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OfflineKorgman
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Registered: 06/30/21
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Can psilocybin actually replace 25 years of SSRI continued use ??
    #27431620 - 08/17/21 12:46 PM (2 years, 5 months ago)

I've been taking 40 mg daily Prozac / SSRI 25 years now, for depression.    Anxiety was also part of my issue initially.  It has really helped me both initially and continually throughout all these years.    I've tried cutting back a few times, but always feel the depressive feelings gradually working back in,  after a few weeks.  I've consulted my doctors in the past….never with mushrooms stated though….just on other depression alternative medications.  All alternatives carry the same negative sexual side effects.    Is there anyone out here who can relate personal depression  experience , where psilocybin mushrooms have successfully replaced (long term 25 years) SSRI usage ?    Any specific online resources recommended?    Any Florida recommendations ?    From what I'm learning here so far, I think a microdose  regimen would be ok.    Have tried a few shroom trips back in the early 70's.
Thank you.for reading and hopefully responding.


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OfflineTheFourthEyE
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman]
    #27431705 - 08/17/21 01:59 PM (2 years, 5 months ago)

Hi, yes i believe it can, ive used anti deps in the past for long periods of time, the last one i was on was Sertraline. And also wellbutrin.

I felt that they dont do much for me anymore becasue i had bad spells of feeling very bad with debilitating anxiety.
After doing shrooms again after years i remembered what it felt like to feel good and content about life so i used shrooms every weekend sometimes more, for like a month or two while i was coming off of the antidepressants.

BUT then i did some research on herbs and stuff that act as natural moodstablizers and came across

1) morninga
2) cancerbush
3) sceletium

I take a cap or 2 of each in the morning and drink cellfood drops in some water with
it has 36 trace elements including lithium which is a very good for mood.
And i am feeling much better than ive felt than on any antidepressant.

And im telling you all these herbs really have a positive effect on your mood and energy levels i would 100% recommend you look into it

Goodluck:nyan:


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:mushroom2:dankie vir die tyd geneem het om dit te vertaal:mushroom2:


Edited by TheFourthEyE (08/17/21 02:03 PM)


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: TheFourthEyE]
    #27431829 - 08/17/21 03:10 PM (2 years, 5 months ago)

thank you, i'll check out.    Specifically, how long in years on each antidep ?    25 years on Prozac a long time, concerning go me to stop after so lkng.


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InvisibleCreonAntigone
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Registered: 05/30/21
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman] * 1
    #27432266 - 08/17/21 08:00 PM (2 years, 5 months ago)

Quote:

Korgman said:
thank you, i'll check out.    Specifically, how long in years on each antidep ?    25 years on Prozac a long time, concerning go me to stop after so lkng.




Do not go cold turkey. You talked before about experiencing worsened depression after stopping. Unfortunately SSRIs have a 'discontinuation' syndrome that involves severe reactions upon stopping the drug. Doctors sadly are incredibly ignorant about it so you'll have to rely on your own feelings to see if you're experiencing it.

I recommend you taper slowly at first to see how you react. The first week, cut down your dose by 1/4th or less. If there's no reaction, cut it down by half the next week. But if you start reacting to the 1/4th taper then return to your original dose and taper even slower.


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: CreonAntigone]
    #27432355 - 08/17/21 08:56 PM (2 years, 5 months ago)

Yes I've read about the discontinuation syndrome , think it will take me awhile tapering down the Prozac , like you've suggested.    I'll consult my physician and or a psychiatrist also, and mention microdosing done together with the tapering down the Prozac.  Any other similar experiences out there ?    New frontier for sure.


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman]
    #27432692 - 08/18/21 05:22 AM (2 years, 5 months ago)

Psilocybin might still cause sexual dysfunction if your plan is to micro dose it.  It's my understanding that serotonin downregulation (tolerance basically to your SSRI or psilocybin) inhibits oxytocin production, which is the cause of sexual dysfunction.

Oxytocin nasal spray is something that's a thing now.  I don't know a lot about it but it's an avenue I would research in your shoes.

Something else to consider is IV Ketamine.  Though it's very expensive ($450 a shot here, they suggest six shots in your first few weeks and then booster shots once a month) and not covered by insurance.  If you have the means it's an alternative to consider.  I don't think there's any serotonin action with it and even if there was because the goal isn't steady states you wouldn't run into the oxytocin production issue with it.

Other options are to look at other receptors.  Venlafaxine has much less binding at SERT (That's the serotonin transporter) and more at NET (norepenephrine transporter).  Bupropion works more at DAT (Dopamine transporter) and NET and has no binding at SERT.  Though both of these drugs come with their own issues I've been on both and they're generally well tolerated.  Just don't ever, and I mean like, ever, miss a dose of Venlafaxine.  The half life is really low and you can go into withdrawal with a single missed dose.

And I hope that made some sense.  I just spotted some typos (it's before my morning coffee).


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27432745 - 08/18/21 07:06 AM (2 years, 5 months ago)

very detailed, you've given me much to investigate, thank you very much.    Do you do psilicybin ?


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman]
    #27432830 - 08/18/21 08:47 AM (2 years, 5 months ago)

Not currently.  I'm on parole for growing it and have an ex-wife that's got a vindictive streak so I have to be very very careful in that regard.

I've been on Effexor, Welbutrin, Venlaxine, and I'm currently weaning myself off Duloxotine.

I did a lot of meditation in prison and managed to work through a lot of my anxiety.  More recently I was able to connect with a lot of my childhood trauma and I'm in the process of integrating that.  My partner and I have an appointment tomorrow with a counselor that seems to have a good understanding of trauma and systemic and interpersonal oppression.  So I'm hopeful that I'll find more healing there.

I'm way more on the anxious scale than the depressive one.  My depression is more of mental and physical exhaustion from anxiety, trauma, and oppression.

But macrodose psilocybin, for me, is a spiritual thing.  I have ancestry that goes back to the part of the U.S. that would have been using it medicinally long before my white ancestors set foot on this continent.  It gives me a sense of connection and continuance beyond birth and death. And in that sense, is very relieving when it comes to anxiety and depression.


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


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Offlineorison
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Registered: 01/19/09
Posts: 5,468
Last seen: 23 days, 16 hours
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27432853 - 08/18/21 09:09 AM (2 years, 5 months ago)

Quote:

paperbackwriter said:
Psilocybin might still cause sexual dysfunction if your plan is to micro dose it.  It's my understanding that serotonin downregulation (tolerance basically to your SSRI or psilocybin) inhibits oxytocin production, which is the cause of sexual dysfunction.





that explains that, I thought I was just laughing to hard at everything to get hard.. :awewtf:


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: orison]
    #27432884 - 08/18/21 09:37 AM (2 years, 5 months ago)

If it's long term, and you're microdosing, it could be related.

If it's macro, yeah, I don't know.  Unless you're macrodosing multiple times a month and have continuous tolerance basically. 

I generally don't find psilocybin very sexual unless it's someone I'm very comfortable with as I just feel more vulnerable on it than on say, LSD.  But I have a trauma history that I'm sure has a role here.

Stimulation of serotonin receptors is what's thought to cause oxytocin release with MDMA.  And continued stimulation (and thus downregulation) is thought to interfere with oxytocin release and cause the sexual side effects.

But none of this is settled science and I'm still mostly a layperson (I had to take introduction to pharmacology for my degree and read a lot about what I put into my body, but that's about the extent of it). 

Plus we're just now learning about oxytocin really as one of the major gateways to understanding this hormone has been prohibited for so long.


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


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Offlineorison
mcfluffysugarnuts


Registered: 01/19/09
Posts: 5,468
Last seen: 23 days, 16 hours
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27432887 - 08/18/21 09:42 AM (2 years, 5 months ago)

id taken a few micro in the evening before bed, also noticed a little lack of dick power .. thought it was my clonidine ..


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: orison]
    #27433118 - 08/18/21 01:46 PM (2 years, 5 months ago)

Small doses of serotonin on occasions should promote healthy release of oxytocin.  It's when the dosing becomes consistent and the body compensates that we're seeing these patterns.  Like in the case of SSRIs.

Erectile dysfunction is a common side effect of clondine.  Which makes sense.  It lowers blood pressure.


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


Edited by paperbackwriter (08/18/21 01:47 PM)


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27433734 - 08/18/21 10:36 PM (2 years, 5 months ago)

The sexual dysfunction is delayed orgasm, which can take a very long time.  I'll look up that nasal spray you mentioned.    Bottom line, I want to taper off prozac, while microdosing.    I can put up with delayed orgasm,  and hope microdosing can work to make up for the lack of prozac.  I've felt pretty good for a lot of years now, not sure of early trauma, but probably so.    Paperback writer, appreciate hearing your observations, and wish you the best in your struggles.    Also, would like to macrodose again.    It could bring up a few surprises emotionally.  I understand your comment on bringing you connection with something bigger than our day to day outlook, feeling of enlightenment and connection.


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman]
    #27433988 - 08/19/21 05:37 AM (2 years, 5 months ago)

Thanks Korgman and likewise.  I'm tapering off Duloxotine myself.  Planning to check out Kava for some of my continuing struggles, which are mostly related to chronic physical pain at this point and legal issues with my ex-wife. 

So I'm hoping it will help as a muscle relaxant and sleep aid while I await surgery and for this court battle to play itself out.


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27434217 - 08/19/21 08:59 AM (2 years, 5 months ago)

best wishes going forward , paperbackwriter😉


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OfflineEnthralus
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Korgman] * 1
    #27434547 - 08/19/21 01:16 PM (2 years, 5 months ago)

Let me echo the challenge of getting off these anti depressants.  I was using effexor for about ten years.  The side effects were brutal but was the only thing that "worked" for me.
I quit cold turkey at least 5 separate times for periods of 6 months and more.  Each time quiting was absolutely nightmarish.  But who are we kidding?  Depression is already brutal for some of us.  In many cases, we're tough as bricks in that regard. 

I was eventually able to switch to Wellbutrin which I eventually stopped using after seeing a psychologist for regularly for a year. (totally worth the money by the way)

I believe shrooms force you to acknowledge the thoughts you are hiding from yourself which may actually be a form of psychotherapy.  I suspect this perspective will maximize it's effectiveness for you.  In other words, don't expect this to be easy.


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: Enthralus]
    #27434568 - 08/19/21 01:33 PM (2 years, 5 months ago)

Wow, I hear you.  You were able to wean off after 10 years SSRI usage or so, and all that hard work.    25 years for me, not sure I could do it successfully, will take some time, work, psychologist visits.    I'll microdose at .2 g , 2.5 times per week.    Hopefully will help the gradual tapering.    The sexual issue is a moot point for me at 71 years old.    Had my prostate removed 1.5 years ago, cancer....all good now, now orgasm can still be accomplished even without prostate, but I'd  still rather not be depressed.  Prozac's worked well last 25 years for me.    We'll see how tapering works out.    I might eventually macrodose psilicybin eventually, am aware of how issues will present themselves, yes....even with microdosing too.


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InvisibleCreonAntigone
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: paperbackwriter]
    #27434937 - 08/19/21 05:42 PM (2 years, 5 months ago)

Quote:

paperbackwriter said:
Planning to check out Kava for some of my continuing struggles, which are mostly related to chronic physical pain at this point and legal issues with my ex-wife. 





If you do try kava please tell us how it goes! I've been meaning to try it.


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OfflineKorgman
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: CreonAntigone]
    #27434953 - 08/19/21 05:55 PM (2 years, 5 months ago)

thank you CreonAntigone


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InvisibleNoChill
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Re: Can psilocybin actually replace 25 years of SSRI continued use ?? [Re: CreonAntigone]
    #27435900 - 08/20/21 12:00 PM (2 years, 5 months ago)

I love me some Kava!

Used to drink it in HI all the time!

It tastes like mud with added tannins and makes your mouth a little numb, but it's a wonderful anti-anxiety herb. It's also very social. The Kava bar always was a place to have a great convo with a total stranger.

It also has a bit of a reverse-tolerance. The first time you try it, you may be unimpressed. Keep drinking!

-NC


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Agar Saves!


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