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OfflineLouisBell
Growbo


Registered: 12/06/21
Posts: 69
Last seen: 1 year, 9 days
Trazodone and Syrian Rue
    #27671243 - 02/24/22 06:12 AM (1 year, 10 months ago)

Hey guys.

I take 100mg of trazodone at night for mostly sleep, and at one point for depression. Now it's just a sleep aid.

Does anyone know if Syrian Rue and Trazodone interact?

Also I have a high tolerance to psychedelics, could this be the cause?

I did consult my doctor, but I'd like more than his opinion, which I'm still waiting on to make a decision about whether or not I still need these pills.


--------------------
A humble psychonaut with an interest in using psychedelic medicine to purge the bad and nurture the good.


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Offline99.99
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Registered: 12/22/14
Posts: 1,933
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Re: Trazodone and Syrian Rue [Re: LouisBell]
    #27681289 - 03/03/22 04:52 PM (1 year, 10 months ago)

I use trazodone to end mushroom trips, i know some also use it to stop lsd so im sure it would affect any psychedelic substance you’re taking


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OfflineAlan RockefellerM
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Registered: 03/10/07
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Re: Trazodone and Syrian Rue [Re: LouisBell] * 1
    #27682810 - 03/04/22 04:42 PM (1 year, 10 months ago)

Interestingly, a new paper that is going to come out soon on Psilocybe found that Psilocybe cubensis likely contains trazodone hydrochloride, a molecule was previously thought to be only synthetic.

"Some of the chemical compounds in the P. cubensis metabolome that were assigned matches to the reference database had some surprising identities. For example, both serotonin and trazodone hydrochloride were detected. Serotonin is a neurotransmitter that modulates a large number of neurological processes 39 while trazodone hydrochloride is a triazolopyridine derivative with serotonin-selective reuptake inhibition (SSRI) activity commonly prescribed as an antidepressant 40. However, chemical standards of these compounds were not used to confirm these identifications, so they may be spurious. Nonetheless, the possible presence of an SSRI in the metabolome of P. cubensis would be potentially significant in providing synergistic activity alongside psilocybin for the psychoactivity from consuming whole mushrooms. Even if these two compounds were incorrectly identified, these results clearly demonstrate that additional chemicals in the metabolome of P. cubensis have real potential to contribute to physiological and neurological activity if consumed."


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OfflineLouisBell
Growbo


Registered: 12/06/21
Posts: 69
Last seen: 1 year, 9 days
Re: Trazodone and Syrian Rue [Re: Alan Rockefeller]
    #27683425 - 03/05/22 05:30 AM (1 year, 10 months ago)

source?

I have a great open dialogue with my Psych. I would love to have him comment on that. He has a positive view of therapeutic use of mushies.


--------------------
A humble psychonaut with an interest in using psychedelic medicine to purge the bad and nurture the good.


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OfflineAlan RockefellerM
Mycologist
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Registered: 03/10/07
Posts: 48,266
Last seen: 11 hours, 52 minutes
Re: Trazodone and Syrian Rue [Re: LouisBell]
    #27694445 - 03/13/22 11:13 PM (1 year, 10 months ago)

Quote:

LouisBell said:
source?






Title: DNA authentication and chemical analysis of Psilocybe mushrooms reveal widespread taxonomic misdeterminations and inconsistencies in metabolites

By Alexander J Bradshaw, Talia A. Backman, Virginia Ramírez-Cruz, Dale L. Forrister,
Jaclyn M. Winter, Giuliana Furci, Paul Stamets, Laura Guzmán-Dávalos, Bryn T.M.
Dentinger


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