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OfflineAlan RockefellerM
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The chemistry of psilocybin: A new podcast interview with Dirk Hoffmeister * 5
    #27959824 - 09/20/22 09:33 PM (1 year, 4 months ago)

This podcast is awesome and anyone interested in psilocybin chemistry should listen to it.    Dirk's English isn't perfect, but the information is the newest available, directly from one of the world's top psilocybin researchers.

One of the most interesting things I learned is that psilocybin mushrooms don't have much psilocin when fresh - they contain enzymes that quickly phosphorylate psilocin back into psilocybin.  When damaged the psilocybin dephosphorylates into psilocin and is rapidly polymerized into blue polymers.  Dirk thinks that the point of psilocybin is a stable way to store the psilocin monomer, and the point of the whole chemical pathway is that the blue polymer is a defense mechanism that inhibits slugs or insects.  It is interesting that the defense mechanism itself is inactive in humans, and it's the intermediate molecules that have the psychoactive effect.  None of this is proven but it makes more sense to me than any other explanation I have seen so far.

https://podcasts.google.com/feed/aHR0cHM6Ly9taW5kYW5kbWF0dGVyLnN1YnN0YWNrLmNvbS9mZWVk/episode/aHR0cHM6Ly9taW5kYW5kbWF0dGVyLnN1YnN0YWNrLmNvbS9wL2RpcmstaG9mZm1laXN0ZXItYmlvY2hlbWlzdHJ5LW9m?sa=X&ved=0CAUQkfYCahcKEwigqtHcw-z5AhUAAAAAHQAAAAAQCg&hl=en-MX


See also the thread in Advanced: https://www.shroomery.org/forums/showflat.php/Number/27923950


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OfflineBenderr
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Registered: 06/05/22
Posts: 96
Last seen: 10 months, 16 days
Re: The chemistry of psilocybin: A new podcast interview with Dirk Hoffmeister [Re: Alan Rockefeller]
    #27959834 - 09/20/22 09:44 PM (1 year, 4 months ago)

:crazy2: saving for later


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OfflineKROM
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Registered: 07/20/19
Posts: 1,005
Last seen: 11 months, 4 days
Re: The chemistry of psilocybin: A new podcast interview with Dirk Hoffmeister [Re: Benderr]
    #27960128 - 09/21/22 05:08 AM (1 year, 4 months ago)


Thanks, Alan!


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