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OfflineAsanteA
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Tolicyclidine - 5 + 5mg 3-Me-PCPy
    #27336460 - 06/05/21 05:39 PM (12 days, 21 hours ago)

Quote:

Asante said @ Bluelight:

sooo... Very strong SERT activity (usually antagonist), strong agonism and reuptake inhibition of DA and NA along with the dissociative effect, potentially more potent per mg than PCP..

Sheesh.

This is one that shouldnt be high dosed or binged, if those metrics work out that way in vivo. This is probably an activating/fun/mania one, the hole can probably not be safely reached.

Its bound to be exceptionally delusional/supernatural/psychotic in nature, with a tendency to be mobile while out of your gourd, so PCP zombies.

Its also very likely to be more-ish/compulsive/bingy but thats exactly what you shouldnt do with this.

Obviously, with such a grapeshot at receptors, there will be more side effects and interactions than with your average disso: it simply does more things, strongly.

Extra caution with people prone to compulsion, addiction, risk taking/aggressive behavior when disinhibited, of diminished mental or physical health, those mixing drugs and those exerting themselves.

This one seems more prone to reckless actions, trainwrecks, addiction and toxicity than the dissos that are most treasured, aside from PCP.

All this is SPECULATION based on:

    Notably, 3-Me-PCPy showed high affinities for DAT, NET, and SERT compara-
    ble to or higher than its NMDAR affinity (39, 45, 5.6, and 52.3 nM, respectively),
    which was not shared by its PCP counterpart 3-Me-PCP. Furthermore, 3-Me-PCPy
    was also shown to act as a reuptake inhibitor at these transporters (Wallach 2014).


This piece sort of implies the above. In reality it may work out much different from that, but these cautions are sensible enough to be taken in consideration.

Chemically speaking, its the HCl salt of a no frills arylcyclohexylamine, so under an inert atmosphere (or hydrocarbon solvent like dry heptane) in the complete dark, this one should be relatively permanent at room temperature. The Freebase is probably crystalline and , being a tertiary amine, less basic so less harsh to smoke than open chain arylcyclohexylamines. It having a 3-tolyl group and pyrrolidine will likely make the smoke more unpleasant than that of PCP. It looks as smokable as PCP is.

Because its a non-keto arylcyclohexylamine chemically very much akin to PCP, including probable high potency, this one is less likely to be bladder toxic and more likely to be liver toxic, like PCP.
Unlike PCP this molecule dangles an enticing 3-methyl group off the phenyl. Its not unlikely metabolism will latch onto that to turn it into 3-COOH-Rolicyclidine, likely inactive and conjungated for excretion. If that methyl is favorably accessible, this might with a bit of luck be a shorter lasting compound than many forever-dissos.

By the way, the name is 3-methylrolicyclidine, drug enforcement horndogs could construe it to be a structural isomer of PCP, both being C17H25N weighing 243.394 g per mol, on the upside, it is that, at the receptor, too. Expect this to be a hard hitter.




Quote:

Asante said @ Bluelight:


its 3-Me-PCPy = 3-Methyl-PCPy = 3-methylrolicyclidine.

I want to propose a name for this substance, that is both chemically informative and way more pleasant than the alphabet soup.

The parent molecule of this is Rolicyclidine (with a phenyl group).
This one has a 3-Tolyl group instead of the phenyl.
It is, kinda "tolyl-rolicyclidine", but thats overcomlicating it.

Tolicyclidine

Think about it.

Its Rolicyclidine, the tolyl way. Of course there are also the ortho and para tolyls, but these appear to be dead ends throughout arylcyclohexylamines

Tenocyclidine
Eticyclidine
Phencyclidine
Rolicyclidine
Tolicyclidine

Fits right in, rolls off the tongue like Chardonnais ^_^

You got the -olicyclidine because of the pyrrolidine, but with the T the Toly and Toli nicely overlap, and its very clear we're dealing with a rolicyclidine derivative here and, which kind.

It just strikes me as a pretty name for this one.

I read elsewhere online that it "in low doses imparts a mild psychostimulant effect we believe people will like" so if that is actually based on bioassays, it kinda says: "dont dose it too high, you'll get massive stim effects"

Someone said "so basically a Calvin & Klein combi in one" (Coke & Ket)

Intrigueing.

Has someone seen actual bioassays?










1 gram of Tolicyclidine HCl found its way my way.

I've quit drugs (last dose 2019) so the plan is, one session, discard the rest. I may use the leftovers (if any ) to more precisely establish water solubility.

Whats immediately apparent is that the label says 3-Me-PCPy and shows this structure, but the IUPAC name given is that of 4-methyl-eticyclidine (3-Me-PCE)

Its an off white powder with a very slight odor, somewhat phenolic, color and consistency kinda like coffee creamer, 25mg dissolved readily, completely and clearly into 1ml lukewarm water. Solution is bitter, as expected.

I diluted it further to 5ml, of this, 1ml=5mg will be rectally administered, the way I was used to take my dissociatives.

One hour in, the 5mg rectal came up fast, alert within 3 minutes, significantly developed in 10,min, mostly there at 30 min after the plunge. It started out anxious for me, but so does 3-MeO-PCP. It soon gave way to a dreamy state with a stimmy, slightly restless undertone. The euphoria of the dissociation and stimulation, go well together. The dreamy dissociation outweighs the stimulant component. You physically "got to do something" but you're way dreamy so, whoa, not too much  My palms are warm and sweaty, ,especialy in the beginning A low dose of this could potentially be sexy - this might be just the ticket for sensual exploration. Its about as potent, I think, as typical PCP type drugs, so probably 3-15!mg, like PCP and 3-MeO-PCP.
I am sufficiently intoxicated, 5mg rectal is a strong ++ for me, despite that I had a considerable dissociatives tolerance 2 years back. Dreamy yet alert, disinhibited but euphoric a tad restless, these are wilder waters than the 3-MeO-PCP lotus pond of tranquility. Its like a dissoi with a hint of MDMA, the euphoria is reactive and genuine.

I'm confident, good as I feel, drugs are no longer The Way for me. I poured the remaining 4ml = 20mg away.

PCP is usually smoked as the freebase.

Smoking is sooo 20th century, so I was wondering whether this Tolicyclidine HCl as such was suitable for vaping. Not that I vape, but, people will want to do that.

1 weighed out 100mg 3-Me-PCPy and with teaspoon, wineglass and graduated syringe I managed toi dissolve it into 3ml of propylene glycol.

Can you credibly say "For Science" when you have a great time on 5mg and pour 100mg down the sink? For science guys!

I anticipate that glycerin/glycerol (another vaping carrier) will dissolve more of it, being more polar. Let's go find that out.

..And nope, it did not work out that way.

100mg Tolicyclidine HCl did not satisfactorily dissolve into 10ml glycerin, so it is of little practical vaping use.

500mg did however dissolve completely in 2.5ml water at 26.5'C (its hot here) making it remarkably aq sol,

The leftovers were discarded, except for a second 5mg, this time in 2ml water, for rectal use, now 2:15 hour after the first dose when I'm still comfortably on the plateau.

99% of the 3-Me-PCPy used in this experiment went down the drain.

After the work, the reward! Here's to 5mg more!


2h after the second dose and about 4:30h after the first dose, I must say first of all that both doses caused a bit of localized irritation of the bowel wall, a slight itch, and this at 0.25-0.5% concentration. Tasting the solution did not have irritant effects, but this may affect people intending to vape or inject IM. Since Tolicyclidine is a tertiary amine so, less basic than HCl is acidic, maybe the fact that its a somewhat acidic salt contributed to that effect.

The second dose had NOTHING of the anxiety, it was this wave of eyes-closed dreaminess engulfing me, I peacefully floated, a lotus upon the tranquil pond, an effect shared with 8mg 3-MeO-PCP but, more pronounced. As the dose increases, the dreamy/anesthetic effects overcome the alert/stimulant ones. I take back my previous assumption, if one were to take bolder doses and more repetitions one could probably hole out fantastically on this one. At 5+5mg, I do believe I'll sleep like a rose tonight unless stimulation takes over on the tail end.

In terms of non-keto arylcyclohexylamines I tried, this one takes the cake.

It feels better to me than 3-MeO-PCP, 3-MeO-PCE, 4-MeO-PCP and 3-MeO-PCMo. Tolicyclidine has that wonderful -anesthetic- feeling I appreciate so much in the Keto drugs like Methoxetamine. Of these, for me this one would no doubt be the most binge-able.

Its *peaceful*, and yet you are alert. This promises that the further down the path you go, the more seductive and rich the dreamlike state becomes.

At 5+5mg I an still fully agile, but definitely wouldnt take part in traffic, not even on a bicycle. If I had to calibrate it, I would place 5mg Tolicyclidine on the level of 30mg Methoxetamine and 7.5mg 3-MeO-PCP.

You probably do good taking a small dose first to dissappate anxieties before going deeper, to prevent perhaps the stimulant effect whipping those up to something unpleasant.

Like MXE, the virtue in my book is in repeat increments, where I equate 5mg Tolicyclidine with 30mg Methoxetamine.

I wrote an email to the vendor to tell them about the mislabelling of their product, how the abbreviation and structure read 3-Me-PCPy, while the IUPAC chemical name given on the baggie is of 3-Me-PCE.

I'd be surprised if this turned out to be the Eticyclidine analog, it has a different feel from the N-monoalkyls, it really feels like a cyclic amine.

I'm stimulant intolerant, 1 cup of coffee is too much, but this 5+5mg is just sweet to me. Its the Disso kind of stimmy, not the phenethylamine/cathinone/caffeine kind. It vibes well even with me.

Disso head + Stimmy typing urge: this thread will probably get some utterly WTF contributions

I'll see what develops more, the drug is out of my house and in the plateau in my body.

I love the feeling but I've come to dislike "being high", so its great stuff, dig in with due caution, but I won't be repeating. I won't repeat, because I'd slip right into the disso habit again if I did.

Black holes are to slingshot you to lightspeed, not to spiral into.

Respect the substance: I can totally feel this one WILL be bad if you dose too high or too often.

Its good stuff.

3:30h after the booster, I feel I'm pleasantly descending, but that it might be quite a pleasant long descent ahead. Stims almost invariably have a comedown, this stimulating dissociative doesn't have that so far.

I used to have Methoxetamine issues, precisely because this new one feels so good, do I not want to take it again, because repeat use would lead me to ruin. So, using it and enjoying it strengthened my desire never to use dissociatives again. I felt the seductive pull of the center of the cyclone again. Consider this a community service by a former disso devotee.

Its now six hours after the second dose. Its mostly over, but it lingers pleasantly if you want to surrender to it and annoyingly if you want to do something else. Its lets say 1/5 of what it was, but I wouldnt be surprised if that fifth lingered till midnight, 4 hours more.


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OfflineAsanteA
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Re: Tolicyclidine - 5 + 5mg 3-Me-PCPy [Re: Asante]
    #27337776 - 06/06/21 06:21 PM (11 days, 20 hours ago)

Out of respect for my special time shared with this substance, the chemical structure of 3-methylrolicyclidine in 24 carat photographic gold:



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OfflineChristianMeteor
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Re: Tolicyclidine - 5 + 5mg 3-Me-PCPy [Re: Asante]
    #27341598 - 06/09/21 02:35 PM (9 days, 8 minutes ago)

"You probably do good taking a small dose first to dissappate anxieties before going deeper, to prevent perhaps the stimulant effect whipping those up to something unpleasant." Goodness does this statement ring truth in many realms of psychoactive exploration. I could have avoided many negative experiences with psychedelics had I simply utilized this..

Interesting report though-I have never heard of this drug before. That cyclone you describe, and it's enticing nature, I have been drawn to it as well on dextromethorphan. What is it? Sheer bliss in detachment, or some alluring aspect of the void that holds a treasure? I do believe such places hold value, but how to go about channeling such things into a tangible form?

You describe a past of difficulty with these substances, and I would like to ask about what aspect of them you found alluring. I, too, sense it, but how is it described?


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OfflineAsanteA
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Re: Tolicyclidine - 5 + 5mg 3-Me-PCPy [Re: ChristianMeteor]
    #27345062 - 06/12/21 03:41 AM (6 days, 11 hours ago)

Its the gateway to another world, crossing over from the world of the waking to the world of the dreaming.


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