Home | Community | Message Board


ElevationChemicals.com - Reagent Test Kits
Please support our sponsors.

Feedback and Administration >> Shroomery News Service

Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Shop: Left Coast Kratom Buy Kratom Capsules, Buy Kratom Extract, Kratom Powder For Sale   North Spore North Spore Mushroom Grow Kits & Cultivation Supplies   Kraken Kratom Kratom Capsules for Sale   Bridgetown Botanicals CBD Capsules   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Amazon Scales

Jump to first unread post. Pages: 1
InvisibleveggieM

Registered: 07/26/04
Posts: 14,576
Loc: Flag
Psilocybin therapy appears to be at least as effective as a leading conventional antidepressant
    #27338231 - 06/07/21 01:05 AM (11 days, 13 hours ago)

Psilocybin therapy appears to be at least as effective as a leading conventional antidepressant
June 6, 2021 - PsyPost

Psilocybin, the active compound in magic mushrooms, may be at least as effective as selective serotonin reuptake inhibitors, the leading type of antidepressant medication, according to research published in the New England Journal of Medicine. The phase 2, double-blind, randomized, controlled trial compared psilocybin to the antidepressant medication escitalopram.

“Our previous research in treatment-resistant depression and as well as human brain scanning strongly suggested the therapeutic potential of psilocybin. Pitting psilocybin in a head to head versus a conventional antidepressant felt like a brave and interesting test to do,” said study author Robin Carhart-Harris, the head of the Centre for Psychedelic Research at Imperial College London and founder of MyDelica.

The researchers recruited 59 men and women between the ages of 18 and 80 years who suffered from moderate-to-severe depression for their 6-week trial. Thirty patients were randomly assigned to the psilocybin group, while the remaining 29 patients were assigned to the escitalopram group.

Patients in the psilocybin group received 25 mg of psilocybin during two sessions. Those in the escitalopram group, on the other hand, only received 1 mg of psilocybin during their sessions — a dose with negligible effects. The patients received their dose in a controlled clinical setting as they listened to a curated music playlist and were guided through their experiences by a psychological support team, which included registered psychiatrists.

The patients were also instructed to take one capsule each morning. Those in the psilocybin group took a placebo pill, while those in the escitalopram group received an active dose of the antidepressant medication.

The patients completed a standardized scale of depressive symptom severity known as the Quick Inventory of Depressive Symptomatology–Self Report. At the start of the trial, the mean score was 14.5 out of 27 for the psilocybin group and 16.4 for the escitalopram group. After six weeks, scores reduced by an average of 8.0 points for those in the psilocybin group and 6.0 points for those in the escitalopram group — a difference that was not statistically significant.

“Psilocybin therapy appears to be at least as effective as a leading conventional antidepressant and is faster acting with a reassuring safety profile when given by professional therapists,” Carhart-Harris told PsyPost.

The researchers also found that patients in the escitalopram group were more likely to report side effects such as anxiety, dry mouth, sexual dysfunction, and reduced emotional responsiveness compared to those in the psilocybin group. Patients in the psilocybin group reported greater improvements in the ability to cry and feel compassion, intense emotion, and pleasure.

“Remedicalizing psilocybin and related drugs is the most interesting project in contemporary psychiatry,” Professor Guy Goodwin, an emeritus professor of psychiatry at University of Oxford who was not involved in the study, told the Science Media Centre. “The present study is not a quantum leap: it is under-powered and does not prove that psilocybin is a better treatment than standard treatment with escitalopram for major depression. However, it offers tantalizing clues that it may be.”

While the initial findings are encouraging, the study has some limitations.

“A bigger trial with a straight placebo condition would have further helped to clarify results and our interpretation of them,” Carhart-Harris explained.

The duration of treatment could also be a factor. SSRIs like escitalopram can take several weeks to start reducing symptoms. “Had the course of escitalopram been extended, it is possible that better efficacy would have been observed among the patients in the escitalopram group,” the researchers noted.

“The next big question is ‘how will psilocybin therapy fair in a big licensing trial?’ These are needed before medicine regulators can make a decision about whether to approve psilocybin therapy as a licensed treatment for depression,” Carhart-Harris said.

The study, “Trial of Psilocybin versus Escitalopram for Depression“, was authored by Robin Carhart-Harris, Bruna Giribaldi, Rosalind Watts, Michelle Baker-Jones, Ashleigh Murphy-Beiner, Roberta Murphy, Jonny Martell, Allan Blemings, David Erritzoe, and David J. Nutt.


Post Extras: Filter  Print Post  Remind Me! Notify Moderator
Offlinedurian_2008
Cornucopian Eating an Elephant
 User Gallery


Registered: 04/02/08
Posts: 6,399
Last seen: 2 days, 13 hours
Re: Psilocybin therapy appears to be at least as effective as a leading conventional antidepressant [Re: veggie]
    #27338264 - 06/07/21 01:52 AM (11 days, 13 hours ago)

Quote:

a reassuring safety profile when given by professional therapists




What does professional therapy involve?


Post Extras: Filter  Print Post  Remind Me! Notify Moderator
Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,129
Re: Psilocybin therapy appears to be at least as effective as a leading conventional antidepressant [Re: durian_2008]
    #27338923 - 06/07/21 03:18 PM (10 days, 23 hours ago)

Quote:

durian_2008 said:
Quote:

a reassuring safety profile when given by professional therapists




What does professional therapy involve?




For psilocybin, in the broadest sense it has typically included standard psychotherapy about expectations of psilocybin (adverse effects and how to hand anxiety etc.) There are usually two "sitters" for an all day session and follow-up the next day.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


Post Extras: Filter  Print Post  Remind Me! Notify Moderator
Jump to top. Pages: 1

Shop: Left Coast Kratom Buy Kratom Capsules, Buy Kratom Extract, Kratom Powder For Sale   North Spore North Spore Mushroom Grow Kits & Cultivation Supplies   Kraken Kratom Kratom Capsules for Sale   Bridgetown Botanicals CBD Capsules   Unfolding Nature Unfolding Nature: Being in the Implicate Order   Amazon Scales

Feedback and Administration >> Shroomery News Service

Similar ThreadsPosterViewsRepliesLast post
* Stage IV cancer patients and psilocybin - Patient Interviews blink 1,812 3 10/24/04 10:19 PM
by veggie
* The looming effects of shrooming motamanM 2,666 15 03/10/04 02:46 PM
by mjshroomer
* SEPT DEA MICROGRAM 40 YEAR OLD PSILOCYBIN TABLETS motamanM 4,528 6 09/27/03 06:06 PM
by HarveyWalbanger
* Baby sleep problems lead to drugs AnnoA 704 0 04/26/04 06:17 AM
by Anno
* Study: Marijuana leads to hard drugs TinMan 3,640 11 11/03/03 10:52 AM
by Seraph
* New year noise complaint leads to drug bust motamanM 1,855 0 01/07/04 07:40 PM
by motaman
* Ecstasy has dramatic effect on Parkinson's symptom Eightball 3,857 5 01/24/03 03:42 PM
by TeKn0
* Hampton University Wins Grant To Study Effects Of Ecstasy motamanM 2,691 6 07/15/03 07:52 PM
by Fungushungry

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: motaman, veggie, karode13, Alan Rockefeller, naum, Mostly_Harmless
300 topic views. 0 members, 4 guests and 21 web crawlers are browsing this forum.
[ Print Topic | ]
Search this thread:
Edabea
Please support our sponsors.

Copyright 1997-2021 Mind Media. Some rights reserved.

Generated in 0.024 seconds spending 0.009 seconds on 17 queries.