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Offlinelandonjacob
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Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Dosing with SSRI
    #27290987 - 05/02/21 07:54 PM (2 years, 8 months ago)

I’ve been told by every source that you can’t combine ssris’s with shrooms because it will diminish the effects. I take Paxil, and I normally just skip a day of my Paxil before I dose. I started out microdosing but leaned more towards macrodosing. But as I’ve started dosing more frequently I’ve noticed that even when I take my Paxil and dose on the same day, I still feel the shrooms intensely. If I’m not noticing it weakening the effects of the shrooms, can I keep taking my Paxil? I want to be safe and not combine anything that’s not safe. I only take 20 mg. Should I stop my Paxil completely or can I benefit from both? I take 1-2 grams every 3-5 days or so. With more “therapeutic” doses about once a month. 

Any advice would be helpful and appreciated! 🙏🏼☺️


Edited by landonjacob (05/02/21 09:23 PM)


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OfflineSpaceDawg
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Registered: 09/01/14
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Last seen: 1 month, 25 days
Re: Dosing with SSRI [Re: landonjacob]
    #27291035 - 05/02/21 08:15 PM (2 years, 8 months ago)

Honestly I highly doubt you are feeling the "full force" of the mushroom while on an SSRI. When I was younger I was on Paxil and would "Trip" on mushrooms. Later as an adult when I was no longer taking the medication I tried mushrooms again.....Completely different experience.

Have you taken mushrooms while completely off Paxil before? I'm not talking about a couple days I'm talking like a month or more of not being on an SSRI.

Also taking 1-2 grams every 3 days on top of heavier doses 1-2 times a week you are bound to experience tolerance issues or at the very least a diminished sense of "awe" the experience brings. Tread carefully my friend. If you truly need Paxil then its probably not a smart idea to constantly tapering off your dose. But I'm no Doctor.

If I may ask what is the reason you feel the need to take mushrooms so frequently? Or I guess what are you trying to achieve through this dosing regimen?


--------------------
I must not fear.
Fear is the mind-killer.
Fear is the little-death that brings total obliteration.
I will face my fear.
I will permit it to pass over me and through me.
And when it has gone past I will turn the inner eye to see its path.
Where the fear has gone there will be nothing.
Only I will remain.


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Offlinelandonjacob
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Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Re: Dosing with SSRI [Re: SpaceDawg]
    #27291101 - 05/02/21 08:58 PM (2 years, 8 months ago)

I was just skipping a days worth of medication. So it’s not really a hassle. I started out microdosing but leaned more towards low doses. You’re completely right though, I haven’t dosed completely off of my Paxil. I might notice more without Paxil in my system but I’m getting life changing trips from 2-3 grams as it is. Even when I take low doses and my Paxil on the same day, I can notice the effects of 1 gram. So the need to stop taking my Paxil, which helps with my anxiety, isn’t really there. I’m eating a small shroom leaning towards every 3-5 days now. It’s not really a lot for me or my system. I just want to make sure it’s safe to combine the two. I would be willing to completely taper of my Paxil to continue benefiting from the mushrooms. You think 1-2’grams once or twice a week is too much?


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Offlinelandonjacob
Stranger
Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Re: Dosing with SSRI [Re: landonjacob]
    #27291107 - 05/02/21 09:02 PM (2 years, 8 months ago)

I should have explained myself better.. so I edited the first post..  i don’t take low doses and therapeutic doses in the same week. I go a week clean from dosing before trying to achieve that type of trip. It’s been probably three weeks since my last heavy dose. I’ve been diagnosed with PTSD, depression and anxiety and noticed I really benefit from psilocybin. And it’s something I want to incorporate more frequently into my life. But I don’t want to overdo it or burn myself out. I don’t have an exact regime. It’s something I take day by day. Right now I’m leaning towards ever five days closer than three. Because it’s something I have to prepare for an incorporate with meditation. Im hoping to see improvement with my overall mood, and confidence. I’m willing to learn, and appreciate the input!



Edited by landonjacob (05/02/21 09:39 PM)


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OfflineSpaceDawg
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Re: Dosing with SSRI [Re: landonjacob]
    #27291140 - 05/02/21 09:27 PM (2 years, 8 months ago)

I mean if you are having life changing experiences and you feel that this is benefiting your life in a positive way that's all that matters right?

As to whether it is safe to take Paxil while taking mushrooms, I have not heard about anything that would seem to make it an unsafe combination. But again I'm no Doctor.

Tapering off Paxil is only a decision you can make for yourself.

My Mother, Father, and Sister all are on a SSRI and they are all adamant that they help them function and feel better in day to day life. Me on the other hand have found way more help through learning to work with my own mind then I ever did from any medication.

I guess what I'm trying to get at is do whatever you feel is right.


--------------------
I must not fear.
Fear is the mind-killer.
Fear is the little-death that brings total obliteration.
I will face my fear.
I will permit it to pass over me and through me.
And when it has gone past I will turn the inner eye to see its path.
Where the fear has gone there will be nothing.
Only I will remain.


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Offlinelandonjacob
Stranger
Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Re: Dosing with SSRI [Re: SpaceDawg]
    #27291158 - 05/02/21 09:41 PM (2 years, 8 months ago)

Thanks for the input! I’ll take it day by day. I just want to make sure nobody’s heard any horror stories about people combining the two. 😂


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OfflineSpaceDawg
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Registered: 09/01/14
Posts: 328
Last seen: 1 month, 25 days
Re: Dosing with SSRI [Re: landonjacob]
    #27291178 - 05/02/21 09:51 PM (2 years, 8 months ago)

I haven't heard of any horror stories of mushrooms and ssri's. The thing you have to worry about with combining SSRI's and other drugs is serotonin syndrome but that's from mixing with drugs like cocaine or mdma.


--------------------
I must not fear.
Fear is the mind-killer.
Fear is the little-death that brings total obliteration.
I will face my fear.
I will permit it to pass over me and through me.
And when it has gone past I will turn the inner eye to see its path.
Where the fear has gone there will be nothing.
Only I will remain.


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InvisibleAsante
Mage
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Registered: 02/06/02
Posts: 86,795
Re: Dosing with SSRI [Re: SpaceDawg]
    #27291672 - 05/03/21 09:00 AM (2 years, 8 months ago)

Almost anyone I heard comment on Paxil and Mushrooms said the Paxil distorted the trip.


--------------------
Omnicyclion.org
higher knowledge starts here


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Offlinelandonjacob
Stranger
Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Re: Dosing with SSRI [Re: Asante]
    #27292286 - 05/03/21 03:29 PM (2 years, 8 months ago)

Quote:

SpaceDawg said:
I haven't heard of any horror stories of mushrooms and ssri's. The thing you have to worry about with combining SSRI's and other drugs is serotonin syndrome but that's from mixing with drugs like cocaine or mdma.



Same. Maybe its because I’m on a low dose.


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OfflineFun_Guy5387
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Registered: 05/04/21
Posts: 161
Last seen: 1 year, 1 month
Re: Dosing with SSRI [Re: landonjacob]
    #27308542 - 05/14/21 02:47 PM (2 years, 8 months ago)

I, like you, don't take my anti depressants on the day I shroom. I am on Prozac, and frankly it does not do much for me.

On the other hand, a good solid dose of shrooms completely cures my depression. A recent study by John Hopkins (published in the prestigious journal JAMA. found strong evidence that Mushrooms are very effective.

They do not give dosages, but they were fairly large (many participants reported hallucinations). Also, they found that 2 doings a month greatly reduced major depression..the findings were very robust.

In my case, I take prozac and it does little for me. A solid 3 grams, however, removes my depression completely. Unfortunately, the effect only lasts 7-8 days.


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OfflineschmutzenS
King of the side-pins
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Registered: 12/03/02
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Re: Dosing with SSRI [Re: Fun_Guy5387]
    #27314731 - 05/19/21 07:48 AM (2 years, 8 months ago)

I've been on Paxil (20 mg) about 4 years and have been eating mushrooms for 27 years.  I don't notice any diminished effects.  Eating an orange or a grapefruit right after the mushrooms always gives me solid trip.  Generally I eat 2-4 grams every 3/4 weeks, they help me relax and work through my problems.


--------------------


"Blow up your TV, throw away your paper.  Go to the country, build you a home."


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OfflineBartTheOracle
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Registered: 05/19/21
Posts: 9
Last seen: 1 month, 17 days
Re: Dosing with SSRI [Re: schmutzen]
    #27315485 - 05/19/21 07:30 PM (2 years, 8 months ago)

Great info, thanks!


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Offlinelandonjacob
Stranger
Registered: 03/02/21
Posts: 25
Last seen: 2 years, 7 months
Re: Dosing with SSRI [Re: BartTheOracle]
    #27316869 - 05/20/21 07:39 PM (2 years, 8 months ago)

It’s comforting to know other people are using SSRI’s with shrooms, and it’s not just me. If I’m benefiting from both, I would like to continue using both. I just wanted to make sure it was safe and wasn’t counterproductive. Too bad we don’t have better studies yet!


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InvisibleCreonAntigone
Stranger

Registered: 05/30/21
Posts: 2,875
Re: Dosing with SSRI [Re: landonjacob]
    #27379495 - 07/08/21 05:11 PM (2 years, 6 months ago)

Paxil's half-life is 21-24 hours. So most of the paxil is still in your blood when you do this. I'd say don't bother going on-off like that. It won't accomplish anything and might make it harder for your body to get used to it.

Now, one user suggested going off it for a month then trying. THAT could be an idea...


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Invisiblepaperbackwriter
Edward Lear


Registered: 03/31/14
Posts: 1,888
Re: Dosing with SSRI [Re: Asante]
    #27408068 - 07/30/21 02:49 AM (2 years, 5 months ago)

Quote:

Asante said:
Almost anyone I heard comment on Paxil and Mushrooms said the Paxil distorted the trip.




Whenever you mix two things you get a new third thing.

One of the biggest issues I've seen with mixing SSRIs and classical psychedelics is people's expectations.  Which to me is silly.  I don't expect weed + shrooms to be just like shrooms alone.  Likewise, paxil + shrooms is going to be different than just shrooms.

And in my personal experience, shrooms + SSRIs/SNRIs have been just fine.  Different, yes.  But just fine.


--------------------
Why should we strive with cynic frown
To knock their fairy castles down?  ~ Eliza Cook

It's rather embarrassing to have given one's entire life to pondering the human predicament and to find that in the end one has little more to say than, 'Try to be a little kinder.' ~Aldous Huxley


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