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InvisibleveggieM

Registered: 07/26/04
Posts: 14,975
A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold * 1
    #27502506 - 10/12/21 11:19 PM (8 days, 23 hours ago)

A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold
October 12, 2021 - ZME Science

Early results suggest the drug shows good anti-cancer activity in patients with advanced cancer

There is no shortage of traditional herbal remedies that allegedly can treat cancer. The vast majority, however, don’t hold up to scrutiny. But a fungus that has been used for centuries in Chinese medicine for its anti-cancer properties is different — it really works. Now, researchers at the University of Oxford have supercharged a compound derived from the fungus and boosted its anti-cancer potency by up to 40 times.

Cordycepin, one of the bioactive ingredients found in Cordyceps, a genus of ascomycete fungi that parasitizes the larvae of arthropods in the Himalayan region, can kill cancer cells and retard their cancerous properties, studies have previously shown.

The fungus was first recorded as Ben-Cao-Bei-Yao in 1694 and is usually called ‘Dong-Chong-Xia-Cao’ in China. There are over 400 species of Cordyceps, of which Cordyceps sinensis and Cordyceps militaris are the most broadly researched. Both Cordyceps species contain similar bioactive ingredients, including cordycepin as a major component.

A 2018 study by Chinese researchers concluded that Cordycepin, a derivative of adenosine (a signaling molecule that affects various types of cells, tissues, and organ systems) regulates tumor microenvironment via suppressing tumor metastasis-related pathways.

However, despite its promising anti-cancer properties, Cordycepin is broken down too quickly once it hits the blood stream. As a result, just a minute amount reaches tumors while the rest is lost.

In order to amplify its potency, researchers at Oxford University teamed up with biopharma company NuCana to devise a new chemotherapy drug and succeeded in doing so by employing a novel technology that can bypass the resistance mechanisms that break down the anti-cancer metabolites.

Called ProTide, this technology works by attaching chemical groups to nucleoside analogs like Cordycepin that are metabolized only once they reach the patient’s cancer cells. Previously, the same technology has been used in the FDA-approved antiviral drug Remsidivir, which is used to treat COVID-19.

The new chemotherapy drug, called NUC-7738, is up to 40 times more potent in killing cancer cells than the original compound derived from the Himalayan fungi. The researchers have commenced the Phase 1 clinical trial for NUC-7738, which involves cancer patients with advanced solid tumors that are resistant to conventional chemotherapy. Early results suggest the drug is well tolerated and there are signs of anti-cancer activity.

“Our study provides proof that NUC-7738 overcomes cellular resistance mechanisms and support its further clinical evaluation as a novel cancer treatment within the growing pantheon of anti-cancer ProTides,” researchers wrote.

The findings appeared in the journal Clinical Cancer Research.


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InvisibleModularMind
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Registered: 02/09/10
Posts: 6,712
Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: veggie]
    #27502530 - 10/12/21 11:56 PM (8 days, 22 hours ago)

Quote:

veggie said:
Quote:


Remsidivir, which is used to treat COVID-19.









:archiebunker:


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Invisiblejack_straw2208
Doctor

Registered: 02/12/07
Posts: 1,426
Loc: yo mamma's house
Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: ModularMind]
    #27502656 - 10/13/21 04:36 AM (8 days, 17 hours ago)

It has been used but that doesn't mean they're not just trying to sell more drugs.


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Invisiblepablokabute
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Registered: 11/22/11
Posts: 4,671
Loc: rural ghetto
Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: jack_straw2208] * 1
    #27502660 - 10/13/21 04:49 AM (8 days, 17 hours ago)

"Cordyceps cultivation group" on fb is also active, if anyone is interested to grow them. :smile:

Just type those exact keywords and it would appear.


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InvisiblePsychoReactive
CocaTea.com
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Registered: 05/22/09
Posts: 2,467
Loc: Cocalero
Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: pablokabute]
    #27504105 - 10/14/21 01:24 PM (7 days, 9 hours ago)

Remsidivir doesn't treat covid patients... it kills them in hospitals.
Ivermectin or plain old zinc, sleep, echinacea and vitamin C DO treat anyone with a cold or a flu which is what "covid 19" is.


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InvisibleModularMind
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Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: PsychoReactive]
    #27504247 - 10/14/21 04:09 PM (7 days, 6 hours ago)

Quote:

PsychoReactive said:
Remsidivir doesn't treat covid patients... it kills them in hospitals.
Ivermectin or plain old zinc, sleep, echinacea and vitamin C DO treat anyone with a cold or a flu which is what "covid 19" is.




Remdesivir. Remsidivir


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Offlinedurian_2008
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Registered: 04/02/08
Posts: 7,202
Last seen: 1 day, 9 hours
Re: A Himalayan fungus has been used to treat cancer for centuries. Scientists now boost its potency 40-fold [Re: veggie]
    #27504952 - 10/15/21 02:30 AM (6 days, 20 hours ago)

Quote:

Psaki said:
...protect marked people.




The mRNA jab does not seem to protect marked people from catching  or spreading CV19. So, marked people are supposed to keep their masks on, even while social distancing.

So long as it protects marked people, marked people should be grateful for therapeutics. :shrug:

As for the mushroom...
Quote:

A 2018 study by Chinese researchers concluded that Cordycepin, a derivative of adenosine (a signaling molecule that affects various types of cells, tissues, and organ systems) regulates tumor microenvironment via suppressing tumor metastasis-related pathways.



Quote:

Adenosine integrates light and sleep signalling for the regulation of circadian timing





Does cancer have a bodyclock, or does it result from being out rhythm?

Does Cordycepin affect the perception of light or otheriwse interfere with Circadian rhythms?


Edited by durian_2008 (10/15/21 08:59 AM)


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