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EdibleStereos
Healthy Body, Sick Mind


Registered: 01/02/13
Posts: 4,899
Loc: South Africa
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Lucid Toast]
#20206072 - 06/30/14 12:54 AM (9 years, 7 months ago) |
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Lucid Toast said:
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EdibleStereos said:
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usulpsychonaut said:
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Jestr said: I think its all about tolerance. This is why newbies claim to get "laced" weed. They have no tolerance and get way to high. It happens but only when you've never smoked or having for a really long time especially with a bong
I never get a single bit of tolerance. I use every day and every day a little blows me away. I never feel that I cannot get stoned...
Studies on THC tolerance have shown it is largely due to the time frame in which one smokes. Consuming more THC within 90 minutes of last exposure is what causes the majority of receptor downregulation.
So people can smoke multiple times daily without developing too much tolerance as long as they space out the highs.
Once tolerance builds, it can feel almost impossible to get high without taking a few weeks T-break.
Smoking extracts can also really increase tolerance if you dont space it out by a few hours.
I believe you I'd like to read this study if you have a link
I cant find the exact study, but here is an article i found posted on another forum. its almost 3am here, so ill try to remember to find the proper link in the morning.
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Due both to its common use as a recreational intoxicant and its employment in medicine, cannabis has been widely examined for its therapeutic potential and side effects. Among these side effects is tolerance, the regulation of cannabinoid uptake as a result of over stimulation. Tolerance is indicated by the requirement of larger doses to achieve a consistent desired effect, or when a given dose no longer provides it. Higher doses commonly result in the indication of higher impact of undesirable effects though, as with cannabinoids, tolerance can be achieved for many of these as well. Tolerance to cannabinoid stimulation results in withdrawal, most notably marked at 12 hours after cessation of “heavy” use by inner-unrest, increased activity and irritability. During a flushing period of 4 weeks following a 4 week daily ingestion period of 210 mg smoked THC, determined by Georgotas and Zeidenberg (comprehensive psychology), mild-withdrawal symptoms were reported to last between 5-7 days, with no inflammation or indication of desire for THC in the remaining 3 weeks.
Unlike the mythic ‘street-knowledge’ assay, which implies cannabinoid re-absorption through lipid deposits resulting in ‘occupied’ receptors due to constant stimulation, modern neuroassays have concluded tolerance to be based solely in receptor regulation. The cannabinoid content of endogenous lipid deposits has been shown to be less than active physiologically and psychologically.
A non-tolerant ingestion of smoked marijuana results in peak plasma concentrations of 90-95 ng/ml and peak effects lasting 75-90 minutes at which time plasma levels drop below psychoactive concentrations at 10 ng/ml. Plasma concentrations are unaltered by tolerance, indicating no change in endocannabinoid signaling, however cannabinoid stimulation, especially in ligand activation, decreases as a result of receptor based regulation. As has been widely explained and explored, availability of bonding-sites is reduced by down-tolerance and phosphorylation after prolonged or extreme exposure to cannabinoid agonists, resulting in a notable decrease in efficacy of stimulation and effects.
Down Regulation and Phosphorylation: Importunate exposure of receptors to agonist behavior, both with respect to time and dose, results in the endogenous desensitization of Cannabinoid receptors. G protein receptors CB1 and CB2, the primary sites of action for Cannabinoid stimulation, recede from their bonding heights into the cell-membrane after prolonged agonist action. This recession, known as downregulation, is coupled with phosphorylation in the desensitization of overestimated receptors in the mechanistic action of Cannabinoid tolerance. Phosphorylation creates ‘rapid-tolerance’, or the tolerance normally experienced during a single smoke session, normally receding at an equally rapid rate.
Specific Activation: Various Cannabanoids are active at different receptors, both by their affinity for CB1 or CB2 or their digested distribution. As a result, specific tolerance occurs effecting specific site of action.
-Tolerance to the pharmacological effects of ataxia, analgesia, motor inhibition, and anticonvulsant activity usually occurs within 3-7 days of administration, depending on dose and frequency, as a result of cerebellum based CB1receptor-binding and WIN55,212-2 stimulation.
-Long-term memory inhibition, as well as certain neuroendocrine actions (including neuroprotective), take several weeks to develop tolerance desensitization, the former in part due to anandamide’s relatively high endogenous availability. Anandamide levels in the striatum show reduction after prolonged exposure to cannabinoid receptor agonists, though the availability of the precursors was not diminished, suggesting a superficial alteration of productivity.
-More resistant populations of CB1 receptors, primarily located in the limbic regions responsible for emotional stimulation, were uniquely resilient in prolonging the onset of tolerance regulation. Tolerance to immunosuppressive effects of CP-55,940 through stimulation of CB2 receptors is largely insignificant even over extended periods of exposure.
-CB1 activation in Hipocampal neuron populations responsible for short-term memory develops down-tolerance within 24 hours of Δ9-THC administration and showed no impact (positive or negative) from increased anadamide availability or administration.
-Cannabinoid analogues WIN55,212-2, CP-55,940 and 11-hydroxy-Δ8-THC, more infinitively specific cannabinoid agonists take 7-9 days to develop normal tolerance shown to take 3-7 days in administration of less-specific agonists. Due to their specific affinity for bonding efficiently with CB1 receptors (predominant site of CNS stimulant and psychoactive activity), tolerance develops more slowly than with less accurately coupled agonists such as Δ9-THC, CBN and CBD.
-In vitro cultures of neuroblastoma cell line (N18TG2) exhibited rapid-tolerance to chronic exposure to cannabinoid agonist stimulation, showing a natural cellular response.
Tolerance as Dependence Indication: Though tolerance and dependence often develop concomitantly, in the case of cannabinoid stimulation, since the primary actions of tolerance are neuroreceptive as opposed to adaptive endocannabinoid signaling, tolerance and dependence are independently significant. There is no scientific consensus on the implications of cannabinoid dependence and withdrawal. As there is no indication of somatic and/or neurovegetative periods after abrupt cessation of high-dose cannabinoid therapy, the criteria for physical dependence remain unfulfilled as defined by worldwide health ministries. Psychological withdrawal implications failed to appear in any animal study, though have occurred in human and some non-human primates, to a notably lesser degree than opiods. Primary indicated factors of “heavy” marijuana use behavioral withdrawal include irritability, sleep deficits, attentional deficits, and anxiety, and have been shown to noticeably recede within a 3-day period of cessation, dissipating completely within 1 week.
Application: Recreational tolerance is relatively minute, if existent, in occasional users or ‘weekend-smokers’. Daily consumption for medicinal or recreational purposes however, can have greater, though still relatively diminutive, tolerance implications. Allowing receptor recuperation every 90 minutes could greatly decrease the impact of downregulation, and ingestion of appropriate doses rather than the commonly high recreational dose could aid in the resistance of phosphorylation tolerance. A recent study employing capsaicim antagonists and markers during Δ9-THC administration for analgesic property showed a low ceiling of consumption efficiency, followed by a rapid phosphorylation at high doses, implying a ‘sweet-spot’ theory, in which an exact dose is exponentially more efficient than an overdose. Recreational tolerance is relatively minute, if existent, in occasional users or ‘weekend-smokers’, due to the allowed recovery time. Daily consumption for medicinal or recreational purposes however, can have greater, though still relatively diminutive, tolerance implications. Forecasting scientific developments imply that through integration of specific agonists at specific bonding sites could reduce selective tolerance while achieving reasonable effects. The application of esoteric agonists could potentially alleviate tolerance based dosing and the complications it implies. Additionally, dosing with cannabinoid antagonists, such as CBD and CBG, can combat downregulation of receptors and expose increased availability.
For a full review of the lengthy cannabinoid tolerancedependence deliberation see: H. Kalant, Adverse effects of cannabis on health: an update of the literature since 1996, Progressive Neuropsychopharmacol Biol Psychiatry 28 (2004), pp. 849–863
Other resources:
González, Sara, Maribel Cebeira, and Javier Fernández-Ruiz. "Cannabinoid Tolerance and Dependence." Pharmacology Biochemistry and Behavior 81 (2005).
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jsncrs
DYEL


Registered: 01/16/14
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Re: .15 gram Cannabis from my bong = Level 5 [Re: EdibleStereos]
#20206084 - 06/30/14 01:00 AM (9 years, 7 months ago) |
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I'm a weekend toker, smoked a joint before cooking dinner on Saturday and for some reason I tripped my balls off for about 30 seconds 15 - 20 minutes after smoking. Never happened before. I was standing at the stove cooking some steak and all of a sudden it was like I was outside of my own body. The only thing I feel like I can compare it too is a mild Salvia trip. Weird shit man.
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Psychedelics yummy
Humanoid



Registered: 05/13/14
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Re: .15 gram Cannabis from my bong = Level 5 [Re: jsncrs]
#20206153 - 06/30/14 01:26 AM (9 years, 7 months ago) |
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That's how the whole high is for me with out a tolerence, but I can have near OBE's sober, so I guess I'm prone
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Psychedelics yummy
Humanoid



Registered: 05/13/14
Posts: 1,819
Loc: 'Murica
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Lucid Toast]
#20206163 - 06/30/14 01:30 AM (9 years, 7 months ago) |
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Yeah, I don't think OP grasps what a level 5 experience is, then again, how can you until you've truly experienced it? Comparing pot to dmt
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Screep5
Drugs & Music


Registered: 06/16/14
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Last seen: 9 years, 1 month
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My first times with Cannabis were Level 3 experiences. It was a full on trip and a near ecstatic experience. I had CEVs and very overwhelming feelings.
I started to question the characters of friends and other familiar faces I thought I knew in my sober mindstate.
But after 2 months I have gotten used to smoking Weed and it lost its magic. I only feel a light buzz now when I smoke it, never got a high like the first couple of times ever again ...
It's so disappointing, but fuck it. I'll take more acid then...
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EdibleStereos
Healthy Body, Sick Mind


Registered: 01/02/13
Posts: 4,899
Loc: South Africa
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Screep5]
#20208626 - 06/30/14 08:14 PM (9 years, 7 months ago) |
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Screep5 said: My first times with Cannabis were Level 3 experiences. It was a full on trip and a near ecstatic experience. I had CEVs and very overwhelming feelings.
I started to question the characters of friends and other familiar faces I thought I knew in my sober mindstate.
But after 2 months I have gotten used to smoking Weed and it lost its magic. I only feel a light buzz now when I smoke it, never got a high like the first couple of times ever again ...
It's so disappointing, but fuck it. I'll take more acid then...
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leon trout
Estimated Prophet



Registered: 09/13/12
Posts: 1,089
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Re: .15 gram Cannabis from my bong = Level 5 [Re: EdibleStereos]
#20208917 - 06/30/14 11:38 PM (9 years, 7 months ago) |
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leon trout said: this thread just keeps delivering...
 
-------------------- “I read somewhere that 77 per cent of all the mentally ill live in poverty. Actually, I’m more intrigued by the 23 per cent who are apparently doing quite well for themselves.” ~ St. Jerome of Marin
the bus come by & i got on, that's when it all began
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spacechimp
touching the cosmos



Registered: 12/01/13
Posts: 667
Last seen: 2 years, 4 months
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Quote:
leon trout said:
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leon trout said: this thread just keeps delivering...
  
Yeah its somethin Quote:
Psychedelics yummy said: Yeah, I don't think OP grasps what a level 5 experience is, then again, how can you until you've truly experienced it? Comparing pot to dmt 
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Lucid Toast
Suggestion expert



Registered: 08/24/11
Posts: 820
Loc: Canada
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Re: .15 gram Cannabis from my bong = Level 5 [Re: EdibleStereos]
#20213069 - 07/01/14 10:14 PM (9 years, 7 months ago) |
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Thankyou
-------------------- You have to let it go neo, fear, doubt. Disbelief
"The menu is not the meal." Alan watts “Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Heres Tom with the Weather.” Bill Hicks
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SixStripsDeep
Groove Master


Registered: 04/08/14
Posts: 411
Loc: Groove Town, USA
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Lucid Toast]
#20213796 - 07/02/14 02:20 AM (9 years, 7 months ago) |
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no, you did not reach level five. im sorry to say it. and that's that end of story.
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nssurge
Stranger



Registered: 02/20/13
Posts: 511
Last seen: 4 years, 3 months
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Re: .15 gram Cannabis from my bong = Level 5 [Re: SixStripsDeep]
#20213907 - 07/02/14 03:38 AM (9 years, 7 months ago) |
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yo i smoked some weed last night, most intense drug experience nearly ever on par with a tab of strong DOB. No visuas apart from size changing but mentally very odd
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SixStripsDeep
Groove Master


Registered: 04/08/14
Posts: 411
Loc: Groove Town, USA
Last seen: 9 years, 2 months
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Re: .15 gram Cannabis from my bong = Level 5 [Re: nssurge]
#20214114 - 07/02/14 06:46 AM (9 years, 7 months ago) |
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take 7 grams of mushrooms or 400 mg of mescaline then come talk to me about your level 4 trip. still not 5. if you don't go outside of your body and experience ego death and forget your body and earth exists and time becomes irrelevant. then you will have had a true trip. no offence tho my brother. weed just doesant do that. people only think it does because they truly haven't talked to god face to face yet. you will tho if you want. peace and love brother. I just ate 3 gram shroom and molly last night and that was like 2.7 level trip. weed level 5? no sir ree bob.
Edited by SixStripsDeep (07/02/14 06:47 AM)
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chiln
Humble Waterboy Intern


Registered: 05/21/14
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Re: .15 gram Cannabis from my bong = Level 5 [Re: SixStripsDeep]
#20216162 - 07/02/14 06:34 PM (9 years, 7 months ago) |
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SixStripsDeep said: take 7 grams of mushrooms or 400 mg of mescaline then come talk to me about your level 4 trip. still not 5. if you don't go outside of your body and experience ego death and forget your body and earth exists and time becomes irrelevant. then you will have had a true trip. no offence tho my brother. weed just doesant do that. people only think it does because they truly haven't talked to god face to face yet. you will tho if you want. peace and love brother. I just ate 3 gram shroom and molly last night and that was like 2.7 level trip. weed level 5? no sir ree bob.
My friend. I am probably going to make this the last time I will try to share a true set of experiences. This is pointless and I am allowing some pride or something within me to convince you to believe me.
The original post I made with my marijuana trip was real. In fact I probably only gave 5% of what I was experiencing. It was something I could never ever believe in all of my experience with drugs.
Explanation of this possibility:
-Chronic marijuana use for 4 years(7-10 times a day) followed by a 2 year break = Well trained CB receptors rushed with a fair amount of potent marijuana that they haven't seen in years. -Also taking 25mg Adderall XR daily which could definitely be synergistic with the psychotic effects of THC. -History of mental illness.
So I thought I'd just get reallly really high, a good WEED high. But fuck no. Whole different world. Level 4 Easy easy easy.
It is impossible to explain. It feels like I am in a constant strong salvia trip when I smoke weed now. Last night for instance... WTF no attachment to reality, no attachment to my self. Constant swinging between multiple conscious states. Seeing many shades of the save universe. Switching one to the other over and over. The hallucinations are very hard to put in normal terms. As far as open eye visuals, there were all kinds of complete distortions of my visual perception. Sounds mild but I cant explain it. It seemed like I was attracted to closed eye instead of open. Closed eye.. same thing, I wasn't seeing too many colors or anything this time. It seems that Open or closed eye mean nothing to me. I was completely attracted to mental hallucination.
Instead I was shifting through completely different shades of perceptions. Thoughts were totally psychotic, and always assimilated into wonderful epiphanies. Non stop. NON STOP. The urge to write down all of these realizations to remember, impossible to do so because I would get stuck in these mental hallucinations for long period of time, and only have a few seconds close enough to my body so that I could perform any quick task that I needed to do. All of these realizations, and shortly after realizing they, as well as all else is an illusion, including myself, and therefore none of it matters.
The other type of hallucination was the tactile synesthesia. My body folding and bending and shifting all over the place, and into its self. Feeling music cause heavy vibration in my body, I mean really strong as if I was on some heavy machinery that was at 200 decibels and vibrating like crazy to go with it. Most of the time so much overwhelming shit was happening to my body, and all of it a wild mix of infinite senses.
Again, I can only put so much in words, and this is probably the last time I will report on this post. Believe if you will, and learn about possibilities. Or don't. As you wish.
Peace my friends
-------------------- Everything that is written in my posts are completely fictional, and does not refer to any real people or real events. m = E/c2 Matter is merely Energy condensed to a slow vibration.
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Bluntlock
Mushroom Man



Registered: 06/29/14
Posts: 493
Last seen: 1 year, 2 months
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Re: .15 gram Cannabis from my bong = Level 5 [Re: nssurge]
#20216653 - 07/02/14 08:38 PM (9 years, 7 months ago) |
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nssurge said:
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Nihon_Hyperspace said: People claiming level 5 off of weed? No, just no end of story. Popular rebuttals:
"It's different for everyone maaaan." "Some people have very low tolerances to weed." "You can't just make a claim like that because you didn't experience what I experienced." "Just because it hasn't happened to you doesn't mean it isn't true." "Are you calling me a liar?"
Yes, I am calling you a liar. No offense or anything, it's just complete bullshit. This is not an opinion.
Fuck off. How closed minded are you that you can't accept that everyones brains are different ? Seriously if i had the option of taking 100hits of acid, or 10grams of weed all in one go i would chose acid every time, because at least with the acid i would come back from it. If i did that much weed in one go I would likley end up in a mental hospital for half my life. Weed has a very strong effect on some people, just becuase your probably smoking several grams a day or whatever and coping fine doenst mean other people would....
This is quite possibly the dumbest shit I have ever read on the Shroomery. I don't even think greenterror's claims of being a messiah amount to how hard I facepalmed after reading this. Jesus Christ.
-------------------- Enjoy your mind trip but don't trip on your mind.
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Lucid Toast
Suggestion expert



Registered: 08/24/11
Posts: 820
Loc: Canada
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Re: .15 gram Cannabis from my bong = Level 5 [Re: EdibleStereos]
#20218390 - 07/03/14 07:34 AM (9 years, 7 months ago) |
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EdibleStereos said:
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Screep5 said: My first times with Cannabis were Level 3 experiences. It was a full on trip and a near ecstatic experience. I had CEVs and very overwhelming feelings.
I started to question the characters of friends and other familiar faces I thought I knew in my sober mindstate.
But after 2 months I have gotten used to smoking Weed and it lost its magic. I only feel a light buzz now when I smoke it, never got a high like the first couple of times ever again ...
It's so disappointing, but fuck it. I'll take more acid then...
Anyone elce thnk this is knd of skitzo?!
-------------------- You have to let it go neo, fear, doubt. Disbelief
"The menu is not the meal." Alan watts “Today a young man on acid realized that all matter is merely energy condensed to a slow vibration, that we are all one consciousness experiencing itself subjectively, there is no such thing as death, life is only a dream, and we are the imagination of ourselves. Heres Tom with the Weather.” Bill Hicks
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Psychedelics yummy
Humanoid



Registered: 05/13/14
Posts: 1,819
Loc: 'Murica
Last seen: 4 years, 7 months
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Lucid Toast]
#20220057 - 07/03/14 03:56 PM (9 years, 7 months ago) |
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What?
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searching



Registered: 06/08/11
Posts: 4,128
Last seen: 6 months, 5 days
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I keep hearing of people tripping hard from weed. I definitely have had visuals from it, but never anything I would call a trip. I don't doubt your experience. Something about your brain chemistry or something caused you to have an extremely rare experience from weed. If weed causes you to trip that hard then what would lsd do? You have to do it for science!
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chiln
Humble Waterboy Intern


Registered: 05/21/14
Posts: 39
Last seen: 9 years, 6 months
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Re: .15 gram Cannabis from my bong = Level 5 [Re: searching]
#20261383 - 07/12/14 03:22 AM (9 years, 7 months ago) |
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Theoretical pharmacology:
Adderall + Marijuana(OG Kush strains, sativa end of spectrum) ------ What do you think is the closest psychoactive substancethat could express the same(or best) chemical reactions?
I want to know this so that I can see if the effects of that drug are similar to what I am getting.
Thank you.
And Searching I agree that I am spitting on psychonauts everywhere by not going further. When the time is right.
-------------------- Everything that is written in my posts are completely fictional, and does not refer to any real people or real events. m = E/c2 Matter is merely Energy condensed to a slow vibration.
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uninc4life2010
Unincorporated



Registered: 06/05/10
Posts: 1,124
Last seen: 8 months, 13 days
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Re: .15 gram Cannabis from my bong = Level 5 [Re: Jimmy Sage]
#28201883 - 02/24/23 03:48 AM (1 year, 6 days ago) |
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Jimmy Sage said: First time I smoked cannabis I had an intense level 5 experience. I smoked three 4 paper joints with a couple of friends and thought I could handle it as I didn't feel the effects kick in until after smoking. I have never had such a terrifying yet strange experience on any psychedelic since. I was actually hallucinating my English teacher (OEV) in a cafe and talking to her, except only her head was floating and spinning around with a smile. I have never been that high in my life since, even on psychedelics. I feel these kind of highs are rarely repeatable, so if you didn't smoke as much weed as I did for your first time then you kind of missed the boat. I have never been able to achieve that kind of high and I smoke practically every day.
Maybe with some SUPER dank edibles and no tolerance I might be able to repeat it, but tbh it's more of a once in a lifetime experience, and I do not wish to go back there.
Also, don't be ignorant saying that you can't trip on weed. Even Terence McKenna said that Cannabis must be done a few times a year in a dark room (like mushrooms), and a lot must be smoked in a short amount of time. Why? To trip.
I know this is 8 years old, but what you are describing is remarkably similar to what I experienced getting high for the first time. For me, the effects also didn't kick in until I finished the whole joint I was smoking. I have to be clear that I intentionally was taking the largest drags I could, and I was holding them for as long as I could. Despite all of that, I finished the entire joint and had become convinced that I was some rare breed of person who couldn't get high. My disappointment quickly turned into fear as my body was filled with a terribly uncomfortable vibration-type body high. I got so high that I eventually couldn't stand and had to lie down on the cold concrete as I experienced CEVs for the next 10 minutes, lost the ability to relate to reality, and became convinced that I was never coming back to reality.
Some people can have intense psychedelic experiences on weed under the right conditions. Don't let anyone tell you otherwise.
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