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Potential effect of mescaline use on genome of native Andeans * 3
    #28156020 - 01/25/23 03:22 AM (10 days, 7 hours ago)


Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti

Cultural transformations of lifestyles and dietary practices have been key drivers of human evolution. However, while most of the evidence of genomic adaptations is related to the hunter-gatherer transition to agricultural societies, little is known on the influence of other major cultural manifestations. Shamanism is considered the oldest religion that predominated throughout most of human prehistory and still prevails in many indigenous populations. Several lines of evidence from ethno-archeological studies have demonstrated the continuity and importance of psychoactive plants in South American cultures. However, despite the well-known importance of secondary metabolites in human health, little is known about its role in the evolution of ethnic differences. Herein, we identified candidate genes of adaptation to hallucinogenic cactus in Native Andean populations with a long history of shamanic practices. We used genome-wide expression data from the cactophilic fly Drosophila buzzatii exposed to a hallucinogenic columnar cactus, also consumed by humans, to identify ortholog genes exhibiting adaptive footprints of alkaloid tolerance. Genomic analyses in human populations revealed a suite of ortholog genes evolving under recent positive selection in indigenous populations of the Central Andes. Our results provide evidence of selection in genetic variants related to alkaloids toxicity, xenobiotic metabolism, and neuronal plasticity in Aymara and Quechua populations, suggesting a possible process of gene-culture coevolution driven by religious practices

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Re: Potential effect of mescaline use on genome of native Andeans [Re: morrowasted]
    #28162946 - 01/29/23 11:01 PM (5 days, 12 hours ago)

You would want to be more sensitive to alkaloids, if they provided a survival advantage. The purpose of drug use was as medicine for the physical body or to solve an abstract problem.

And, to reinforce the theory of evolution via vertical gene transfer, you would want to find orthology in the trunk of the phylogenetic tree, rather than in distant branches -- in what is purported to be the common ancestor of two species existing contemporaneously.

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