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Offlineherbstation
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Registered: 01/05/23
Posts: 217
Last seen: 2 days, 4 hours
Body weight does not affect psilocybin dose
    #28283357 - 04/18/23 08:24 AM (9 months, 6 days ago)

Just wanted to throw it out there that psilocybin  dose is independent of body weight. This makes sense because it's hydrophilic. No need to adjust for weight when dosing.



Garcia-Romeu, Albert et al. “Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches.” Journal of psychopharmacology (Oxford, England) vol. 35,4 (2021): 353-361. doi:10.1177/0269881121991822


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OfflineLongtimenosee
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Registered: 12/05/22
Posts: 254
Last seen: 1 day, 18 hours
Re: Body weight does not affect psilocybin dose [Re: herbstation]
    #28285900 - 04/19/23 06:42 PM (9 months, 4 days ago)

The Mystical experience, challenging experiences and intensity seam to be highly variable in all three test groups. I just do not see a trend suggesting that a fixed dose was any different then a weight based dose in terms of effects, both seemed highly variable. Below is a quote from the article.

"Therefore, the results were somewhat mixed in the sense that the overall lack of significant effects did not provide definitive evidence supporting either weight-adjusted or fixed dosing. Contrary to the assumption implicit in most contemporary research with psilocybin, these findings do not indicate an advantage of weight-adjusted dosing over the simpler method of fixed dosing. In analyzing weight-adjusted doses in the 20 mg/70 kg and 30 mg/70 kg groups, we did not find significant evidence that weight-adjusted dosing produced unintended stronger effects in heavier individuals, which would be expected if weight-adjusted dosing was unnecessary to produce comparable effects across individuals of different body weights. However, in analyzing fixed doses approximating 25 mg, we also did not find significant evidence that lighter individuals showed stronger effects, which would be expected if weight-adjusted dosing was necessary to produce comparable effects across individuals of different body weights."


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OfflineLongtimenosee
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Registered: 12/05/22
Posts: 254
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Re: Body weight does not affect psilocybin dose [Re: Longtimenosee] * 1
    #28285907 - 04/19/23 06:47 PM (9 months, 4 days ago)

I am just not sure that this study really confirmed anything other then fixed doses are more convent take less work and therefore are cheaper and simpler then weight adjusted doses.:shrug:

After reading the article, in my option the jury is still out on this subject and more tests are needed.


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