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InvisibleIcyurmt
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Registered: 04/02/20
Posts: 1,625
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Re: Melatonin added to substrate, and also Tryptophan added to substrate [Re: nektar61] * 2
    #28499416 - 10/10/23 09:11 PM (3 months, 16 days ago)

Quote:

nektar61 said:
Quote:

Stipe-n Cap said:
Yeah, I have doubts that dmt just converts to psilocin when introduced to the sub. I have no idea why he'd think such a thing, but maybe I'm wrong. I'm not a a famous drug chemist, or any kind of chemist, and I doubt he was much of a mycologist.




Yes.

I think he might have tried it if shrooms were as easy to grow back then as they are now.

But the fact that he thinks there is something that would do it means someone might want to try different things.




When Shulgin was alive the psilocybin biosynthesis pathway and specific enzymes involved were still unknown. At that time it was believed that DMT was one of the metabolites/steps involved so it seems he was likely working off of what turned out to be a false assumption. The paper identifying the 4 enzymes and true pathway didn’t come out until 2017.
Enzymatic Synthesis of Psilocybin


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Hunt for the habitat not the mushroom.


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InvisibleIcyurmt
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Registered: 04/02/20
Posts: 1,625
Loc: 5a
Re: Melatonin added to substrate, and also Tryptophan added to substrate [Re: Icyurmt] * 1
    #28499450 - 10/10/23 09:56 PM (3 months, 16 days ago)

It seems that trying to get the organism to take up either more of or a different compound altogether, could be a problem here even if you used a substrate/precursor that the enzymes would work on.

I’ve been wondering if pickling/soaking them fresh using a doped brine of some sort could have any impact. Or maybe using an extract or a slurry and incubating something in that? Lemon chemist tek?


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👁️ 🌊 why you are empty.

Hunt for the habitat not the mushroom.


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