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OfflineSkydoggy
The Mystic
Male

Registered: 03/03/22
Posts: 69
Loc: Third rock from the sun.
Last seen: 16 hours, 56 minutes
Mushrooms having no effect
    #28004488 - 10/18/22 10:25 AM (1 year, 3 months ago)

Hi everyone, I’m reposting this from the psychedelic experience forum.

My friend and I are planning to micro dose and as preparation we wanted to baseline the mushroom batch that I have..
We tried 1 gram and I lightly tripped with visuals for a couple of hours but for her, nada.
Normally I  wouldn’t feel much from 1 gram but these mushrooms seem a bit stronger than ones I have grown in the past.
This evening I made a new chocolate with 2 grams but still no effect. She has used LSD and mushrooms in her college days.
I harvested and dried the mushrooms about 3 weeks ago.
She is on the following medications. (no ssri’s)

Amlodipine
Wellbutrin, weaning off them and hasn’t taken it for about a week
Lisinopril
Hydrochlorothiazide
Metoprolol

I’d appreciate input from others on where to head next.


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OfflineWhoManBeing
PsychedelicYogi
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Registered: 09/01/13
Posts: 3,773
Loc: Oregon
Last seen: 3 days, 32 minutes
Re: Mushrooms having no effect [Re: Skydoggy]
    #28004519 - 10/18/22 10:52 AM (1 year, 3 months ago)

I not sure but that list of medications, if they all psyche like meds, then, again, what pill isn't?, Anyway, that many sure be keeping the mind busy on some wires.


--------------------
Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.



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OfflineSeaSalt
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Registered: 12/08/21
Posts: 495
Loc: PNW WWA
Last seen: 4 months, 25 days
Re: Mushrooms having no effect [Re: WhoManBeing]
    #28022295 - 10/29/22 12:49 AM (1 year, 2 months ago)

I don't seem to metabolize mushrooms like my friends do. I have to take twice as much and don't even half as high. Don't expect your girlfriend to metabolize mushrooms like you do.


--------------------
Avatar by Sol_Exposure


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OfflineHappyHigh
Stranger

Registered: 05/05/17
Posts: 892
Last seen: 1 day, 22 hours
Re: Mushrooms having no effect [Re: SeaSalt]
    #28027142 - 10/31/22 11:04 PM (1 year, 2 months ago)

Wellbutrin is the devil. idk about the other, but that shit is really meth but also works on the receptors.
but real shit that's what you issue is you will need a month for your system too get right.


--------------------
Had I the heavens' embroidered cloths,
Enwrought with golden and silver light,
The blue and the dim and the dark cloths
Of night and light and the half light,
I would spread the cloths under your feet:
But I, being poor, have only my dreams;
I have spread my dreams under your feet;
Tread softly because you tread on my dreams.


Edited by HappyHigh (10/31/22 11:06 PM)


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Offlinedanman78
Amateur Enthusiast

Registered: 12/25/21
Posts: 35
Loc: Washington
Last seen: 1 day, 6 hours
Re: Mushrooms having no effect [Re: HappyHigh]
    #28027595 - 11/01/22 09:39 AM (1 year, 2 months ago)

Lisinopril is for high blood pressure, I take it and has no effect for me when taking mushrooms. I get a trip every time.


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Invisibleredcrow

Registered: 03/25/22
Posts: 384
Re: Mushrooms having no effect [Re: HappyHigh]
    #28028052 - 11/01/22 03:56 PM (1 year, 2 months ago)

Quote:

HappyHigh said:
Wellbutrin is the devil. idk about the other, but that shit is really meth but also works on the receptors.
but real shit that's what you issue is you will need a month for your system too get right.




Just a reminder that everybody metabolizes thing in their own way. I've been taking Bupropion for years, and it doesn't affect my response to mushrooms at all. And not to put too fine a point on it, it is in no way even vaguely like "meth" either physically or chemically.


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InvisibleCreonAntigone
Stranger

Registered: 05/30/21
Posts: 2,875
Re: Mushrooms having no effect [Re: redcrow]
    #28028084 - 11/01/22 04:12 PM (1 year, 2 months ago)

Quote:

redcrow said:
Quote:

HappyHigh said:
Wellbutrin is the devil. idk about the other, but that shit is really meth but also works on the receptors.
but real shit that's what you issue is you will need a month for your system too get right.




Just a reminder that everybody metabolizes thing in their own way. I've been taking Bupropion for years, and it doesn't affect my response to mushrooms at all. And not to put too fine a point on it, it is in no way even vaguely like "meth" either physically or chemically.




Chemically it actually is similar to stimulants such as amphetamines. It blocks dopamine and norepinephrine reuptake - methamphetamines' does that in addition to promoting release of dopamine - so amphetamines have a stronger effect, but there's an analogous effect between the two drugs, and I'd say both have clear simulant effects.

As you said, 'everybody metabolizes things in their own way' so don't delegitimize someone else's experience. I was first put on Wellbutrin at the age of 18 as an adjunct to SSRIs to reduce their side-effects. I was barely able to sleep the first 3 days on it. I felt intense euphoria, almost like I was 'invincible'. It wasn't pleasant though because I knew prescription anti-depressants aren't supposed to make you feel that way. Another occasion when I tried to start it again to increase my focus, I experienced again insomnia, panic and palpitations.

In some individuals, Wellbutrin can increase the risk of psychosis, anxiety or seizures, even in individuals who don't have those syndromes presently. This is well-documented. I had to stop it due to intense panic-attacks. Maybe this is a rare reaction, judging by the incidence reports, but it's not an unheard of reaction.

Although, it should be noted that the recommended dose of Wellbutrin had to be reduced before FDA approval was achieved due to the too-high seizure incidence. Initially 450mg was recommended, but this was reduced to 300mg.


Edited by CreonAntigone (11/01/22 04:20 PM)


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OfflineHappyHigh
Stranger

Registered: 05/05/17
Posts: 892
Last seen: 1 day, 22 hours
Re: Mushrooms having no effect [Re: CreonAntigone]
    #28028452 - 11/01/22 06:49 PM (1 year, 2 months ago)

Ty, I'm saying this from the heart. stuff is bad.
Quote:

CreonAntigone said:
Quote:

redcrow said:
Quote:

HappyHigh said:
Wellbutrin is the devil. idk about the other, but that shit is really meth but also works on the receptors.
but real shit that's what you issue is you will need a month for your system too get right.




Just a reminder that everybody metabolizes thing in their own way. I've been taking Bupropion for years, and it doesn't affect my response to mushrooms at all. And not to put too fine a point on it, it is in no way even vaguely like "meth" either physically or chemically.




Chemically it actually is similar to stimulants such as amphetamines. It blocks dopamine and norepinephrine reuptake - methamphetamines' does that in addition to promoting release of dopamine - so amphetamines have a stronger effect, but there's an analogous effect between the two drugs, and I'd say both have clear simulant effects.

As you said, 'everybody metabolizes things in their own way' so don't delegitimize someone else's experience. I was first put on Wellbutrin at the age of 18 as an adjunct to SSRIs to reduce their side-effects. I was barely able to sleep the first 3 days on it. I felt intense euphoria, almost like I was 'invincible'. It wasn't pleasant though because I knew prescription anti-depressants aren't supposed to make you feel that way. Another occasion when I tried to start it again to increase my focus, I experienced again insomnia, panic and palpitations.

In some individuals, Wellbutrin can increase the risk of psychosis, anxiety or seizures, even in individuals who don't have those syndromes presently. This is well-documented. I had to stop it due to intense panic-attacks. Maybe this is a rare reaction, judging by the incidence reports, but it's not an unheard of reaction.

Although, it should be noted that the recommended dose of Wellbutrin had to be reduced before FDA approval was achieved due to the too-high seizure incidence. Initially 450mg was recommended, but this was reduced to 300mg.





Ty. I really am speaking from the heart with a tear in my eye, It's a bad drug too be on.
I know the reason I can't see my kids atm is cause my wife went on a Wellbutrin bender, In her eyes she can do no wrong and is on cloud 9, who cares if the kids are balling asking too see the father that raised them...

She also couldn't feel mushys on it.


--------------------
Had I the heavens' embroidered cloths,
Enwrought with golden and silver light,
The blue and the dim and the dark cloths
Of night and light and the half light,
I would spread the cloths under your feet:
But I, being poor, have only my dreams;
I have spread my dreams under your feet;
Tread softly because you tread on my dreams.


Edited by HappyHigh (11/01/22 07:28 PM)


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Offlinecaptaink
Stranger
Registered: 08/30/22
Posts: 11
Last seen: 4 months, 20 days
Re: Mushrooms having no effect [Re: HappyHigh]
    #28038102 - 11/07/22 11:40 AM (1 year, 2 months ago)

Follow


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OfflineSexBurrito
Wontons and WAP
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Registered: 09/08/22
Posts: 322
Loc: United States
Last seen: 1 day, 22 hours
Re: Mushrooms having no effect [Re: captaink]
    #28043265 - 11/10/22 07:07 AM (1 year, 2 months ago)

Its the Wellbutrin 100%.  That drug is so incredibly bad for your and doctors hand it out like candy. I had to stop taking it cause like Creon said it causes psychosis, panic attacks and seizures and caused me to permanently lose my vision in my left eye from a seizure.  It also exponentially increased the damage to my nervous system from my MS. Always get a second opinion on what they say is ok to put in your body cause sometimes the side effects far out way the benefits.  All the damage that has been done to my body can't be reversed.  Think about how'd you feel if your lost your eyesight or your ability to drink from a glass.


--------------------
:female:GYT with SexBurrito :female:


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InvisibleBigwormS
Male User Gallery


Registered: 03/19/22
Posts: 1,868
Loc: Murica
Re: Mushrooms having no effect [Re: SexBurrito]
    #28049314 - 11/13/22 05:06 PM (1 year, 2 months ago)

Wellbutrin is probably the cause but other factors can play a huge part as well. Just asking, maybe I missed it, how did you prep your shrooms for the first dose and chocolates? I would assume you powdered and homogenized them before mixing with the chocolate? I'm only trying to rule out potency variation from 1 shroom to the next. A clone grow is more consistent with potency over a multispore grow as well.
A bigger meal, what was eaten and how fast one metabolizes food could also play a part. I need a larger dose most of the time just because I have a high tolerance for any drug. My base dose is 3g of Melmac for a level 2 maybe a low 3 where it only take my trip partner 1-2g to have a level 3 or 4 trip.


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OfflineSkydoggy
The Mystic
Male

Registered: 03/03/22
Posts: 69
Loc: Third rock from the sun.
Last seen: 16 hours, 56 minutes
Re: Mushrooms having no effect [Re: Bigworm]
    #28087305 - 12/07/22 12:17 PM (1 year, 1 month ago)

Hi everyone, just sharing an up date:

My friend has now been off meds for 6 weeks. . She recently took 6 grams made into chocolates and only got light visuals. The most I have taken from this current batch is 2 grams in chocolates and I experienced a level 3 trip.

It looks like she is naturally tolerant to mushrooms. Based off this she is micro dosing .6 grams and I am doing .1 grams.  We have using the Stamets Stack protocol and I am really liking  it. My mood is improved and so is my motivation which has always been a challenge for me in the northern winter months. She isn’t feeling any benefit so far and if this continues she wants to switch to LSD for micro dosing. If anyone has a recommendation for a .onion url to a trust worthy market place I would greatly appreciate a PM.

Thanks everyone for your input.


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OfflineDERRAYLD
Constructus
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Registered: 05/13/02
Posts: 9,284
Loc: South Africa
Last seen: 2 hours, 32 minutes
Re: Mushrooms having no effect [Re: Skydoggy] * 1
    #28088309 - 12/08/22 08:18 AM (1 year, 1 month ago)

It doesn't help to switch microdosing schedules, she should stick it out for a good few months before making a decision.
Flip flopping from drug to drug is not going to help.


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OfflineNeurotech
Stranger

Registered: 05/05/20
Posts: 642
Last seen: 2 days, 8 hours
Re: Mushrooms having no effect [Re: DERRAYLD]
    #28106099 - 12/20/22 01:49 PM (1 year, 1 month ago)

Amlodipine also raises serum serotonin levels, like the SSRI's do, just differently. Lisinopril also affects serotonin levels. Both can result in serotonin syndrome when stopped abruptly. The beta blockers, like Metopolol also have an effct on hallucinating: https://www.sciencedirect.com/science/article/abs/pii/0091305786903357


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