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Offlinerocky_raccoon
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Registered: 12/12/22
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What exactly happens during tolerance buildup?
    #28154125 - 01/23/23 03:54 PM (1 year, 5 days ago)

Does anyone here have some knowledge about the exact biochemical process behind tolerance after psilocybin consumption? What exactly happens to the receptors/synapses while and after tripping? Is this known already?


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Nothing in life is to be feared, it is only to be understood.
-Marie Curie



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OfflineVP123
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Re: What exactly happens during tolerance buildup? [Re: rocky_raccoon]
    #28154207 - 01/23/23 04:43 PM (1 year, 4 days ago)



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Offlinerocky_raccoon
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Re: What exactly happens during tolerance buildup? [Re: VP123]
    #28154919 - 01/24/23 03:39 AM (1 year, 4 days ago)

Thanks for the link! So we are talking about genetic downregulation? Less receptor production while the existing receptors are still getting recycled and therefore less receptors are present on the synapse?

Could this be the reason for the "hangover" the next one or two days?


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Nothing in life is to be feared, it is only to be understood.
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OfflineVP123
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Re: What exactly happens during tolerance buildup? [Re: rocky_raccoon] * 1
    #28155006 - 01/24/23 06:48 AM (1 year, 4 days ago)

I'm not sure what you meant by genetic downregulation. It's probably a decrease in gene expression so that the number of receptors decrease in response to binding of psilocybin to the receptors. I think the "hangover" could be related to dehydration since you end up peeing more in order to eliminate the substance through the kidneys but I am not completely sure. Only occasionally I get a slight headache the day after. Usually I feel actually better and with a clear mind the day after tripping.


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Offlinerocky_raccoon
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Re: What exactly happens during tolerance buildup? [Re: VP123]
    #28155662 - 01/24/23 02:27 PM (1 year, 4 days ago)

Yes, decrease in gene expression is what I meant. Makes sense to me.

I don't think it's the dehydration. I usually drink enough water. After shrooming I experience more like an emotional hangover, feeling a bit exhausted or dizzy and somehow more vulnerable. Nothing severe, just kind of moody. The positive (and desired) effects start later for me in the following days. I feel more energetic and motivated, less anxious and depressed. Works better than the SSRIs did.
Everybody's brain chemistry is a bit different I guess but for me it's like that.


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Nothing in life is to be feared, it is only to be understood.
-Marie Curie



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OfflineLucisM
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Re: What exactly happens during tolerance buildup? [Re: rocky_raccoon]
    #28157830 - 01/26/23 02:30 AM (1 year, 2 days ago)

drink a smoothie with greens and all sorts of berries, you'll be feeling great in no time!


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