Home | Community | Message Board

MagicBag Grow Bags
This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Kraken Kratom Kratom Capsules for Sale   PhytoExtractum Buy Bali Kratom Powder   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Amanita Muscaria Store Amanita Extract   Mushroom-Hut Mono Tub Substrate

Jump to first unread post Pages: 1
InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
A new psilocybin microdosing study from the University of Southern Denmark * 1
    #28491738 - 10/04/23 06:43 AM (3 months, 23 days ago)

Psilocybin microdosing may improve mental health by boosting stress resilience

Researchers from the University of Southern Denmark have found that โ€œmicrodosingโ€ psilocybin may have a beneficial effect on mental disorders.

Read full article on Earth.com here:
https://www.earth.com/news/psilocybin-microdosing-may-improve-mental-health-by-boosting-stress-resilience/


Extras: Filter Print Post Top
OfflineCapt. Ramius
Submarine commander

Registered: 11/22/22
Posts: 107
Loc: Bottom of tea sea
Last seen: 12 days, 8 hours
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: veggie]
    #28491891 - 10/04/23 09:58 AM (3 months, 23 days ago)

Nice find!
Too bad the actual study (https://www.nature.com/articles/s41380-023-02280-z) is behind a paywall :undecided:


Extras: Filter Print Post Top
OfflineJanus62
Call me Hugh
Male User Gallery


Registered: 08/27/22
Posts: 365
Loc: Midlands UK
Last seen: 11 hours, 29 minutes
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: Capt. Ramius]
    #28491931 - 10/04/23 10:49 AM (3 months, 23 days ago)

It's not available on Sci-Hub yet (https://sci-hub.wf/https://www.nature.com/articles/s41380-023-02280-z), but it's only been a couple of days, so it might be soon.  I'll keep an eye open for it.


--------------------
๐Ÿ…ƒ ๐Ÿ„ด ๐Ÿ„ฐ ๐Ÿ„ผ    ๐Ÿ„ฒ ๐Ÿ„ป ๐Ÿ„ธ ๐Ÿ„ฝ ๐Ÿ„ถ ๐Ÿ…† ๐Ÿ… ๐Ÿ„ฐ ๐Ÿ„ฟ


Extras: Filter Print Post Top
Offlinetree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: Janus62] * 1
    #28495231 - 10/07/23 08:42 AM (3 months, 20 days ago)

I wrote the research team and have a copy of the study.

Can I share it on sci-hub to post the link?  I've never done that so unsure how that works.

Dosing regimen was 0.05mg/kg every other day.  About 2.5mg every other day in an average sized woman.

No tolerance build up observed.

edit:  Someone in the psychedelic experience asked for it and I found a link in the paper that should work.

https://osf.io/gy6m9/


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Edited by tree frog (10/07/23 11:28 AM)


Extras: Filter Print Post Top
Offlinejnotorious
notorious
Male

Registered: 05/06/23
Posts: 8
Loc: Oregon
Last seen: 3 months, 18 days
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog]
    #28497166 - 10/08/23 10:52 PM (3 months, 18 days ago)

Anyone got a quick overview of the article?


Extras: Filter Print Post Top
Offlinetree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: jnotorious]
    #28497282 - 10/09/23 05:46 AM (3 months, 18 days ago)

They dosed rats 0.05mg/kg every other day.  No tolerance build up.  Many positive physiological changes, better neural connectivity in some regions of the brain, fewer physical anxiety responses, etc.  Dose was well tolerated as far as they could tell.

I mostly skimmed it so don't have much more than that


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Extras: Filter Print Post Top
OfflineB Traven
Stranger
Male User Gallery


Registered: 03/10/20
Posts: 2,479
Loc: Central Megalopolis
Last seen: 2 hours, 56 minutes
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog] * 1
    #28497290 - 10/09/23 05:59 AM (3 months, 18 days ago)

Something really rubs me the wrong way about raising rodents just to slice their brains up. Feels pointless to me.

Even more so when the focus is on microdosing psilocybin. I'm sure the only reason they're going to animal models with that, aside from some scientists' obsession with looking at brain cross-sections, is because of legal considerations.

I had just assumed this was some sort of clinical trial at first.


--------------------
Beware of advice- even this.


Extras: Filter Print Post Top
Offlinetree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: B Traven] * 1
    #28497323 - 10/09/23 07:05 AM (3 months, 18 days ago)

Quote:

B Traven said:
Something really rubs me the wrong way about raising rodents just to slice their brains up. Feels pointless to me.

Even more so when the focus is on microdosing psilocybin. I'm sure the only reason they're going to animal models with that, aside from some scientists' obsession with looking at brain cross-sections, is because of legal considerations.

I had just assumed this was some sort of clinical trial at first.




This is why I skimmed it.  I have some education on neurochemistry so understood a lot of it.  But I also keep rats as pets so reading the details was difficult.


--------------------
Listen to the silence behind the engines' noise.  Jesus, Sweets, listen.  Hear it?  It's a love song.
For whom?
You are loved.
~ David Foster Wallace, Westward the Course of Empire Takes Its Way


Extras: Filter Print Post Top
InvisibleveggieM

Registered: 07/25/04
Posts: 17,504
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog] * 1
    #28497358 - 10/09/23 08:02 AM (3 months, 18 days ago)

There have been many phase 1 and phase 2 trials with psilocybin with humans completed. The results have been very postive, but without a definitive conclusion as to benefits. But what we have learned so far is that psilocybin is safe for people at high recreational doses. There is no reason to continue to perform rat or any other animal studies when there are so many willing humans available.


Extras: Filter Print Post Top
OfflineKuroKitsune
Stranger
Registered: 11/05/22
Posts: 50
Last seen: 11 days, 14 hours
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: veggie]
    #28509042 - 10/18/23 06:49 AM (3 months, 9 days ago)

Interesting. For a 70kg human, the HED (human equivalent dose) would be 0.05 X (6/37) X 70 = 0.567567568mg. I should look at what has been used in studies in humans.


Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: Kraken Kratom Kratom Capsules for Sale   PhytoExtractum Buy Bali Kratom Powder   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Amanita Muscaria Store Amanita Extract   Mushroom-Hut Mono Tub Substrate


Similar ThreadsPosterViewsRepliesLast post
* How much "Host Defense Lion's Mane Capsules" should I take for the "Stamets Stack"? Entheo-G 1,199 12 09/30/22 09:56 PM
by ilus

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: geokills, veggie, LogicaL Chaos, Pastywhyte
467 topic views. 0 members, 2 guests and 2 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.021 seconds spending 0.004 seconds on 13 queries.