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InvisibleveggieM

Registered: 07/25/04
Posts: 17,538
[MS] State health officials sounding alarm on ‘gas station heroin’
    #27709980 - 03/26/22 10:39 PM (2 years, 1 month ago)

State health officials sounding alarm on ‘gas station heroin’
March 25, 2022 - WLOX

JACKSON, Miss. (WLBT) - It’s been described as “gas station heroin” - a drug that people of all ages can legally buy at the local convenience store.

And while only a handful of people in Mississippi have gotten sick from using the substance in recent years, state health leaders are sounding the alarm.

The Mississippi State Department of Health recently released a Health Action Network (HAN) Alert on tianeptine.

The drug, which is marketed to do everything from treat anxiety to help opioid addiction, is typically sold under names like ZaZa, Tianna, and Red Dawn.

And it’s legal in Mississippi.

Officials discussed the drug at Friday’s Mississippi State Medical Association COVID-19 briefing.

“We’ve been seeing it probably the last five years, but a trickle,” said Dr. Daniel Edney, deputy state health officer. “Every once in a while, somebody would come in, you know, on ZaZa, ZaZa Red or Super T... And usually what’s happened is they were in the gas station. You’ve got the shelf that’s got kratom and ZaZa Red on it... and they may have heard enough about kratom that they want to stay away from it, but hey, this is something that is an antidepressant.”

“And the gas station guy says, ‘Yeah, it will help your pain or depression or whatever,’ so they’ll choose that and, as you know, in good addiction form, instead of taking one a day... they’re coming in taking three bottles a day.”

Since July 2020, the Mississippi Poison Control Center has received 11 tianeptine exposure-related calls, including 9 in 2020 and one so far this year, the HAN alert states.

Four people were hospitalized as a result of their exposure to the substance, with 36 percent of victims reporting chest pain or hypertension and 18 percent reporting diarrhea or vomiting.

Seventy-three percent of those calling in told poison officials they purchased the drug at a local gas station, the HAN states.

The drug has not been approved by the U.S. Food and Drug Administration.

“It was developed in France. It’s an atypical antidepressant. It does work. It heals anxiety, but so does heroin,” Edney said. “And it’s approved in the EU, but thankfully, it’s not over here. But it’s not illegal to sell it over here.”

“Except for in Alabama it is,” State Health Officer Thomas Dobbs said.

Lawmakers there passed legislation banning tianeptine in 2021, according to the Energy Institute of Alabama.

Edney urged people to avoid the substance, saying it could be especially hard on those with a predisposition to addiction and those with a history of opioid abuse.

“If you’re taking more than what should be recommended, then you’re going to be activating those new opioid agonists too much. And if you have the predisposition - the genetic disposition for addiction - that’s enough to activate you,” he said. “And people won’t stay on tianeptine... They’ll soon go on to pain pills or heroin and fentanyl.”

“And then, on the reverse side, we’re seeing people come in who are addicted to heroin or fentanyl and they’re trying to do withdrawal management, and it’s just not going to work.”

The HAN says the age range of cases reported to poison control is between the ages of 32 and 46 and predominately white men.

However, the drug is not off-limits to children, with gas station attendants usually left making the determination of who can and can’t purchase it.

“I have a problem with people with addiction and adults going through it... but children being able to walk in and buy these things is so scary,” said Dr. Jennifer Bryan, also with MSMA. “It is so scary.”

“And think of the toxicity. Just imagine if a medicine like Lexapro gave you a buzz, and you decide you’re going to start taking 30 Lexapro a day. Something’s going to happen,” Edney said. “That’s what’s going on with tianeptine.”

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Invisiblenooneman
Male

Registered: 04/24/09
Posts: 14,714
Loc: Utah
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: veggie]
    #27710048 - 03/27/22 12:45 AM (2 years, 1 month ago)

Never heard of it, but apparently it's an opiate. There's a lot of beating around the bush, but literally the only thing it does is bind to the main opiate receptor in the brain. It has no other action. It's not an antidepressant (or anything else), it's just an opiate.

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Offlinethirtygoats
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Registered: 12/29/11
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Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: veggie] * 1
    #27710103 - 03/27/22 02:27 AM (2 years, 1 month ago)

Stupid assholes banning everything. smh

Instead of taking away what makes people happy, why not teach them how to be healthy enough so that they can control their addictions, and the people who prove that they are not smart enough to handle this responsibility and therefore do a lot of stupid things because of a drug are forbidden by law to use that drug. It's a lot better than being fucking fascists and forbidding everyone to use a drug. Just because some people cannot handle themselves when on a drug does not mean it should be illegal, ignorant fucks.

edit: Just wanted to elaborate on something I said even though it's probably pointless. When I said "Just because some people cannot handle themselves when on a drug does not mean it should be illegal", I meant that just because a small number of people, either while high, overdosing, withdrawing or coming down, can't stop a drug from making them do things they would normally be too scared or anxious to do while sober doesn't mean the drug should be illegal. It should just be illegal for that particular person. Basically the same thing that happens with alcohol. If you drink too much and get into trouble, they can make it a condition of your probation that you can't drink.


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No one knows who I am.
Therefore, I am not anyone.

Edited by thirtygoats (03/27/22 04:21 PM)

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OfflineVisionary Tools
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Registered: 06/23/07
Posts: 7,953
Last seen: 1 year, 11 months
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: thirtygoats]
    #27710142 - 03/27/22 05:22 AM (2 years, 1 month ago)

I skimmed over the article, it's the usual bullshit of "When people take 50 times the intended dose, bad things happen."

There was a drug sold in the UK called contac 400, a superb decongestant. The chemical name was phenylpropanolamine, which as I found out when searching for what the chemical name was, marketed in the US as an appetite supressant. What happened? About 20 years ago in the UK, a bunch of dumby fucks took far too much because lol lmao, got strokes, and then it was banned, replaced with pseudoephidrine.

This drug, tianeptine, looks interesting. Invented in France in the 1960's (what was it with that decade and all the innovative new chemicals being invented?) and touted as safer than SSRI's and tricyclics.

https://www.evidence.nhs.uk/search?q=tianeptine

NICE is investigating it. I was trying to find if it was banned in the UK, it's, not? But it's not available on prescription, or it is? Doctors won't prescribe it if not familiar, thus the trials being done by NICE.

I got a new headline: "Dumb fucks, with a degree in dumbfuckery from dumby fuck U, take too much of a drug and bad things happen."

More news at 11.


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InvisibleAmanita86
OTD Keymaster
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Registered: 09/26/12
Posts: 89,464
Loc: hades
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: Visionary Tools]
    #27710156 - 03/27/22 05:48 AM (2 years, 1 month ago)

You see it on a lot of Nootropic sites.  I thought it was already banned.  It didn’t seem that dangerous to me but I don’t typically take 50 times the recommended dose.


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:mushroom2:Orange clock, pencil:bouncysmoke:
"They threw me off the hay truck about noon...":fishing:
:mushroom2:*Mark 15:34:levitate::mushroom2::blueninja:
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Invisibleopenmind
curious
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Registered: 08/03/07
Posts: 13,990
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: nooneman]
    #27710497 - 03/27/22 12:31 PM (2 years, 1 month ago)

It seems like it is always the southern and eastern states that have random "drugs" like this being sold at gas stations. I've seen & heard about all sorts of "drugs" being sold in gas stations in other parts of the country.....Kratom, kratom extracts, D8 flower/oil/edibles, DXM (in a tiny bottle like the tianeptine is sold in but with a high dose of DXM that is marketed to get high on and not as a cough suppressant), tianeptine, kava, phenibut, etc etc etc.


In California/western states, I never ever see any of this stuff being sold in gas stations lol.

Is it because there are no good "drugs" in available in those parts of the country? I just find it interesting this only happens in certain states or parts of the country.






Quote:

nooneman said:
Never heard of it, but apparently it's an opiate. There's a lot of beating around the bush, but literally the only thing it does is bind to the main opiate receptor in the brain. It has no other action. It's not an antidepressant (or anything else), it's just an opiate.





I heard about it a handful of years ago. I was curious about trying it a while back, mostly just purely our of curiosity and to see if it was more effective than or a better alternative to kratom. Seems kinda similar to kratom in some ways, basically an "atypical opioid" with a broad range of activity.

Lots of folks that dabbled with kratom tried it.

It kinda started to become more well "known" a few years ago, but I haven't heard much talk about it in recent times.

Kinda surprised to see it being sold over the counter in gas stations like this, though at the same time not really lol. It's a shame tho, this is what will bring in a ban/make it illegal.







When looking at the receptors it has affinity for, it really does mostly only hit opioid receptors...Tianeptine has affinity for/binds to various opiate receptors, but it also has activity/influence on a lot of other systems.

"Tianeptine has been found to bind to the same allosteric site on the serotonin transporter (SERT) as conventional TCAs. However, whereas conventional TCAs inhibit serotonin reuptake by the SERT, tianeptine appears to enhance it.....tianeptine acts as a positive allosteric modulator of the SERT, or as a "serotonin reuptake enhancer".

Although tianeptine was originally found to have no effect in vitro on monoamine reuptake, release, or receptor binding, upon acute and repeated administration, tianeptine decreased the extracellular levels of serotonin in rat brain without a decrease in serotonin release, leading to a theory of tianeptine enhancing serotonin reuptake."


"Research suggests that tianeptine produces its antidepressant effects through indirect alteration and inhibition of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity. Some researchers hypothesize that tianeptine has a protective effect against stress induced neuronal remodeling. There is also action on the NMDA and AMPA receptors. In animal models, tianeptine inhibits the pathological stress-induced changes in glutamatergic neurotransmission in the amygdala and hippocampus. It may also facilitate signal transduction at the CA3 commissural associational synapse by altering the phosphorylation state of glutamate receptors. With the discovery of the rapid and novel antidepressant effects of drugs such as ketamine, many believe the efficacy of antidepressants is related to promotion of synaptic plasticity. This may be achieved by regulating the excitatory amino acid systems that are responsible for changes in the strength of synaptic connections as well as enhancing BDNF expression, although these findings are based largely on preclinical studies"






-OM

.


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Invisibledurian_2008
Cornucopian Eating an Elephant
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Registered: 04/02/08
Posts: 18,037
Loc: Raccoon City
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: openmind]
    #27710531 - 03/27/22 01:21 PM (2 years, 1 month ago)

Quote:

children being able to walk in and buy these things is so scary




None of the sane, grown, adults in this story would have been able to explain it's pharmacology, before downing X amount of pills like so much pretty candy.

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OfflineTheShroomanizer
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Registered: 06/12/09
Posts: 1,571
Loc: The Swamp
Last seen: 1 year, 26 days
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: durian_2008]
    #27710703 - 03/27/22 03:52 PM (2 years, 1 month ago)

I have seen many places around where I live that sell it, however I have never seen it sold in gas stations...ever...the places that do sell it, it is marketed with different blends of organic substances with the addition of Tianeptine, they also card every person purchasing anything from their stores. But obviously everywhere is different. I have tried certain brands and have found them very therapeutic, obviously problems will arise when people take entire bottles of the stuff, and don’t properly educate themselves.

Case report of someone I knew; not what you would call an intelligent person, he was desperate to get high, found a bottle that contained Phenibut and tianpetine (among others). He consumed the whole bottle (despite the fact that it clearly stated dose was not to exceed 3 capsules per 24 hours) and low-and-behold he had a severe overdose of phenibut. Of course when reviewing the medical report, it said that tianpetine was cause of his overdose. (It’s also important to note that the overdose did NOT cause opiate/opioid type overdose symptoms). Symptoms where renal issues, fever, sweating, and tachycardia.


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-Nature gave us one tongue and two ears so we could listen twice as much as we speak-

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Invisibledurian_2008
Cornucopian Eating an Elephant
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Registered: 04/02/08
Posts: 18,037
Loc: Raccoon City
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: TheShroomanizer]
    #27710881 - 03/27/22 07:12 PM (2 years, 1 month ago)

In any low morale job, and especially on the nightshift, pharms, r/c's and illicit street drugs practically rained from the sky until you could fill an Easter basket.

Anyone who really, truly wanted to start a revolution, would just need to remove so many avenues for escapism.

It wasn't at the gas station, for all the couch potatoes. It was for commuters who hit the ground running.

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Invisiblenooneman
Male

Registered: 04/24/09
Posts: 14,714
Loc: Utah
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: openmind] * 1
    #27711031 - 03/27/22 10:31 PM (2 years, 1 month ago)

Quote:

openmind said:
"Tianeptine has been found to bind to the same allosteric site on the serotonin transporter (SERT) as conventional TCAs. However, whereas conventional TCAs inhibit serotonin reuptake by the SERT, tianeptine appears to enhance it.....tianeptine acts as a positive allosteric modulator of the SERT, or as a "serotonin reuptake enhancer".

Although tianeptine was originally found to have no effect in vitro on monoamine reuptake, release, or receptor binding, upon acute and repeated administration, tianeptine decreased the extracellular levels of serotonin in rat brain without a decrease in serotonin release, leading to a theory of tianeptine enhancing serotonin reuptake."


"Research suggests that tianeptine produces its antidepressant effects through indirect alteration and inhibition of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity. Some researchers hypothesize that tianeptine has a protective effect against stress induced neuronal remodeling. There is also action on the NMDA and AMPA receptors. In animal models, tianeptine inhibits the pathological stress-induced changes in glutamatergic neurotransmission in the amygdala and hippocampus. It may also facilitate signal transduction at the CA3 commissural associational synapse by altering the phosphorylation state of glutamate receptors. With the discovery of the rapid and novel antidepressant effects of drugs such as ketamine, many believe the efficacy of antidepressants is related to promotion of synaptic plasticity. This may be achieved by regulating the excitatory amino acid systems that are responsible for changes in the strength of synaptic connections as well as enhancing BDNF expression, although these findings are based largely on preclinical studies"



Right, the weird thing is I saw that stuff about it affecting SERT and NMDA and other stuff, but when you look at it's binding profile, there doesn't seem to be any evidence. It's odd. They claim it does a bunch, but I don't see any evidence, and the things they claim it does are really far apart. Like NMDA and SERT have nothing to do with each other normally. I can see some crossover between normally related things (dopamine and serotonin, for example), but these are massively different system.

It's possible that there is evidence for all this stuff, but it just seems suspicious to me when looking at its binding profile, and without having any real evidence of these other actions.

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Offlinethirtygoats
Male
Registered: 12/29/11
Posts: 1,992
Last seen: 2 months, 20 days
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: veggie]
    #27722804 - 04/06/22 02:43 AM (2 years, 1 month ago)

I just got 90 10mg Tianeptine Sodium pills. I'm only gonna be taking very low doses to see what happens, and read as much online about it as possible before taking it, like on Erowid and Reddit, etc.


--------------------
No one knows who I am.
Therefore, I am not anyone.

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InvisibleHolybullshit
Stranger
Registered: 01/06/19
Posts: 1,576
Re: [MS] State health officials sounding alarm on ‘gas station heroin’ [Re: thirtygoats]
    #27723008 - 04/06/22 08:18 AM (2 years, 1 month ago)

You have to take pretty insane doses to get any real opioid effects. And then they are fairly mild and short lived. Injecting pure tianeptine is the only way for an experienced opiophile to get much out of it, and it doesn't lend itself well to being one's DOC or any kind of maintenance drug. Too short lived, too many side effects at chronic high dosage. Orally...packed like this...it's somewhat analogous to codeine in the UK.

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