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OfflineNoitartst
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When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance?
    #27078147 - 12/08/20 03:47 AM (3 years, 2 months ago)

Are we talking one hour?  Two? Three?


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OfflineNorthernerM
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Noitartst]
    #27078172 - 12/08/20 04:28 AM (3 years, 2 months ago)

Take more the first time, don't be chicken.

Stacking harmalas is an art, you feel it. DMT has no noticeable tolerance.


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The nearest we ever come to knowing truth is when we are witness to paradox.


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Offlineindividualist
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Northerner]
    #27078405 - 12/08/20 08:59 AM (3 years, 2 months ago)

You can’t.


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Offlineindividualist
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: individualist]
    #27078406 - 12/08/20 09:00 AM (3 years, 2 months ago)

You have about a 45 minute window from your first ingestion to complete your dose for the session.

Then you have to wait weeks for the same effects


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Offlineindividualist
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: individualist]
    #27078407 - 12/08/20 09:00 AM (3 years, 2 months ago)

Sorry disregard my posts, I thought you meant psilohuasca.


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OfflineSabnock
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: individualist]
    #27078609 - 12/08/20 11:21 AM (3 years, 2 months ago)

You can redose Pharmahuasca anytime you want to, but you have to dose more Harmalas with the DMT because MAO-A inhibition only lasts about 2 hours max ime from the first dose of Harmalas. Personally going by how the experience is i'd say redose about 4 hours in, perhaps.


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Edited by Sabnock (12/08/20 03:24 PM)


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OfflineskOsH
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27078657 - 12/08/20 11:54 AM (3 years, 2 months ago)

I did pharmahuasca once. I aborted it because I definitely did a lot

I dosed 75mg

Then redosed 75mg an hour later

All while redosing harmalas

It was horrifying. Everything just ended up looking like it was made of liquid/ everything was melting and reality looked more real than real

That was maybe two hours after the first dose

I vomited uncontrollably through my mouth and also my nose

I took 8mg klonopin to bail myself out

If there was a way for me to not vomit during pharmahuasca, I would do it again. I don't think I could escape it getting more intense because I ended up falling asleep but I thought I was alive in a different reality...with a different version of me...but slightly different--like I jumped universes into the multiverse

I woke up and I was still tripping


Edited by skOsH (12/08/20 11:55 AM)


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OfflineNoitartst
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: individualist]
    #27078900 - 12/08/20 02:58 PM (3 years, 2 months ago)

Quote:

individualist said:
Sorry disregard my posts, I thought you meant psilohuasca.




No offense taken; I'm ingesting DMT, and wanna know how long after ingesting DMT I can reingest.


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OfflineNoitartst
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27078940 - 12/08/20 03:29 PM (3 years, 2 months ago)

Quote:

Sabnock said:
You can redose anytime you want to Pharmahuasca anytime you want to, but you have to dose more Harmalas with the DMT because MAO-A inhibition only lasts about 2 hours max ime from the first dose of Harmalas. Personally going by how the experience is i'd say redose about 4 hours in, perhaps.



  Sounds about right.  As for the quality of my Rue, I
I seem to need nigh double the 180mgs of high-quality Rue which is normally deems necessary to go tripping; using less seems to get me into trouble.  Is this common?


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Offlinejesusfish
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27078993 - 12/08/20 04:10 PM (3 years, 2 months ago)

I don't mean to derail this thread by any means, but do you happen to know why DMT doesn't cause tolerance in the way other psychedelics do?

From what I understand, it acts on the same receptors and in a very similar way to say psilocybin, but it doesn't cause the two week tolerance that mushrooms would.

I always thought that it was just destroyed so fast by monomaise enzymes that it couldn't damage serotonin receptors but if ayahuasca doesn't cause tolerance even with its built in MAOI that wouldn't make sense, so I'm at a loss rn.


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OfflineSabnock
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Noitartst]
    #27079219 - 12/08/20 06:26 PM (3 years, 2 months ago)

Quote:

Noitartst said: As for the quality of my Rue, I seem to need nigh double the 180mgs of high-quality Rue which is normally deems necessary to go tripping; using less seems to get me into trouble.  Is this common?




Well Harmala/Rue dosage depends on the person, for the average person there is a consistent dosage range, but some people need more or less, has to do with if someone is low or high in MAO-A as well as CYP2D6. So needing a higher dosage isn't a weird thing.


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OfflineSabnock
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: jesusfish]
    #27079232 - 12/08/20 06:33 PM (3 years, 2 months ago)

Quote:

jesusfish said:
I don't mean to derail this thread by any means, but do you happen to know why DMT doesn't cause tolerance in the way other psychedelics do?

From what I understand, it acts on the same receptors and in a very similar way to say psilocybin, but it doesn't cause the two week tolerance that mushrooms would.

I always thought that it was just destroyed so fast by monomaise enzymes that it couldn't damage serotonin receptors but if ayahuasca doesn't cause tolerance even with its built in MAOI that wouldn't make sense, so I'm at a loss rn.




I was told it has to do with base compounds/tryptamines, so DMT, NMT, DPT, etc, base compounds, have no tolerance, but that substituted compounds (like 4-HO-DMT) will have tolerance. I'm not sure if that's true or not though, i've always just attributed DMT having no tolerance to it being an endogenous compound, and endogenous compounds not having tolerance, which i'm also not sure of, but that's my take. And the Harmalas found in Aya that inhibit MAO-A have a reverse tolerance, so the more the Harmalas are consumed, the stronger the same dosage becomes, and you get more sensitive to it and the side-effects go away like the nausea, vomiting, diarrhea, body load cleans up and motor function impairment is reduced, and due to the reverse tolerance, you can lower the dosage bit by bit as you go along to keep a relatively consistent dosage, until eventually you only need a little bit of Harmalas to go a long way.


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Offlinejesusfish
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27079614 - 12/08/20 10:09 PM (3 years, 2 months ago)

Fair enough. Those both sound like plausible theories. Thanks for the info!


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OfflineNoitartst
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27092517 - 12/16/20 04:31 PM (3 years, 1 month ago)

Quote:

Sabnock said:
Quote:

Noitartst said: As for the quality of my Rue, I seem to need nigh double the 180mgs of high-quality Rue which is normally deems necessary to go tripping; using less seems to get me into trouble.  Is this common?




Well Harmala/Rue dosage depends on the person, for the average person there is a consistent dosage range, but some people need more or less, has to do with if someone is low or high in MAO-A as well as CYP2D6. So needing a higher dosage isn't a weird thing.



Do you know what triggers the need for higher doses of rue and DMT, respectively?

It seems my body needed smaller doses of both, once.  Now, I need bigger doses.  Also, how pure  would rue powder be that is only filtered once, and not had a lot of washing for impurities?


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OfflineNoitartst
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Re: When Taking Pharmahuasca, After How Many Hours Can You Reingest Without a Tolerance? [Re: Sabnock]
    #27092542 - 12/16/20 04:46 PM (3 years, 1 month ago)

Quote:

jesusfish said:
I don't mean to derail this thread by any means, but do you happen to know why DMT doesn't cause tolerance in the way other psychedelics do?

From what I understand, it acts on the same receptors and in a very similar way to say psilocybin, but it doesn't cause the two week tolerance that mushrooms would.

I always thought that it was just destroyed so fast by monomaise enzymes that it couldn't damage serotonin receptors but if ayahuasca doesn't cause tolerance even with its built in MAOI that wouldn't make sense, so I'm at a loss rn.




So just waiting two to three hours before re-ingesting rue followed by DMT should work?  How many have done this, successfully?  No side effects?

Quote:

Sabnock said:
Quote:

jesusfish said:
I don't mean to derail this thread by any means, but do you happen to know why DMT doesn't cause tolerance in the way other psychedelics do?

From what I understand, it acts on the same receptors and in a very similar way to say psilocybin, but it doesn't cause the two week tolerance that mushrooms would.

I always thought that it was just destroyed so fast by monomaise enzymes that it couldn't damage serotonin receptors but if ayahuasca doesn't cause tolerance even with its built in MAOI that wouldn't make sense, so I'm at a loss rn.




I was told it has to do with base compounds/tryptamines, so DMT, NMT, DPT, etc, base compounds, have no tolerance, but that substituted compounds (like 4-HO-DMT) will have tolerance. I'm not sure if that's true or not though, I've always just attributed DMT having no tolerance to it being an endogenous compound, and endogenous compounds not having tolerance, which I'm also not sure of, but that's my take. And the Harmalas found in Aya that inhibit MAO-A have a reverse tolerance, so the more the Harmalas are consumed, the stronger the same dosage becomes, and you get more sensitive to it and the side-effects go away like the nausea, vomiting, diarrhea, body load cleans up and motor function impairment is reduced, and due to the reverse tolerance, you can lower the dosage bit by bit as you go along to keep a relatively consistent dosage, until eventually you only need a little bit of Harmalas to go a long way.




So over time you can lower the oral harmala dosing whilst getting the result?  I've heard it works the same with the DMT which the Rue activates.  Is this the case?


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