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darkmeridian
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Mushrooms Ineffective due to SSRI/SNRIs?
#27517459 - 10/25/21 12:49 PM (2 years, 3 months ago) |
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I have been taking Cymbalta 60 mg and Wellbutrin SR 100 mg for the last four years for the treatment of major depression. I started with 1.5 grams of Albino A+, and didn't have any results. A few days later, I took about 2 grams. No effect. Took 3.5 grams of a mushroom chocolate bar on Saturday from another vendor. No effect. So am I just getting bunk doses, or are the SNRIs just stopping the mushrooms from working?
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Pastywhyte
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: darkmeridian] 2
#27519316 - 10/26/21 07:22 PM (2 years, 3 months ago) |
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SSRI's will seriously impede the mushrooms from working to the point of them being completely inactive. You will need to be off them for around 2-3 weeks to get to baseline. Do not discontinue them without consulting your doctor and be sure to read up on negative interactions. SSRI's have been implicated in serotonin syndrome where people have been using MDMA or MDA in conjunction. I'm not a doctor or an expert but I do know SSRI's and many other drugs do not mix well.
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GrimCreeper


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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: darkmeridian]
#27532567 - 11/06/21 02:13 PM (2 years, 2 months ago) |
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Quote:
darkmeridian said: I have been taking Cymbalta 60 mg and Wellbutrin SR 100 mg for the last four years for the treatment of major depression. I started with 1.5 grams of Albino A+, and didn't have any results. A few days later, I took about 2 grams. No effect. Took 3.5 grams of a mushroom chocolate bar on Saturday from another vendor. No effect. So am I just getting bunk doses, or are the SNRIs just stopping the mushrooms from working?
These are not something you can just stop taking either. You had to titrate on to them, to get to the dose your at, it will takes 3 to 6 weeks typically to titrate off them.
My wife has had to deal with these. Yes, they do greatly reduce the mushrooms effect.
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psilocybinmansions
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: GrimCreeper]
#27540675 - 11/12/21 02:44 PM (2 years, 2 months ago) |
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Going off SSRIs too fast brings up nightmares and profound depression. You might find even when you have been off them for a long time (6+ months) mushrooms aren't the same. Some of these pharms permanently inhibit certain receptors, or so that's the gist I get from Wikipedia when it says the duration of inhibition is "indefinite"
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schmutzen
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Talk to your doctor about changing to Paxil, doesn't affect my ability to get effects from mushrooms. 2gm can be more than enough.
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"Blow up your TV, throw away your paper. Go to the country, build you a home."
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Fun_Guy5387
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: schmutzen]
#27540876 - 11/12/21 05:43 PM (2 years, 2 months ago) |
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I take 150 Bupiron (Wellbuterin) daily. If I am taking mushrooms I don't take that day, but I get very high. Less than a gram does not do much but 1.5 hits me decidedly.
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Pastywhyte
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Fun_Guy5387] 1
#27540941 - 11/12/21 06:43 PM (2 years, 2 months ago) |
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Wellbutrin isn’t a SSRI. But it’s also not for everyone. I took it for smoking cessation and while it did make me want to stop smoking, it also made me into a twitchy mess. It was not good.
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Fun_Guy5387
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Pastywhyte]
#27541246 - 11/13/21 01:27 AM (2 years, 2 months ago) |
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Correct. I took an SSRI (Prozac) and it did little for me anyways. One thing, I have been growing tiny shrooms off brf cakes and it is true that the smaller the more potent. I think that when I used Prozac I still got results because the tiny shrooms are so strong.
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cokane
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Fun_Guy5387]
#27541384 - 11/13/21 06:33 AM (2 years, 2 months ago) |
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RIP tripping... Less effective for sure, try larger doses and or some LSD. I know someone who can only trip off liquid lsd and shes got to take a lot of of it and it wears off faster than normal.
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Pastywhyte
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Fun_Guy5387]
#27541386 - 11/13/21 06:36 AM (2 years, 2 months ago) |
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Quote:
Fun_Guy5387 said: One thing, I have been growing tiny shrooms off brf cakes and it is true that the smaller the more potent. I think that when I used Prozac I still got results because the tiny shrooms are so strong.
This is not correct and I’m going to have to ask that we keep it on topic here. Cultivation discussion should go in the mushroom cultivation board. Thanks.
PS fruit size has more to do with genetics and availability of water. BRF cakes have little water and so often produce little fruits. There are ways to increase the yields but this doesn’t effect the potency.
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I envy your penis
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Pastywhyte]
#27548593 - 11/18/21 05:03 PM (2 years, 2 months ago) |
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It is true that a lot of depression medications negate the effects of the magic mushrooms. I have failed to trip on several dosages 3-5 grams while taking cymbalta, celexa, lexapro. I did how ever feel “better” for several weeks afterwards even though the trip experience failed. I have severe treatment resistant depression and have since been switched to MAOIs which are more dangerous with different foods. I am now on Parnate and as a WARNING if anyone is on Parnate and tries mushrooms be extremely careful. I took 3 grams fresh golden teacher shortly after my morning meds and it sent me into cardiac arrest with a blood pressure of 265/190 and cut off circulation to my brain. I am just posting this as a warning to be careful while using mushrooms while taking antidepressants!!!!!
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lmao
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Yes, antidepressants will render magic mushrooms effect zero. If you have been taken antidepressants for a few years before stopping, it will take a long time before you can feel the effects.
I know someone who weaned off from SSRIs over 1 month. Of course, his physician told him that it is now completely out of his system. However, he couldn't feel any effects from mushrooms until 6 months later. It's not always as simple as physicians tell you.
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Timeofyear
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: lmao]
#27560277 - 11/28/21 03:18 AM (2 years, 1 month ago) |
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I would be very careful, i've been on mirtazapine for quite a while, i reduced my dose to 15mg and i got a profound experience last night, words can't even describe the whole experience and it was borderline on the edge. I think if i felt anymore it would have been too much..
All i can say is becareful i almost got more than i wished for.
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penicilliam
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Timeofyear]
#27560999 - 11/28/21 04:35 PM (2 years, 1 month ago) |
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I don't think mirtazapine/remron is an SSRI. If I recall mirtazapine is a receptor agonist in some cases.
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Rhizomorph
Psychedelic Researcher



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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Pastywhyte]
#27574932 - 12/09/21 03:40 PM (2 years, 1 month ago) |
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Quote:
Pastywhyte said: SSRI's will seriously impede the mushrooms from working to the point of them being completely inactive. You will need to be off them for around 2-3 weeks to get to baseline. Do not discontinue them without consulting your doctor and be sure to read up on negative interactions. SSRI's have been implicated in serotonin syndrome where people have been using MDMA or MDA in conjunction. I'm not a doctor or an expert but I do know SSRI's and many other drugs do not mix well.
Surfacing research is indicating that some SSRIs may not negate the effects of at least some psychedelics.
For example this study on escitalopram indicated that "Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment": https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2487
It seems likely that some SSRIs interact with the positive effects of psychedelics while others don't. I hypothesize that it has to do with which receptor subtypes are being interacted with by the SSRI in question.
Of course, I'm talking about the classical psychedelics here; SSRIs don't pose any significant danger for classical psychedelics (only a potential reduction of positive effects) - these include mescaline, psilocybin, LSD & DMT.
MDMA or MDA & SSRI's should be avoided as you mentioned. Potential interactions may exist with other atypical psychedelics as well, but further research is needed.
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penicilliam
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Rhizomorph]
#27575351 - 12/09/21 10:08 PM (2 years, 1 month ago) |
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Thanks for pointing that out! Super fascinating. Are there other studies that corroborate or follow in the same vein as these findings?
For my own curiosity: did you find this by looking and keeping up with the early views? https://ascpt.onlinelibrary.wiley.com/toc/15326535/2021/0/0
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CreonAntigone
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Rhizomorph]
#27576064 - 12/10/21 12:19 PM (2 years, 1 month ago) |
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Quote:
Rhizomorph said: Surfacing research is indicating that some SSRIs may not negate the effects of at least some psychedelics.
For example this study on escitalopram indicated that "Escitalopram pretreatment had no relevant effect on positive mood effects of psilocybin but significantly reduced bad drug effects, anxiety, adverse cardiovascular effects, and other adverse effects of psilocybin compared with placebo pretreatment": https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2487
Very good research, thanks for sharing!
The study explores the use of acute-SSRIs given on psilocybin, which had little effect. However the study leaves untested a central question: what about those who chronically use SSRIs?
"Pretreatment consisted of 10 mg escitalopram daily for 7 days, followed by 20 mg daily for 7 days, including the day of psilocybin administration, or 14 days of placebo pretreatment before psilocybin administration". EG, no patient had been on escitalopram longer than 2 weeks, administration was on-the-dot at the 2 week mark.
Doctors who use these drugs say that full anti-depressant effect may not even start for some at all after 14 days, and full effect would take much longer; this suggests long-term changes in serotonin. This study would not explore that possibility; since it only assigned use of the SSRI for 14 days, it actually stopped the study right at the point when doctors say serotonin will start getting effected.
It could be the type of SSRI involved as you suggest... but to my mind, a more likely possibility is that it is a chronic effect of SSRI use, and won't be picked up on tests shorter than a month. It seems to be an individual effect also, some on chronic SSRI don't get the dampening of efficacy, some do.
I'd like to see a longer-term study, or a study that uses patients currently on anti-depressants. One could test efficacy easily and exactly: same dose of psilocybin on SSRI. One could have a taper condition if they wished, a select few are tapered off and we could see if the efficacy was restored: obviously tapering would only be considered for those who already don't like their SSRIs, biasing the results somewhat, but it is still useful data.
Quote:
It seems likely that some SSRIs interact with the positive effects of psychedelics while others don't. I hypothesize that it has to do with which receptor subtypes are being interacted with by the SSRI in question.
Is there any good research suggesting different SSRIs target different receptor types? That all seemed like branding to me. Back when I was on them my SSRI stopped working entirely and starting making me much more sick. I talked to a few doctors and I tried many other SSRIs; I never detected a single difference in the effect of any of them. SNRs were the same but worse. However, though each one was not much different starting each new one would trigger new headaches. Increasingly severe side-effects and mental hog, all symptoms got much worse, I also had symptoms of serotonin toxicity - excessive stiffness of the limbs.
A doctor who suggests an SSRI after one has failed is not using sound medicine, by the way. All these differences supposed between them are supported in limited studies, not strong clinical evidence. If you ask me, these drugs have a horrendous safety record and should never ever be used; some response safely and others get horrible side effects, and it is a rollercoaster to find which group you are in. If there's a detection of loss of efficacy or new unpleasant side-effects a taper should be tried; if the doctor won't help a taper, they are probably a poor quality doctor.
The only anti-depressant that was ever any good for me (and still wasn't worth it long-term) was mirtazapine: that one actually blocks serotonin at the 2a receptor, preventing some serotonin-toxicity related effects. There are other atypical antidepressants with interesting binding profiles worth exploring.
Quote:
Of course, I'm talking about the classical psychedelics here; SSRIs don't pose any significant danger for classical psychedelics (only a potential reduction of positive effects) - these include mescaline, psilocybin, LSD & DMT.
I'd be careful with mescaline of those three - it has stronger action at adrenal receptors than it does with serotonin, and it also targets the TAAR1 receptor -which is the target of amphetamine drugs. TAAR1 can cause a massive release in serotonin, dopamine, norepinephrine and many other neurotransmitters. I wouldn't think the risk of serotonin syndrome is high, but I think it is there. And MAOI is a worse combination, but an SSRI with a serotonin-releasing agent might be bad.
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Rhizomorph
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: penicilliam]
#27576837 - 12/11/21 01:57 AM (2 years, 1 month ago) |
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Quote:
penicilliam said: Thanks for pointing that out! Super fascinating. Are there other studies that corroborate or follow in the same vein as these findings?
For my own curiosity: did you find this by looking and keeping up with the early views? https://ascpt.onlinelibrary.wiley.com/toc/15326535/2021/0/0
I believe it is one of the first to look at the interaction between SSRIs and psychedelics, at least directly. Psychedelic research is still fairly new with all the red tape finally being (slowly) lifted
I found it while doing a literature review for a research project I'm working on
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Rhizomorph
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: CreonAntigone]
#27576859 - 12/11/21 02:44 AM (2 years, 1 month ago) |
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Quote:
CreonAntigone said: The study explores the use of acute-SSRIs given on psilocybin, which had little effect. However the study leaves untested a central question: what about those who chronically use SSRIs?
Doctors who use these drugs say that full anti-depressant effect may not even start for some at all after 14 days, and full effect would take much longer; this suggests long-term changes in serotonin. This study would not explore that possibility; since it only assigned use of the SSRI for 14 days, it actually stopped the study right at the point when doctors say serotonin will start getting effected.
Although you're right that SSRIs occasionally take longer than 14 days to take noticeable effect, physiological changes are detectable well before this. Also, those who experience delayed onset tend to be outliers. Although the sample was fairly small (23 participants), any large interactions would still likely be detected as they require less statistical power (and thus can account for outliers). Smaller effects however may not be detected.
The placebo group also indicated statistically significant decreases in the negative effects of psychedelics; I'm positive that if the SSRIs had not taken effect, this difference would not have been measurable.
This study is of course preliminary and should not be considered the final word; you're definitely right that the short time span is a limitation. Yet, for the purposes of the study, 14 days is likely sufficient. I would also like to see a follow up study, but I don't believe these limitations discredits this study to a great extent; I mainly just want to see a follow up study so these limitations can be put to rest and the research be considered the final word. The authors even acknowledge the limitation by stating that "[f]urther studies are needed with a longer antidepressant pretreatment time and patients with psychiatric disorders to further define interactions between antidepressants and psilocybin"
My point being that the notion that SSRIs will nearly entirely prevent the positive effects of psychedelics (which is commonly stated) reflects an extremely large effect size, so even if some of the participants did not experience the full range of effects from escitalopram, at least a handful of the participants likely would have. For an effect size this large (nearly 100% haha) it would only take a few participants experiencing this reduction for it to be measured. The same is likely true for moderate effect sizes.
Much research (not all) is low budget/low resource as they don't need huge samples to detect these larger effects. Often the more nuanced effects that require sample sizes of 1000+ are explored later on to address the gaps in research such as this study (e.g., maybe taking escitalopram induces subtle changes in the positive effects of psilocybin, yet this effect is one most participants are not aware of and is only reflected by a minority of peopl... maybe women experience it but not men, etc.)
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CreonAntigone said: Is there any good research suggesting different SSRIs target different receptor types? That all seemed like branding to me.
I believe they have different binding affinities for different receptors. I'm not certain about if they actually bind to different receptors comparatively - the differences in binding affinity is what I meant though; I just wasn't being specific. But this in itself has been measured using neuroimaging so there's certainly empirical evidence showing there are differences. How that plays out in peoples' subjective experiences may not represent as big of a difference. Also there is a lot of inter-individual differences which indicate some evidence of difference. I'm not entirely certain though as I lack specialized knowledge in psychiatry and neurochemistry - my background is in studying clinical psychology.
I certainly agree that their safety record is murky, which is one of the reasons I'm interested in psychedelic research as a potential replacement for antidepressants. But, I do believe SSRIs can be a great tool in the right context (or with the right doctor). They're not for everyone, and if we can come up with a less risky alternative we should do so. Ultimately for some it boils down to a dilemma between being depressed or subjecting oneself to potential health risks. I also believe the risks are in a grey area that complicates things further, both in the decisions made by the medical system & the individual. Lots of pros and cons...
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CreonAntigone said: I'd be careful with mescaline of those three
You're probably right - I maybe shouldn't have included mescaline. Unfortunately there hasn't been any research examining the risk of serotonin syndrome with mescaline and SSRIs. Yet, a lot of anecdotal reports & underground research has suggested there likely isn't any major interaction. I mean even LSD and psilocybin haven't been proven to not increase risk of serotonin syndrome if combined with SSRIs. I don't fully understand the neurochemistry behind it, but I do believe that binding with a receptor that can cause downstream releases of serotonin is a very hypothetical determinant of risk. If it were this simple, the downstream release of (endogenous) serotonin from LSD would also be a risk factor (and I maintain that it very well could be; but unlikely). I think a more reliable criterion with the evidence that currently exists is whether or not serotonin syndrome is commonly documented in hospitals as there are certainly millions of people who have used both mescaline and SSRIs together, indicating a substantial probability that there would be many documented cases. Yet, to my knowledge, it is not something that has occurred in isolation (maybe with other drugs in the mix)
Of course the risk may be greater for people already prone to serotonin syndrome and whatnot, but for the average person, it doesn't appear to carry any measurable risk. MDMA on the other hand has been associated with many documented hospital visits. Even with MDMA though, most people just report a really nasty hangover that isn't quite at the level of serotonin syndrome. Not to understate the risk of course - life threatening cases do occur.
Of course, as with all understudied & prohibited drugs, it's impossible to be certain about many of these effects.
Edited by Rhizomorph (12/11/21 03:06 AM)
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WalkTall
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Rhizomorph]
#27578104 - 12/11/21 10:34 PM (2 years, 1 month ago) |
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I've been one SSRI or another for past 2 years. I have not been able to trip at all on doses up to 3g and haven't tried anything higher. But I still love taking mushrooms because I still get the afterglow which lasts for days or sometimes a couple weeks!
That leads me to wonder if the effects we call the "afterglow" may be distinct from the effects we call "tripping." I'm so curious and can't wait to dig into it more.
I've actually come to the shroomery to learn how I might use mushrooms to help myself transition off my prescription medication.
Cheers all.
-------------------- -- WalkTall
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badchad
Mad Scientist

Registered: 03/02/05
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: CreonAntigone]
#27596590 - 12/27/21 05:39 PM (2 years, 1 month ago) |
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Quote:
CreonAntigone said:
Doctors who use these drugs say that full anti-depressant effect may not even start for some at all after 14 days, and full effect would take much longer; this suggests long-term changes in serotonin. This study would not explore that possibility; since it only assigned use of the SSRI for 14 days, it actually stopped the study right at the point when doctors say serotonin will start getting effected.
This was my take as well. It's likely the pretreatment time wasn't long enough. It's also notable there was a statistically significant decrease in VAS measures of drug effects. I think an alternative interpretation is that these results are in keeping with our previous though that SSRIs decrease the effects of serotonergic hallucinogens.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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Rhizomorph
Psychedelic Researcher



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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: badchad]
#27596604 - 12/27/21 05:59 PM (2 years, 1 month ago) |
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Quote:
badchad said: This was my take as well. It's likely the pretreatment time wasn't long enough. It's also notable there was a statistically significant decrease in VAS measures of drug effects. I think an alternative interpretation is that these results are in keeping with our previous though that SSRIs decrease the effects of serotonergic hallucinogens.
If you read a bit closer in terms of what the VASs measured, they were mostly "bad drug effects" such as anxiety that were reduced. This is consistent with the effects of SSRI's when taken alone. This effect was also quite small and if you look at figure 2, there were recurrent time periods where the effect surpassed that of the placebo group. The reductions in "any drug effect" can be postulated to be due to the reductions in "bad drug effects" considering the lack of reduced positive effects (e.g., "good drug effects", "Oceanic Boundlessness", "Visionary Restructuralization" "stimulation", "drug high" etc. were not affected)
I'm not sure how this evidence is consistent with "our previous though that SSRIs decrease the effects of serotonergic hallucinogens" as you say considering that the positive effects of psychedelics were not impacted.
I'll bet comparing the effect of meditation would yield a larger reduction on the "bad drug effects" VAS measure than escitalopram, but that's just a guess. All I'm saying is that this itself is not evidence of escitalopram reducing the primary therapeutic/hallucinatory effects of LSD, if we're to be specific about which dimensions of the VASs were reduced.
Edited by Rhizomorph (12/27/21 06:17 PM)
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badchad
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Rhizomorph]
#27596694 - 12/27/21 07:05 PM (2 years, 1 month ago) |
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Quote:
Rhizomorph said:
Quote:
badchad said: This was my take as well. It's likely the pretreatment time wasn't long enough. It's also notable there was a statistically significant decrease in VAS measures of drug effects. I think an alternative interpretation is that these results are in keeping with our previous though that SSRIs decrease the effects of serotonergic hallucinogens.
If you read a bit closer in terms of what the VASs measured, they were mostly "bad drug effects" such as anxiety that were reduced. This is consistent with the effects of SSRI's when taken alone. This effect was also quite small and if you look at figure 2, there were recurrent time periods where the effect surpassed that of the placebo group. The reductions in "any drug effect" can be postulated to be due to the reductions in "bad drug effects" considering the lack of reduced positive effects (e.g., "good drug effects", "Oceanic Boundlessness", "Visionary Restructuralization" "stimulation", "drug high" etc. were not affected)
I'm not sure how this evidence is consistent with "our previous though that SSRIs decrease the effects of serotonergic hallucinogens" as you say considering that the positive effects of psychedelics were not impacted.
I'll bet comparing the effect of meditation would yield a larger reduction on the "bad drug effects" VAS measure than escitalopram, but that's just a guess. All I'm saying is that this itself is not evidence of escitalopram reducing the primary therapeutic/hallucinatory effects of LSD, if we're to be specific about which dimensions of the VASs were reduced.
I was referring to Emax on the measure of "Any drug effect," which is on of the most face valid, global measures of whether a subject is "feeling" a drug. The reason its such a valuable measure is because it takes into account "all" of the effects regardless of whether a subject thinks they are positive or negative. In these types of studies, it's the second measure you typically examine, then view the others to figure out more specifically what the subjects were experiencing.
Escitalopram produced a significant decrease of about 10 points on the any drug effect measure, which isn't small at all. It's consistent with the older, survey-based studies that first appeared suggesting SSRI's decreased the effects of hallucinogens. Unfortunately, there is not true placebo condition to compare to.
-------------------- ...the whole experience is (and is as) a profound piece of knowledge. It is an indellible experience; it is forever known. I have known myself in a way I doubt I would have ever occurred except as it did. Smith, P. Bull. Menninger Clinic (1959) 23:20-27; p. 27. ...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely. Osmond, H. Annals, NY Acad Science (1957) 66:418-434; p.436
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Rhizomorph
Psychedelic Researcher



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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: badchad]
#27596829 - 12/27/21 10:08 PM (2 years, 1 month ago) |
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If the purpose of the study is to assess whether escitalopram attenuates the positive effects of psilocybin, I don't see how "all drug effects", including negative effects is a valid measure in the way you describe.
I'm not criticizing the face validity of the measure outright, I am criticizing using the face validity as the primary determinant for the validity of a specific effect (or effects) aggregated within this measure; doing so would undermine the content validity determined by the study design and hypotheses of the study. Construct validity composes both face validity & content validity for a reason - both must be considered 
I trust the authors & peer-review board who decided the interpretation was sound when the authors say that "Escitalopram slightly but significantly [statistically] reduced psilocybin-induced increases in “any drug effect”" and "[d]aily escitalopram treatment for 2 weeks did not reduce the positive mood or mind-altering effects of a full dose of psilocybin in healthy subjects. Additionally, escitalopram pretreatment reduced untoward acute effects of psilocybin, including subjective bad drug effects, anxious-ego dissolution, anxiety, and nadir effects, compared with placebo pretreatment"
Perhaps I/the authors are missing something though... Happy to discuss the merits of the research methodology - I thoroughly enjoy doing so
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EmQuartz

Registered: 12/27/21
Posts: 16
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: Rhizomorph]
#27613387 - 01/09/22 07:33 PM (2 years, 18 days ago) |
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Does anyone know of any real data regarding psilocybin and SNRIs? Most of what I've seen just assumes the same effects as SSRIs.
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Fungi.Love
Human
Registered: 01/08/22
Posts: 12
Loc: Rocky Mountains
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Re: Mushrooms Ineffective due to SSRI/SNRIs? [Re: EmQuartz]
#27616194 - 01/12/22 01:19 PM (2 years, 16 days ago) |
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This is kind of fascinating.
I did a genetics test a while back and the results are that most SSRI's cause negative side effects for me, or best case scenario... just don't work. (Had experienced it before the genetics test, so already knew that I didn't do well with SSRI's. Test just confirmed that it wasn't "all in my head")
Psychedelic's work very well for me though. I have never had a bad trip. Micro-dosing almost helps me like a dose of Vyvanse. I am diagnosed ADHD and have a prescription for Vyvanse. I don't combine the psychedelic's and the Vyvanse though.
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