|
veggie

Registered: 07/25/04
Posts: 17,504
|
A new psilocybin microdosing study from the University of Southern Denmark 1
#28491738 - 10/04/23 06:43 AM (3 months, 23 days ago) |
|
|
Psilocybin microdosing may improve mental health by boosting stress resilience
Researchers from the University of Southern Denmark have found that โmicrodosingโ psilocybin may have a beneficial effect on mental disorders.
Read full article on Earth.com here: https://www.earth.com/news/psilocybin-microdosing-may-improve-mental-health-by-boosting-stress-resilience/
|
Capt. Ramius
Submarine commander

Registered: 11/22/22
Posts: 107
Loc: Bottom of tea sea
Last seen: 12 days, 8 hours
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: veggie]
#28491891 - 10/04/23 09:58 AM (3 months, 23 days ago) |
|
|
Nice find! Too bad the actual study (https://www.nature.com/articles/s41380-023-02280-z) is behind a paywall
|
Janus62
Call me Hugh



Registered: 08/27/22
Posts: 365
Loc: Midlands UK
Last seen: 11 hours, 29 minutes
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: Capt. Ramius]
#28491931 - 10/04/23 10:49 AM (3 months, 23 days ago) |
|
|
It's not available on Sci-Hub yet (https://sci-hub.wf/https://www.nature.com/articles/s41380-023-02280-z), but it's only been a couple of days, so it might be soon. I'll keep an eye open for it.
-------------------- ๐
๐ด ๐ฐ ๐ผ ๐ฒ ๐ป ๐ธ ๐ฝ ๐ถ ๐
๐
๐ฐ ๐ฟ
|
tree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: Janus62] 1
#28495231 - 10/07/23 08:42 AM (3 months, 20 days ago) |
|
|
I wrote the research team and have a copy of the study.
Can I share it on sci-hub to post the link? I've never done that so unsure how that works.
Dosing regimen was 0.05mg/kg every other day. About 2.5mg every other day in an average sized woman.
No tolerance build up observed.
edit: Someone in the psychedelic experience asked for it and I found a link in the paper that should work.
https://osf.io/gy6m9/
-------------------- Listen to the silence behind the engines' noise. Jesus, Sweets, listen. Hear it? It's a love song. For whom? You are loved. ~ David Foster Wallace, Westward the Course of Empire Takes Its Way
Edited by tree frog (10/07/23 11:28 AM)
|
jnotorious
notorious


Registered: 05/06/23
Posts: 8
Loc: Oregon
Last seen: 3 months, 18 days
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog]
#28497166 - 10/08/23 10:52 PM (3 months, 18 days ago) |
|
|
Anyone got a quick overview of the article?
|
tree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: jnotorious]
#28497282 - 10/09/23 05:46 AM (3 months, 18 days ago) |
|
|
They dosed rats 0.05mg/kg every other day. No tolerance build up. Many positive physiological changes, better neural connectivity in some regions of the brain, fewer physical anxiety responses, etc. Dose was well tolerated as far as they could tell.
I mostly skimmed it so don't have much more than that
-------------------- Listen to the silence behind the engines' noise. Jesus, Sweets, listen. Hear it? It's a love song. For whom? You are loved. ~ David Foster Wallace, Westward the Course of Empire Takes Its Way
|
B Traven
Stranger



Registered: 03/10/20
Posts: 2,479
Loc: Central Megalopolis
Last seen: 2 hours, 56 minutes
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog] 1
#28497290 - 10/09/23 05:59 AM (3 months, 18 days ago) |
|
|
Something really rubs me the wrong way about raising rodents just to slice their brains up. Feels pointless to me.
Even more so when the focus is on microdosing psilocybin. I'm sure the only reason they're going to animal models with that, aside from some scientists' obsession with looking at brain cross-sections, is because of legal considerations.
I had just assumed this was some sort of clinical trial at first.
-------------------- Beware of advice- even this.
|
tree frog
eats bugs


Registered: 09/14/23
Posts: 443
Loc: lives in trees
Last seen: 6 hours, 18 minutes
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: B Traven] 1
#28497323 - 10/09/23 07:05 AM (3 months, 18 days ago) |
|
|
Quote:
B Traven said: Something really rubs me the wrong way about raising rodents just to slice their brains up. Feels pointless to me.
Even more so when the focus is on microdosing psilocybin. I'm sure the only reason they're going to animal models with that, aside from some scientists' obsession with looking at brain cross-sections, is because of legal considerations.
I had just assumed this was some sort of clinical trial at first.
This is why I skimmed it. I have some education on neurochemistry so understood a lot of it. But I also keep rats as pets so reading the details was difficult.
-------------------- Listen to the silence behind the engines' noise. Jesus, Sweets, listen. Hear it? It's a love song. For whom? You are loved. ~ David Foster Wallace, Westward the Course of Empire Takes Its Way
|
veggie

Registered: 07/25/04
Posts: 17,504
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: tree frog] 1
#28497358 - 10/09/23 08:02 AM (3 months, 18 days ago) |
|
|
There have been many phase 1 and phase 2 trials with psilocybin with humans completed. The results have been very postive, but without a definitive conclusion as to benefits. But what we have learned so far is that psilocybin is safe for people at high recreational doses. There is no reason to continue to perform rat or any other animal studies when there are so many willing humans available.
|
KuroKitsune
Stranger
Registered: 11/05/22
Posts: 50
Last seen: 11 days, 14 hours
|
Re: A new psilocybin microdosing study from the University of Southern Denmark [Re: veggie]
#28509042 - 10/18/23 06:49 AM (3 months, 9 days ago) |
|
|
Interesting. For a 70kg human, the HED (human equivalent dose) would be 0.05 X (6/37) X 70 = 0.567567568mg. I should look at what has been used in studies in humans.
|
|