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InvisibleveggieM

Registered: 07/26/04
Posts: 15,298
[ISR] Now Psychedelics are Coming to Your Medicine Cabinet * 1
    #27618293 - 01/14/22 11:18 AM (4 days, 18 hours ago)

Now Psychedelics are Coming to Your Medicine Cabinet
January 12, 2022 - The Jewish Voice

An Israeli startup is producing natural pharmaceutical-grade psychedelic extracts for a new generation of mental health therapeutics.

“The world urgently needs a new way to treat mental health issues, and at PsyRx we believe psychedelics are a big part of the solution,” says Itay Hecht.

Hecht is CEO and cofounder of this Israeli company, which is developing standardized pharma-grade psychedelics from natural sources – not synthetics – as active pharmaceutical ingredients.

Using an agro-medical bioreactor invented at the Hebrew University Faculty of Agriculture, PsyRx produces psychedelic botanic extracts psilocybin (from “magic” mushrooms) and ibogaine (from the root bark of the iboga shrub).

Psilocybin has been shown to have positive effects in treating depression, anxiety and addiction, and has been suggested as a potential treatment for obesity, PTSD, cluster headaches and more.

Ibogaine has shown promise as an anti-addiction drug, among other indications. PsyRx is focusing on its potential to improve current SSRI (selective serotonin reuptake inhibitor) antidepressants.

“SSRIs have some very bad side effects on libido and appetite, and patients often stop using them. We believe adding a micro dose of ibogaine will counter those effects and make a better drug,” Hecht says, emphasizing that micro doses of psychedelic substances do not cause hallucinations.

“We are starting small animal trials soon to check safety and efficacy. Hopefully in a year’s time we can start human trials” to test this ibogaine application.

On trend

Adding psychedelics to mainstream drugs may seem a bit “out there,” but in fact it’s on trend.

According to market intelligence report CB Insights, funding for psychedelic medicine companies is growing rapidly as traditional pharma giants see declines in return on investment for drug R&D and are interested in exploring alternative products. Consumer interest in the hallucinogenic drugs also is growing, according to this report.

Synthetic versions of psychedelic substances are easier to manufacture uniformly according to industry standards, but they may not work as well as natural versions.

“We believe there’s a big difference between biological and synthetic molecules, especially in how they interact with receptors in the brain,” says Hecht.

“Synthetics are not as successful as a ‘key’ fitting into the ‘lock.’ But it is complicated to work with biological molecules.”

That’s where the bioreactor comes in. This innovative machinery is what may enable PsyRx to transform the growing psychedelics market.

From cannabis to psilocybin

Hecht started his career 20 years ago in The Netherlands, managing cannabis dispensaries and seed companies. He moved back to his native Israel in 2007 to study water and soil engineering to better understand the world of botanicals.

Five years ago, taking advantage of new regulations in Israel, Hecht established Hi Pharma, the first cannabis cultivation company to go public on the Tel Aviv Stock Exchange.

He then moved on to another cannabis enterprise, Stickit Labs. The president of Stickit, Dr. Asher Holzer, is a serial biotech entrepreneur whose successful ventures have included InspireMD, TheraCoat and UroGen. He was also part of the management team of Biosense, an Israeli company acquired by Johnson & Johnson in 1997.

“Two and a half years ago, we saw an opportunity in the psychedelic sector; there were no licensed companies in Israel,” says Hecht, so PsyRx became the first.

Holzer is PsyRx’s chairman and cofounder. CTO-cofounder Kobi Buxdorf is a microbiologist with a PhD from Hebrew University.

Buxdorf developed tissue-culture bioreactors for producing cannabis at a pharmaceutical standard and founded Cannadorf to commercialize this technique.

“He then developed a bioreactor for psilocybin and moved it forward to the commercial stage,” says Hecht.

“There are not yet standards for the regulation of psilocybin, so we expect it will take at least a few months to receive GMP [good manufacturing practices] designation for the pharma industry,” he says.

“Hopefully by the end of next year we’ll have the ability to sell our psilocybin worldwide for clinical research and drug development.”

Hecht said additional research on psilocybin is coming out of Hebrew University, fueling new ideas for how micro doses of this powerful substance could improve pharmaceuticals.

PsyRx has about 10 employees and has raised “a couple of million dollars” from private investors. “We want to go public,” says Hecht. “We really believe in what we do.”


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Offlinesonoramo
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Re: [ISR] Now Psychedelics are Coming to Your Medicine Cabinet [Re: veggie]
    #27618594 - 01/14/22 03:34 PM (4 days, 14 hours ago)

Something's not right when a fellow claims to produce "Pharmaceutical Grade Psychedelics," ">99 percent pure psilocybin" and at the same time says “We believe there’s a big difference between biological and synthetic molecules, especially in how they interact with receptors in the brain.”

If you are growing your own, of course you have a different relationship with the mushrooms. That doesn't mean anything is different about the molecules themselves. Once you extract to high purity and sell it to somebody else, there is no physical or medical difference.

Edit: I checked their web page. Essentially, they are growing LC in a bioreactor and extracting actives directly from it. Jeezus, Ott and Oeric wrote about that approach 40 years ago.


Edited by sonoramo (01/14/22 03:36 PM)


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OfflineYukon Cornelius
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Re: [ISR] Now Psychedelics are Coming to Your Medicine Cabinet [Re: sonoramo]
    #27618615 - 01/14/22 03:50 PM (4 days, 14 hours ago)

Quote:

sonoramo said:
Something's not right when a fellow claims to produce "Pharmaceutical Grade Psychedelics," ">99 percent pure psilocybin" and at the same time says “We believe there’s a big difference between biological and synthetic molecules, especially in how they interact with receptors in the brain.”

If you are growing your own, of course you have a different relationship with the mushrooms. That doesn't mean anything is different about the molecules themselves. Once you extract to high purity and sell it to somebody else, there is no physical or medical difference.

Edit: I checked their web page. Essentially, they are growing LC in a bioreactor and extracting actives directly from it. Jeezus, Ott and Oeric wrote about that approach 40 years ago.




This has me doubtful that they can scale that up to a commercial level. It's been discussed for several novel psychoactives but little proof of concept for the process to generate enough compared to good old extraction from the plant/fungal material.

Any scientist claiming there's a difference in a natural vs synthetic at that purity also casts some doubt. If I recall correctly there's no chiral center for psilocybin, so enanantiomers and their ratios are out of the question for explaining a difference from natural to synthetic sources.


--------------------
"I didn't know chicken's wore suspenders" - Towelie



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InvisibleAmanita86
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Registered: 09/26/12
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Re: [ISR] Now Psychedelics are Coming to Your Medicine Cabinet [Re: Yukon Cornelius]
    #27618724 - 01/14/22 05:10 PM (4 days, 13 hours ago)

It makes me nervous when people start doing things… real talk.


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:mushroom2:Orange clock, pencil:bouncysmoke:
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:mushroom2:*Mark 15:34:levitate::mushroom2::blueninja:
Gam zeh ya’avor...:sunny:


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OfflineYukon Cornelius
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Re: [ISR] Now Psychedelics are Coming to Your Medicine Cabinet [Re: Amanita86]
    #27618867 - 01/14/22 06:56 PM (4 days, 11 hours ago)



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"I didn't know chicken's wore suspenders" - Towelie



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