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Offlinehowdidigethere
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Registered: 08/02/20
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amitriptyline for migraines effect on mushroom trip??
    #27089285 - 12/14/20 06:02 PM (3 years, 1 month ago)

my wife has suffered from migraines for decades and a few of her siblings do as well. her doctor prescribed amitriptyline daily to  "help"prevent the migraines. It has done nothing to stop them. So a few months back she has tried micro doses and feeling a headache come on she has tried doses up to approx 2 1/2 dried grams. She was never a recreational pot user or any other drugs. At the 2 gram dose or slightly more she got some physical relief but none of the effects one one should get at that dose. I was shocked as id never seen this happen to anyone that took mushrooms before.I tried the mushrooms at the 2 gram plus dose and had a pleasant experience like I have had in years past. I had not done any in decades but it was like a reunion  with an old friend. Is the Amitriptyline blocking any psychedelic part of it. She and I are concerned about mixing any more meds and on her next visit to the doctors will ask and has stopped taking the Amitriptyline as its proved useless. Any thoughts or experiences would be helpful. She started at very low doses before trying any of the bigger doses so not to cause a negative reaction or experience.


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Invisible4HO-DMT
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Registered: 01/11/11
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Re: amitriptyline for migraines effect on mushroom trip?? [Re: howdidigethere]
    #27096774 - 12/18/20 10:17 PM (3 years, 1 month ago)

Amitriptyline is probably the culprit. It will significantly mute the psychedelic experience. In my experience, amitriptyline has about 25 negative side effects to counter each positive side effects. Get input from her doctor. But, it is an old antidepressant and with that comes significant side effects. For me it was unbearable.


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OfflineKurterino
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Registered: 09/02/20
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Re: amitriptyline for migraines effect on mushroom trip?? [Re: 4HO-DMT]
    #27108488 - 12/26/20 09:21 AM (3 years, 1 month ago)

That is very interesting for me, since I'm decade-long migraine sufferer myself. I'm also on Amitriptyline again, but only a couple of weeks. I remember having been on it a few years ago, and  having stopped because it didn't help (anymore). A few things:
- Amitriptyline isn't usually prescribed to prevent migraines, but it helps with chronic pain. Personally, I'm suffering from headaches that sometimes become migraines, so the Amitriptyline could be seen as preventing a migraine, by helping with 'these' headaches, but only indirectly. To prevent migraines (or at least make them less painful), doctors sometimes prescribe the anti-epileptic Topamax (or Topiramat). While it does help in many cases, a lot of people also find its side-effects unbearable. But it's worth a try. I would however drop the Amitriptyline again immediately if it is ineffective (for now it really helps), because it also messes with my libido, I hate that.
- I have had one or two migraines since I've started taking Amitriptyline  again, and it got better at my habitual dosage, i.e. 0.3-0-5g dried, ground Golden Teachers (in capsules). But it's only been a few weeks (since I'm on Amitriptyline again), apparently it can take some time (until you feel all of its effects).

So, for your wife, I think it's worth giving the mushrooms another try, now that she's off the Amitriptyline. For me, it has changed my life quite substantially, even though it's something that makes it harder to travel now lol (I have to take into account that I will be without my preferred medicine for the duration of my travelling, which kind of sucks...)


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