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InvisibleQM33
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Registered: 04/09/20
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Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain * 1
    #27711487 - 03/28/22 12:17 PM (2 years, 2 months ago)

https://scitechdaily.com/long-term-benzodiazepine-xanax-klonopin-ativan-use-destroys-neural-connections-in-the-brain/

Long-Term Benzodiazepine Use Attacks Synapses
LMU scientists have discovered the means by which the long-term taking of benzodiazepines leads to cognitive impairments.

Benzodiazepines are effective and widely used drugs for treating states of anxiety and sleep disorders. While short-term treatments are considered safe, their long-term intake can lead to physical dependence and, particularly in the case of older people, to cognitive impairments. The mechanisms by which benzodiazepines trigger these changes had previously been unknown. Researchers led by Prof. Jochen Herms and Dr. Mario Dorostkar from LMU’s Center for Neuropathology and Prion Research and the German Center for Neurodegenerative Diseases (DZNE) have now been able to demonstrate in an animal model that the active ingredient leads to the loss of neural connections in the brain.

Common Benzodiazepines

Xanax (alprazolam)
Klonopin (clonazepam}
Ativan (lorazepam)
Valium (diazepam)
Librium (chlordiazepoxide)
Restoril (temazepam)

A key role is played by immune cells of the brain known as microglia. Benzodiazepines bind to a specific protein, the translocator protein (TSPO), on the surface of cell organelles of the microglia. This binding activates the microglia, which then degrade and recycle synapses — that is, the connections between nerve cells. Experiments carried out by the scientists showed that the synapse loss in mice that had received a daily sleep-inducing dose of the benzodiazepine diazepam for several weeks led to cognitive impairments.

“It was known that microglia play an important role in eliminating synapses both during brain development and in neurodegenerative diseases,” said Dr. Yuan Shi and Mochen Cui, co-authors of the study. “But what really surprised us was that such well-researched drugs as benzodiazepines influence this process.” When diazepam treatment was discontinued, the effect persisted for some time, but was ultimately reversible.

In the opinion of the researchers, the study could have effects on how sleep disorders and anxiety are treated in people at risk of dementia. “Drugs that are known to have no binding affinity to TSPO should be preferred where possible,” say the authors.

Reference: “Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)” by Yuan Shi, Mochen Cui, Katharina Ochs, Matthias Brendel, Felix L. Strübing, Nils Briel, Florian Eckenweber, Chengyu Zou, Richard B. Banati, Guo-Jun Liu, Ryan J. Middleton, Rainer Rupprecht, Uwe Rudolph, Hanns Ulrich Zeilhofer, Gerhard Rammes, Jochen Herms and Mario M. Dorostkar, 28 February 2022, Nature Neuroscience.
DOI: 10.1038/s41593-022-01013-9


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InvisibleQM33
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Registered: 04/09/20
Posts: 4,739
Loc: Oregon
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: QM33]
    #27711489 - 03/28/22 12:19 PM (2 years, 2 months ago)

Shared for harm reduction purposes.

Really no surprise to me, but maybe more severe consequences than I figured.
People love these things to, especially in the scene.

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InvisibleveggieM

Registered: 07/25/04
Posts: 17,640
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: QM33] * 1
    #27711503 - 03/28/22 12:31 PM (2 years, 2 months ago)

Psilocybin and also ketamine has been shown to repair and restore neural connections in the brain. I wonder if the use of these substances can offset the damage caused by benzodiazepines.

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InvisibleQM33
(NOT A PUPPET!) ❤❤❤❤❤
I'm a teapot User Gallery


Registered: 04/09/20
Posts: 4,739
Loc: Oregon
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: veggie]
    #27711520 - 03/28/22 12:43 PM (2 years, 2 months ago)

Totally! I wonder as well, but I think the research suggests it.

Lions mane as well!

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Invisiblenooneman
Male

Registered: 04/24/09
Posts: 14,851
Loc: Utah
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: QM33]
    #27711559 - 03/28/22 01:24 PM (2 years, 2 months ago)

Quote:

QM33 said:
When diazepam treatment was discontinued, the effect persisted for some time, but was ultimately reversible.



Well that's a relief!

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OfflineDave Bowman
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Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: nooneman]
    #27711571 - 03/28/22 01:34 PM (2 years, 2 months ago)

Anyone who has had the "pleasure" of experiencing a withdrawal from benzos, especially the fast-acting ones like alprazolam, can tell you these things can be nasty.

I've always liked to have some on hand especially for difficult trips but man can this class of drugs be nasty.

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InvisibleLSDylan
bass music enjoyer
Male


Registered: 05/26/10
Posts: 4,992
Loc: Michigan
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: Dave Bowman]
    #27711773 - 03/28/22 04:46 PM (2 years, 2 months ago)

Makes me wonder if benzos might go the way of ludes one day


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OfflineStromriderM
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Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: LSDylan]
    #27712035 - 03/28/22 07:59 PM (2 years, 2 months ago)

Quote:

LSDylan said:
Makes me wonder if benzos might go the way of ludes one day





Speaking of ludes I finally got to try methaqualone a couple of months ago. Been on my list a long time and it did not disappoint. Pretty cool drug. Wish I could get more

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OfflinePs.NoName
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Registered: 08/03/18
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Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: Stromrider]
    #27712809 - 03/29/22 12:00 PM (2 years, 2 months ago)

Seems like I have noticed a correlation between violent crime and people eating a lot of xanax.  People get so fucked up on xanax bars they apparently don't feel bad or even remember doing horrible shit.

I would not be surprised if more bad stuff gets linked to benzos and it at least stops being prescribed as a taken every day maintenance drug.

Quote:

Stromrider said:

Speaking of ludes I finally got to try methaqualone a couple of months ago. Been on my list a long time and it did not disappoint. Pretty cool drug. Wish I could get more




After seeing the cheech & chong movies I always wanted to try "ludes".


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Set me off, see what I'm worth. Turn me on, I go berserk.


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Invisibledurian_2008
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Registered: 04/02/08
Posts: 18,288
Loc: Raccoon City
Re: Long-Term Benzodiazepine (Xanax, Klonopin, Ativan) Use Destroys Neural Connections in the Brain [Re: Ps.NoName]
    #27713942 - 03/30/22 11:42 AM (2 years, 2 months ago)

When particularly aggressive amounts were mixed with stimulants, I have had to go find members of my party.

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