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sudly
Darwin's stagger

Registered: 01/05/15
Posts: 10,797
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Re: Zoloft took away my ability to see psychedelic visuals on any substance [Re: redgreenvines]
#28418835 - 08/03/23 02:21 PM (5 months, 23 days ago) |
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Quote:
redgreenvines said: what is your usual psychedelic hindrance period from ssri's, is it related to duration of course of treatment and variety of ssri, any permanent ssri modifications among the serotonin receptors?
these are areas I have not explored, and really don't want to but if you have the good true info I want to hear it once and for all.
1-3 months according to this study. No where near the 3 years suggested by iPear.
Quote:
The findings of the study suggest that using antidepressant medications, specifically SSRIs and SNRIs, concurrently with psilocybin (the active compound in magic mushrooms) may weaken the effects of psilocybin in some individuals. However, this effect was observed in only about half of the participants.
“About half of people on an SSRI or SNRI reported lower than expected drug effects when taking psilocybin together with their antidepressant,” Gukasyan told PsyPost. “Based on anecdotal reports we expected this number to be higher.”
The researchers also found that the likelihood of reduced psilocybin effects decreases over time after discontinuing SSRIs or SNRIs, but this reduction may still be significant for up to 1-3 months after discontinuation. The finding was not strongly influenced by fluoxetine, an SSRI with a long half-life. This suggests that the decreased effects of psilocybin are likely due to longer-term changes in the brain rather than the immediate effects of the antidepressant.
“Commonly used antidepressants (e.g. SSRI’s, SNRI’s) may be associated with reduced psychedelic drug effects, and this may last even 1-3 months after discontinuing an antidepressant,” Gukasyan explained to PsyPost. “The effect is less pronounced with antidepressants whose mechanisms do not involve serotonin, such as bupropion (Wellbutrin).”
“The duration of these effects suggests that this change is mediated by something other than serum drug levels. We suspect that it may be related to antidepressant-induced changes in serotonin receptor density, which can take a few months or more to return to higher levels after medication is discontinued.”
In clinical trials, psilocybin is typically not given to participants who are taking serotonergic antidepressants due to concerns about reduced efficacy and potential adverse interactions such as serotonin syndrome. However, the study did not find clear evidence that higher doses of antidepressants or longer duration of use lead to a greater reduction in psilocybin effects.
“We also expected that people who were on antidepressants for longer periods of time would be more likely to see reduced psilocybin effects, but we found the opposite: those who reported being on medications for >12 months had lower likelihood compared to those who had been on them for shorter periods of time,” Gukasyan said. “This might have been related to sampling issues (i.e. not enough respondents who had info about using a psychedelic shortly after discontinuing the medication).”
https://www.psypost.org/2023/06/antidepressants-may-diminish-psilocybins-effects-even-after-discontinuation-165826
3 years would be quite an extreme outlier and a case study of its own.
Again I would've thought any mushrooms used three years after ssris to no effect were excessively oxidized or just aged to little potency. And Lucy, maybe fake..
-------------------- I am whatever Darwin needs me to be.
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The Blind Ass
Bodhi


Registered: 08/16/16
Posts: 26,657
Loc: The Primordial Mind
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Re: Zoloft took away my ability to see psychedelic visuals on any substance [Re: sudly]
#28418852 - 08/03/23 02:35 PM (5 months, 23 days ago) |
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Hnnn...it would depend, but that kinda sounds about right, more or less, for a large majority of cases at least anyways. Myself, I was overly cautious and did not want my first dive back into tripping after i'd gotten clear of the withdrawals from the SSRI I'd been on daily for approx. ~ 9 or so months (weaned myself off) to end up being a huge disappointment somehow.
The above took place sometime during the pandemic, mid lockdowns, btw. So lame... 
*Spoiler Alert*: It all 'came back'. 
Idk what could be going on with OP but if I were him/her or w/e then i'd probably try to be a bit more rigorous wrt 'testing' and also slightly more open minded as to the nature of what's really going on with this particular matter. Just in case.
-------------------- Give me Liberty caps -or- give me Death caps
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