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InvisibleveggieM

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From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides * 1
    #28399403 - 07/18/23 05:15 AM (9 months, 27 days ago)

From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides
July 17, 2023 - Sociedelic

Explore the inception of 1D-LSD, a pioneering force reshaping the future of legal lysergamides.

In the evolving landscape of psychedelic substances, 1D-LSD is another new ‘frankendrug’ designed to circumvent European laws. With the tightening of regulations on known substances, inventive chemists have turned their efforts towards creating analogs and derivatives that offer similar effects while remaining within the boundaries of the law, at least for now. The appearance of 1D-LSD and other such substances is a direct response to this regulatory environment, raising questions about the effectiveness of current drug policies and the need for harm reduction measures in the face of such innovations.

Ever found yourself contemplating the mysteries of the universe and the human mind? If so, then you’ve probably stumbled upon the fascinating world of psychoactive substances. Among these intriguing compounds, one stands out – 1D-LSD. What was it about this particular lysergamide that captured the attention of scientists and psychonauts alike?

Introducing 1D-LSD The Successor to 1V-LSD

Before we had 1D-LSD, there was 1V-LSD, also known as 1-valeryl-LSD. This compound was widely accepted in Germany and other parts of the world due to its legal status and similar effects to LSD, the most well-known lysergamide.

From the pioneering minds at Lizard Labs comes an exciting breakthrough in the field of psychedelic research – 1D-LSD. The journey in this realm has led to the synthesis of this novel German-legal lysergamide, a highly-anticipated successor to 1V-LSD. Months of meticulous research, exploration, and overcoming significant challenges have yielded the first batches of this compelling compound.

1V-LSD, or 1-valeryl-D-lysergic acid diethylamide, is an artificial derivative of natural lysergic acid, which occurs in ergot alkaloids, and is an analogue of LSD. It is believed to serve as a prodrug for LSD and might also act as a weak partial agonist at the 5-HT2A receptor. This means that while it may become active LSD in the body, it might also have some direct effects of its own.

A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.

1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety. This means that it is a chemically modified version of LSD, with an additional valeroyl group attached.

1D-LSD: The Basics

In the labyrinth of psychoactive substances, 1D-LSD has carved its niche as a research chemical. It shares similarities with other lysergamides, a class of compounds known for their potent effects on the human mind. But what distinguishes 1D-LSD from its kin? Let’s dive in and discover.

1D-LSD: An Innovative Lysergamide with Unique Pharmacological Profile

Initial tests have revealed that 1D-LSD distinguishes itself from its predecessors with a faster onset and a slightly shorter duration of effect. Interestingly, our researchers have reported that 1D-LSD consistently provides reproducible results, a quality that positions it as a potential contender to surpass even well-established compounds like 1P-LSD or 1cP-LSD in terms of its qualitative effects.

The chemical structure of 1D-LSD may explain its unique characteristics. It features a highly strained 1,2-dimethylcyclobutane group, which may facilitate rapid metabolism and hydrolysis to LSD in the body. The potency of 1D-LSD appears to be equivalent to 1V-LSD, prompting us to maintain the standard blotter dose at 150mcg.

Chemistry of 1D-LSD

With an ergoline backbone, 1D-LSD is an LSD prodrug and 1V-LSD analogue. As a prodrug, it’s essentially an inactive compound that becomes active upon ingestion due to chemical reactions through metabolisation. The exact mechanism of action is likely similar to that of other LSD prodrugs like 1cP-LSD and 1P-LSD, though further research is required to confirm this hypothesis.

1D-LSD is a derivative of LSD, meaning it shares a similar chemical structure with some slight alterations. Just like a twist in a familiar tale, these minor modifications can produce remarkably different effects. The chemistry of 1D-LSD is a captivating subject, unveiling the delicate balance between structure and function in the world of psychoactive compounds.

The quick onset of 1D-LSD can be attributed to the highly-strained 1,2-dimethylcyclobutane group. It possibly facilitates swift metabolism and hydrolysis to LSD in-vivo. As for its potency, 1D-LSD mirrors 1V-LSD, allowing us to maintain the standard blotter dose at 150mcg.

Comparisons to LSD

In comparison to its older cousin LSD, 1D-LSD is said to offer a similar, yet subtly different experience. Some users report that it’s somewhat gentler, with less intensity in its visual effects. However, the overall quality of the experience – the enhanced perception, the sense of connection – remains similar.

Comparisons to Psilocybin

When compared to psilocybin, the active compound in magic mushrooms, 1D-LSD tends to have a more analytical and clear-headed effect. While psilocybin can often lead to emotional and introspective journeys, 1D-LSD is often described as more neutral, allowing for a more controlled exploration of the psychedelic space.

Effects and Potency of 1D-LSD

The effects of 1D-LSD are yet to be fully explored. However, preliminary reports suggest it has a similar pharmacological profile to other lysergamides. What does this mean for the user, and how does it translate to potential applications?

Initial reports suggest that 1D-LSD shares many effects with 1V-LSD and LSD-25. However, a few key differences have been noted:
  • Shorter/faster onset: 1D-LSD takes about 30-60 minutes for the full effects to take hold, as compared to 1-2 hours for 1cP-LSD and LSD-25.
  • Consistency: Researchers report that 1D-LSD produces more consistent and reproducible results, making it potentially suitable for microdosing or therapeutic applications.
  • Shorter Duration: 1D-LSD has a shorter duration even than 1V-LSD, which lasts around 6-8 hours as compared to the 10-12 hours duration of 1cP-LSD and LSD-25.
  • Comparable potency: The potency of 1D-LSD appears to be similar to that of 1V-LSD.

On Reddit, the potency of 1D-LSD compared to LSD-25 was also a topic of discussion. A user noted that if their calculations were correct, 1D-LSD should be approximately 34% less potent than LSD by weight. This would mean that a 150μg dose of 1D-LSD would be roughly equivalent to a 100μg dose of LSD. However, this is a rough estimate and individual experiences can vary significantly.

In another comparison of different LSD analogs, one user provided a list of analogs with their respective weight percentages compared to LSD. In their list, they calculated the weight of 1D-LSD to be 134% of LSD, suggesting that it is 74.6% as potent by weight, making it 25.4% weaker. This user also highlighted the fact that when taking a dose of an LSD analog like 1P-LSD or 1D-LSD, the weight of the dose includes the weight of the added group that eventually gets cleaved off in the body.

It’s worth noting that these are user observations and calculations, and while they provide interesting insights, they should not replace scientific research or medical advice. Always approach the use of substances like 1D-LSD with caution and respect.

Physical Effects of 1D-LSD

Users have reported a variety of physical effects after consuming 1D-LSD. These include changes in sensory perception, body temperature, and heart rate, among others. It’s essential to note that these effects vary greatly from person to person, underscoring the complexity of the human body’s response to psychoactive substances.

Psychological Effects of 1D-LSD

On the psychological front, 1D-LSD is said to induce effects reminiscent of classical psychedelics. These can range from enhanced sensory perception and introspective experiences to profound shifts in consciousness. However, as with all psychoactive substances, the psychological effects of 1D-LSD are highly subjective and can be influenced by various factors, including dosage, set, and setting.

Personal Experiences with 1D-LSD

A user on Reddit reported their firsthand experience with 1D-LSD, indicating that it could potentially become their new favorite LSD prodrug.

In the world of psychoactive substances, firsthand experiences can provide valuable insights. One user shared their trip report of 1D-LSD, detailing their experience with a 150mcg dose taken orally on an empty stomach. They described a rapid onset of effects, with light and floaty sensations within 20 minutes, and escalating to visual distortions and a very active mental state within the hour. The peak effects seemed to diminish after a few hours, but lingering sensations were noted for several hours afterward. This user compared 1D-LSD favorably to 1P-LSD, even suggesting it could become their new favorite LSD prodrug due to its intense and short-lived effects.

In a discussion of the compound’s structure, one commenter speculated that 1D-LSD would likely break down into two LSD molecules in the body, echoing the prodrug concept mentioned earlier. However, they emphasized that the precise mechanism of this breakdown is still hypothetical and not fully understood.

Another user pointed out that the substitution on the 1-position of the LSD molecule in 1D-LSD is a carbonyl (C=O), unlike in the LSD-25 molecule. They further noted that this substitution could potentially influence the metabolic process in the body.

How to Take 1D-LSD

1D-LSD is most commonly taken orally, either by swallowing a blotter or in liquid form. It’s important to remember that the onset of effects can take anywhere from 20 minutes to 2 hours, so patience is key to prevent overconsumption.

Legal Status and Safety of 1D-LSD

Navigating the legal landscape of psychoactive substances can be as complex as understanding their chemistry. Laws differ from country to country, and what is considered legal in one jurisdiction might be prohibited in another. So, where does 1D-LSD stand in this legal maze?

Legal Status

1D-LSD is currently legal in Germany, France, Japan, and almost every country in the world where there isn’t a blanket ban on psychoactive compounds.

In many jurisdictions, 1D-LSD is considered a research chemical and is not currently covered by existing drug laws, like Germany’s BtMG or NpSG. However, the sale of this substance could be punishable, while possession and acquisition might not be. As always, legality should never be assumed and should always be thoroughly researched before acquiring any substance.

The reason why 1D-LSD has caught so much attention is because of its legal status in Germany. Here’s the thing, 1D-LSD replaced 1V-LSD after the latter became covered by the German NpSG law in 2022. This means that while 1V-LSD is no longer legal, 1D-LSD has stepped in to fill the void.

Safety Profile

While 1D-LSD is a new substance, its safety profile remains largely unknown. It’s crucial to approach any new psychoactive substance with caution, particularly those with potential psychedelic effects. As with all substances, potential users are advised to pay close attention to dosage, set, and setting to mitigate potential risks.

Conclusion

Exploring the world of 1D-LSD opens a door to new understandings and experiences. As we journey through this psychedelic landscape, it’s crucial to approach with respect, awareness, and care. Always prioritize safety, stay informed about the legal implications, and remember – each journey is unique. So, whether you’re an experienced psychonaut or just curious about the world of psychedelics, 1D-LSD is a fascinating substance that begs exploration.


Read also: A German company is selling a reportedly legal LSD prodrug - Benzinga

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Offlinemorrowasted
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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: veggie] * 1
    #28400153 - 07/18/23 10:00 PM (9 months, 26 days ago)

Quote:


Another user pointed out that the substitution on the 1-position of the LSD molecule in 1D-LSD is a carbonyl (C=O), unlike in the LSD-25 molecule. They further noted that this substitution could potentially influence the metabolic process in the body.


If anyone intentionally gets some for whatever reason (and is willing), please, provide the most objective anecdote possible. Time to onset, peak, qualia/phenomenology. Be as specific as you can. For science. There's a metric fuckton of blotter being sold as LSD but there seem to be substantial qualitative differences and I cant help but wonder if some it is actually analogues. I can't see any financial incentive for someone to do that but I'm not a chemist, I'm just basing that off of the fact that I've heard it's necessary to produce plain old LSD25 in order to produce any of these derivative analogues. That's what was said about the 1p analog. Perhaps there is another way to make some analogues that does not involve producing LSD25? IDK.




Just seems odd given how practically free actual LSD has become. You cant buy very many things in this world with $1.50 anymore, but apparently a 10 hour trip on LSD is one of them...

I just looked up German laws and apparently you can have roughly 45 (6mg or 30-60 tabs, depending on whether theyre dosed at 100, 150, or 200) tabs without worrying about Jail time

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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: morrowasted]
    #28400503 - 07/19/23 09:22 AM (9 months, 26 days ago)

Get a soda pop for a dollar.


--------------------
Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.


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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: WhoManBeing]
    #28400749 - 07/19/23 01:20 PM (9 months, 25 days ago)

Not even bro. Maybe in rare locations

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Offlineviraldrome
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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: morrowasted]
    #28403054 - 07/21/23 03:43 PM (9 months, 23 days ago)

Quote:

morrowasted said:
Quote:


Another user pointed out that the substitution on the 1-position of the LSD molecule in 1D-LSD is a carbonyl (C=O), unlike in the LSD-25 molecule. They further noted that this substitution could potentially influence the metabolic process in the body.


If anyone intentionally gets some for whatever reason (and is willing), please, provide the most objective anecdote possible. Time to onset, peak, qualia/phenomenology. Be as specific as you can. For science. There's a metric fuckton of blotter being sold as LSD but there seem to be substantial qualitative differences and I cant help but wonder if some it is actually analogues. I can't see any financial incentive for someone to do that but I'm not a chemist, I'm just basing that off of the fact that I've heard it's necessary to produce plain old LSD25 in order to produce any of these derivative analogues. That's what was said about the 1p analog. Perhaps there is another way to make some analogues that does not involve producing LSD25? IDK.




Just seems odd given how practically free actual LSD has become. You cant buy very many things in this world with $1.50 anymore, but apparently a 10 hour trip on LSD is one of them...






LSD hits you different doesnt not equal its something else. I have some 1-V and 1-D and i can already guess its going to feel like 1-p which just feels likes acid to me.

Stop expecting consistency from something that is not consistent


--------------------
Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD

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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: viraldrome]
    #28403366 - 07/21/23 09:59 PM (9 months, 23 days ago)

Huh???


None of what you said makes sense other than the first sentence.


Even with something as simple as alcohol it's obvious that setting makes a difference. If I'm sitting at home and there's not a rhythm and bass playing I'm not liable to dance regardless of what I drink. If there is a rhythm and bass playing I may dance even without any drink and if I do drink then I'm a lot more likely to


That's totally different from the idea that there might be varieties of ethanol molecules that have different effects and that the black market nature of producing this molecule may have obscured such potential difference is today at

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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: morrowasted]
    #28403394 - 07/21/23 11:09 PM (9 months, 23 days ago)

You are probably just taking LSD. Any variation in the trip is because LSD is not a drug that produces consistent results. This shit has been going on so long and is never borne out with testing or proof of any sort, just people suspecting the acid is "something else". I just got some 1v and 1d and have no plans to write anything about them, because I suspect it will just feel like LSD again.
'
  Its easier to simply test this strange LSD than to speculate about it by reading every trip report on 1d. Its not impossible its LSB, the guy who made it died in 2017. You can read every report in the world and you will never have a definitive answer. Highly unlikely its 1d/v though


--------------------
Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD

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Re: From 1V-LSD to 1D-LSD: The Evolution of Legal Lysergamides [Re: viraldrome]
    #28403445 - 07/22/23 01:56 AM (9 months, 23 days ago)

but even among LSD, there seem to be potential correlations between how it is made, the nature of the product itself (which is essentially always bound to something; not 'freebase', unless you made it yourself and you dont plan on taking it all very soon), that plays a role in the potential for one batch to produce different qualia on average than others. differences certainly very greatly but people who take a lot of LSD frequently are in a sense able to control for set whether they want to or not AND setting if they want to. the ancedote pendulum seems to be swinging away from the formerly well-accepted notion that LSD itself is always the same


my friend has epilepsy. he is a PhD chemist. he refuses to take a particular brand of dilantin because he states the way it is complexed does not work for him, and every time he tried it, he had seizures. he can explain in detail why the other brands do work even though the active molecule is the same shape- the lattice that contains it varies according to how it is complexed. he had to write a detailed letter to his insurance to, after months, finally get authorization to use the brand of dilantin they don't cover- the only one that he knows actually works for him

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