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Offlinerobert_d
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Registered: 07/26/22
Posts: 1
Last seen: 1 year, 5 months
Micro Dosing, Bipolar and Lithium Safety Concerns
    #27878183 - 07/26/22 04:40 PM (1 year, 6 months ago)

Hi.  I deal with bipolar, ocd and some other difficult issues.  I take lithium.  People have been recommending micro dosing and i have grown very interested in it.  I can't take ocd meds because they can cause mania so mushrooms could be extremely helpful.  However, I read that in a study of bipolar macro dosing that people on lithium had very high amounts of seizures and a significant number had bad trips.  https://pubmed.ncbi.nlm.nih.gov/34348413/
I also read that it was not a micro dose.  Do people here think that a micro dose could be safe for someone on lithium?  Thank you for all of your help it is greatly appreciated.


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OfflineAnTron
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Registered: 10/31/14
Posts: 229
Loc: IN, USA
Last seen: 25 days, 1 hour
Re: Micro Dosing, Bipolar and Lithium Safety Concerns [Re: robert_d]
    #27878327 - 07/26/22 06:43 PM (1 year, 5 months ago)

Personal opinion: Interesting, I wonder what causes the seizures. I'd say if there is a literal scientific study stating people who take lithium are likely to experience seizures on psilocybin then I wouldn't dabble in mushrooms until I was off lithium.

Maybe someone here has experience with combining lithium and psilocybin containing mushrooms without having a seizure; if so great. That is a sample size of one. Scientific studies will generally have a much larger sample size (62 patients in this one) so if they say 47% of people had seizures then you have a 47% chance of having a seizure.

As far as "micro dosing" goes: the study doesn't mention the dosage used so you can't say if your idea of a "micro dose" is significantly less than the dose they used or if dosage has an effect on the likelihood of a seizure. Also, (still personal opinion) micro dosing is pretty much 100% placebo. There are actually studies that debunk micro dosing's medicinal potential by showing that people that took a placebo had the same results as people who took a real "micro dose" over a period of a month or so.

I'd listen to scientists over anonymous people on the internet. But hey, I'm an anonymous person on the internet so don't listen to me either .


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OfflineNorthernerM
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Registered: 07/29/12
Posts: 14,139
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Re: Micro Dosing, Bipolar and Lithium Safety Concerns [Re: AnTron]
    #27879235 - 07/27/22 01:25 PM (1 year, 5 months ago)

As far as I know lithium is one of the very few contraindicated substances for psilocybin.

If you want to take the chance with it OP start out with very low dosages. You should be able to gauge the effects.

If you also take an SSRI or SNRI the effect may be blocked completely. These substances prevent the serotonin reuptake mechanism that psilocybin triggers.


--------------------
The nearest we ever come to knowing truth is when we are witness to paradox.


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OfflineAverroes
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Registered: 02/18/22
Posts: 9
Last seen: 1 year, 4 months
Re: Micro Dosing, Bipolar and Lithium Safety Concerns [Re: Northerner]
    #27882167 - 07/29/22 07:09 PM (1 year, 5 months ago)

I am BP1 and have been dealing with a significant depression for 16 months.  I was hospitalized for 9 days.  Most of the traditional anti-depressants I have tried have caused mania, which is pretty typical. 

Last December, I went through a series of 8 IV ketamine infusions, which were incredibly effective, but the effects only lasted 4 or 5 days.  I asked my doctor about daily sub-lingual ketamine, but he declined.  Not sure why.  That is when I turned to the idea of psilocybin micro-dosing. I should note that I take 900mg of Lithium and 60 mg of Latuda.  In February, I started microdosing, starting with 0.1g of B+ that I cultivated.  For several months, I tested doses (.1-1.0) and schedules (3 days on, 2 days off, etc).  I have to say it improved my mood but fell short of making me feel like a human being.  Ketamine did make me feel like a human being.

Two weeks ago I began twice-weekly esketamine (Sprevato) treatments which seem to be longer lasting.  This new doctor told me that if I feel it necessary to shroom, then I should.  I haven't felt the need.  This new doctor thinks that the shrooms might come into play once the esketamine treatment tapers down to once a month.  My hunch is that she is more optimistic about psilocybin.

When it comes to a macro-dose, I am going to have to think VERY HARD about that.  The Hopkins team seems to think the macro-dose is the therapeutic way. 

Hope this helps.


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OfflineMr_Mushrooms
Stranger
Registered: 07/29/22
Posts: 87
Last seen: 1 year, 5 months
Re: Micro Dosing, Bipolar and Lithium Safety Concerns [Re: Northerner]
    #27883592 - 07/30/22 10:57 PM (1 year, 5 months ago)

I've had all the drugs and even some of the RC's I would urge people to reconsider doing drugs because 90+ of the hard ones are laced with a powerful narcotic jiller called fentqany and also I would avoid drugs on the street PERIOD.Stop it. Stop doing drugs on the street. RIGHT NOW


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