Home | Community | Message Board


This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Kraken Kratom Red Vein Kratom   PhytoExtractum Maeng Da Thai Kratom Leaf Powder   Mushroom-Hut Mono Tub Substrate   North Spore Bulk Substrate   Unfolding Nature Unfolding Nature: Being in the Implicate Order

Jump to first unread post Pages: 1
InvisibleWeStoneded
Rambler
Male
Registered: 12/21/23
Posts: 1
Ergot Alkaloids added to substrate * 1
    #28592650 - 12/21/23 11:40 AM (1 month, 6 days ago)

Over the years I've kept up with many old threads of people adding alien tryptamines and other things to their substrate because Mr. shulgan said the enzymes would simply add a 4ho ring to the front of the drug. Many people have tried but never came up with any conclusive evidence this works. However in the book Ergot Alkaloids by Albert Hofman he describes something I haven't read anywhere on this site.

"The Mexican psychoactive fungus Psilocybe semperviva Heim Cailleux hydroxylates tryptophan in the 4-position during the biosynthesis of psilocybin, a hallucinogenic agent of this magic drug. When this basidiomycete acted on the ergot Alkaloids of the clavine series, which are foreign to it and in which the 4-position of the indole system is already occupied, hydroxylation occurred in the 8-position of the ergoline system. Elymoclavine added to shaking cultures or standing  cultures of the fungus Psilocybe semperviva Heim et Cailleux was converted into penniclavine and isopennicalvine. In parallel with this hydroxylation, degradation proceeds to products that no longer show color reactions of the ergot Alkaloids."

If anyone knows where I can find more info on Penniclavine, Ive read that it's active but that's about it. Also if this is not the correct forum to post about this I apologize it's my first post.


Extras: Filter Print Post Top
OfflineNichrome
I'm a torso!
I'm a teapot User Gallery

Registered: 12/17/18
Posts: 6,475
Loc: Zone 5
Last seen: 8 hours, 36 minutes
Trusted Cultivator
Re: Ergot Alkaloids added to substrate [Re: WeStoneded] * 1
    #28593463 - 12/21/23 09:59 PM (1 month, 5 days ago)



--------------------
Better to be deprived of food for three days, than tea for one.


Freedom is not the right to do as you please, but the liberty to do as you should. ~Emerson


Extras: Filter Print Post Top
InvisibleNillion
Nobody

Registered: 04/14/22
Posts: 1,000
Loc: Terra Firma
Re: Ergot Alkaloids added to substrate [Re: WeStoneded] * 1
    #28599874 - 12/27/23 02:17 PM (1 month, 7 hours ago)

First, the reason that people believe that tryptamine can be added to media and incorporated into alkaloids is because of work by Jochen Gartz showing just that. Shulgin had nothing to do with it. Look for: Gartz, J." Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe", J. Basic Microbial. 29(6) (1989) 347–352.

https://files.shroomery.org/cms/Biotransformation_of_tryptamine_derivatives.pdf


In the Hoffman papers at Erowid you can find a couple of Japanese studies done on the activity of Clavine alkaloids.

A case can be made that LSA is not actually very active and that in Ipomoea species the primary psychedelic compounds are clavine alkaloids like elymoclavine and others. This is one of the areas I focus on but there is not a lot of work done on it, largely due to widespread misconceptions about psychelic molecules. Still some work is being done on this like:
https://www.researchgate.net/publication/375851515_Biological_studies_of_clavine_alkaloids_targeting_CNS_receptors
which was published just last month.

I think the abstract of that paper speaks well enough for itself:
Quote:

In contrast to well established psychedelics such as lysergic acid diethylamide
(LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been
thoroughly investigated, in spite of their broad occurrence in nature and their
well-established potent physiological effects. This study presents the current
knowledge on the biological properties of clavine alkaloids, draws comparisons
to the pharmacology of ergolines and related psychedelics, and demonstrates
opportunities to develop novel structure–activity relationship (SAR) profiles.
The latter could usher in a new stage of medicinal chemistry studies that enable
an expansion of the currently structurally limited portfolio of psychedelic
therapeutics.




Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: Kraken Kratom Red Vein Kratom   PhytoExtractum Maeng Da Thai Kratom Leaf Powder   Mushroom-Hut Mono Tub Substrate   North Spore Bulk Substrate   Unfolding Nature Unfolding Nature: Being in the Implicate Order


Similar ThreadsPosterViewsRepliesLast post
* Ergot Sclerotia in Rye Grain altarego 16,687 17 02/01/09 07:31 PM
by inski
* Chocolate Substrate agar 1,893 8 12/08/04 10:25 PM
by chocbruce
* Increasing alkaloid levels
( 1 2 3 4 all )
iudexk 11,418 62 01/28/23 09:26 AM
by Thomas Envisio
* For doubters of the DMT substrate method.
( 1 2 all )
Explorer 9,215 30 05/22/01 09:10 AM
by gray1
* effect of phosphorus in substrate........................... ph_plus 3,055 6 07/12/03 01:10 AM
by micro
* Putting HBWR seeds in the substrate. theshiftingwalls 2,469 18 09/06/03 11:35 PM
by IdLeMiND
* Mushrooms as substrate? Anonymous 1,591 13 01/23/03 02:37 AM
by MAIA
* Lets start fresh...DMT substrate
( 1 2 3 4 5 all )
Bleuboxo 26,263 98 05/18/06 06:48 AM
by nimmen

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: RogerRabbit, Pastywhyte, bodhisatta
253 topic views. 1 members, 3 guests and 5 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.031 seconds spending 0.004 seconds on 12 queries.