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Offlinebutterflydawn
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A whole genome atlas of 81 Psilocybe genomes (research) * 1
    #28437732 - 08/18/23 12:35 AM (5 months, 7 days ago)

A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin production.

Abstract:

The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity of Psilocybin synthesis in Psilocybe has been attributed to a horizontal gene transfer mechanism of a ~20Kb gene cluster. A recently published highly contiguous reference genome derived from long read single molecule sequencing has underscored interesting variation in this Psilocybin synthesis gene cluster. This reference genome has also enabled the shotgun sequencing of spores from many Psilocybe strains to better catalog the genomic diversity in the Psilocybin synthesis pathway. Here we present the de novo assembly of 81 Psilocybe genomes compared to the P.envy reference genome. Surprisingly, the genomes of Psilocybe galindoi, Psilocybe tampanensis and Psilocybe azurescens lack sequence coverage over the previously described Psilocybin synthesis pathway but do demonstrate amino acid sequence homology to a less contiguous gene cluster and may illuminate the previously proposed evolution of psilocybin synthesis.

GOLD


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OfflineJust M
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Re: A whole genome atlas of 81 Psilocybe genomes (research) [Re: butterflydawn]
    #28437736 - 08/18/23 12:48 AM (5 months, 7 days ago)

Cool
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