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WeStoneded
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Registered: 12/21/23
Posts: 1
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Ergot Alkaloids added to substrate 1
#28592650 - 12/21/23 11:40 AM (1 month, 6 days ago) |
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Over the years I've kept up with many old threads of people adding alien tryptamines and other things to their substrate because Mr. shulgan said the enzymes would simply add a 4ho ring to the front of the drug. Many people have tried but never came up with any conclusive evidence this works. However in the book Ergot Alkaloids by Albert Hofman he describes something I haven't read anywhere on this site.
"The Mexican psychoactive fungus Psilocybe semperviva Heim Cailleux hydroxylates tryptophan in the 4-position during the biosynthesis of psilocybin, a hallucinogenic agent of this magic drug. When this basidiomycete acted on the ergot Alkaloids of the clavine series, which are foreign to it and in which the 4-position of the indole system is already occupied, hydroxylation occurred in the 8-position of the ergoline system. Elymoclavine added to shaking cultures or standing cultures of the fungus Psilocybe semperviva Heim et Cailleux was converted into penniclavine and isopennicalvine. In parallel with this hydroxylation, degradation proceeds to products that no longer show color reactions of the ergot Alkaloids."
If anyone knows where I can find more info on Penniclavine, Ive read that it's active but that's about it. Also if this is not the correct forum to post about this I apologize it's my first post.
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Nichrome
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Re: Ergot Alkaloids added to substrate [Re: WeStoneded] 1
#28593463 - 12/21/23 09:59 PM (1 month, 5 days ago) |
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-------------------- “Better to be deprived of food for three days, than tea for one.”
Freedom is not the right to do as you please, but the liberty to do as you should. ~Emerson
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Nillion
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Re: Ergot Alkaloids added to substrate [Re: WeStoneded] 1
#28599874 - 12/27/23 02:17 PM (1 month, 7 hours ago) |
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First, the reason that people believe that tryptamine can be added to media and incorporated into alkaloids is because of work by Jochen Gartz showing just that. Shulgin had nothing to do with it. Look for: Gartz, J." Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe", J. Basic Microbial. 29(6) (1989) 347–352.
https://files.shroomery.org/cms/Biotransformation_of_tryptamine_derivatives.pdf
In the Hoffman papers at Erowid you can find a couple of Japanese studies done on the activity of Clavine alkaloids.
A case can be made that LSA is not actually very active and that in Ipomoea species the primary psychedelic compounds are clavine alkaloids like elymoclavine and others. This is one of the areas I focus on but there is not a lot of work done on it, largely due to widespread misconceptions about psychelic molecules. Still some work is being done on this like: https://www.researchgate.net/publication/375851515_Biological_studies_of_clavine_alkaloids_targeting_CNS_receptors which was published just last month.
I think the abstract of that paper speaks well enough for itself:
Quote:
In contrast to well established psychedelics such as lysergic acid diethylamide (LSD) and psilocybin, ergot alkaloids of the clavine subclass have not been thoroughly investigated, in spite of their broad occurrence in nature and their well-established potent physiological effects. This study presents the current knowledge on the biological properties of clavine alkaloids, draws comparisons to the pharmacology of ergolines and related psychedelics, and demonstrates opportunities to develop novel structure–activity relationship (SAR) profiles. The latter could usher in a new stage of medicinal chemistry studies that enable an expansion of the currently structurally limited portfolio of psychedelic therapeutics.
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