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OfflineBaby_Hitler
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Cannabinoids found in Japanese Umbrella Pine?
    #2753955 - 06/01/04 06:58 PM (18 years, 2 months ago)

Occurrence of a novel cannabimimetic molecule 2-sciadonoylglycerol (2-eicosa-5',11',14'-trienoylglycerol) in the umbrella pine Sciadopitys verticillata seeds.

Nakane S, Tanaka T, Satouchi K, Kobayashi Y, Waku K, Sugiura T.

Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan.

The umbrella pine Sciadopitys verticillata seeds were found to contain a substantial amount (16.7 nmol/g) of sciadonic acid (all-cis-5,11,14-eicosatrienoic acid)-containing 2-monoacylglycerol, i.e., 2-sciadonoylglycerol (2-eicosa-5',11',14'-trienoylglycerol). Because the structure of 2-sciadonoylglycerol closely resembles that of 2-arachidonoylglycerol, the endogenous natural ligand for the cannabinoid receptor, we examined whether or not 2-sciadonoylglycerol exhibits cannabimimetic activity using NG108-15 neuroblastomaxglioma hybrid cells which express the cannabinoid CB1 receptor. We found that 2-sciadonoylglycerol induces rapid transient elevation of intracellular free Ca2+ concentration in NG108-15 cells through a cannabinoid CBI receptor-dependent mechanism similar to the case of 2-arachidonoylglycerol, yet the activity of 2-sciadonoylglycerol was apparently lower than that of 2-arachidonoylglycerol. The activity of 2-sciadonoylglycerol was detectable from 3-10 nM, reaching a maximum at around 10 microM. To our knowledge, this is the first report showing the occurrence of a cannabimimetic monoacylglycerol in higher plants.

PMID: 10864031 [PubMed - indexed for MEDLINE]

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http://www.ncbi.nlm.nih.gov/entrez/query...1&dopt=Abstract


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Offlinefelixhigh
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2755439 - 06/02/04 02:10 AM (18 years, 2 months ago)

cool find!


FH


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OfflineLegoulash
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: felixhigh]
    #2755557 - 06/02/04 02:51 AM (18 years, 2 months ago)

I know its interestign but i have not idea what that meant.. would this umbrella pine be worth growing??


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OfflineLocus
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Legoulash]
    #2755880 - 06/02/04 06:36 AM (18 years, 2 months ago)

hehe does this mean you can get high off it?


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:


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Invisibleshamantra
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Legoulash]
    #2755882 - 06/02/04 06:38 AM (18 years, 2 months ago)

no :smile: well it might be worth growing but not as a source for cannabinoids, then mj is still your best bet :smile:


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note: english is my 3rd languange, please ignore misspelling and poor english, im doing my best :smile:

http://youtube.com/watch?v=ug98TKkWKy0


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InvisiblePsychoslut
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2756261 - 06/02/04 11:23 AM (18 years, 2 months ago)

ROLL IT UP!!!!!!!!!!


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[quote]KristiMidocean said:
Good now thats clear.WHO FUCKING CARES. If I am fat u all keep pointing it out like its suppose to be a secret.LIke u really have nothing better to do then make fat jokes. If o know its like I do I know yall can come up with NEW AND BETTER SHIT . This shit is old and boring . I left in the first place cause this shit got boring not because of the fat jokes . Fat jokes dont bother me but seriously its old[/quote]


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Offlineneuro
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2756520 - 06/02/04 01:13 PM (18 years, 2 months ago)

That's pretty fucking interesting, and i could read it and understand it too!


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OfflineBaby_Hitler
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: neuro]
    #2756650 - 06/02/04 02:06 PM (18 years, 2 months ago)

So then you tell me, if it reacts with CB1 receptors does that mean there's a chance it might get you high?

I know some medical MJ users are looking into this for it's potential medical value.


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OfflineLegoulash
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2756678 - 06/02/04 02:13 PM (18 years, 2 months ago)

I read awhile ago that a sponge was breaded or geneticly changed to contain cannabinoids.. The kind of sponge in hte ocean not the bathroom


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InvisibleZepplin
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Legoulash]
    #2762394 - 06/04/04 07:18 AM (18 years, 2 months ago)

Quote:

Magic_rah said:
I read awhile ago that a sponge was breaded or geneticly changed to contain cannabinoids..  The kind of sponge in hte ocean not the bathroom



Yum,Breaded sponge! :laugh:


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Offlinebeforetimetook
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2763170 - 06/04/04 02:06 PM (18 years, 2 months ago)

so can we get down with the Japanese Umbrella Pine? Is it the chronic?


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OfflineBaby_Hitler
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: beforetimetook]
    #2763235 - 06/04/04 02:24 PM (18 years, 2 months ago)

Its teh smismonic!!!!!!!!!!!


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OfflineLocus
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2763281 - 06/04/04 02:36 PM (18 years, 2 months ago)

hahaha word :spliff:  :tongue2:


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The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:


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OfflineBaby_Hitler
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Locus]
    #2764060 - 06/04/04 05:55 PM (18 years, 2 months ago)

By "smizmonic" I mean "I have no idea".


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OfflineLocus
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2764070 - 06/04/04 06:00 PM (18 years, 2 months ago)

oh yeah hehe, i knew that :wink: ..hence the tongue :tongue2:


--------------------

The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery every day. Never lose a holy curiosity. ~ Albert Einstein
"Fear is the great barrier to human growth." ~ Dr. Robert Monroe



~~~*Dosis sola facit venenum*~~~

*Check my profile to listen to my music* :smile:


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Anonymous

Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2764397 - 06/04/04 09:56 PM (18 years, 2 months ago)

Just to let everyone know, the seeds and even live plant are available online for this species. They appear to be very popular in bonsai :smile: :thumbup: I know what tree I am growing this summer :smile:

http://www.bonsaiboy.com/catalog/product470.html?SSAID=102414
^ Link to live tree, very beautiful.

http://vandusen.plantexplorers.com/product_info.php/products_id/436
http://www.driftwoodgardens.com/bulkseeebonsaiseeds.htm
^ Seeds, second link is VERY cheap.

Google will reveal more :thumbup:


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Anonymous

Re: Cannabinoids found in Japanese Umbrella Pine? [Re: neuro]
    #2764432 - 06/04/04 10:12 PM (18 years, 2 months ago)

I await Neuro's reply on the pharmacological action... :rasta:


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OfflineBaby_Hitler
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Organic]
    #2764505 - 06/04/04 10:46 PM (18 years, 2 months ago)

That first link for seeds doesn't ship to the US, and the second one is ther wrong species.

The correct species is Sciadopitys verticillata


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Anonymous

Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2764913 - 06/05/04 12:58 AM (18 years, 2 months ago)

Yes, you're right, the second one is not the Japanese variety but still very nice if you are into bonsai.

As for the first link, know anyone in Canada? :smirk:

Looking for a US Supplier of seeds instead of trees, let me know if you find one.


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Offlineneuro
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Re: Cannabinoids found in Japanese Umbrella Pine? [Re: Baby_Hitler]
    #2766039 - 06/05/04 01:55 PM (18 years, 2 months ago)

Sorry about not replying, i didn't realize there were new posts in this thread, i've been busy lately and hte posts in EG have been piling up on me... anyways:


Quote:


We found that 2-sciadonoylglycerol induces rapid transient elevation of intracellular free Ca2+ concentration in NG108-15 cells through a cannabinoid CBI receptor-dependent mechanism similar to the case of 2-arachidonoylglycerol, yet the activity of 2-sciadonoylglycerol was apparently lower than that of 2-arachidonoylglycerol.





That there says that it does seem to bind to the CB1 receptor and cause a physiological change/action potential in the cell. So yes there is a chance it might get you high, but it also might not. There are other cannibanoids that bind to the CB1 that don't get you high. But if it binds it's a start. Now to see if it gets you high.


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