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veggie

Registered: 07/25/04
Posts: 17,538
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New DMT Study Shows Positive Results for Depression 4
#27835359 - 06/24/22 11:30 PM (1 year, 10 months ago) |
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New DMT Study Shows Positive Results for Depression June 24, 2022 - Microdose
A new study published in Nature has a variety of interesting results for the use of DMT, showing positive results for depression and potential for easier patient access.
First, the use of DMT was shown to be safe and tolerable (there were some increases to patients’ blood pressure and heart rate that dissipated soon after treatment began). Being a Phase 1 trial, and with other DMT trials taking place across the industry, these results add another safety data point to the growing catalog of supporting evidence.
Second, the results of the trial showed that DMT had positive effects on patients with Major Depressive Disorder. The study was small in size (only 10 participants), and did not have a placebo group, not ideal but not the end of the world in an exploratory Phase 1 study. There were two doses of DMT administered intravenously according to the patient’s weight (dose-escalation of 0.1 mg/kg followed by a larger 0.3 mg/kg dose). The most significant positive results were seen the day after receiving the larger DMT treatment, with HAMD-17 scores (a measure of depression symptoms) decreasing by −4.5 points. These aren’t revolutionary scores, as other studies for psilocybin have shown much more dramatic improvements, still they are statistically significant and surely welcome relief for patients.
The most interesting part, however, may be the third aspect. The study was distinctly different from other psychedelic medicine trials in that it forgoed much of the usual psychotherapy and attention to “set and setting” that usually takes place. The study was “conducted in a typical hospital setting with strategic psychoeducation/support, but minimal psychotherapy” and “participants were dosed in a booth containing a medical-grade reclining chair and desk that was lit with overhead fluorescent lighting. There was no art adorning the room and no music was played. Participants were provided pillows and hospital-issued linens.”
Not very ceremonial, nor did it follow the usual model with psychotherapy sessions before and after treatment, yet still the results were positive.
While plant medicine purists might bemoan this antiseptic approach to healing, this study shows that patients could potentially receive therapeutic benefits with minimal time and resources spent on pre and post talk therapy — something that could go a long way in reducing restrictive time and cost hurdles, potentially removing barriers to access for those with less financial means.
* You can find a link to the study and abstract here.
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Fridgedoor
Psssssst!



Registered: 09/13/20
Posts: 1,136
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Re: New DMT Study Shows Positive Results for Depression [Re: veggie] 1
#27835585 - 06/25/22 06:25 AM (1 year, 10 months ago) |
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Quote:
veggie said: The most interesting part, however, may be the third aspect. The study was distinctly different from other psychedelic medicine trials in that it forgoed much of the usual psychotherapy and attention to “set and setting” that usually takes place. The study was “conducted in a typical hospital setting with strategic psychoeducation/support, but minimal psychotherapy” and “participants were dosed in a booth containing a medical-grade reclining chair and desk that was lit with overhead fluorescent lighting. There was no art adorning the room and no music was played. Participants were provided pillows and hospital-issued linens.”
Not very ceremonial, nor did it follow the usual model with psychotherapy sessions before and after treatment, yet still the results were positive.
I am not really surprised by the conclusion above. When I use DMT I am gone. It doesn't really matter in which set and setting I do it, as it becomes irrelevant. DMT is a great tool to snap out of a depressive loop and focus on the beautiful things in life.
-------------------- Hokus Pokus Fidibus!
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viraldrome



Registered: 09/21/18
Posts: 4,227
Loc: Parts Unknown
Last seen: 1 hour, 13 minutes
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Re: New DMT Study Shows Positive Results for Depression [Re: veggie]
#27836399 - 06/25/22 05:08 PM (1 year, 10 months ago) |
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Quote:
veggie said: There were two doses of DMT administered intravenously
Relief from depression though, is temporary. It's not do it once and you are cured for life, when the afterglow wears off you probably won't get the same of anti depressant effects after doing to 50 times is my prediction. I don't get any anti depressant effects from DMT, but with shrooms and 5-meo-dmt I found the anti depressant effects (or afterglow as I call it) were temporary and difficult to replicate on a regular basis. 5-meo-dmt has no afterglow for me at all anymore because I abuse it, and mushrooms I need to fully reset tolerance to see it at all. If you were suffering serious depression you need to know this is not a 365 day solution and to do it right you need long periods of no use, You will be suffering in cycles with very brief respite, that won't always work. And worst of all it will work in beginning and give you a glimmer of hope....
-------------------- Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD
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PsychoReactive
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Registered: 05/22/09
Posts: 2,563
Loc: Cocalero
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Re: New DMT Study Shows Positive Results for Depression [Re: viraldrome]
#27838243 - 06/26/22 11:23 PM (1 year, 10 months ago) |
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Meanwhile customs and border force are chasing harder than ever after DMT root bark while letting hundreds of kilograms of fentanyl get imported into the US every month.
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MaineCannaReview
Gonzo


Registered: 05/11/22
Posts: 3
Loc: United States
Last seen: 1 year, 10 months
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Re: New DMT Study Shows Positive Results for Depression [Re: PsychoReactive]
#27842044 - 06/29/22 09:07 AM (1 year, 10 months ago) |
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can i sign up for these studies?
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