Home | Community | Message Board


This site includes paid links. Please support our sponsors.


Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Left Coast Kratom Kratom Powder For Sale   Kraken Kratom Red Vein Kratom   MagicBag.co All-In-One Bags That Don't Suck   Original Sensible Seeds Autoflowering Cannabis Seeds   Unfolding Nature Unfolding Nature: Being in the Implicate Order

Jump to first unread post Pages: 1
OfflineYthanA
ᕕ( ᐛ )ᕗ
Male User Gallery

Registered: 08/08/97
Posts: 18,817
Loc: NY/MA/VT Borderlands Flag
Last seen: 9 hours, 5 minutes
Genetically modified tobacco plant produces cocaine in its leaves * 5
    #28071507 - 11/27/22 12:51 PM (1 year, 3 months ago)

Genetically modified tobacco plant produces cocaine in its leaves
www.newscientist.com

The complex biochemistry that sees coca plants make cocaine has been unpicked and replicated in a relative of the tobacco plant. Recreating the process by modifying other plants or microorganisms could lead to a way to manufacture the stimulant or produce chemically similar compounds with unique properties.

Biochemists have tried to map out how cocaine is made by the coca plant for more than a century, both because of its unique structure and for its uses in medicine, most recently as an anaesthetic. Much of this process had been identified, but there was still a missing link between cocaine and a chemical precursor called MPOA.

Now, Sheng-Xiong Huang at the Kunming Institute of Botany in China and his colleagues have found how to bridge this final gap by adding two previously missing enzymes during the process, known as EnCYP81AN15 and EnMT4.

Huang and his team then genetically modified a close relative of the tobacco plant, Nicotiana benthamiana, to produce cocaine using these two enzymes and found it could produce about 400 nanograms of cocaine per milligram of dried leaf, about a 25th of the level in a coca plant.

“At present, the available production of cocaine in tobacco is not enough to meet the demand on a mass scale,” says Huang, but the constructed biosynthetic pathway could be assembled in organisms with large biomass and quick growth, such as the bacterium Escherichia coli or the yeast Saccharomyces cerevisiae, he says.

The demonstration of cocaine production in tobacco is an important proof of concept, says Benjamin Lichman at the University of York, UK. Transferring this mechanism to other microorganisms could have significant impacts on the supply of cocaine for research purposes. “It may allow pharmaceutical companies to ferment it, essentially, and so completely get rid of plant-based production. That will have huge impacts on supply chain and potentially impacts on, even, illicit production.”

But using other plants to produce cocaine won’t offer an advantage for illicit producers, says Lichman. Growing and harvesting coca, and purifying cocaine from naturally productive plant tissue, is orders of magnitude more scalable and cheaper than producing it in another plant, he says, but having the biosynthetic pathway mapped out could lead to the production of chemically similar compounds to cocaine that have unique medicinal properties.

Journal reference: Journal of the American Chemical Society, DOI: 10.1021/jacs.2c09091

Extras: Filter Print Post Top
Invisiblesplit_by_nine
i am the liquor

Registered: 07/11/18
Posts: 21,288
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Ythan]
    #28071796 - 11/27/22 04:05 PM (1 year, 3 months ago)

very cool!


--------------------
🐴:poop:
hpoo or die

Extras: Filter Print Post Top
InvisiblePatrickKn
I'm a teapot

Registered: 07/10/11
Posts: 20,676
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: split_by_nine] * 3
    #28071799 - 11/27/22 04:06 PM (1 year, 3 months ago)


Extras: Filter Print Post Top
Invisiblesplit_by_nine
i am the liquor

Registered: 07/11/18
Posts: 21,288
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: PatrickKn]
    #28071800 - 11/27/22 04:07 PM (1 year, 3 months ago)

classic. i just rewatched that one a few days ago.


--------------------
🐴:poop:
hpoo or die

Extras: Filter Print Post Top
InvisibleHartford
Lawful Good
Male User Gallery


Registered: 11/27/19
Posts: 1,149
Loc: Tennessee
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Ythan]
    #28071896 - 11/27/22 05:15 PM (1 year, 3 months ago)

:wellholyshit:
Sheng-Xiong Huang!

Extras: Filter Print Post Top
Invisibledurian_2008
Cornucopian Eating an Elephant
 User Gallery


Registered: 04/02/08
Posts: 17,572
Loc: Raccoon City
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Hartford]
    #28072240 - 11/27/22 08:39 PM (1 year, 3 months ago)

:cokeitch:

Menthols were made illegal, here.

Extras: Filter Print Post Top
Invisibleruawakeyet
 User Gallery

Registered: 05/03/21
Posts: 1,862
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: durian_2008]
    #28072645 - 11/28/22 08:47 AM (1 year, 3 months ago)

I don't support anything GMO, and this really sounds like a waste of time. Producing 1/25th as much cocaine as actual coca plants means that 25 times more plant material is required to obtain the same amount of cocaine. It's already a ridiculous ratio of plant material required to produce a kilo of blow.

Extras: Filter Print Post Top
InvisiblePatrickKn
I'm a teapot

Registered: 07/10/11
Posts: 20,676
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: ruawakeyet] * 1
    #28072733 - 11/28/22 09:47 AM (1 year, 3 months ago)

The yield isn't too important here. :shrug:

Quote:

but the constructed biosynthetic pathway could be assembled in organisms with large biomass and quick growth, such as the bacterium Escherichia coli or the yeast Saccharomyces cerevisiae, he says.



Extras: Filter Print Post Top
InvisibleHartford
Lawful Good
Male User Gallery


Registered: 11/27/19
Posts: 1,149
Loc: Tennessee
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Ythan]
    #28072774 - 11/28/22 10:30 AM (1 year, 3 months ago)

Coca is a very finicky plant that only produces well at high elevations, so any improvements in the ability to plant it elsewhere would be good, too.

But, I'm sure cigarette companies are interested in this new Coca-tobbacco.

Extras: Filter Print Post Top
InvisibleThe Blind Ass
Bodhi
I'm a teapot User Gallery

Registered: 08/16/16
Posts: 27,349
Loc: The Primordial Mind
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Hartford] * 2
    #28072786 - 11/28/22 10:44 AM (1 year, 3 months ago)

Tobacco & cocaine is a pretty nice combo imhoe. I'd strongly consider picking smoking back up again if someone could pull off getting a 2 in 1 ciggy out to market.  Just so I could have a few cigs in the morning with my coffee and also after dinner/sex. :geordinod: :stoned:



--------------------
Give me Liberty caps -or- give me Death caps

Extras: Filter Print Post Top
InvisibleZeeBow
 User Gallery

Registered: 03/19/18
Posts: 2,124
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: Ythan] * 1
    #28072960 - 11/28/22 12:48 PM (1 year, 3 months ago)

:homerdrool:

Plow the fields, boys... We ain't growin' corn no mo'!

Extras: Filter Print Post Top
Invisibledurian_2008
Cornucopian Eating an Elephant
 User Gallery


Registered: 04/02/08
Posts: 17,572
Loc: Raccoon City
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: ZeeBow]
    #28073076 - 11/28/22 01:55 PM (1 year, 3 months ago)

I don't believe that any of the plants or animals we eat are in their ancestral forms.

Though, many have gone feral, reproduced, and created what are called landraces.

It is probably most ethical to stick to lower lifeforms in closed systems.

Also, there is a speculative law of robotics, in which there is ideally a kill switch, because unmitigated reproduction is assumed to be a cancer. The beginning and end of it might be written-in, as a matter of genetic construction.

Extras: Filter Print Post Top
Offlinetwighead
mͯó
I'm a teapot


Registered: 08/27/08
Posts: 30,332
Loc: Glenn Gould's Fuck Windmill
Last seen: 1 hour, 59 minutes
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: durian_2008]
    #28074028 - 11/29/22 05:45 AM (1 year, 3 months ago)

Awwwesome:O


--------------------
¿Check out some art m8?


Extras: Filter Print Post Top
Invisiblepablokabute
Hari ng Amag
 User Gallery


Registered: 11/22/11
Posts: 5,186
Loc: rural ghetto
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: durian_2008]
    #28075426 - 11/30/22 02:41 AM (1 year, 3 months ago)

Quote:

durian_2008 said:

Also, there is a speculative law of robotics, in which there is ideally a kill switch, because unmitigated reproduction is assumed to be a cancer. The beginning and end of it might be written-in, as a matter of genetic construction.





Where can we read more about this? Sounds interesting.


--------------------

Fermented Mushrooms!!
--- https://www.shroomery.org/forums/showflat.php/Number/23378638/fpart/1/vc/1

'The second seal: “All CONTAMINATED things and events are unsatisfactory.”'



"I envy you. You North Americans are very lucky. You are fighting the most important fight of all - you live in THE HEART OF THE BEAST."

--Anonymous Guerilla, or is he..

Extras: Filter Print Post Top
InvisibleThe Blind Ass
Bodhi
I'm a teapot User Gallery

Registered: 08/16/16
Posts: 27,349
Loc: The Primordial Mind
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: pablokabute]
    #28075898 - 11/30/22 11:12 AM (1 year, 3 months ago)

Sounds Asimovish.


--------------------
Give me Liberty caps -or- give me Death caps

Extras: Filter Print Post Top
Invisibledurian_2008
Cornucopian Eating an Elephant
 User Gallery


Registered: 04/02/08
Posts: 17,572
Loc: Raccoon City
Re: Genetically modified tobacco plant produces cocaine in its leaves [Re: pablokabute]
    #28076935 - 11/30/22 07:43 PM (1 year, 3 months ago)

Quote:

durian_2008 said:
Also, there is a speculative law of robotics, in which there is ideally a kill switch, because unmitigated reproduction is assumed to be a cancer. The beginning and end of it might be written-in, as a matter of genetic construction.




Quote:

pablokabute said:
Where can we read more about this? Sounds interesting.




Terminator seeds.

Extras: Filter Print Post Top
Jump to top Pages: 1

Shop: Left Coast Kratom Kratom Powder For Sale   Kraken Kratom Red Vein Kratom   MagicBag.co All-In-One Bags That Don't Suck   Original Sensible Seeds Autoflowering Cannabis Seeds   Unfolding Nature Unfolding Nature: Being in the Implicate Order


Similar ThreadsPosterViewsRepliesLast post
* The Mystery of the Coca Plant That Wouldn't Die (long) blink 2,075 3 11/16/04 08:45 PM
by schmutzen
* Drug lords develop high-yield coca plant motamanM 4,953 5 08/29/04 04:03 PM
by Randolph_Carter
* Film about legendary Kentucky 'Cocaine Bear' starring Ray Liotta to be released in 2023 Icyurmt 448 3 12/03/22 01:31 AM
by viraldrome
* Brain's 'Master Molecule' Produces Same Behavior In Mice Fro motamanM 1,771 1 11/28/03 04:16 AM
by monoamine
* Europol seize 30 tonnes of cocaine in 'super-cartel' bust veggieM 213 0 11/30/22 05:02 PM
by veggie
* Ingesting plants risky, CDC warns motamanM 2,314 15 11/03/06 09:49 AM
by beatnicknick
* Cocaine 'greatest drug threat' AnnoA 1,525 1 04/26/04 01:54 PM
by MOTH
* Study: Cocaine use by teens up motamanM 1,187 1 12/28/03 12:34 AM
by DailyPot

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: motaman, veggie, Alan Rockefeller, Mostly_Harmless
1,008 topic views. 0 members, 1 guests and 2 web crawlers are browsing this forum.
[ Show Images Only | Sort by Score | Print Topic ]
Search this thread:

Copyright 1997-2024 Mind Media. Some rights reserved.

Generated in 0.026 seconds spending 0.006 seconds on 14 queries.