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OfflineSabnock
Be Your Own Shaman
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Registered: 01/02/14
Posts: 3,249
Last seen: 14 hours, 50 minutes
Re: The official psilohuasca thread [Re: Blue_Lux]
    #28335762 - 05/26/23 03:35 PM (7 months, 29 days ago)

Quote:

Blue_Lux said:
Do you have to not eat something in particular before you drink the harmalas? I have heard this can have side effects if you don't take the proper precautions. What precautionary measures would you recommend?




Naw, there's no dietary interactions with Harmalas, and i've personally never abstained from any kind of food and have eaten plenty of different foods while on stiff doses of Harmalas and with gut MAO-A fully inhibited, never had any issues, i also haven't had any issues with Moclobemide. Harmalas and Moclobemide are reversible and selective MAO-A inhibitors, which is a certain class of MAOI, the kind of MAOI's that do require dietary restrictions are called irreversible MAOI's, usually non-selective as well (non-selective meaning they inhibit MAO-A and MAO-B, while selective means it only inhibits MAO-A or MAO-B but not both), and the issue with those is that because they're irreversible inhibitors, they knock out the MAO enzyme(s), usually both, for approx 2 weeks until MAO can regenerate itself, so Tyramine can build up to levels which can potentially cause a hypertensive crisis, whereas with the reversible inhibitors they only temporarily/transiently inhibit MAO. But Harmalas and Moclobemide are both reversible and selective MAO-A inhibitors meaning they only inhibit MAO-A (and not MAO-B) and they only inhibit gut MAO-A for approx two hours, after which gut MAO-A goes back to normal, plus Tyramine can be broken down by MAO-B while MAO-A is inhibited, or Tyramine can act as a competitive substrate for MAO-A if MAO-B can't handle it all and can displace the reversible MAO-A inhibition.

So basically a Tyramine reaction with Harmalas or Moclobemide is pretty impossible. Some people can experience headaches sometimes from Harmalas and then automatically blame Tyramine even though headaches can be a side-effect of quite a few properties of Harmalas and has nothing to do with Tyramine or diet.

The only thing i'd recommend would be to have an empty stomach and not eat anything like 6 hours beforehand, so that the Huasca is absorbed properly, as food in the stomach can throw off absorption/digestion of the medicine.


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OfflineShiroiTora
LBM
I'm a teapot


Registered: 03/16/21
Posts: 616
Loc: South Africa Flag
Last seen: 2 days, 7 hours
Re: The official psilohuasca thread [Re: Sabnock] * 3
    #28402392 - 07/21/23 01:42 AM (6 months, 5 days ago)

Yo quick bump to the psilohuasca thread..

I fucking did it again, psilohuasca down the hatch last night. It took a while to come back to since the last experience was so difficult, but I did a lot of preparation and I think it paid off. I also ditched the dealer shrooms and started growing myself, so this is only the second time I've tripped on my own home grown shrooms. It is for sure a game changer:mushroom2:

In terms of specifics for preparation, I made sure I was more familiar with Syrian rue's effects this time round, as the previous time I hadn't done rue in the weeks or even months preceding the trip. I think this was a contributing factor in the confusion and later angst in the first trip because I was expecting mushrooms, and the psilohuasca experience is a whole different animal. This time I made full strength rue tea(~6g) most days in last month, and a few times this month too.

As for dose I went a bit lower, 16g fresh p. Transkei mushrooms and only 3.7g Syrian rue. I could have probably went higher on the mushrooms but it was a one flush harvest from a particularly fast cake that looked ready, I didn't want to ruin yields of other cakes just because I was impatient so I stuck with that.

When it comes to the actual trip itself, I'm glad I followed Sabnock's advice and spread out the dose of the mushrooms this time, not ballz-to-the-wall lemon tek that I chugged like it was koolaid. I had 3 bigger mushrooms and 2 smaller ones, so I made 4 roughly equivalent doses and waited 10 minutes between each after I finished chewing. This prolonged the come-up, and also arranged it into 4 'waves' so I knew what was on the horizon at least. I noticed a liminal stage where it seems while the Syrian rue is peaking, the combo doesn't feel like either mushrooms or rue on its own, this thankfully didn't catch me as off guard as it did last time. This state intrigued me quite a bit, I remember in the trip thinking about something Jonathan Ott wrote about the interaction between receptor agonists and antagonists taken together that produce potentiation beyond that of any other method(this was for opiate receptors, but the same would probably apply to 5HHTin this case). It definitely felt like mainly physiological confusion, with my body not knowing what to do and going through cycles of hot and cold. I had heard others report about this stage as a full body electric buzzing sensation. I think my dose was a bit low to experience buzzing but I did feel that contradictory warm and cold fuzzy feeling in my chest like from just after taking a hit of DMT, only very drawn out.

This phase ended at about T+1.5h(after the last mushroom dose), and was the most "panicky" part of the experience, as my heart rate was pretty much up there for most of it. After that the mushrooms started coming through more and I started having visuals. At some point I had the unique sensation that I'm a skeleton powered by spirit energy or some shit dragging my muscles around which was quite interesting. I took a long ass bath as I always do(or want to do when I can't) on mushrooms, and afterwards at around T+3 I went out for a smoke of the ole devil's cabbage, once I was sure the come-up was over. This kicked the visuals into overdrive, I can not explain how fucking beautiful everything looked, and it has been a while since I have had such multicolored richly detailed and immersive CEVs on anything. It sure was great knowing I grew the lil' boomers that were blowing my mind at that moment.:grin:

After that, not much happened, slowly tapered off to the comedown. I was mostly back to baseline at about T+7h, so not that long for psilohuasca, but then again the dose was fairly low and I did wait a full hour after the rue to start eating the mushrooms, and also ate them for about an hour. All in all a wonderful trip with a wonderful afterglow, it was totally worth getting a grow setup going. I hope to report again in the future, until then keep it real shroomerites:rockon:


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InvisibleLithop
Spaghetti Days
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Registered: 04/09/22
Posts: 764
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Re: The official psilohuasca thread [Re: ShiroiTora]
    #28402408 - 07/21/23 02:52 AM (6 months, 5 days ago)

Quote:

ShiroiTora said:
Yo quick bump to the psilohuasca thread..




Sounds like a great one and glad that your homegrown mush really elevated things for you this time around :awesomenod: Everything from the bath to the devils cabbage (I laughed on that one, a nice hybrid of devils lettuce and moon cabbage) thanks for the report!
I'm very curious about haramalas/psilohuasca, will be doing some research...

:diademuertos:
^artists rendering of you in the spirit skeleton stage.


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๐ŸŒฌ๏ธ ๐ŸŒป โžžโžžโžž โฎโฎโฎโฎ ๐ŸŒˆ โนโ‘คโ“ฟ ๐ŸŒฌ๏ธ ๐ŸŒป โžžโžžโžž โฎโฎโฎโฎ ๐ŸŒˆ โนโ‘คโ“ฟ  ๐ŸŒฌ๏ธ ๐ŸŒป โžžโžžโžž โฎโฎโฎโฎ ๐ŸŒˆ โนโ‘คโ“ฟ


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OfflineShiroiTora
LBM
I'm a teapot


Registered: 03/16/21
Posts: 616
Loc: South Africa Flag
Last seen: 2 days, 7 hours
Re: The official psilohuasca thread [Re: Lithop] * 2
    #28403864 - 07/22/23 12:47 PM (6 months, 3 days ago)

Harmalas are the shit my dude, the genuine article. I highly recommend trying them, especially Syrian rue, its nice all on its own too, and isn't endangered.

Quote:


:diademuertos:
^artists rendering of you in the spirit skeleton stage.




Yea pretty accurate :lol:


Edited by ShiroiTora (07/22/23 12:47 PM)


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Offlineorphee
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Registered: 03/07/22
Posts: 282
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Last seen: 29 days, 2 minutes
Re: The official psilohuasca thread [Re: ShiroiTora] * 4
    #28406846 - 07/24/23 06:03 PM (6 months, 1 day ago)

big up to Sabnock.


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OfflineTrKyNcKmSk
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Registered: 07/29/23
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Re: The official psilohuasca thread [Re: orphee]
    #28423723 - 08/07/23 01:16 AM (5 months, 19 days ago)

Hey how does this work if you use the harmalas sublingually instead of orally? Do you still dose the shrooms approximately 45 minutes after sublingual dosing or maybe a little sooner? I have a gram of harmine hcl and lots of shrooms. I want to try both ways but was wondering what a good sublingual dose for psilohuasca is and how the duration differs when done this way. Also what about if I took 100-150mg harmine and later maybe 30-50mg sublingually at the peak of the experience or maybe right before it or do I need more or less than that?. How would taking a sublingual dose near the peak effect the trip? Also, what dose would you suggest for a first timer? I am versed in many psychedelics including ayahuasca but I have taken a few years break from hallucinogens and have only just started taking them again, so even though I'm experienced it has been a while. I was thinking of starting at 1.5 to 2g cubensis and maybe 150-200 mg harmine hcl. Is it better to go higher with the harmalas and lower with the shrooms or lower with the harmalas and higher with the shrooms? For example is it worth it to take 50mg orally to boost shrooms or would that not do anything? Lastly, has anyone tried harmalas via the IV or IM route? I have syringe disk filters... Just curious. Thanks


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OfflineBra
grow panaeolus, it's easy

Registered: 07/12/19
Posts: 341
Loc: Europe
Last seen: 13 minutes, 29 seconds
Re: The official psilohuasca thread [Re: TrKyNcKmSk]
    #28586008 - 12/16/23 07:51 PM (1 month, 11 days ago)

Quote:

TrKyNcKmSk said:
Hey how does this work if you use the harmalas sublingually instead of orally?



It works good, but the trip was different and shorter than oral rue in my experience. It was more smooth and dreamy as well.


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Bra's spores giveaway


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