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Offlinebsharp321
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Registered: 08/13/22
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Last seen: 10 months, 9 days
SSRI's canceling effects of psilocybin * 2
    #27902475 - 08/13/22 09:55 PM (1 year, 5 months ago)

So I've been on SSRIs for about 16 years now and am just waking up to the concept of microdosing psilocybin.  Over the past few weeks I've drenched my brain with mycology the therapeutic potential of psychedelics although I've never taken them...until now.  I found an online vendor that seems legit so I purchased capsules containing 200mg psilocybin mushroom powder.  I tried to seek out a subperceptual dose by ramping up to a perceptual dose.  I ended up getting to 1.6g and had no response so my assumption is the SSRIs are doing there job at blocking the receptor that psilocyn needs to bind for an effect.  I've decided to slowly taper the SSRI and microdose concurrently to help avoid the effects of discontinuation syndrome.  Can I get some advice on this??  20mg Citalopram is what I'm taking. 

Thanks in advance,  Tim


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Offlinebrightonv
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Registered: 01/11/20
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Last seen: 1 year, 4 months
Re: SSRI's canceling effects of psilocybin [Re: bsharp321]
    #27902937 - 08/14/22 09:34 AM (1 year, 5 months ago)

A close family member has recently made the move away, and slowly discontinued the SSRI Escitalopram, after about the same 16-20 years.  She was on 10mg per day and reduced by 1mg per month.  Early on she tried a little more aggressively but got scared from the brain zaps.  So that's when she slowed to the 1mg per month.  Everyone is different so tolerance obviously varies.  But eesh that stuff is NOT candy.

Now with the absence of the SSRI she is letting the receptors normalize, allowing for plasticity.  She's feeling a good bit of resentment having been prescribed the SSRI at all, and for so many years adds to it.

Thoughts would be for you to take your time on the one, to monitor changes and normalize a bit, before starting the other.

If legit, one of the capsules you mention at 200mg or .2g should be enough.  It's possible frequency played into your results.  But if you've allowed for that, common is three days, then yeah good question.


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Offlinebsharp321
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Registered: 08/13/22
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Re: SSRI's canceling effects of psilocybin [Re: brightonv] * 1
    #27903216 - 08/14/22 01:51 PM (1 year, 5 months ago)

Thanks so much for the information.  I'm hoping that microdosing will help to reduce the effects of discontinuation syndrome and it seems that it might.  Getting off these SSRIs can be really difficult so I'd like every advantage possible.

Cheers!  Tim


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OfflineShiroiTora
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I'm a teapot


Registered: 03/16/21
Posts: 616
Loc: South Africa Flag
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Re: SSRI's canceling effects of psilocybin [Re: brightonv]
    #27910503 - 08/19/22 11:07 PM (1 year, 5 months ago)

Quote:

brightonv said:
A close family member has recently made the move away, and slowly discontinued the SSRI Escitalopram, after about the same 16-20 years.  She was on 10mg per day and reduced by 1mg per month.  Early on she tried a little more aggressively but got scared from the brain zaps.  So that's when she slowed to the 1mg per month.




How exactly did she do that? As far as I know 10mg is one pill and it's the smallest one Lexamil has. Volumetric dosing is my guess, but what do you do with all the fillers in the pills and stuff? She should post a tek lol.. :lol:


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OfflineJaydub69
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Registered: 07/28/21
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Re: SSRI's canceling effects of psilocybin [Re: brightonv]
    #27912616 - 08/21/22 04:19 PM (1 year, 5 months ago)

Quote:

brightonv said:
…Escitalopram, after about the same 16-20 years.  She was on 10mg per day and reduced by 1mg per month




Thanks for helping, but this may need clarification. Lexapro (Escitalopram) is almost exclusively prescribed in units of 20mg tablets. Each tablet may be split in half since it’s scored symmetrically, however it’s very rare to be prescribed at 10mg. Evidently it can be prescribed up to 30mg., but again- very rare since it may have adverse effects in the cardiovascular system at that dosage.


Edited by Jaydub69 (08/21/22 04:20 PM)


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Offlinebrightonv
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Registered: 01/11/20
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Re: SSRI's canceling effects of psilocybin [Re: ShiroiTora]
    #27955865 - 09/18/22 10:55 AM (1 year, 4 months ago)

Oh, the hard way, a little rough but she split the pills.  If needed she'd crush and divide.

I think in hindsight a compound pharmacy might be able to help.


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OfflineCognitive_Entropy
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Registered: 06/11/15
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Last seen: 2 months, 5 days
Re: SSRI's canceling effects of psilocybin [Re: brightonv]
    #27956521 - 09/18/22 07:18 PM (1 year, 4 months ago)

It doesn't block the receptor, it downregulates the receptor. Chronic elevation of serotonin downregulates the 5-HT2A receptor subtype.

I tapered off 20mg of escitalopram in 2010. I had been on for around four years.  What I did was just cut the pill into smaller portions, starting at the beginning of May and finishing just after the 4th of July.  No discontinuation syndrome. Volumetric dosing would be even better like someone else suggested.

This isn't a hard drug, the tapering doesn't need to be precise to get down to zero. Just chip away at the pill a little day by day. It is nothing compared to trying to taper benzos.


Edited by Cognitive_Entropy (09/18/22 07:20 PM)


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OfflineJim I.T.I
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Registered: 07/01/22
Posts: 265
Loc: Eleusis
Last seen: 2 days, 2 hours
Re: SSRI's canceling effects of psilocybin [Re: bsharp321]
    #27962016 - 09/22/22 06:53 AM (1 year, 4 months ago)

Hello my friend. ijust read this post and commented on it from @Izyn last night. the OP is long but a worth while read on the subject. Also look at my reply for my own personal experience weening off SSRIs to microdose.

Lets talk about SSRIs and Mushrooms

My experience with SSRIs was about a year. My therapist told me that though in the past they were considered long term if not forever prescriptions, that now there's a growing theory that people go on them for only about 6 months as a "lift" or "jolt" out of what ever their funk may be. at least for Depression which is why i started them.

when i weened at the end i was on zoloft. I worked with my therapist and my doctor through a 2 month process. Doc had me finish my pills as i had like 10 days left. then, they had me refill  a lower dose to 25 mg. i took those for about 2 weeks. then, take half a pill and a whole pill every other day for about 2 weeks. then half a pill a day for about 2 weeks. then just half a pill ever other day 2 weeks, then as best as possible cut the half in half for the duration of the two months taken every other day.

i still had some discontinuation syndrome, brain zaps, moody, easily frustrated and a temper. but after a month off of them those all subsided and i started to feel again.

personal experience here is great to get opinions and hear what others have done. however, my recommendation is to talk to your therapist and your prescribing doctor. i was straight up with my therapist about what i was going to do and figured with patient confidentiality they were the safest outsider to talk about microdosing a technically illegal substance with. to my surprise they were quite supportive of the experiment and they had already been in the psychedelic therapy space for a minute just on the down low.

healing is hard and painful work, but worth it.

mush love. mush luck my friend.


--------------------
Be patient & Let it happen


Edited by Jim I.T.I (09/22/22 06:54 AM)


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