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OfflineMelantriz

Registered: 12/29/20
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Loc: Europe
Last seen: 2 years, 10 months
Shrooms with Seroquel 25mg respectively against anxiety and depression
    #27113835 - 12/29/20 09:40 AM (3 years, 30 days ago)

Hi all,

I'm a 33yr old woman suffering for more than a decade of depression and anxiety. For a while now, I have the impression that the pharmaceuticals you can get legally failed to help. In January I stopped taking SSRIs. What was hell for a while, but got better. Unfortunately with all that COVID-F*** and a change in my hormone system it got worse again. At the moment I'm on Seroquel 25mg and for a week now I take Trittico 75mg (Trazodon).
I was impressed about some experiences from people and also some studies of the effects of psilocybin on anxiety and depression.
After reading and also thinking about it for quite a while, I would like to do some micro-dosing of shrooms or truffles and maybe have some light trip for once or twice.

So my questions:
1) Is there any negative effect with Seroquel or Trazodon? A bad trip wouldn't be the best to think of


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Invisible4HO-DMT
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27114194 - 12/29/20 12:49 PM (3 years, 30 days ago)

Not sure about trazodone. But, Seroquel will negate the shrooms. If you search, you can find anecdotal accounts of people aborting a trip with Seroquel.

Quote:

Melantriz said:
... I have the impression that the pharmaceuticals you can get legally failed to help...




That has been my experience. I don't have experience with microdosing. I have found that a single large dose does wonders for treating depression though.


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27114300 - 12/29/20 01:56 PM (3 years, 30 days ago)

The other question was about personal experiences. I forgot.

Thanks a lot


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: 4HO-DMT]
    #27114305 - 12/29/20 01:58 PM (3 years, 30 days ago)

thanks for the reply.

when did you do it though? reading quite a lot of stuff in the forum and the mind set is quite important. but it's not so easy suffering from depression finding the perfect mood to do some shrooms.
and I have to be honest, I get lost in all the different posts and experiences. and yes, there is never an easy way or a single answer. :smile:


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OfflineJohn in WI
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27114442 - 12/29/20 03:12 PM (3 years, 30 days ago)

I'm sorry to hear about your struggle.  I too am in the process of getting off SSRIs.  I'm bipolar, but in recent years, the depression part of bipolar has gotten very, very bad.

I occassionally take low doses of mushrooms (less than 1g, very rarely 1.5g), and am on Lithium, Seroquel, and sometimes Trazadone. (trazadone doesn't seem to do much for me).

I've never experienced any problem mixing psilocybin wth Seroquel, Lithium, or Trazadone.

My concern, for my own safety, is that the psilocybn mixed with severe depression or bipolar can get pretty intense, and for me, very dark. I feel like it improves the depression, but while under the influence of psilocybin it can be spooky.  Don't mean to scare you--but I'd start light, see what happens. I personally haven't had a bad reaction to those.


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Invisible4HO-DMT
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27114861 - 12/29/20 08:03 PM (3 years, 30 days ago)

Quote:

Melantriz said:
when did you do it though? reading quite a lot of stuff in the forum and the mind set is quite important. but it's not so easy suffering from depression finding the perfect mood to do some shrooms.





Mind set is important. So is setting, but that is easier to dial in. I learned about all of that the hard way, years ago. So it's not too much of an issue for me anymore. That doesn't help you though. :strokebeard:

Have you tripped before? Do you know anyone who trips? If so, ask them to be a guide for you. That can go a long way to keeping a healthy set. I realize that may not be available, though. Another option is to look for groups that do ayahuasca ceremonies or the like.  You have to be careful with pharms and MAOIs though. The other thing you could do is talk to your psychologist or therapist about this. They may be open to helping you or have some advice on the topic.

The in-vitro research that has been done on psilocybin and depression happened in a clinical setting with experienced guides. I think this is part of why these studies have been so successful. Without experience or a competent guide, it really could go either way. Just munching some shrooms and winging it with depression could go well, but it could also be a disaster.

Keep in mind that, while tripping, difficult subjects can and do manifest. I found it best to acknowledge and address these difficulties head on. The result, though it maybe uncomfortable in the moment, is that I came out of it with a new perspective on the topic and feeling better having thought deeply about it. Then, those experiences get integrated into your life, which can take months or more. This is the work that you put in to healing, that people often refer to.

Whatever you decide to do, make sure you do some research and be careful. I hope you can find a way to treat your depression. Good luck!


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OfflineBrian Jones
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: 4HO-DMT]
    #27115387 - 12/30/20 03:12 AM (3 years, 29 days ago)

I'm sorry to hear about the issues you are having. I never had any improvement from SSRI's either. I think my depression was situational and not chemical at all. I don't think there would be an interaction with shrooms and Seroquel or Trazadone, but it might diminish the mushrooms effect. I have only taken each of those once when I was out of sleeping pills. They were not good for me. I hope they work for you.


--------------------
"The Rolling Stones will break up over Brian Jones' dead body"    John Lennon

I don't want no commies in my car. No Christians either.

The worst thing about corruption is that it works so well,


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: 4HO-DMT]
    #27116122 - 12/30/20 11:48 AM (3 years, 29 days ago)

Quote:

4HO-DMT said:

Have you tripped before? Do you know anyone who trips? If so, ask them to be a guide for you. That can go a long way to keeping a healthy set. I realize that may not be available, though. Another option is to look for groups that do ayahuasca ceremonies or the like.  You have to be careful with pharms and MAOIs though. The other thing you could do is talk to your psychologist or therapist about this. They may be open to helping you or have some advice on the topic.







I did trip once on Ayahuasca, still taking a small dose of SSRIs. I was with someone that did it regularly and had was a assistant in some shamanic ceremonies. I also know someone who has quite some experienced with shrooms. It was my intention to do it with someone. I don't really want to make things worse.

I already thought about asking my psyhiatrist or my therapist (he does some systemic hypnotherapy - what is not hypnoses though) if they would agree. I doubt that though my psychiatrist works with such strong meds, he would agree to do some private clinical trial. However, at the moment I'm quite desperate so I might try. :smile:

Anyways, thank you very much for sharing and answering my questions!


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: John in WI]
    #27116146 - 12/30/20 12:02 PM (3 years, 29 days ago)

Quote:

Brian Jones said:
I'm sorry to hear about the issues you are having. I never had any improvement from SSRI's either. I think my depression was situational and not chemical at all. I don't think there would be an interaction with shrooms and Seroquel or Trazadone, but it might diminish the mushrooms effect. I have only taken each of those once when I was out of sleeping pills. They were not good for me. I hope they work for you.




Thanks for sharing. I'm not so sure if Seroquel and Trazodone ar working for me. I had some tough suicide ideation and I read it's one of the side effects of trazodone.


Quote:

John in WI said:
I'm sorry to hear about your struggle.  I too am in the process of getting off SSRIs.  I'm bipolar, but in recent years, the depression part of bipolar has gotten very, very bad.

I occassionally take low doses of mushrooms (less than 1g, very rarely 1.5g), and am on Lithium, Seroquel, and sometimes Trazadone. (trazadone doesn't seem to do much for me).

I've never experienced any problem mixing psilocybin wth Seroquel, Lithium, or Trazadone.

My concern, for my own safety, is that the psilocybn mixed with severe depression or bipolar can get pretty intense, and for me, very dark. I feel like it improves the depression, but while under the influence of psilocybin it can be spooky.  Don't mean to scare you--but I'd start light, see what happens. I personally haven't had a bad reaction to those.




Thanks. Why you still do it, if it's sometimes spooky? Wanted to start light, as I'm quite cautious about having some bad side effects that will make it worse.


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OfflineJohn in WI
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27116163 - 12/30/20 12:15 PM (3 years, 29 days ago)

I never approached taking hallucinogens as being something fun.  They always seemed pretty intense, and left me feeling tired and a little bit rattled.

That said, being uncomfortable isn't the worst thing that can happen.  Sometimes the drugs can help you see what you need to see, and that isn't always a lot of fun.

I would be reluctant to take a full blown psilocybin trip these days, although I used to when i was a kid.  In my advanced years, I've been microdosing fairly frequently, and it seems to be helping me work through depression.


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: John in WI]
    #27116227 - 12/30/20 12:44 PM (3 years, 29 days ago)

Apart from experiencing Ayahuasca, some weed and alcohol I don't have any experience with drugs. Ayahuasca was quite intense and it was for sure one of the reasons why I stopped taking the SSRIs what I wanted to do for a long time. This led me to new insights and quite a bunch of stuff to work on. I totally agree with you that personal insights aren't "fun" and for me too it's a new path to deal with depression.

Good to hear that microdosing is helping you, I hope it's helping me too.


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OfflineJohn in WI
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27120113 - 01/01/21 10:40 AM (3 years, 27 days ago)

Microdosing has been a little odd.  I've been careful to take very small, sub-threshold doses.  I took 3 microdoses, 2 days apart.  And one afternoon, I found myself playing with my cat. Really enjoying hanging out with him.  It was the first time in probably 3 years that I didn't feel this incredible darkness and hopelessness. 

Just like any other drug, I don't think I'm going to find "the answer" with mushrooms.  But it does appear to be a viable tool in the tool box.

I think much of my serious depression is situational.  I graduated with a PhD 6 solid years ago--and since that time I've been forced to take every shit, low paying, no benefits job.  Just struggling, giving 100% of my income to student loans and basic health care expenses.  I struggled with depression my whole life, but my circumstances today are actually really bad.    Trying to find peace, or hope, or comfort when the world is up in flames?  I have no idea how to accept that.  I'm trying--I study zen, I haven't drank alcohol for years.  Trying to stay healthy...  But it feels very heavy and hopeless.  What can you do?  The two choices are to give up (and most certainly die), or keep fighting.


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Offlinekanemush
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Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: John in WI]
    #27129816 - 01/06/21 07:17 AM (3 years, 22 days ago)

i take daily 800mg of seroquel xr, 1mg klonopin, and 80mg of prozac for about 9-10 years. i have always tripped but i also do 2-10g at a time. i however would not take my pills then take mushrooms. I just make sure it has been 10-12 hours since i took my meds. obviously the longer the better but never just quit these kind of meds. So too micro-dosing as long as you keep your does around .25 up to .5g you will be fine. They are using seroquel to help with long term addiction such as prolonged use of cocaine and other type of various drugs.


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: kanemush]
    #27135094 - 01/08/21 11:54 AM (3 years, 20 days ago)

Quote:

John in WI said: 

Just like any other drug, I don't think I'm going to find "the answer" with mushrooms.  But it does appear to be a viable tool in the tool box.




Yeah, that's what I want to try out and see, if it could fit in my tool box. Thanks for sharing your experience.


Quote:

John in WI said:
I think much of my serious depression is situational.  I graduated with a PhD 6 solid years ago--and since that time I've been forced to take every shit, low paying, no benefits job.  Just struggling, giving 100% of my income to student loans and basic health care expenses.  I struggled with depression my whole life, but my circumstances today are actually really bad.    Trying to find peace, or hope, or comfort when the world is up in flames?  I have no idea how to accept that.  I'm trying--I study zen, I haven't drank alcohol for years.  Trying to stay healthy...  But it feels very heavy and hopeless.  What can you do?  The two choices are to give up (and most certainly die), or keep fighting.




Reading about your situation, I think I can agree with you. I'm sorry that the circumstances you're in are difficult for you. I don't find the right words to express my empathy for how you struggle. I find it very brave and courageous that you're holding on to all of it, to fight and to care for yourself.


Quote:

kanemush said:
i take daily 800mg of seroquel xr, 1mg klonopin, and 80mg of prozac for about 9-10 years. i have always tripped but i also do 2-10g at a time. i however would not take my pills then take mushrooms. I just make sure it has been 10-12 hours since i took my meds. obviously the longer the better but never just quit these kind of meds. So too micro-dosing as long as you keep your does around .25 up to .5g you will be fine. They are using seroquel to help with long term addiction such as prolonged use of cocaine and other type of various drugs.




wow, these are heavy meds. I will consider the breakt between my meds and the mushrooms. I already read about that.
thanks for sharing too.


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OfflineMelantriz

Registered: 12/29/20
Posts: 13
Loc: Europe
Last seen: 2 years, 10 months
Re: Shrooms with Seroquel 25mg respectively against anxiety and depression [Re: Melantriz]
    #27135141 - 01/08/21 12:14 PM (3 years, 20 days ago)

My idea for the future was to start microdosing or take a higher dose once in a while and so slowly stop the meds. My hope would be to quit them for good.

Kanemush, was it possible for you to reduce your meds or doesn't that work for you?


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