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OfflineMeerkatsMycology
Noob Saffer
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Registered: 09/28/21
Posts: 35
Loc: South Africa
Last seen: 7 months, 14 days
Psilocybin with dementia, possible treatment or terrible idea?
    #28232210 - 03/16/23 03:11 PM (10 months, 8 days ago)

Hello guys (and girls), I need some input here from people a bit more experienced with this topic than I am. My mother is getting up there in age, Alzheimers runs in our family, and recently she has been extremely worried that her mind is starting to fail her. She has been taking some supplements along with lion's mane at my suggestion in order to help improve her brain function, but she isn't seeing much noticeable improvement. I have seen a few studies recently suggesting that both microdosing and macrodosing psilocybin may help people with alzheimers, but study on the topic still seems extremely limited. We are going into mushroom season soon and we do have a few actives growing around here, would you risk it? If it was for myself that would be one thing, but my mother has no experience with psychedelics at all and i don't feel particularly good about the idea of using her as some sort of guinnea pig. I understand that generally, mental disorders and psychedelics don't mix well, and i don't want to be the one responsible for sending my mother into a psychosis.

Note: i am talking mainly about macrodosing here, i don't see many ways that microdosing could go wrong and we will be trying that.


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OfflineVP123
Strange
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Registered: 06/27/19
Posts: 1,341
Loc: Midwest
Last seen: 9 days, 22 hours
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: MeerkatsMycology] * 6
    #28232306 - 03/16/23 04:42 PM (10 months, 8 days ago)

If you want to know whether mushrooms are safe or not for someone in the early stages of dementia, the answer is that we don't know. Probably nobody knows. Although used by indigenous cultures for generations, we don't have good documentation on potential contraindications for many conditions. All we are doing here is experimenting with ourselves. And because of this, the person using them should be fully aware of what they are trying to do.

In my opinion, lack of experience using psychedelics is not a big issue. Just start low and go slow. By this I mean introducing the person to low doses first and see how they handle it. Maybe begin with a low dose and gradually increase it every new trip until you find out what works best. I wouldn't suggest an intense trip the very first time.

One of the biggest issues I see here is whether the person is fully aware and capable of comprehending the implications of experimenting with psychedelics. I would never recommend making a person trip against their will, knowledge, or by deception. Maybe someone else with a similar experience to yours will offer a better insight. I just wanted to express my point of view here.


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OfflineMeerkatsMycology
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Registered: 09/28/21
Posts: 35
Loc: South Africa
Last seen: 7 months, 14 days
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: VP123]
    #28236225 - 03/19/23 09:59 AM (10 months, 5 days ago)

Solid reply, yeah I think that starting her on a lower dose would likely be a good idea. The only rationale that I could think of for a heavier dose early on is that generally, the first few experiences somebody has with mushrooms are always good ones, almost as if the mushroom wants you to get to know it before it starts to get rough with you. I will probably start her on a 1.5g and take her out into the forest. Don't worry, I will make sure that she understands fully the risks and weight involved, she is fully lucid and just beginning to worry that it is coming on, she is starting to become very forgetful.


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Offlineherbstation
Child


Registered: 01/05/23
Posts: 217
Last seen: 2 days, 4 hours
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: MeerkatsMycology] * 1
    #28236240 - 03/19/23 10:10 AM (10 months, 5 days ago)

Alzheimer's and dementia have the most positive outcomes I've read from microdosing. She should get some neuroprotection (theoretically causing improvement) from microdosing. Many patients report better mobility and lucidity compared to placebo.

Macro-dosing for end-of-life processing is a totally different beast. Also very beneficial, but I would say macro-dosing would be more for the psychological benefits. It might make her feel comfortable even though her body is degrading, she might be able to forgive herself for her forgetfulness and still live a happy life. Improved creativity and imagination couldn't hurt if you're getting elderly too. I know those are strongly tied to feelings of "youthfulness".

Best of luck
Cheers


--------------------
Expanding my mind until I can join the collective


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OfflineFungiForest
Male

Registered: 03/01/23
Posts: 2
Last seen: 9 months, 24 days
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: herbstation]
    #28253104 - 03/29/23 02:47 PM (9 months, 26 days ago)

Yes, start with a micro-dose of 1g (fresh truffle) every 2-3 days, if it's mushrooms take a calculator to measure a micro-dose. Then gradually increase the doses to 1.5gr (she will clearly be under the effects of psilocybin but given her advanced age it is necessary). A minimum of 3 months of treatment per year.

She must absolutely increase the doses of Lion Mane (5 gr dried per day minimum then increase if it goes well) it is impossible that she does not feel anything!

I also recommend 5 gr dry minimum of Cordyceps Sinensis or Militaris, as well as the same dose for Reishi. A minimum of 4 months of treatment with a one month break!

I also advise you to take these supplements to maintain good brain health and avoid dementia: Alpha GPC, Vinpocetin, Bacopa, Gotu Kola, PS Caps, Ginkgo Bilboa (mod edit: removed source per site's rules).


Edited by veggie (03/31/23 09:55 PM)


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InvisibleRhizomorph
Psychedelic Researcher
Other


Registered: 04/24/20
Posts: 785
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: MeerkatsMycology] * 1
    #28255598 - 03/31/23 01:33 AM (9 months, 24 days ago)

The proposed mechanism for psychedelic treatment of dementia assumes it facilitates neurogenesis (birth of new neurons) which, to date, no studies have proven. Neurogenesis essentially helps to repair damage.

We know that psychedelics promote neuroplasticity (ability to form new neural connections) but this has more to do with learning. It can help to learn more effective coping, which can reduce the symptoms, but it likely won't have as substantial direct impacts on the neural causes of dementia as neurogenesis would.

At the end of the day it probably won't hurt. Your mother is probably beyond the age where schizophrenia (chronic psychosis) is a risk, and the risk of acute psychosis is incredibly small if harm reduction (set, setting, & dose) are accounted for. But, if you think dementia may be manifesting, have her see a psychologist to determine if she can get a clinical diagnosis or to rule out other reasons for cognitive impairment

Although there could be concerns regarding consent if your mother already has dementia, if consent is established, I don't think the risk is very high. Psychedelics are not associated with the development of future mental health disorders or problems according to research (let me know if you want me to cite it), contrary to popular belief.

If your mother can still reliably consent (which it sounds like she can if the symptoms are mild/early), then just focus on psychedelic harm reduction (harm generally referring to the risk of a bad/challenging trip in this context) and you should be fine. We have more data on the safety of psychedelics than people like to think; your mother isn't really a guinea pig in that domain.

Even if it isn't promoting neurogenesis, the neuroplastic effects or just the ability to have a mystical or incredibly meaning-inducing experience can be marvelous. Especially if it's in good company :smile:


--------------------

:cookiemonster: Major Issues in the Psychedelic Movement: Why 'Psychedelic People' and the Psychedelic Movement Sucks:elmo:

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OfflineCallMeCraig
Danger


Registered: 05/18/23
Posts: 11
Last seen: 7 months, 8 days
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: MeerkatsMycology]
    #28339373 - 05/29/23 12:16 PM (7 months, 27 days ago)

Hello, just wondering if there are any updates on this situation.


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Invisiblecopelandiao
Old School
Registered: 04/23/04
Posts: 38
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: CallMeCraig]
    #28373490 - 06/24/23 10:57 PM (7 months, 17 hours ago)

I'm looking forward to reading updates. Cannabinoids greatly reduce plaques in the aging brain. Cubensis certainly connects regions of the brain, it's a great networker. :smile:

I'm curious.


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OfflineLucisM
Nutritional Yeast

Registered: 03/28/15
Posts: 15,622
Last seen: 1 month, 28 days
Re: Psilocybin with dementia, possible treatment or terrible idea? [Re: MeerkatsMycology] * 1
    #28373563 - 06/25/23 12:50 AM (7 months, 16 hours ago)

Lots of good advice in here, but I think that given how certain mushrooms can open up new neural networks/connections in the brain it's definitely something interesting to look into in relation to dementia.

A microdose (0.3-0.5 grams) would probably begin to help.

I am not a doctor though, so please research further and see what comes up. 



--------------------
©️


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