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aquabomber
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Registered: 12/20/21
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[Help] Olanzapine and Psychedelics
#27587988 - 12/20/21 06:52 AM (2 years, 1 month ago) |
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Hello, Let me share with you my experience with olanzapine. I took olanzapine 5mg for 8 months . I gradually tapered off(took less and less) till in 1 1/2 months i stopped taking olanzapine.
Yesterday i tried taking taking 16 g of fresh shrooms, about 1.6 dry. After not taking olanzapine or any other medication for 60 days.
The trip was pretty much ruined, i felt the interference with "Something", that im not sure what it is, olanzapine remains, receptors changed, I don't know at this point.
I need answers, why is this still happening after 2 months of no meds? How long do I have to wait for a good experience?
I beg you if anyone has experience with this medication and shrooms/lsd, please let me know.
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ReynardTheFox
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Re: [Help] Olanzapine and Psychedelics [Re: aquabomber]
#27588043 - 12/20/21 08:09 AM (2 years, 1 month ago) |
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As far as I know, not a lot of research has been done in this area, so probably no one on this site can give you an adequate answer. 1 possibility to consider though: These substances (psychedelics) can be incredibly powerful, varied, and peculiar in their effects. People have new and unexpected dimensions to their trips all the time (even people who trip often). It may be that this effect you are talking about was entirely caused by the psilocybin. Psychedelics are true trickster molecules, and I wouldn't be surprised if some anticipation of the possibility of things not going right after taking your medication might be contributed to the feeling of something like this.
Just a possibility. Of course it's also possible that your medication really did interfere with the experience even after two months.
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quake235


Registered: 03/29/12
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Re: [Help] Olanzapine and Psychedelics [Re: ReynardTheFox] 1
#27588312 - 12/20/21 01:11 PM (2 years, 1 month ago) |
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https://en.wikipedia.org/wiki/Olanzapine
"] Although how it works is not entirely clear, it blocks dopamine and serotonin receptors.[7]"
"Olanzapine has a higher affinity for 5-HT2A serotonin receptors than D2 dopamine receptors"
Elimination half-life 33 hours, 51.8 hours (elderly)[5]"
Seems it could certainly block a trip while its in your system, I dont know of any way to be sure whether or not there was some downregulation in the 5ht2a receptors but its possible, although I would imagine any downregulation would fix itself after enough time.
It could also be possible like Reynard said that your expectations may have influenced the trip to a large degree.
Wait a bit longer and take a little bit more, if youre comfortable with a higher dose.
-------------------- the shroomery is my sangha. may all beings be happy, may all beings be at peace, may all beings be free
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redgreenvines
irregular verb


Registered: 04/08/04
Posts: 37,526
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Re: [Help] Olanzapine and Psychedelics [Re: quake235]
#27588682 - 12/20/21 06:55 PM (2 years, 1 month ago) |
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agree with ^^ above, next week maybe 2.0 dry
--------------------
_ 🧠_
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longeDD
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Registered: 03/29/23
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Re: [Help] Olanzapine and Psychedelics [Re: aquabomber]
#28253079 - 03/29/23 02:30 PM (9 months, 25 days ago) |
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hey were you ever able to trip successfully?
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myc_ousin_vinny
Keeping_It_Real



Registered: 04/29/20
Posts: 1,415
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Re: [Help] Olanzapine and Psychedelics [Re: longeDD]
#28253115 - 03/29/23 02:55 PM (9 months, 25 days ago) |
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Maybe they were just weak shrooms? 1.6 isn’t that high of a dose either.
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Abombs
Chaotic Neutral



Registered: 08/17/21
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1.6 g just keeps me feeling like the come up never ends.
But I my trips seem to be broken anyways
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Enjoil



Registered: 10/29/20
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Re: [Help] Olanzapine and Psychedelics [Re: redgreenvines]
#28253871 - 03/29/23 10:29 PM (9 months, 25 days ago) |
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Quote:
redgreenvines said: agree with ^^ above, next week maybe 2.0 dry
Maybe even more. I always recommend an 8th to my people that are healthy… I hate low doses. I don’t like that jittery tension from low doses.
I like to smoke pot til I’m tripping face and know im going to be gone for a while.
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AvidTraveler
Locked in an escape room...


Registered: 02/27/23
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Re: [Help] Olanzapine and Psychedelics [Re: Enjoil] 1
#28253887 - 03/29/23 10:38 PM (9 months, 25 days ago) |
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I take 10mg olanzapine, daily and I've been tripping fine on between 3 and 4.5 grams cubes
I see this is an old post, but for posterity...
I haven't reduced my dose or tapered off and I have no problems.
I also take 80mg of fluoxetine, daily.
Haven't tapered off of that, either.
-------------------- "Approach thy grave like one who wraps the draperies of his couch about him and lies down to pleasant dreams." -W.C.B
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longeDD
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Registered: 03/29/23
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Re: [Help] Olanzapine and Psychedelics [Re: AvidTraveler]
#28287288 - 04/20/23 07:42 PM (9 months, 3 days ago) |
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when you do shrooms can you get good visuals and euphoria?
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AvidTraveler
Locked in an escape room...


Registered: 02/27/23
Posts: 66
Loc: All over
Last seen: 7 months, 15 days
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Re: [Help] Olanzapine and Psychedelics [Re: longeDD]
#28306019 - 05/04/23 07:49 AM (8 months, 20 days ago) |
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As a matter of fact, no...to either.
The most I've done is 4.5 grams lemon tek.
Abombs has experimented with much higher doses.
I got decent visuals once with 4 grams of steel magnolias in chocolate form
I was doing it every week though.
It's been three weeks since my last dose. I intend to within the next week.
I've been micro dosing though .300mg stamets
So I don't know how that will effect my next macrodose
Regardless of the visuals or euphoria, it has had a tremendously positive impact on my mental health and life in general.
Maybe one day I'll get off the olanzapine/fluoxetine combo altogether
-------------------- "Approach thy grave like one who wraps the draperies of his couch about him and lies down to pleasant dreams." -W.C.B
Edited by AvidTraveler (05/04/23 07:50 AM)
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