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Invisiblemyc_ousin_vinny
Keeping_It_Real
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Registered: 04/29/20
Posts: 1,415
Macrodosing for the win…. * 5
    #28214629 - 03/04/23 06:12 PM (10 months, 19 days ago)

https://www.hopkinsmedicine.org/news/newsroom/news-releases/psychedelic-treatment-with-psilocybin-relieves-major-depression-study-shows

Seems like the biggest studies of psilocybin being done right now are the ones being done by Johns Hopkins.
From what I’ve gathered they are seeing the best results treating depression with macrodoses of psilocybin.

Microdosing seems to have little support by the current research: https://www.nature.com/articles/d41586-022-02876-5


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Offlinechris77
Archaic Revivalist
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Registered: 01/17/22
Posts: 1,868
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Re: Macrodosing for the win…. [Re: myc_ousin_vinny] * 1
    #28215188 - 03/05/23 12:29 AM (10 months, 19 days ago)

thank you for posting this.

and if i may say, to me, this is in the nature of the substance.
psilocybin is a boundary dissolving, perplexing and unpredictably psychedelic molecule. the healing comes with surrender and getting lost in order to find anew.

why would it be well suited to increase performance, enhance mood etc?

lets take alcohol for example. if i have one small glass i might feel kind of euphoric and speedy. not always the case.
but if i keep drinking i will become "drunk".
i would not use alcohol in "microdoses" to enhance my mood because it sometimes does so.
its not reliable.

whereas macrodoses do what they are supposed to.
and this goes for psilocybin and alcohol and many others.

me personally, i have tried microdosing and it either did nothing at all (when too weak) or it made me tired (when slightly higher dose).
maybe I haven't found the sweet spot.

Macrodoses on the other hand ....
:aweyeah:


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the observer is the observed
            j. krishnamurti


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OfflineInnerWisdom
Male


Registered: 08/09/19
Posts: 1,936
Loc: North EU
Last seen: 4 days, 6 hours
Re: Macrodosing for the win…. [Re: chris77]
    #28215245 - 03/05/23 01:48 AM (10 months, 19 days ago)

I have found microdosing in the range of .2-.3 grams to work as a stimulant and to bring to consciousness repressed feelings in a way. It seems to often but not always change my thinking a little bit. That being said, I very rarely have taken microdoses.


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OfflineHysteria
Bum Looker

Registered: 02/19/23
Posts: 841
Loc: New England USA
Last seen: 4 hours, 5 minutes
Re: Macrodosing for the win…. [Re: myc_ousin_vinny]
    #28216704 - 03/05/23 10:34 PM (10 months, 18 days ago)

I just recently started microdosing and so far it's been spotty, but never negative. Some days I feel like I have enhanced mood, creativity, and clarity of thought, other days I feel no different. I will keep at it for a few months to see if it's the microdose that actually makes a difference on the "good" days, or if it's simply random and/or placebo effects. I would love to hear others report their findings, since as you said, there isn't much scientific research to draw from at this point in time (kind of disappointing, considering it's been quite a few years since this became a thing).


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OfflineWhiteDemon
Mr.


Registered: 08/11/19
Posts: 152
Last seen: 4 hours, 7 minutes
Re: Macrodosing for the win…. [Re: Hysteria]
    #28230325 - 03/15/23 05:35 AM (10 months, 9 days ago)

How many days per week do you do that? I love 0.3 -0.5 doses but dont know how many days should i rest.


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- A Dreamer in the Nightmare of being Awake -


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Invisiblemyc_ousin_vinny
Keeping_It_Real
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Registered: 04/29/20
Posts: 1,415
Re: Macrodosing for the win…. [Re: WhiteDemon] * 1
    #28230415 - 03/15/23 08:04 AM (10 months, 9 days ago)

Quote:

WhiteDemon said:
How many days per week do you do that? I love 0.3 -0.5 doses but dont know how many days should i rest.




There are a couple "protocols" out there. This is one of them.

https://healthnews.com/family-health/drugs/the-stamets-stack-should-you-try-microdosing/

Here is a list:

https://microdosinginstitute.com/how-to/microdosing-protocols/

Again, the studies done have not shown efficacy like the macrodosing studies have :shrug:

Worth a shot I guess.


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Let's stay focused on what works consistently.

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Offlinedamngoodcoffee
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Registered: 04/24/21
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Re: Macrodosing for the win…. [Re: myc_ousin_vinny]
    #28230448 - 03/15/23 08:23 AM (10 months, 9 days ago)

There's some studies about microdosing with good results, I'm not a scientist so I can't really tell if the study conditions are adequate but I wouldn't rule them out
https://www.nature.com/articles/s41598-022-14512-3
https://www.sciencedirect.com/science/article/pii/S2772408522010134


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Invisiblemyc_ousin_vinny
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Registered: 04/29/20
Posts: 1,415
Re: Macrodosing for the win…. [Re: damngoodcoffee]
    #28230849 - 03/15/23 03:25 PM (10 months, 9 days ago)

Quote:

damngoodcoffee said:
There's some studies about microdosing with good results, I'm not a scientist so I can't really tell if the study conditions are adequate but I wouldn't rule them out
https://www.nature.com/articles/s41598-022-14512-3
https://www.sciencedirect.com/science/article/pii/S2772408522010134




Interesting. I'll check them out. Nature is for sure a legit source. Never heard of ScienceDirect but that's because I'm not a scientist :grin:

Thanks for sharing them.


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Bod's Easy AF Search Engine TEK

Let's stay focused on what works consistently.

"Sitting in a bunker here behind my wall..."


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OfflineWhiteDemon
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Registered: 08/11/19
Posts: 152
Last seen: 4 hours, 7 minutes
Re: Macrodosing for the win…. [Re: myc_ousin_vinny]
    #28231553 - 03/16/23 04:48 AM (10 months, 8 days ago)

Wow thank you so much! Its any of them better than others? Also what happens if you never take a break, just tolerance build up or can it negatively affect health? :crazy2:


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- A Dreamer in the Nightmare of being Awake -


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OfflineMeerkatsMycology
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Registered: 09/28/21
Posts: 35
Loc: South Africa
Last seen: 7 months, 14 days
Re: Macrodosing for the win…. [Re: WhiteDemon]
    #28232261 - 03/16/23 03:55 PM (10 months, 8 days ago)

Quote:

WhiteDemon said:
Wow thank you so much! Its any of them better than others? Also what happens if you never take a break, just tolerance build up or can it negatively affect health? :crazy2:



Excessive use of any good thing can be bad generally


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Offlinemrmyc
Stranger
Registered: 03/25/23
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Last seen: 6 months, 11 days
Re: Macrodosing for the win…. [Re: MeerkatsMycology] * 1
    #28245610 - 03/25/23 04:57 AM (9 months, 30 days ago)

For me the macro doses have definitely been more beneficial for treating my depression. I feel microdosing helps with emotions and being able to accept rather than react to them. Microdosing is just a subtle teaching of just being and goes hand in hand with macrodosing


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OnlineYahra
Meow


Registered: 03/06/23
Posts: 1,843
Loc: Earth
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Re: Macrodosing for the win…. [Re: mrmyc]
    #28246057 - 03/25/23 01:14 PM (9 months, 30 days ago)

Microdosing doesn't work. It's a placebo. A hipster fairytale.


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Offlineviraldrome
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Registered: 09/21/18
Posts: 4,049
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Re: Macrodosing for the win…. [Re: Yahra]
    #28246492 - 03/25/23 05:54 PM (9 months, 29 days ago)

Quote:

damngoodcoffee said:
There's some studies about microdosing with good results, I'm not a scientist so I can't really tell if the study conditions are adequate but I wouldn't rule them out
https://www.nature.com/articles/s41598-022-14512-3
https://www.sciencedirect.com/science/article/pii/S2772408522010134




Neither of those studies used a blind placebo control group. The problem I and many others have with microdosing is I could not determine if it worked if I was given the dose by someone else and not told if it was microdose or placebo. The "benefits" only seem to occur when you know you took it. Its a placebo effect

Quote:

Yahra said:
Microdosing doesn't work. It's a placebo. A hipster fairytale.




I agree


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Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD


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InvisibleImatryin
Stranger
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Registered: 07/06/21
Posts: 411
Re: Macrodosing for the win…. [Re: viraldrome]
    #28247530 - 03/26/23 12:28 PM (9 months, 29 days ago)

If the placebo works then go for it!
My doctor prescribed me a headache medication that retails for over $1000 a month. I read the research on it and it was twice as effective as placebo in reducing the frequency of headaches. 40% for the drug, 20% for the placebo. I asked my doc if he could prescribe the placebo first and if it worked, I could save $1000 a month. He said it didn’t work that way ☹️.


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OnlineYahra
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Registered: 03/06/23
Posts: 1,843
Loc: Earth
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Re: Macrodosing for the win…. [Re: Imatryin]
    #28247544 - 03/26/23 12:33 PM (9 months, 29 days ago)

Doctors don't want you to be healthy. They won't make money otherwise. I don't trust the pharma whores.


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Disobey


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OfflineWhoManBeing
PsychedelicYogi
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Registered: 09/01/13
Posts: 3,773
Loc: Oregon
Last seen: 3 days, 35 minutes
Re: Macrodosing for the win…. [Re: Yahra]
    #28247572 - 03/26/23 12:48 PM (9 months, 29 days ago)

Biggest studies?

This psilocybin thing old news. What was Sandoz doing with their mushroom pills?  Making counterculture America and a whole lot other.

Mostly to this news as today, see it as those with money and power to have their society how they want it are dying away and their need to have our society as they see it is dying along with them.

How long it take to bring electric cars to consumer market?  Porsche said to make electric carriage 1890.

Fabricating of America. Hideous dramas of ‘this is happening.’


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Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.



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OfflineWhoManBeing
PsychedelicYogi
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Registered: 09/01/13
Posts: 3,773
Loc: Oregon
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Re: Macrodosing for the win…. [Re: WhoManBeing]
    #28247575 - 03/26/23 12:49 PM (9 months, 29 days ago)

Need not be hideous dramas. Much more dumb founded lack there of intellect.


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Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.



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OfflineMushalla
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Registered: 01/07/23
Posts: 183
Loc: Massachusetts
Last seen: 10 days, 1 hour
Re: Macrodosing for the win…. [Re: WhoManBeing] * 1
    #28247891 - 03/26/23 04:02 PM (9 months, 29 days ago)

Over the past 2 years I tried both methods before I realized macro was the only way. Micro was good for a little extra visual acuity. That’s about it. My situation required much more.

This was after 10 years of trying to get my head straight by plenty of other means (my therapist saw such a difference, after watching my mental health severely degrade, that she has now decided to go back and get certified for working strictly with psychedelic therapy) …. Nothing ever helped like MACRO dosing and consistent meditation. Don’t get me wrong, every now and again I’ll macro to just have a fun night but when it’s about my mental well being…. Macro for the win!

This is why I’m so serious about my harvesting. Nothing better then cultivating your own medicine!

Great post my_cousin_vinny!


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OfflineHysteria
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Registered: 02/19/23
Posts: 841
Loc: New England USA
Last seen: 4 hours, 5 minutes
Re: Macrodosing for the win…. [Re: WhiteDemon]
    #28267007 - 04/07/23 02:20 PM (9 months, 17 days ago)

Quote:

WhiteDemon said:
How many days per week do you do that? I love 0.3 -0.5 doses but dont know how many days should i rest.




Sorry for the late reply. I have been doing the Stamets 4 days on, 3 days off. I do add lions mane 500mg - 1000mg, but I skip the niacin. So far, same results as before. I troubleshoot a lot as part of my job, and on some of the on days I have noticed especially easy and sometimes creative solutions coming to mind. If I feel tired/get the yawns I know the dose was too high and those days usually don't turn out to be anything special.


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Offlineinkoming
Microscope Hobbyist
Male


Registered: 01/10/23
Posts: 53
Loc: Australia
Last seen: 12 days, 12 hours
Re: Macrodosing for the win…. [Re: Hysteria]
    #28268307 - 04/08/23 08:14 AM (9 months, 16 days ago)

Quote:

Hysteria said:
Quote:

WhiteDemon said:
How many days per week do you do that? I love 0.3 -0.5 doses but dont know how many days should i rest.




Sorry for the late reply. I have been doing the Stamets 4 days on, 3 days off. I do add lions mane 500mg - 1000mg, but I skip the niacin. So far, same results as before. I troubleshoot a lot as part of my job, and on some of the on days I have noticed especially easy and sometimes creative solutions coming to mind. If I feel tired/get the yawns I know the dose was too high and those days usually don't turn out to be anything special.




I appreciate you sharing your experience and perspective on this. I also troubleshoot in my job on a regular basis. I tried microdosing in the 0.15-0.25 range. Seems insignificant, but I have felt some sensations like a little tingling around the jaw or teeth. Sometimes I had great moods, energetic and felt like I was connecting better with people and communicating well. Other days, I got anxiety and an underlying sense of dread I couldn't shake. I eventually had to stop because I was afraid it was starting to affect my sanity and well being. It could have been factors other than the microdosing, but who knows. So much of our bioassays are very non-scientific in nature and it's hard to glean reliable and repeatable information...


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Offlineergo_97
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Registered: 08/26/22
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Re: Macrodosing for the win…. [Re: inkoming]
    #28282349 - 04/17/23 04:24 PM (9 months, 7 days ago)

It make’s me happy so it is a win in my book


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InvisibleTucky
Smart ass.
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Registered: 12/13/20
Posts: 131
Loc: Near a tree by a lake
Re: Macrodosing for the win…. [Re: ergo_97] * 1
    #28285213 - 04/19/23 11:44 AM (9 months, 5 days ago)

The only thing micro dosing did for me was increase my tolerance so when I did a macro I had to take more to get a therapeutic effect.  Macro dosing has helped me more than anything.


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