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OfflineShroomNugget
Mycologist Wannabe
I'm a teapot User Gallery


Registered: 02/10/23
Posts: 355
Last seen: 26 days, 5 hours
5-HT2A Receptors, Trazodone, and Shrooms. Looking for more info! * 1
    #28295177 - 04/25/23 06:57 PM (8 months, 29 days ago)

I've been reading up on my prescriptions and their interactions with psilocybin due to a lack of effects I've recently experienced. I was on an SSRI which I am no longer taking. I'm also taking very low dose xanax roughly once daily for a sleep aid, and low dose Trazodone at night for insomnia.

I've read that the 5-HT2A receptors are what the psilocybin grabs on to for the psychedelic effect, as psilocybin is a 5-HT2A agonist. Now trazodone is a 'potent' 5-HT2A antagonist. Here is info on the half life of trazodone as well:
Quote:

The distribution half-life (t1/2a) which represents the amount of time required for the plasma concentration to decline by 50% during the distribution phase. The elimination half-life (t1/2b) which represents the amount of time required for the plasma concentration to decline by 50% during the elimination phase.




Is there anybody out there that understands pharmacology(???) enough to understand this gibberish that could please explain this to me like I'm 5 years old? lol

I believe if I take 50mg trazodone at night as usual then I'd have roughly 12.5mg in my system at the time I take shrooms the next day. Anyway back to the explain like I'm 5, is this equivalent to trying to stuff 10 lbs of shit into a 5 lbs bag or something? 😆

Ditching trazodone would be considerably difficult as its a godsend for insomniacs. Any help would be greatly appreciated! I'm sure this post could help hundreds in the future if we can get an expert in here!


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InvisibleElvishKlingonSith
Not here to do math
Male
Registered: 10/22/22
Posts: 237
Loc: Satan’s Nutsack
Re: 5-HT2A Receptors, Trazodone, and Shrooms. Looking for more info! [Re: ShroomNugget] * 1
    #28296565 - 04/26/23 06:10 PM (8 months, 28 days ago)

I have been on Traz for about 10 years. 150mg pre bed, prescribed for sleep.

I found my way back to shrooms around 3 years ago. I started out with 2-3 gram doses of cubes, and took more when I was comfortable doing so. I have a small circle to compare against (and I adventure more frequently than they do), but I commonly take 3-4x more than they do.  FWIW I never do anything but tea.

Everything was peachy until 2 months ago. Before then, I had fantastic (and recent) experiences on 10g PE blob, 6g Jack Frost, 6g Semperviva. I wondered if I would ever tell Drew Carey “that’s too much”.  A week following an absolute bust of a tampensis dose, I took 8g of Semperviva, and it was not a pleasant experience.  3 weeks after that I took 5g of semp, and had an unremarkable time (albeit not challenging like the 8g experience was).  Was my bust on tamps and ass kicking on 8g semps just something that can happen, did I screw my self by not waiting my usual 3 weeks, could it have been related to trazodone/neurotransmitters/receptors, the magnesium or apigenin supplements that I had recently started? 

I’ll never fully know.

There is no way anyone can state equivalency or give you a working model or formula to arrive you at a suggestion on what to take.  We don’t have anything remotely controlled enough on the shroom side to do that.

I am happy to share anything further I can. In truth, I hope I am wrong - and someone has evidence based and useful guidance.

I am rooting for you. 

TLDR - if it were me, start low, space adventures out, take your time when increasing dose, and accept that there are lots of other factors beyond the number on the scale.


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OfflineShroomNugget
Mycologist Wannabe
I'm a teapot User Gallery


Registered: 02/10/23
Posts: 355
Last seen: 26 days, 5 hours
Re: 5-HT2A Receptors, Trazodone, and Shrooms. Looking for more info! [Re: ElvishKlingonSith]
    #28297357 - 04/27/23 09:25 AM (8 months, 28 days ago)

Thanks dude, that's helpful insight!


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