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OfflinePlok
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Permanent tolerance due to DMT usage * 2
    #28532259 - 11/06/23 08:04 PM (2 months, 20 days ago)

A friend of mine smoked copious amounts of DMT years ago until he got to a point where it didn't effect him anymore.  Since then he has not been able to feel anything when he takes psychedelics (mushrooms or acid).

It doesn't matter how long he waits in between doses, he hardly feels anything anymore.  He took 3.5g of mushrooms last night after nearly a year between his previous dose and felt almost nothing.  He said he just got the yawns and felt a little energized but that was about it.

He's not on any kind of psychiatric medication.  Has anybody experienced anything like this before, or heard of anyone who has?  He's pretty bummed about it.


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OfflineNorthernerM
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Re: Permanent tolerance due to DMT usage [Re: Plok] * 2
    #28532319 - 11/06/23 08:51 PM (2 months, 20 days ago)

Yeah being locked out from DMT by overuse is pretty common. Usually it only lasts up to a year, but I have heard of it being permanent.

It's not commonly talked about here but you can read a lot about it on Nexus.

I'm surprised LSD doesn't work on him though, usually that still works even when tryptamines won't anymore.


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OfflineThe Mycologist
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Re: Permanent tolerance due to DMT usage [Re: Northerner] * 1
    #28532381 - 11/06/23 10:32 PM (2 months, 20 days ago)

Intriguing. Thats wild that he smoked it that frequently.


--------------------
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OfflineLogicaL ChaosM
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Re: Permanent tolerance due to DMT usage [Re: Plok]
    #28532496 - 11/07/23 03:14 AM (2 months, 20 days ago)

Thats nutz! Ive heard of permanent tolerances before. Very rare condition.

Has he tried other psychs such as Mescaline or Salvia?


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OfflineSabnock
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Re: Permanent tolerance due to DMT usage [Re: LogicaL Chaos] * 1
    #28532598 - 11/07/23 07:20 AM (2 months, 20 days ago)

I think it seems to be an issue with smoked DMT, idk if anyone has gotten that from purely oral DMT use, i myself took DMT orally daily/near daily for 4 years straight, and have smoked some Changa here and there, it always worked for me and still works to this day. Idk why smoked DMT would be different in that regard compared to oral DMT, but i stuck with oral DMT and i'm glad.


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Offlinetaskamil
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Re: Permanent tolerance due to DMT usage [Re: Sabnock] * 1
    #28532805 - 11/07/23 11:25 AM (2 months, 19 days ago)

Are your friend also has tolerance to mdma ?

I think it may be result of glutamate neurotoxicity (1) or 5 HT 2 receptor down regulation.

Solution may be resetting tolerance by ibogaine, ketamine, st johns worth, harmala alkoloids(2) or lemon balm tea (3).

I found lemon balm tea which I heard from Sabnock is beneficial also after the trip, I think because of glutamate neutralization. Lemon balm  makes me feel good but making afterglow effect lessen.


1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224489/

2. https://europepmc.org/article/med/24506035

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652537/


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OfflineTyperwritermonky
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Re: Permanent tolerance due to DMT usage [Re: LogicaL Chaos] * 2
    #28533422 - 11/07/23 07:54 PM (2 months, 19 days ago)

Quote:

LogicaL Chaos said:
Thats nutz! Ive heard of permanent tolerances before. Very rare condition.

Has he tried other psychs such as Mescaline or Salvia?




Permanent tolerance will absolutely result from abusing a tryptamine like DMT heavily.  Your receptors literally just fucking whither away and will not accept overloads anymore.  You truly burn them out and do damage.  It doesn't make you retarded like the dare ads said, most of these people function fine.  But they just burnt their receptors out completely.

Salvia would definitely work since that's different receptor sites creating most of the effects.  Mescaline I would imagine would still be very muted as it's still those 5HT2x sites.

I've been on ketamine sometimes and feel like I've blown a few receptors during some binges.  NMDA of course that is.  But I didn't get a permanent tolerance, I use it every few months and it's still 100% effective to me.

But I do know with the serotonin type psychedelics that you can just destroy the receptor sites.  That's why 25iNBOME was so bad and dangerous, even if it didn't physically hurt you, the receptor site affinities were so high that it just obliterated the receptor sites and clefts.  Some people who took an nBOME once at too high of a dose since blotters were laid insanely high would blow out their receptors forever, I've seen that happen before.  We also have the medical data for it, I mean nBOME was created to test serotonin sites specifically.  I do not know if after 10+ years they recovered, but years later they still reported very mute effects.

I imagine you could check the affinity chart for DMT and see just which receptors he fucked up.


Edited by Typerwritermonky (11/07/23 07:56 PM)


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InvisibleCreonAntigone
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Re: Permanent tolerance due to DMT usage [Re: Typerwritermonky] * 1
    #28533451 - 11/07/23 08:10 PM (2 months, 19 days ago)

Mescaline is stronger at adrenergic sites than at serotonergic sites, plus some action at TAAR1 at the same affinity as serotonin. I think it'd work fine even past serotonin-based tolerance.


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Invisiblestareatclouds
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Re: Permanent tolerance due to DMT usage [Re: CreonAntigone]
    #28533625 - 11/07/23 10:38 PM (2 months, 19 days ago)

Can he feel pain? What if I broke a bottle on his head? This is not a helpful comment, sorry, I just find it funny. "HE FEELS NOTHING!"


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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: CreonAntigone]
    #28533690 - 11/08/23 01:19 AM (2 months, 19 days ago)

Quote:

CreonAntigone said:
Mescaline is stronger at adrenergic sites than at serotonergic sites, plus some action at TAAR1 at the same affinity as serotonin. I think it'd work fine even past serotonin-based tolerance.




Serotonin receptors are where the psychedelic effects come from though, so you might still get all of the stimulant properties of mescaline with a diminished hallucinogenic effect. Assuming that what Typewritermonkey says is correct?

This is the first I’ve heard of “permanent” tolerance. Maybe a few years down the line this guy will be able to trip again.

I dosed nBomes a handful of times about ten years ago. I didn’t get any diminished effects from serotonergic psychedelics after that. But I also didn’t dose very high, just enough to trip. It’s such a pity that they are so toxic, because I thought the nBome experience was amazing. It had such a warm, happy side to it, and amazing visuals. Haven’t had visuals like that from anything else yet. I’ve yet to try 2cb which I think might be on par from descriptions.


Edited by Bardy (11/08/23 01:22 AM)


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OfflineTyperwritermonky
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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 2
    #28534217 - 11/08/23 12:30 PM (2 months, 18 days ago)

Yes that is what I meant, CreonAntigone is correct that of course the other receptor sites would light up as usual.

I also dosed 25i-nBOME a handful of times, but I had a gram of it in powder form, and broke it down myself, laying it mixed with HPBCD and like 250ug dosages.  The stuff sold on the streets and online was usually around 1-2mg, or a magnitude of 4-8x higher dose.  The few dosages I took of it ranging from 250-750ug didn't leave me with any damage either, but then again the biggest dose I took was significantly less than a single tab of the street stuff of which people took multiple tabs of.  Dosed properly it was fine, in fact everyone I gave it too found it very enjoyable.  Some people who were afraid of LSD enjoyed it very much because the lack of a mental trip.

Regardless, people who knew or didn't were taking anywhere from 2-8mg of 25inBOME at once, which is enough to cause permanent damage to seizures to death.  I also knew someone who accidentally took 55mg of DOB, they meant to take 5.5mg of it, but somehow fucked up weighing it.  They had clear overdose symptoms including hyperthermia, confusion, etc. but didn't need a hospital.  Following that episode, they were really burnt out and disassociated though, so I imagine this is a case where some damage was done.  But this person also abused other RCs such as 25i.


I know DMT is a classical psychedelic, but due to it's almost reverse tolerance sometimes one can use it over and over and over all day every day unlike LSD.  I imagine if there was a similar tolerance for things like LSD and mushrooms, people wouldve caused more damage by now abusing the classical psychedelics.  But most all of them except DMT come in with safety protocols via tolerance that keeps people from dosing every day effectively.


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InvisibleWaterGnome20
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Re: Permanent tolerance due to DMT usage [Re: Typerwritermonky]
    #28534327 - 11/08/23 01:59 PM (2 months, 18 days ago)

Yeah, I have noticed since smoking DMT even once, that I am much more tolerent/resistant/unable to trip from mushrooms now.

*Yet at the same time, I feel somewhat more sensative to shrooms too now, though I think the increased shroom sensativity is because I up-regulated my 5-HT2A receptors with St. Johns Wort for 2+ months.

I can get a solid shroom trip from 1g now. 2G is almost too much.

I don't really get visuals like geometries, it's mostly a brain-experience like intelligence enhancement, closed-eye/imagination visualizations/hallucinations, increased color perception, increased sound perception.

I took a SNRI when I was a teenager which I think permanantly ruined my ability to feel shrooms. Thats why I up-regulated my 5-HT2A with St. Johns Wort and I feel its healed my brain back to normal and given me the ability to trip again, but I can tell I'll never really be able to trip quite as good as I would have been able to if I had never taken the SNRIs (Cymbalta).

That being said, I can confirm that St. Johns Wort DOES work, you just have to take it for weeks straight , every day, for it to start up-regulating your receptors. (Check with your doctor before taking st. johns wort).

I thinking smoking DMT kinda burns you out because:

A. It is just such an extreme overload.

B. Left-over extraction acids and bases can maybe fry your brain a bit? Many extractions use Naptha and Lye both of which can dissolve things, probably including your brain.


I'm glad I didn't smoke DMT any more than that. I'll never smoke DMT again after reading this, luckily I still feel great from shrooms but I do feel kinda... perma-fried from the DMT when it comes to tripping.


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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: WaterGnome20] * 1
    #28534403 - 11/08/23 02:45 PM (2 months, 18 days ago)

“B. Left-over extraction acids and bases can maybe fry your brain a bit? Many extractions use Naptha and Lye both of which can dissolve things, probably including your brain.”

This is definitely not true.

And Typwriter, what makes you think DMT has reverse tolerance? I remember smoking it multiple times a night a few times and it only ever got duller and eventually stopped working altogether by the end of the night.

That’s crazy about your friend’s DOB experience though.. dosage is a bad thing to screw up with potent drugs.

Yeah, the nBOMEs I had were very visual and warm without the super head fuck. It felt kind of like MDMA with crazy visuals. Not sure which one I was taking but I guess they’re all similar


Edited by Bardy (11/08/23 02:52 PM)


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OfflineNorthernerM
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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 2
    #28534467 - 11/08/23 03:37 PM (2 months, 18 days ago)

I had a pretty long romance with DMT and have since found it opened up a set of visuals on mushrooms that I didn't used to perceive before. I only used DMT without harmalas one time though, every other time was with harmalas.


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The nearest we ever come to knowing truth is when we are witness to paradox.


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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: Northerner]
    #28534497 - 11/08/23 04:03 PM (2 months, 18 days ago)

That’s pretty strange 😁 the first few times I did mushies were the most visual for me, then for some reason they tapered down on the visuals… been a fair while since I’ve taken a large dose of them though so maybe my tolerance has reset.


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InvisibleWaterGnome20
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Re: Permanent tolerance due to DMT usage [Re: Bardy]
    #28534980 - 11/08/23 11:46 PM (2 months, 18 days ago)

Quote:

Bardy said:
“B. Left-over extraction acids and bases can maybe fry your brain a bit? Many extractions use Naptha and Lye both of which can dissolve things, probably including your brain.”

This is definitely not true.

And Typwriter, what makes you think DMT has reverse tolerance? I remember smoking it multiple times a night a few times and it only ever got duller and eventually stopped working altogether by the end of the night.

That’s crazy about your friend’s DOB experience though.. dosage is a bad thing to screw up with potent drugs.

Yeah, the nBOMEs I had were very visual and warm without the super head fuck. It felt kind of like MDMA with crazy visuals. Not sure which one I was taking but I guess they’re all similar





Actually, as expected, I am 100% right:

https://en.wikipedia.org/wiki/Naphtha

"The safety data sheets (SDSs) from various naphtha vendors indicate various hazards such as flammable mixture of hydrocarbons: flammability, carcinogenicity, skin and airway irritation, etc."

"Naphtha was later removed as a cancer risk."




https://en.wikipedia.org/wiki/Lye

"potassium hydroxide (LYE) can be used to digest tissues of animal carcasses."


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OfflineNorthernerM
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Re: Permanent tolerance due to DMT usage [Re: WaterGnome20] * 2
    #28535042 - 11/09/23 02:50 AM (2 months, 18 days ago)

So do you expect to trepan yourself and apply these chemicals directly to your brain?  How else would they get to it?

Have you any idea how difficult it is to actually contaminate a DMT extraction?

I'm just trying to figure out how you are 100% right, because it appears you don't know anything about this topic.


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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: WaterGnome20]
    #28535063 - 11/09/23 03:59 AM (2 months, 18 days ago)

Dude 🤦‍♂️ Naphtha isn’t in the final product at all.. Maybe there are teeny tiny trace amounts, but nothing that could  hurt you considering most people aren’t smoking DMT 24/7. It’s a complete non issue if you know what you’re doing with your extraction and you’re not just drinking the shit like a dumbass.

Same goes for sodium hydroxide, which isn’t even that toxic in small amounts anyway. It definitely wouldn’t be good for your lungs, but like I said, if you know what you’re doing with the extraction process then your final product won’t contain any of this anyway.

Like Northerner said, you’re just proving to us how little you actually know about the topic. Now would be the time to gracefully admit you don’t know and you made a mistake.

The dose makes the poison.


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InvisibleWaterGnome20
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Re: Permanent tolerance due to DMT usage [Re: Northerner]
    #28535407 - 11/09/23 10:14 AM (2 months, 17 days ago)

Quote:

Northerner said:
So do you expect to trepan yourself and apply these chemicals directly to your brain?  How else would they get to it?

Have you any idea how difficult it is to actually contaminate a DMT extraction?

I'm just trying to figure out how you are 100% right, because it appears you don't know anything about this topic.





"trepan"

Sorry I only speak real English, what does "trepan" mean?


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Invisibleloladoreen
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Re: Permanent tolerance due to DMT usage [Re: Plok]
    #28535410 - 11/09/23 10:14 AM (2 months, 17 days ago)

Interesting


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InvisibleWaterGnome20
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Re: Permanent tolerance due to DMT usage [Re: Bardy]
    #28535412 - 11/09/23 10:15 AM (2 months, 17 days ago)

And, how exactly do you know that there isn't much Naptha/Lye in the final product? How do you know that?

Did you preform a chemical composition analysis? or are you just assuming based upon a web extraction guide you read?


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OfflineNonagon
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Re: Permanent tolerance due to DMT usage [Re: WaterGnome20] * 2
    #28535502 - 11/09/23 11:09 AM (2 months, 17 days ago)

Lye/water are insoluble in naptha to such an extent that you can see if a single drop gets carried over. And since the drop of bark water is both insoluble and visually apparent in the clear solvent, it’s very easy to remove.

It’s pretty standard practice to evaporate solvents on glass to inspect how cleanly they evaporate - Good solvents for this purpose will leave zero visible residue. Freeze precipitation will drastically minimize solvent waste while also reducing the amount of solvent that could theoretically leave behind a residue to virtually zero.

As with anything, good materials combined with good practices will yield the desired result. If you don’t know/trust your source, know that it’s pretty easy to clean most drugs with a bit of homework.


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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: Nonagon] * 1
    #28535722 - 11/09/23 01:22 PM (2 months, 17 days ago)

:whathesaid:


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OfflinePlok
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Re: Permanent tolerance due to DMT usage [Re: LogicaL Chaos] * 1
    #28537104 - 11/10/23 12:28 PM (2 months, 16 days ago)

Yeah he said salvia still works.  Hasn't tried mescaline.


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OfflineGiro
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Re: Permanent tolerance due to DMT usage [Re: Plok] * 3
    #28558021 - 11/27/23 06:57 AM (2 months, 1 hour ago)

Hey y'all

I'm actually the friend Plok is referring to. (I also forgot I had an account! It looks like I first joined in 2011!)

First, thank you hive-mind! I've been Googling around for a while about this and hadn't found anything, it hadn't occured to me to post onto a forum. Thanks Plok!

Some clarification... I can trip with LSD, it's just VERY muted. My LSD tolerance is almost an inside joke amongst some of my friends. Even when I take 3 or 4 hits, the most visuals I get is a light "breathing" on surfaces. I do get the giggles, and the increased energy (and sometimes anxiety), but the more "trippier" effects like kaleidoscopic patterns, ego loss, and synesthesia are definitely not happening. I really miss tripping like I used to...

SWIM extracted a large amount of DMT around 2008 and tripping has never been the same since. It must have been maybe 6 months where I was experimenting it quite frequently, but then stopped because of diminished effects and a few scary experiences (it seriously felt like a scary admonishments from some being on the other side.)

I don't do shrooms very often, so I really didn't notice how muted it was until now. I ate a full eighth and seriously, I felt almost nothing. A little energy, initially. Maybe the colors brighter? Some mushroom yawns. And then that's it.  It was seriously disappointing, because I've had some amazing experiences in the past.

So to summarize...
- LSD works, but muted.
- Ketamine definitely still works, which makes sense given the receptors involved.
- Nitrous still works.
- THC still works.
- 2CB doesn't work either :frown: 25mg did nothing to me last time I took it.
- MDMA still works
I've never done mescaline, super curious. Maybe someday!
I've tried DMT a few times since the extraction days (with a vape pen) and felt close to nothing.
Also wondering how an old school ayahuasca ceremony would feel, but I'm not hopeful and it would seem a terrible waste of time/expense.

C'est la vie. It was fun while it lasted. I REALLY miss my old trips, but as I get older, I've gotten more into mindfulness, meditation, and other "natural" highs. Maybe it's the universe giving me a sign :grin:

Reminds me of a good quote: Nothing lasts, but nothing is lost.


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Invisiblestareatclouds
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Re: Permanent tolerance due to DMT usage [Re: Giro] * 1
    #28558063 - 11/27/23 07:48 AM (2 months, 43 minutes ago)

Quote:

(it seriously felt like a scary admonishments from some being on the other side.)




Can you expand on this?


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OfflineSizlChest
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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 1
    #28558248 - 11/27/23 11:35 AM (1 month, 30 days ago)

Quote:

Bardy said:
That’s pretty strange 😁 the first few times I did mushies were the most visual for me, then for some reason they tapered down on the visuals… been a fair while since I’ve taken a large dose of them though so maybe my tolerance has reset.



A weird thing I've found is that after tripping a LOT, my "resolution" is migh higher. Meaning, that the "grid" you see when you close your eyes (web, etc) becomes smaller shapes. That's what I've found, and I have to dose higher, no matter how long I've given myself a break. I believe you reach plateaus, where you are able to go deeper because of your enhanced "resolution."

Or, I was just tripping...


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OfflineTyperwritermonky
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Re: Permanent tolerance due to DMT usage [Re: stareatclouds] * 1
    #28559598 - 11/28/23 03:24 PM (1 month, 29 days ago)

Quote:

stareatclouds said:
Quote:

(it seriously felt like a scary admonishments from some being on the other side.)




Can you expand on this?




I've gotten this one time i just decided to smoke some dmt at a bad time.  All my visuals were dark blood red and it was like spirits were wagging their finger in shame at me for doing the dmt and trying to admonish me for it.


I say reverse tolerance for DMT because you can smoke it and get very high, than do it again 30 mintues later, and repeat for a few hours before it gets muted too much.  You can't take LSD, wait an hour after the trip, and take more and trip again.

Quote:

Giro said:
Hey y'all

I'm actually the friend Plok is referring to. (I also forgot I had an account! It looks like I first joined in 2011!)

First, thank you hive-mind! I've been Googling around for a while about this and hadn't found anything, it hadn't occured to me to post onto a forum. Thanks Plok!

Some clarification... I can trip with LSD, it's just VERY muted. My LSD tolerance is almost an inside joke amongst some of my friends. Even when I take 3 or 4 hits, the most visuals I get is a light "breathing" on surfaces. I do get the giggles, and the increased energy (and sometimes anxiety), but the more "trippier" effects like kaleidoscopic patterns, ego loss, and synesthesia are definitely not happening. I really miss tripping like I used to...

SWIM extracted a large amount of DMT around 2008 and tripping has never been the same since. It must have been maybe 6 months where I was experimenting it quite frequently, but then stopped because of diminished effects and a few scary experiences (it seriously felt like a scary admonishments from some being on the other side.)

I don't do shrooms very often, so I really didn't notice how muted it was until now. I ate a full eighth and seriously, I felt almost nothing. A little energy, initially. Maybe the colors brighter? Some mushroom yawns. And then that's it.  It was seriously disappointing, because I've had some amazing experiences in the past.

So to summarize...
- LSD works, but muted.
- Ketamine definitely still works, which makes sense given the receptors involved.
- Nitrous still works.
- THC still works.
- 2CB doesn't work either :frown: 25mg did nothing to me last time I took it.
- MDMA still works
I've never done mescaline, super curious. Maybe someday!
I've tried DMT a few times since the extraction days (with a vape pen) and felt close to nothing.
Also wondering how an old school ayahuasca ceremony would feel, but I'm not hopeful and it would seem a terrible waste of time/expense.

C'est la vie. It was fun while it lasted. I REALLY miss my old trips, but as I get older, I've gotten more into mindfulness, meditation, and other "natural" highs. Maybe it's the universe giving me a sign :grin:

Reminds me of a good quote: Nothing lasts, but nothing is lost.




It seems that you just burnt out you 5Ht2x receptors (your serotonin receptors) by consuming so much DMT.  This explains why your visuals are so muted on serotonin-type psychedelics like LSD as it is those 5ht2 receptors that are responsible for visuals on those drugs.  The same would apply for 2CB as well.  The best thing for you to do is not consume any of those type of drugs for a long time to let those receptor sites reach a new homeostasis.  It won't be the same as before your DMT experiments, but it will be better than it is now.  It's really unhealthy and it will be abuse if you take that class of drugs (LSD, 2CB, mushrooms, DMT, etc.) the serotonin-type psychedelics.  So please take a long break from them for your own sake and health.

Just to repeat, even if you don't return to them, please just start now and take a long break from them.  At least a year minimum, your brain needs to reach a new homeostasis otherwise you are just doing brain damage by preventing it.  You should really stay away from MDMA and MDA too even though it works.  Ketamine, nitrous, salvia, THC, GHB, etc. etc. are fine to take, just do not take any of the serotonin type psychedelics for at least a year.  Also MDMA if you can avoid it.

Odds are is after a year, two if you can wait, that your new homeostasis will be rich with new visual tapestries and your brain will thank you for letting the brain damage heal.


Edited by Typerwritermonky (11/28/23 03:25 PM)


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OfflineLogicaL ChaosM
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Re: Permanent tolerance due to DMT usage [Re: Typerwritermonky]
    #28560251 - 11/29/23 01:45 AM (1 month, 29 days ago)

A whole year?! :omgz:

Welp, its better than permanent right? :sadyes:


--------------------
"What you must understand is that your physical dimension affects everyone in the higher dimensions as well. All things are interconnected. All things are One. Therefore, if one dimension is broken or out of balance, then all other dimensions will experience repercussions." - Pleiadian Prophecy 2020 The New Golden Age by James Carwin

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OfflineTyperwritermonky
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Re: Permanent tolerance due to DMT usage [Re: LogicaL Chaos] * 1
    #28560657 - 11/29/23 11:58 AM (1 month, 28 days ago)

Quote:

LogicaL Chaos said:
A whole year?! :omgz:

Welp, its better than permanent right? :sadyes:




Easily.  I once overdosed on an SNRI because a doctor didn't tell me shit about the medication and I took some St Johns Wort with it.  Fried my circuits hard.  I couldn't even consume THC, even totally sober I felt like a zombie.  It was horrible.  I still think it did a few % of brain damage, but after abstaining from everything for a year or so, I could enjoy it again.  Now, like 5 years later, my psychedelic experiences are just as they were when I first took it.

So yeah, at least a year.  Ideally even more if possible.  I mean why even take them if the effects are so muted that you have to take 400ug to get mild effects?  At that point, taking psychedelics is just abusing them and causing more brain damage by delaying the healing process and fucking up the homeostasis balance as it settles.

But yeah, better to take a year or two off and have good effects again then permanent brain damage.


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OfflineBra
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Re: Permanent tolerance due to DMT usage [Re: Plok]
    #28564007 - 12/01/23 04:34 PM (1 month, 26 days ago)

I think psychedelics are intelligent and remarkable substances, and they actually prompt you to take a break and integrate.
I experienced a diminishing effect with DMT when I used to vape it too often.
However, when I took a longer break, integrated the experience I have recieved and vaped DMT again, I felt the effects as they used to be.

I don't agree with the notion of it causing "burning", it doesn't make any sense since tryptamines aren't toxic or caustic. I believe we may be influenced by certain spirits that control the depth of our experiences. Additionally, some people have reported being banned by entities in the DMT or psilocybin realm, which is quite common.
This world is more mysterious than most people usually think.


--------------------
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Re: Permanent tolerance due to DMT usage [Re: Bra]
    #28564370 - 12/01/23 08:02 PM (1 month, 26 days ago)

People don’t use burnt out in a literal sense, as in the receptors are burning. It’s a metaphor for the receptors or cells “dying off” or malfunctioning in some way. It’s being used here in a similar way to when people say they are “burnt out” from too much work or being too busy.

Not sure exactly what you mean by spirits or entities (I’ve never taken a high enough dose for the entity experience), but these are almost certainly just results of thinking and nothing else. If you’re able to stop thinking, I’d be willing to bet they disappear.


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Offlinewolf8312
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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 1
    #28564617 - 12/02/23 12:22 AM (1 month, 26 days ago)

I think its plausible that DMT may have long term adverse effects over time. Not only because of how utterly powerful it is but also because of how pleasurable it is combined with its crack-like duration which can leave one wanting more.

It's an incredible hit for sure but is IMO really more of a straight up drug experience than something like Ana/Ayahuasca and I do think it has more addiction potential. 

It can be very moreish and pretty much the ultimate rush if you approach it like a roller-coaster and go in ready for it!


--------------------
"I'm every nightmare you ever had. I am your worst dreams come true. I am everything you ever were afraid of."

Pennywise the dancing clown



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OfflineBardy
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Re: Permanent tolerance due to DMT usage [Re: wolf8312] * 1
    #28564758 - 12/02/23 05:20 AM (1 month, 26 days ago)

I’ve experienced this moreish aspect once or twice, just doing enough over and over for crazy closed eye visuals. So yeah, I definitely get what you mean… I don’t think it has much addiction potential in the long run though. I certainly didn’t wake up in the morning wanting more haha


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Re: Permanent but possible reversable damage due to DMT usage [Re: wolf8312]
    #28564773 - 12/02/23 05:44 AM (1 month, 26 days ago)

Well said wolf8312! I think you explained the DMT situation well.


--------------------
"What you must understand is that your physical dimension affects everyone in the higher dimensions as well. All things are interconnected. All things are One. Therefore, if one dimension is broken or out of balance, then all other dimensions will experience repercussions." - Pleiadian Prophecy 2020 The New Golden Age by James Carwin

PROJECT BLUE BOOK ANALYSIS! (312 pages!) | Psychedelics & UFOs | Ready to Contact UFOs? | The Source on Mushrooms:shroomeryhead:| Trippy Gematrix | Dj TeknoLogical | Fentanyl Test Kits R.I.P. Big Worm :tombstone: || The Start of the Ascension Process was 2020. Welcome to the Next Great Era of Earth 🌎🌍🌏                                                         
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Offlinewolf8312
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Re: Permanent tolerance due to DMT usage [Re: Bardy]
    #28564774 - 12/02/23 05:46 AM (1 month, 26 days ago)

Quote:

Bardy said:
I’ve experienced this moreish aspect once or twice, just doing enough over and over for crazy closed eye visuals. So yeah, I definitely get what you mean… I don’t think it has much addiction potential in the long run though. I certainly didn’t wake up in the morning wanting more haha




Defo no addiction potential for me personally either tbh (but maybe if I was 20 years younger). Needing to psych myself up for about a month before hand pretty much eliminates that issue haha, but it is quite easy to get through in a session once one gets past the first hit.

Little point in more than one good blast off dose per session though I think. 

But I can understand why it happens and how a certain kind of person could end up chasing it.

It feels kind of wasteful compared to Ana IMO.

One reason I never liked coke. If its great its soon over and you have to do more with inevitable diminishing returns and waste.

Its either over in a few minutes or you have to keep hitting it.


--------------------
"I'm every nightmare you ever had. I am your worst dreams come true. I am everything you ever were afraid of."

Pennywise the dancing clown



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Offlinetree frog
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Re: Permanent tolerance due to DMT usage [Re: Bardy]
    #28574829 - 12/08/23 07:04 PM (1 month, 19 days ago)

actually I'll have to think about this more when I'm not stoned.  Permanent tolerance is a weird phenomenon.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (12/08/23 07:21 PM)


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OfflineWhoManBeing
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Re: Permanent tolerance due to DMT usage [Re: Northerner] * 1
    #28574845 - 12/08/23 07:14 PM (1 month, 19 days ago)

Quote:

Northerner said:
Yeah being locked out from DMT by overuse is pretty common. Usually it only lasts up to a year, but I have heard of it being permanent.

It's not commonly talked about here but you can read a lot about it on Nexus.

I'm surprised LSD doesn't work on him though, usually that still works even when tryptamines won't anymore.




Most psychedelic drugs fall into one of the three families of chemical compounds: tryptamines, phenethylamines, or lysergamides (LSD is considered both a tryptamine and lysergamide).


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Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.



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Re: Permanent tolerance due to DMT usage [Re: WhoManBeing]
    #28574853 - 12/08/23 07:19 PM (1 month, 19 days ago)

Not only that I think DMT has a higher binding affinity then LSD but it's been a long time since I actually looked.

This is why the nbomes are dangerous btw since someone mentioned them earlier.  They were made to target this receptor site with a very strong electrical charge to study the effects in lab animals.



--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (12/08/23 07:23 PM)


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Re: Permanent tolerance due to DMT usage [Re: wolf8312]
    #28574892 - 12/08/23 07:52 PM (1 month, 19 days ago)

What is Ana?


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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 3
    #28574914 - 12/08/23 08:07 PM (1 month, 19 days ago)

Quote:

Bardy said:
What is Ana?




Just means Analogue Ayahuasca in my case Syrian Rue or Ana-huasca. Saves me having to explain each time (except this time! :laugh:) that I am not actually using Ayahuasca! I'd prefer Rue-huasca to be more specific but that doesn't really have the same ring to it!

The (Syrian rue + a light bearing plant) concoction really does deserve the respect of having it's own specific name like Aya itself (and to expedite efficient communication) but so far I haven't come across one, or not one that is widely in use!

The purists tend to look down on Syrian Rue which is ludicrous as it's an incredibly powerful healing plant and teacher especially combined with an admixture!


--------------------
"I'm every nightmare you ever had. I am your worst dreams come true. I am everything you ever were afraid of."

Pennywise the dancing clown



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Re: Permanent tolerance due to DMT usage [Re: wolf8312] * 1
    #28575236 - 12/09/23 01:55 AM (1 month, 19 days ago)

Aw man, I’ve never tried oral DMT. I would like to one day. I’ve got a bunch of Syrian Rue… just need to buy some root bark


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Offlinetree frog
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Re: Permanent tolerance due to DMT usage [Re: Bardy] * 2
    #28575366 - 12/09/23 07:01 AM (1 month, 19 days ago)

Quote:


The purists tend to look down on Syrian Rue which is ludicrous as it's an incredibly powerful healing plant and teacher especially combined with an admixture!




Rue and extracts made from it are more sustainable anyway.

And the extracts are way easier on the stomach.

Why cut a vine down when rue offers us it's seeds so freely?


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


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Offlinewolf8312
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Re: Permanent tolerance due to DMT usage [Re: tree frog] * 2
    #28575606 - 12/09/23 09:32 AM (1 month, 18 days ago)

Quote:

tree frog said:
Quote:


The purists tend to look down on Syrian Rue which is ludicrous as it's an incredibly powerful healing plant and teacher especially combined with an admixture!




Rue and extracts made from it are more sustainable anyway.

And the extracts are way easier on the stomach.

Why cut a vine down when rue offers us it's seeds so freely?





Caapi is also way more expensive and hit and miss/variable in its potency IME. PITA to prepare too! I would spend days making it and then it wouldn't really work or hit me like a ton of bricks cause I took too much! When I got a new batch I would play it safe (often wasting time and materials) but I never really had enough vine for more than a few experiences. With Rue one bag and you're set for years! 

Rue is much more reliable (you know what you're getting) though I do still prefer to take whole seeds (1.5 to 2 grams does me) for the full spectrum experience, or around twice that if using a simple water extraction.

I've never found rue to be that bad nausea (a bit rough but nothing like say HBWR) or discomfort wise.

For some reason I found that the mansake (or whatever it was called) extraction or bought-online extractions provided MAOI effects but also seemed to eliminate a lot of the rue's own unique effects.

Not sure if I just had bad extractions or others have experienced the same!

I got it in a dropper once and followed the instructions. Didn't really produce any psychoactive effects but it did work as an MAOI.

But maybe I didn't take enough, total rip off those companies.


--------------------
"I'm every nightmare you ever had. I am your worst dreams come true. I am everything you ever were afraid of."

Pennywise the dancing clown



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Re: Permanent tolerance due to DMT usage [Re: wolf8312] * 2
    #28575694 - 12/09/23 10:52 AM (1 month, 18 days ago)

I never played around with the tincture extracts.  Just powders of harmine, harmaline, and thh that you can buy online presently.  Basically someone's doing manske extractions and selling them on their website.  Which cuts out a lot of headache for me because I'm not that great with chemistry.

I liked that I could dial in the ratios of each.  I liked harmine + thh for day trips and harmaline + thh for evenings.  Or combine all three if I wanted something closer full spectrum.  If I decide to do oral DMT again or introduce it to friends I'd go this route.

My first oral DMT experience was with ground rue seeds and I remember feeling like I had an iron ball rolling around in my guts.  Granted, a lot of emotional purging happened during that first experience.  So, I don't know how much was the rue and how much was me, but my experience with it didn't seem uncommon from what I had read.

And heard on vine being all over the place as far as potency.

I learned recently that a lot of psilocybin species have trace maois in the mycelium.  I doubt much will come of it but I really love growing sclerotia and plan to try to isolate this trait through cloning, fruiting, and going back to spores.  We'll see how it goes.

A current jar florescing under UV light.



--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (12/09/23 10:57 AM)


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Offlinetregar
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Re: Permanent tolerance due to DMT usage [Re: tree frog]
    #28576670 - 12/10/23 06:52 AM (1 month, 18 days ago)

Pure thh or tetrahydroharmine in caapi reverses tolerance to all psychedelics, I've used her hundreds of times over many years. You may give her a shot.

I don't smoke dmt but make my own Ayahuasca capsules that are as strong and long lasting as real traditional Ayahuasca brew from the jungle, typical dose these days is 150mg harmine, 90mg dmt freebase, 70mg THH. I mash the DMT into fresh aloe vera gel that I collect from a fresh leaf bought at walmart in the grocery section, more on this here: https://www.shroomery.org/forums/showflat.php/Number/28423951/fpart/all It hits as hard as HPBCD DMT or real psychotria leaf, always a +5 in strength, without the gel penetration polysacharide enhancers, the trips never make it over +3 in strength.  Pictures of capsules in link below.

There is no tolerance to the effects, you can use it as often as you like.

Here are some close up pics of the resulting very pure THH I've used for countless years: https://www.shroomery.org/forums/showflat.php/Number/28189371/page/1

Pure 300mg THH can be seen in weigher at upper top of photos.



Other topics: Alchemy chemistry fun:

Compilation of pan cyan or panaeolus cyanescens or copeandia cyanescens trip reports, crown jewel of mushrooms:
https://www.shroomery.org/forums/showflat.php/Number/28108398/page/1

How to extract 2.4g dmt from 170g bark using a 2 Liter erlenmeyer flask (heat and break resistant), post #15:
https://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/

Tetrahydroharmine or THH and how to make her, Caapi visionary feminine teaching spirit:
https://www.shroomery.org/forums/showflat.php/Number/28423951/page/1

Zero nausea HPBCD or aloe vera enhanced penetration Ayahuasca capsules:
https://www.shroomery.org/forums/showflat.php/Number/28189371/page/1

Cactus tea before waterpark to beat the heat:
https://www.shroomery.org/forums/showflat.php/Number/28411312/page/4



How to make LSI or Lysergic Acid Isovaleraldemide (Greek Eleusis ancient LSD) at home from morning glory seeds (the priests used non poisonous claviceps paspali which grows on paspalum grass adjacent to Eleusis present day in the famous Rarian plane, same alkaloid profile as the sacred Mesoamerican morning glory):
https://www.shroomery.org/forums/showflat.php/Number/27850299/page/2

Make your own 1-acetaldehyde LSD at home from LSD, very similar to ALD-52 or the real orange sunshine:
https://www.shroomery.org/forums/showflat.php/Number/28441105

LSD high dose trip: 20 minute visionary visit from a dead Aztec Shaman:
https://www.shroomery.org/forums/showflat.php/Number/28451382


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Offlinetregar
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Re: Permanent tolerance due to DMT usage [Re: tregar]
    #28576894 - 12/10/23 11:26 AM (1 month, 17 days ago)

Plok, just a suggestion, have your friend take around 70mg pure thh freebase along with a dose of LSD or mushrooms, and your friend should once again be able to trip just fine on LSD or mushrooms again.

All about THH: https://www.shroomery.org/forums/showflat.php/Number/28423951/page/1

I've taken THH with LSD and mushrooms so many times I can't even remember, it really adds quite a bit of extra psychedelia to the experience, like adding a low dose of mescaline, and it reverses tolerance.


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OfflineTyperwritermonky
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Re: Permanent tolerance due to DMT usage [Re: tregar]
    #28576980 - 12/10/23 12:32 PM (1 month, 17 days ago)

Quote:

tregar said:
Plok, just a suggestion, have your friend take around 70mg pure thh freebase along with a dose of LSD or mushrooms, and your friend should once again be able to trip just fine on LSD or mushrooms again.

All about THH: https://www.shroomery.org/forums/showflat.php/Number/28423951/page/1

I've taken THH with LSD and mushrooms so many times I can't even remember, it really adds quite a bit of extra psychedelia to the experience, like adding a low dose of mescaline, and it reverses tolerance.




This is dangerous tregar.  His 5ht2 receptors are damaged; tricking the brain into letting psychedelics work again and further frying damaged receptors is a dangerous and bad idea.


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