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InvisibleballsalsaMDiscord
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Registered: 03/11/15
Posts: 20,808
Loc: Foreign Lands
Have you ever wondered where all the cannabinoids come from? * 1
    #27458929 - 09/07/21 07:35 AM (2 years, 4 months ago)

Well, here you go.

https://vhsfeelsgood.com/the-official-sponsor-of-420-thca-synthase/

Quote:

THCA synthase is the enzyme that catalyzes the reaction of CBGA to THCA, creating the THC precursor known to display psychoactive properties in C. sativa. The structure of THCA synthase was determined using X-ray crystallography. THCA and CBDA synthases share 83% similarity, with CBDA synthase proposed to be the ancestral synthase from which the THCA variant evolved. As CBDA synthase is the ancestral enzyme, THCA synthase has retained the ability to form CBDA as a product as well. In fact THCA synthase can make THCA, CBDA, and CBCA in a pH dependent manner. CBDA is a minor side product while THCA is the dominant product in pH below 7 while this changes to CBCA being the dominant product in pH above 7. The change is believed to be the result in the different protonation step at H292 (pH 6.04).




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