worse than the psychedelics did.


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Re: If you cold design the perfect psychedelic? [Re: Pluviophile]
    #28617991 - 01/11/24 07:08 PM (16 days, 13 hours ago)

Quote:


If I notched my headboard every time I tripped in my life, I would be sleeping in a pile of sawdust.

I feel like all of the other drugs I did hurt my brain and body WAY worse than the psychedelics did.




Have to agree here. Every come down from a full on trip makes me feel like I'm coming out of a baptism. Cleansed, purified.

Well maybe not salvia...


Edited by elasticaltiger (01/11/24 07:10 PM)


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Re: If you cold design the perfect psychedelic? [Re: dovedescent7]
    #28618525 - 01/12/24 09:49 AM (15 days, 22 hours ago)

Quote:

dovedescent7 said:


I've done a TON of MDMA, was a Coke/Heroin (technically speedball) addict for over a decade and nothing messed me up long-term like Acid. 25 years later it still affects me.

I would tell the young-ins try not to trip on LSD more than 5-10 times depending on strength. Like no more than 5-10 separate trips or your playing with losing touch with reality in some sense, for years.

Oh and the wrong dose of MDMA can wipe the brain like a bad hard drive, saw it happen to a good buddy, from 1 dose.




Curious why LSD has fucked you up so bad especially 25 years later?


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Re: If you cold design the perfect psychedelic? [Re: CHUCK.HNTR]
    #28618552 - 01/12/24 10:21 AM (15 days, 22 hours ago)

I'm also curious about this.

I've taken LSD more times than I can remember, including too much one time, that was unpleasant. However I've not had the impression that it harmed me in any lasting way.


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Re: If you cold design the perfect psychedelic? [Re: Pluviophile]
    #28618553 - 01/12/24 10:24 AM (15 days, 22 hours ago)

Quote:

Pluviophile said:
If I notched my headboard every time I tripped in my life, I would be sleeping in a pile of sawdust.

I feel like all of the other drugs I did hurt my brain and body WAY worse than the psychedelics did.




Same here I feel it’s done nothing but help. Short term off and on meth use way back in the day I feel had a negative effect. Heavy daily drinking and anti social behavior for years definitely had a major negative effect.

Psychedelics have been nothing but good to me. There’s been some challenging exposures of forgotten inner demons I had no idea were affecting me. Different lines of questioning and struggling to deal with that aspect at times. Living outside of societies standards so to speak and “common sense expectations” if you will, but going back to child good I’ve never really felt like I fit in or belonged as it is. Not even at home or at school.


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Re: If you cold design the perfect psychedelic? [Re: PancyanterA]
    #28618569 - 01/12/24 10:43 AM (15 days, 21 hours ago)

Quote:

PancyanterA said:
Quote:

Pluviophile said:
If I notched my headboard every time I tripped in my life, I would be sleeping in a pile of sawdust.

I feel like all of the other drugs I did hurt my brain and body WAY worse than the psychedelics did.




Same here I feel it’s done nothing but help. Short term off and on meth use way back in the day I feel had a negative effect. Heavy daily drinking and anti social behavior for years definitely had a major negative effect.

Psychedelics have been nothing but good to me. There’s been some challenging exposures of forgotten inner demons I had no idea were affecting me. Different lines of questioning and struggling to deal with that aspect at times. Living outside of societies standards so to speak and “common sense expectations” if you will, but going back to child good I’ve never really felt like I fit in or belonged as it is. Not even at home or at school.




It's gonna be OK Pan. :hug:


--------------------
First time growing cakes? DON'T make a Shotgun Fruiting Chamber

The Shmuvbox. - The Old TC's Like it :shrug:

Afraid to Start Growing From Your Own Prints? Drop it Like a Tiger!
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Pastywhite's Easy Agar Tek (PastyPlates)

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Re: If you cold design the perfect psychedelic? [Re: elasticaltiger]
    #28618615 - 01/12/24 11:34 AM (15 days, 21 hours ago)

Haha thanks! It absolutely is!


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InvisibleShroomers420
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Re: If you could design the perfect psychedelic? [Re: Northerner]
    #28619185 - 01/12/24 08:56 PM (15 days, 11 hours ago)

If I had the power of the universe, I would create a psychedelic that would cause someone to have a really good trip right before a really bad one, and then bring them back the good trip and then take them back down to a bad one before slowly bringing them back up to a peak and then back down to baseline.

Why?

The reason why, is because this yoyo effect can cause the realization and appreciation of each side and make better for the trip experience.

As a "higher power" having the ability to do this would train the human brain to accept suffering and accept nothing as granted. In addition cause the inner chi of the person to activate.

Once the inner chi is activated, there is no telling what that person could do. They could become martial arts experts or CEO's of powerful lawfirms, or... just the worlds best mountain hiker and survivalist.

Neat thread BTW:mushroom2:


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Invisibleelasticaltiger
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Re: If you could design the perfect psychedelic? [Re: Shroomers420]
    #28619234 - 01/12/24 09:40 PM (15 days, 10 hours ago)

Yeah this is a neat thread. It's interesting to see that the perspectives of what's desirable really range all over the spectrum from people who wouldn't change a thing to people who desire something completely fantastical. Just goes to show you how hard it is to study these compounds when everyone's personal experiences are so unique.


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InvisibleThe Blind Ass
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Re: If you could design the perfect psychedelic? [Re: elasticaltiger]
    #28619242 - 01/12/24 09:50 PM (15 days, 10 hours ago)

Quote:

What would it be like?




Something natural, evolving, almost like….wait a sec…

Sentient Life?

:tripnoob:


--------------------
Give me Liberty caps -or- give me Death caps


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InvisibleShroomers420
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Re: If you could design the perfect psychedelic? [Re: elasticaltiger]
    #28619246 - 01/12/24 09:56 PM (15 days, 10 hours ago)

Quote:

elasticaltiger said:
Yeah this is a neat thread. It's interesting to see that the perspectives of what's desirable really range all over the spectrum from people who wouldn't change a thing to people who desire something completely fantastical. Just goes to show you how hard it is to study these compounds when everyone's personal experiences are so unique.





RIght! This tingles my brain so much to know that my perspective is just one- among billions, but by the way I act and talk sometimes you might thing I am the only person on earth who knows how to slice bread.


--------------------
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Offlinetregar
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Re: If you could design the perfect psychedelic? [Re: Shroomers420]
    #28619314 - 01/13/24 01:36 AM (15 days, 7 hours ago)

Nillion, I'm not a vendor nor ever been, you might be thinking of 69ron, I am not 69ron. Lifelong chemist and researcher. Anyways, I cracked the code on how to make THH at home in only 1.5 hour, no exotic chemicals needed like in TIHKAL, more on this below.

--> To those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by an hour +, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I love that it lasts incredibly long allready.

Sabnock said:
Quote:

There may be some confusion surrounding THH for people. From my understanding, the form of THH found in the B. Caapi vine is purely a Serotonin reuptake inhibitor and ime it certainly feels that way, it doesn't have or at least isn't supposed to have MAOI properties, which that comes from the Harmine and Harmaline.


Sabnock is a legend, read countless posts from him and he is indeed correct.

Bardy said:
Quote:

DMT-nexus says: Like other harmala alkaloids it is a RIMA reversible inhibitor of monoamine oxidase A. However, unlike harmine and harmaline, THH also inhibits reuptake of serotonin.
https://wiki.dmt-nexus.me/Tetrahydroharmine
Are you claiming these folks are wrong?


Yes, that information is incredibly vague or unclear. The sentence is very vague in that it does not tell you it would take a severe overdose of THH to inhibit MAO-A and MAO-B.

From Interprise chemical:
Quote:

THH is a fluorescent indole alkaloid extracted from B. caapi that inhibits MAO-A and MAO-B with much weaker potency (IC50s = 74 nM and >100 μM, respectively) compared to its companion harmala alkaloids: harmaline (IC50s = 2.5 nM and 25 μM, respectively) and harmine (IC50s = 2 nM and 20 μM, respectively)


https://interpriseusa.com/product/tetrahydro-harmine-10-mg/

Keep in mind, the lower the nM, the higher or stronger the activity. Reading those numbers, you would have to take 30 times the normal dosage of 100mg THH, or 30 x 100 = 3,000mg THH just to equal rima activity of 100mg of harmaline, and it takes at least 100mg of harmaline to activate DMT. That much THH would be an overdose and most likely kill a person. My max is 300mg of THH.

It takes around 150mg of harmine to activate DMT, that would require 5500 mg of THH to do the same.

--> If you remember 69ron, I was not around when he used to post, as I was at the mescaline king forum thenook.org for at least a decade (now extinct) he claimed that THH alone would activate DMT, this is completely un-true, this earned him or her a very bad reputation as people found out after his writing of this, that no such thing was possible.

Bardy said:
Quote:

So contrary to what you claim, THH is found in Syrian Rue, but in smaller amounts than Caapi.


When you compare 4.3% harmine and 5.6% harmaline to 0.1% THH, you end up with next to nothing in the seeds as THH.

There is absolutely no significant amount of THH in rue seeds, period...but you can make THH from harmaline in 1.5 hour. Even as a chemist, I spent months trying to make THH from harmaline without using exotic chemicals like TIHKAL, after months of failure, I went into a trance and was given a vision of how to complete the process I was stuck at using an over the counter chemical and explain how to make it simply in link below, I wanted humanity to know how to do this, as I feel it is extremely important.

Hallucinogenic Plants in the Mediterranean Countries, Ioannis D. Passos, Maria Mironidou-Tzouveleki, in Neuropathology of Drug Addictions and Substance Misuse, 2016:
Quote:

The content of dried seeds of the plant in harmine is about 4.3% w/w, 5.6% in harmaline, 0.6% in harmalol, and 0.1% in tetrahydroharmine.


https://www.sciencedirect.com/topics/neuroscience/tetrahydroharmine

Older Caapi is becoming close to extinct as harvesters have to go further and deeper into the Jungle...hence the over hundred spiritual centers in South America are having to harvest younger cappi with much less tetrahydroharmine, here in link below is an alternative to help conserve while it grows over many years:

Traditional true Ayahuasca has always been (1) Caapi by itself or (2) Caapi with psychotria viridis or Diplopterys cabrerana.

12 reasons THH rocks and how to make her here: https://www.shroomery.org/forums/showflat.php/Number/28423951/fpart/all

Nillion, I'm not a vendor nor ever been, you might be thinking of 69ron, I am not 69ron. Lifelong chemist and researcher. Anyways, I cracked the code on how to make THH at home in only 1.5 hour, no exotic chemicals needed like in TIHKAL, more on this below.

Bardy said:
Quote:

We get it Tregar. THH makes shrooms better for you. You’ll find that it is a RIMA as well as being an SRI I think.


I'm a life long chemist, and know my chemistry, THH is 100% SRI and not a significant RIMA at all. Harmine is a RIMA, so is harmaline. THH is the 2nd highest alkaloid in caapi, in same family as ibogaine with a 10.5 hour half life with peak at 5.25 hours.

Be careful if you buy THH from china (liftmode) as there have been reports of it not staining blue under UV (like real THH) but green, indicating harmaline is still in it.  Dab a cue tip in vinegar, then take up a bit of your THH, smear on a paper plate, hold under uv light, if it glows blue you got pure thh, if any yellow or green it's contaminated with harmaline.

Freedom said:
Quote:

Its kind of odd that no one else seems to have any reports of THH combos, not on erowid or blue light as far as i can tell



Freedom, You will find no reports of THH + mushrooms or THH + LSD cause this is brand new cutting edge, but I've been doing it for many years, gorgeous experience, it's like taking a low dose of mescaline with you shrooms or acid.

THH or tetrahydroharmine is the best kept secret in the psychedlic world:

THH and how to make her (along with many trip reports of 300mg THH by itself):

https://www.shroomery.org/forums/showflat.php/Number/28423951/fpart/1/vc/1

More of my research (10 topics), on the cutting edge, and why dmt should always be taken with thh as found in true Ayahuasca:

https://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/

2 minute formed HPBCD DMT liquid very bioavailable sublingually under tongue & outperforms DMT salts orally by many factors in personal trials, combo with tetrahydroharmine, Ayahuasca.

Part 0: 12 reasons pure THH or tetrahydroharmine rocks (this post #1 in middle)
Part 1: HPBCD complexed DMT experimental dosage, effects & duration, over 44 sublingual DMT experiences over a year's time (this post #1 at bottom). Many times stronger than oral DMT. Updated 1-1-2022.
Part 2: Receptorome chart & explanation
Part 3: Tetrahydroharmine (THH) effects
--> Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note
Part 5: Chemist Patrick Arnold's HPBCD prohormones & bloodwork studies
part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal, absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection.
part 7: a little bit on my 70 Ayahuasca experiences, doses & visions
part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water
part 9: 20 minute visionary visit from a dead Aztec Shaman
part 10: One way to make pure tetrahydroharmine
part 11: From the archives of DMT world: How to easily extract 2.3g DMT from 170g bark using a 2 liter Erlenmeyer flask
part 12: Out of print writings on the Divine Plant of the Incas, coca leaf visions...and writings on strong euphoria from coca leaf tea bags soaked in wine, forming orally active cocaethylene in the liver, discovered in 1994. Explains the popularity of Vin Mariani (coca leaf soaked wine) with both popes, Thomas Edison and countless celebrities.
part 13: THH + mushrooms report from JKW.
part 14: Multiple encounters with death & depression.

Northerner said:
Quote:

It's popular enough if you go and read on dmtnexus. Used with DMT orally though rather than shrooms, but it's very much a thing.


Thank you Northerner. I've been taking dmt with THH for many, many years, here is a compilation of my 50 + trip reports with many pics of the 150mg harmine + 70-300mg THH + 90mg dmt true Ayahuasca capsules:

https://www.shroomery.org/forums/showflat.php/Number/28189371/fpart/all

Since harmine has a half life of from 1 to 3 hours, I redose at the 1.5 hour to 2 hour point using only 75mg harmine + 90mg dmt in a single capsule again for a +4 moderately strong experience, as 1/2 the harmine dose is still active from the first dose. You don't have to add anymore THH since THH has a half life of 10.5 hours, peaking at around 5 hours. You can re dose as many times as you want, continues to work strongly.

This gives me a total 4 hour strong trip that is easy to handle, with hours of afterglow. Going beyond 120mg DMT is not recommended, see my trip reports on page 2. I recommend crushing the dmt freebase into fresh aloe vera gel from fresh leaf (*almart carries fresh leaf in grocery section or buy on line, store excess gel in freezer as it only lasts 1 week in fridge, defrost more when needed) only as the polysaccharides in the fresh leaf increase the penetration of the dmt into the intestines by many factors, for an experience that can easily reach +4 to +5 and is all encompassing and super colorful just like real Jungle Ayahuasca, I've noticed no difference in strength between these zero nausea Ayahuasca capsules and real Ayahuasca brew I've prepared from caapi and Hawaiian psychotria.

THH + mushrooms report from JKW:
Quote:


Tregar, just wanted to let you know that I finally tried 3 grams of cubensis with 180 mg of THH, and all I can say is WOW! Intense and beautiful like I've never had before, with a definite DMT edge to it.

I've always been a hard-head, needing 4.5+ grams to get anywhere interesting. I've done up to 9 grams, and never got near this intensity.

Just wanted to thank you for the tip. This is the way for me to go form now on.
I look forward to combining THH with DMT.

All the best, and take care.





Edited by tregar (01/21/24 09:46 AM)


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InvisibleShroomers420
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Re: If you could design the perfect psychedelic? [Re: tregar]
    #28619324 - 01/13/24 02:13 AM (15 days, 6 hours ago)

Quote:

tregar said:
For those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by hours, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I lo
Quote:

tregar said:
For those who experience anxiety on shrooms...If you take shrooms along with 70mg of pure thh or tetrahydroharmine, not only does it eliminate anxiety, add crystal clear clarity, increased euphoria, but the shroom trip is extended by hours, done it countless times myself, absolutely incredible gorgeous experience. Thh is a psychedelic sri not maoi found in cappi. Damn near perfect psychedelic combo....other than that mescaline is all ready the perfect psychedelic, drank cactus tea over 150 times over many years. I love that it lasts incredibly long allready.




WHEN i DID SHROOMS IT WWAS LLIKE i AND WE JUST


--------------------
:potleaf::tomatoface::fairy:
Shroomers with the 420


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InvisibleShroomers420
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Re: If you could design the perfect psychedelic? [Re: Shroomers420] * 1
    #28619327 - 01/13/24 02:19 AM (15 days, 6 hours ago)

i WRITE THIS FROM THE BLANK FACE
i WRITE FROM TTHE
i WRITE FROM TTEH
i WRIE FROM HTE THE
i WRITE FROM THE


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Offlinetree frog
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Re: If you cold design the perfect psychedelic? [Re: CHUCK.HNTR]
    #28619389 - 01/13/24 05:31 AM (15 days, 3 hours ago)

Quote:

CHUCK.HNTR said:
Quote:

dovedescent7 said:


I've done a TON of MDMA, was a Coke/Heroin (technically speedball) addict for over a decade and nothing messed me up long-term like Acid. 25 years later it still affects me.

I would tell the young-ins try not to trip on LSD more than 5-10 times depending on strength. Like no more than 5-10 separate trips or your playing with losing touch with reality in some sense, for years.

Oh and the wrong dose of MDMA can wipe the brain like a bad hard drive, saw it happen to a good buddy, from 1 dose.




Curious why LSD has fucked you up so bad especially 25 years later?




Not the person you asked but I had a bad acid trip in my twenties that fucked me up for about ten years.

DMT and actually, more LSD, helped me sort it out.  Along with good social supports.

What fucked me up wasn't the drugs, but the social context I took them in along with discovering vulnerable parts of myself I felt ashamed of integrating at the time.

Also, tripped well over 100 times on LSD and 100 more on shrooms.  I'd tell the youngins to eat until you're full.  But wait until you're an adult and take them in safe spaces.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


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InvisibleNillion
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Re: If you cold design the perfect psychedelic? [Re: tree frog]
    #28619442 - 01/13/24 07:04 AM (15 days, 1 hour ago)

Interesting.
I had a bad experience with LSD once and wasn't comfortable with taking it again for about 8 years.
Also in my 20s.


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InvisibleCHUCK.HNTR
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Re: If you cold design the perfect psychedelic? [Re: Nillion]
    #28619498 - 01/13/24 08:30 AM (15 days, 7 minutes ago)

Tree frog, I feel you, the way I read dovedescent7’s comments were that it fucked him up physically health wise more like brain damage not a “bad trip” type of fucked up, but that’s why I wanted to hear more.

Like you, I took nearly a decade break from psychedelics after a bad trip in Amsterdam in 2007. It was during the short window that fresh shrooms were legal there.
I’m glad I found my way back to them with more maturity and respect.


--------------------
"What is the practical application of a million universes?" -Alan Watts
:mushroom2::mushroom2::mushroom2::mushroom2::mushroom2:


Edited by CHUCK.HNTR (01/13/24 08:31 AM)


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OfflinePancyanterA
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Re: If you cold design the perfect psychedelic? [Re: Nillion]
    #28619502 - 01/13/24 08:33 AM (15 days, 4 minutes ago)

Quote:

tree frog said:What fucked me up wasn't the drugs, but the social context I took them in along with discovering vulnerable parts of myself I felt ashamed of integrating at the time.




That makes perfect sense. In my opinion people should be older and already on the path of personal development/healing before touching a psychedelic.

Explains why so many people have zero interest or get turned off as well.


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OfflineBardy
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Re: If you cold design the perfect psychedelic? [Re: PancyanterA]
    #28622420 - 01/15/24 05:18 PM (12 days, 15 hours ago)

I’m gonna sound like a real stoner here… Maybe not the perfect psychedelic, but I think it’d be cool if there was a synthetic cannabinoid on the market which:
- lasted only one to two hours
- cleared your system quickly (no next day grogginess)
- was less toxic than THC
- was non addictive.

That’d be cool too I think. Obviously wouldn’t be as enlightening as others people have mentioned here.


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