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ballsalsa
Universally Loathed and Reviled



Registered: 03/11/15
Posts: 20,808
Loc: Foreign Lands
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Mommy, where do cannabinoids come from? 2
#27469118 - 09/15/21 09:12 AM (2 years, 4 months ago) |
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Ever wonder?
Well not anymore, baby! Check it out:
 https://vhsfeelsgood.com/mommy-where-do-cannabinoids-come-from/
Quote:
The biosynthesis of cannabinoids involves both the acetate and the methylerythritol pathways (MEP). The product of the MEP that gets used is geranyl pyrophosphate which is formed from a condensation reaction of two isoprene units. The product of the acetate pathway that gets used is olivetolic acid which comes from the hexanoyl-CoA and three molecules of malonyl-CoA. The addition product of olivetolic acid with geranyl pyrophosphate is cannabigerolic acid (CBGA)... ...The formation of either CBDA or THCA from cannabigerolic acid is done via a cyclization reaction in which the isoprene tail of CBGA undergoes variable cyclization patterns. In addition to the schemes shown that produce CBDA and THCA the chain can cyclize to other conformations generating other cannabinoids including cannabichromene (CBC). The cyclization is FAD dependent and is driven by the formation of a carbocation. It is the final cation quenching step that determines which cannabinoid will be produced.
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Jean-Luc Picard
I only wish i was this good!



Registered: 12/30/07
Posts: 4,177
Loc: New Mexico, USA
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Re: Mommy, where do cannabinoids come from? [Re: ballsalsa] 4
#27469144 - 09/15/21 09:44 AM (2 years, 4 months ago) |
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Hey there ballsalsa!
I actually wrote about this back in 2017 on the Growery [Link to Growery Post], and suggested that there may be a way to boost cannabinoid production via application of dilute hexanoic acid to plant tissues (in my post, it was suggested that root application was the way to go). I never got the chance to test it out, but there it is I guess 
Thanks for the article, it was neat to read back through the biosynthesis pathway. 
&
-Jean-Luc
-------------------- The universe is under no obligation to make sense to you - NDT
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ballsalsa
Universally Loathed and Reviled



Registered: 03/11/15
Posts: 20,808
Loc: Foreign Lands
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Re: Mommy, where do cannabinoids come from? [Re: Jean-Luc Picard] 1
#27469153 - 09/15/21 09:52 AM (2 years, 4 months ago) |
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 Glad you liked it
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Like cannabis topics? Read my cannabis blog here
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openmind
curious


Registered: 08/03/07
Posts: 13,864
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Re: Mommy, where do cannabinoids come from? [Re: Jean-Luc Picard] 2
#27469380 - 09/15/21 01:23 PM (2 years, 4 months ago) |
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Quote:
Jean-Luc Picard said: Hey there ballsalsa!
I actually wrote about this back in 2017 on the Growery [Link to Growery Post], and suggested that there may be a way to boost cannabinoid production via application of dilute hexanoic acid to plant tissues (in my post, it was suggested that root application was the way to go). I never got the chance to test it out, but there it is I guess 
Thanks for the article, it was neat to read back through the biosynthesis pathway. 
&
-Jean-Luc
I've speculated/wondered about the same thing!
I add Lactic Acid Bacteria to my soil, some is already present in soil naturally but I make a culture of it and add some to my soil through out the grow.
As LAB digest sugars they produce/shit out a short-chain fatty-acid known hexanoate. So a soil with plenty of lactic acid bacteria present should lead to a soil that is richer in hexanoate.
So the theory goes...a soil richer in hexanoate can lead to a higher THC/cannabinoid content in the flowers. I'm not sure how much hexanoate LAB produce, but perhaps it is enough to lead to a higher cannabinoid content. Plants grown in live organic soil are known to have better cannabinoid and aroma/flavor profiles, so there is likely something to it and something going on there.
I'm very interested in seeing some experiments done on this.
Cool thread/post ballsalsa!...Didn't realize you were a total cannabis geek. I'll have to check out your blog!

-OM
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ballsalsa
Universally Loathed and Reviled



Registered: 03/11/15
Posts: 20,808
Loc: Foreign Lands
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Re: Mommy, where do cannabinoids come from? [Re: openmind]
#27469739 - 09/15/21 06:51 PM (2 years, 4 months ago) |
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To be fair, my buddy wrote the article. He's a biochemist
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Like cannabis topics? Read my cannabis blog here
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