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Offlineiggycrop
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Psilocybe natalensis & Inflammation * 3
    #28058324 - 11/18/22 02:37 PM (1 year, 2 months ago)

I have seen a few mentions about Nats possibly helping reduce Inflammation.  But I have yet to see any details.  Hoping this can be a place for people to share their experiences.  I'm interested in details/evidence/experiences.  Could be a good way for others to get an idea of how to potentially use Nats to help with inflammation.  Maybe we can eventually get some people to do before & after CRP blood tests or something to "prove" it.


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OfflineMrBlueshrooms
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Re: Psilocybe natalensis & Inflammation [Re: iggycrop] * 2
    #28058543 - 11/18/22 04:24 PM (1 year, 2 months ago)

Great idea, nats really deserve more attention for their anti-inflamitory properties.
  In February I developed trigger-finger. My hands were locking up more and more and becoming increasingly painful. Was dropping cultures and open alcohol bottles. I had trouble opening jars, I gave up playing instruments.
  In July I started microdosing nats  (thanks to the generosity of the community.)
  The change was gradual but after 6 weeks the difference was unbelievable. Now I play instruments, open jars, even go mountain biking several times a week. At one point I seriously though my life was just fucked. Everything I love to do involves my hands.
  My regime has been the same since July:
  1/3 gram 2x a day. I know it is a lot for a microdose, but really you are after different compounds.
  I do not take breaks as I want a continuous supply of the good stuff.

So I have posted this elsewhere around the site, but I am remembering that for the first few months the capsules where half nats half cubes.  I was shy on nats at the time, now they are 100% nats.


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Invisibleaintlifegrand
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Re: Psilocybe natalensis & Inflammation [Re: MrBlueshrooms] * 1
    #28058974 - 11/18/22 07:52 PM (1 year, 2 months ago)



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OfflineMushymang
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Re: Psilocybe natalensis & Inflammation [Re: aintlifegrand]
    #28059052 - 11/18/22 08:31 PM (1 year, 2 months ago)

Very cool paper. Apparently the anti-inflammatory effects are due to compounds that are not related to the psychoactive ones.


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Invisiblemurderlabz
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Re: Psilocybe natalensis & Inflammation [Re: Mushymang]
    #28060115 - 11/19/22 01:33 PM (1 year, 2 months ago)

This is really good info. I am looking into Psilocybe natalensis in regards to structural neurogenesis(re-wiring the brain). One of the reasons I got back into this hobby was to help a friend who had a stroke. They have had some mild positive effects (could be placebo) with micro-dosing P.E.(They stated other cube didn't do anything). Once we can get some spore they are willing to test out nats.


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OfflineKazok4000
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz]
    #28062796 - 11/21/22 07:04 AM (1 year, 2 months ago)

Very interesting!
Thank you for sharing the paper.
Is other psylocibe known with anti inflammatory properties ?


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OfflineMrBlueshrooms
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Re: Psilocybe natalensis & Inflammation [Re: Kazok4000] * 1
    #28062954 - 11/21/22 09:18 AM (1 year, 2 months ago)

Mushroom in general create anti-inflamitory compounds. (there is a study that researched cubes too)
NATs have some special compounds.
Cordyceps, reshi and chaga have also been specifically studied for anti-inflamitory properties.


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Offlineiggycrop
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Re: Psilocybe natalensis & Inflammation [Re: MrBlueshrooms]
    #28062983 - 11/21/22 09:44 AM (1 year, 2 months ago)

O
Quote:


  In July I started microdosing nats  (thanks to the generosity of the community.)




- At this time when you started Nats and begin to see improvements, were there any other changes you made at the same time?  Diet?  Quit drinking, etc?

- Have you done any blood tests at any time to see if you had any biomarkers re:inflammation that were high?


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OfflineMrBlueshrooms
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Re: Psilocybe natalensis & Inflammation [Re: iggycrop]
    #28063319 - 11/21/22 01:27 PM (1 year, 2 months ago)

Quote:

iggycrop said:
O
Quote:

[b ]
  In July I started microdosing nats  (thanks to the generosity of the community.)




- At this time when you started Nats and begin to see improvements, were there any other changes you made at the same time?  Diet?  Quit drinking, etc?

- Have you done any blood tests at any time to see if you had any biomarkers re:inflammation that were high?



Quote:

iggycrop said:
O
Quote:


  In July I started microdosing nats  (thanks to the generosity of the community.)




- At this time when you started Nats and begin to see improvements, were there any other changes you made at the same time?  Diet?  Quit drinking, etc?

- Have you done any blood tests at any time to see if you had any biomarkers re:inflammation that were high?



Quote:

iggycrop said:
O
Quote:


  In July I started microdosing nats  (thanks to the generosity of the community.)




- At this time when you started Nats and begin to see improvements, were there any other changes you made at the same time?  Diet?  Quit drinking, etc?

- Have you done any blood tests at any time to see if you had any biomarkers re:inflammation that were high?




Yes, I cut out sugar and smoked meats. Moved away from a polluted area to the wilderness. Really my sugar use was like 2 small yogurts a day. Never been into sweets or colas. Used to snack on about 2 slices of processed meat a day.
Had quit drinking a year before.
No blood tests but got the 2nd Moderna dose just before the flare up.
Been a chronic pain sufferer for decades in ways that nats can't really treat.
Sorry that triple quoted, I am on a tablet so it is hard to edit.


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Invisiblemurderlabz
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Re: Psilocybe natalensis & Inflammation [Re: aintlifegrand]
    #28064164 - 11/21/22 10:20 PM (1 year, 2 months ago)

Quote:

aintlifegrand said:
This is fascinating I'm interested in nats now

https://www.researchgate.net/figure/Compounds-identified-in-the-cold-water-hot-water-and-70-ethanol-extracts-of-P_tbl1_343999450







Just wanted to post these for ease of use so we can copy/paste for researching.

*************************
Inflammation and Stroke: An Overview
*************************

Compound: Hexadecanoic acid / palmitic acid / C16H32O2
----------------------
Lipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis 2011
----------------------
Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase 2012

------------------------------------------------------

Compound: Dimethyl fumarate / C6H8O4
-----------------------
Dimethyl fumarate for ischemic stroke 2017
"Although our findings point to a therapeutic benefit of DMF in acute ischemic stroke, future studies addressing therapeutic time window, dose-response relationship and drug side effects are indispensable"
-----------------------
Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway 2015
"Although the exact cause of MS is unknown, it is the most common multifocal inflammatory demyelinating disease of the central nervous system"
-----------------------
Tecfidera (Dimethyl Compound: Fumarate Delayed Release Capsules) to treat MS

------------------------------------------------------

Compound: dibutyl phthalate / C16H22O4

------------------------------------------------------

Compound: NONADECANE / n-Nonadecane / C19H40

------------------------------------------------------

Compound: Tetradecane / C14H40


Edited by murderlabz (11/21/22 11:34 PM)


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OfflineKazok4000
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz] * 1
    #28064393 - 11/22/22 08:13 AM (1 year, 2 months ago)

I heard that psk and PSP found in turkey tail has immune booster properties.

It's usually used as extracted from the mushroom and given to patients.

Anyone know how much raw or dried turkey tail gives you 3g of PSk ?

Here are the studies
Yoshitani S, Takashima S: Efficacy of postoperative UFT (Tegafur/Uracil) plus PSK therapies in elderly patients with resected colorectal cancer. Cancer Biother Radiopharm 24 (1): 35-40, 2009. [PUBMED Abstract]

Sakai T, Yamashita Y, Maekawa T, et al.: Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer. Cancer Biother Radiopharm 23 (4): 461-7, 2008. [PUBMED Abstract]

Sakamoto J, Morita S, Oba K, et al.: Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunol Immunother 55 (4): 404-11, 2006. [PUBMED Abstract]

Oka S, Tanaka S, Yoshida S, et al.: A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J Med Sci 59 (1): 1-6, 2010. [PUBMED Abstract]


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Invisibleaintlifegrand
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Registered: 11/16/22
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz] * 1
    #28065372 - 11/22/22 11:04 PM (1 year, 2 months ago)

Thanks murder that really helped.

So palmitic acid is neurotoxic

--- Palmitic Acid-Enriched Diet Increases α-Synuclein and Tyrosine Hydroxylase Expression Levels in the Mouse Brain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087752/

--- The Neuroinflammatory and Neurotoxic Potential of Palmitic Acid Is Mitigated by Oleic Acid in Microglial Cells and Microglial-Neuronal Co-cultures

https://www.semanticscholar.org/paper/The-Neuroinflammatory-and-Neurotoxic-Potential-of-Beaulieu-Costa/a895d46b8dda976b92299d05dc9309976d8a3f9b


Dibutyl pthalate is well known to be not good for you.  "DBP is a common environmental endocrine disruptor (Tu et al., 2019), and has been proven to have reproductive toxicity (Gao et al., 2017), neurotoxicity (Lee et al., 2019), and immunotoxicity (Xu et al., 2015)."

--- Exposure to dibutyl phthalate impairs lipid metabolism and causes inflammation via disturbing microbiota-related gut–liver axis

https://academic.oup.com/abbs/article/52/12/1382/5964134?login=false


I can't find any information about dibutyl phthalate being present in fungi.  Can it be cross contamination at 12%?  Regardless why is it listed as an anti-inflammatory?


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Invisiblemurderlabz
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Re: Psilocybe natalensis & Inflammation [Re: aintlifegrand]
    #28065381 - 11/22/22 11:13 PM (1 year, 2 months ago)

Quote:

aintlifegrand said:
I can't find any information about dibutyl phthalate being present in fungi.  Can it be cross contamination at 12%?  Regardless why is it listed as an anti-inflammatory?




Humm.. not sure, lets see what we can dig up.

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C6&q=dibutyl+phthalate+mushroom&btnG=


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Invisiblemurderlabz
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Re: Psilocybe natalensis & Inflammation [Re: Kazok4000]
    #28065400 - 11/22/22 11:31 PM (1 year, 2 months ago)

Quote:

Kazok4000 said:
Anyone know how much raw or dried turkey tail gives you 3g of PSk ?





Of course we know it will very but having a hard time finding a rough baseline. I am looking under the sci paper's preparation area for Trametes versicolor...


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Invisibleaintlifegrand
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz]
    #28065403 - 11/22/22 11:37 PM (1 year, 2 months ago)

I only see stuff about biodegredation.  Fairly confident dbp is not produced by fungi.

It's only present in the hot extract they tested, maybe it was heated in plastic?  4 scientists were involved and dbp is labeled an anti-inflammatory?  I don't think the paper is trustworthy


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OfflineKazok4000
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz]
    #28065576 - 11/23/22 04:44 AM (1 year, 2 months ago)

Yes from now did not find much
But I'm very interested if you find something about that !

even a rough approximation.  obviously that for each mushroom there will be differences


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Invisiblemurderlabz
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Re: Psilocybe natalensis & Inflammation [Re: Kazok4000]
    #28066359 - 11/23/22 05:46 PM (1 year, 2 months ago)

Quote:

Kazok4000 said:
Yes from now did not find much
But I'm very interested if you find something about that !

even a rough approximation.  obviously that for each mushroom there will be differences




Best I am finding is 2000mg daily

A Turkey Tails Polysaccharide as an Immunochemotherapy Agent in Cancer

"Nor is information readily available on the quantity of PSK
contained in the intact turkey tails mushroom, making it diffi-
cult to calculate an effective dose of PSK with use of the whole
mushroom"


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OfflineKazok4000
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Re: Psilocybe natalensis & Inflammation [Re: murderlabz] * 1
    #28066922 - 11/24/22 03:10 AM (1 year, 2 months ago)

Thx

Yes it's always the problem that the speak about 2 or 3 g of psk but not of turkey tail mushroom.

And it's just impossible that in 2g of mushroom you find 3g of psk....

Anyway thank you for searching:)


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