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InvisibleStudy The CNS
Anecdotal Subtext


Registered: 11/17/20
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“Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.”
    #27066859 - 12/01/20 06:02 PM (3 years, 1 month ago)

https://psychedelicreview.com/catching-up-with-the-psychedelic-entourage-effect-part-2-mydecine-innovations-group/

Catching Up with the Psychedelic Entourage Effect: Part 2 – Mydecine Innovations Group

“Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.”
DECEMBER 01, 2020 - BY BARBARA E. BAUER, MS

This article is the second in a series that Psychedelic Science Review is publishing to keep our readers informed about some of the work being done by psychedelic research companies. Watching where these companies are heading and their research strategies is a critical part of staying up to date with psychedelic science. In particular, this series is focusing on companies using the entourage effect as part of their research and development activities.

Part 1 reviewed the expert opinions of two magic mushroom experts and two pharmacologists working in psychedelic research. Briefly, there is a lot of skepticism about whether there is an entourage effect when it comes to psychedelic compounds. Now, we pose the question, how are psychedelic research companies approaching the entourage effect? Here in Part 2, we take a closer look at Mydecine Innovations Group.

Mydecine’s Rationale and Research Paths

In a June 2020 press release regarding their partnership with the University of Alberta, Mydecine CSO Robert Roscow stated, “We are investigating the potential of mushrooms and their compounds to improve human health and wellness. This research partnership opens up, not only investigation of single molecules from mushrooms but also more complex formulations.”

The formulations Mr. Roscow mentions could contain one or more molecules found in magic mushrooms aimed at treating a particular condition. Additional molecules not naturally occurring in these mushrooms could also be added to give a desired effect or remove one or more side effects. These formulations are in contrast to whole-mushroom extracts, which likely have different effects. In this context, another name for the entourage effect concept could be ‘mushrooms versus molecules.’

NeuroPharm, Inc., the research and development division of Mydecine, clearly states their alignment with the entourage effect on their webpage.

Even in the most potent psychoactive mushrooms, psilocybin is only 1-2% of the total mass. This means that as much as 99% of that mushroom is composed of other molecules. While many of those molecules may have no therapeutic value, some of them are pharmacologically active — either taken alone or in synergy with known psilocybin derivatives.
NeuroPharm also states, “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms. We are studying how these molecules work both alone and in combination with other molecules like THC and CBD.”

The company makes an important observation when it comes to understanding why creating formulations is critical to accurate dosing. NeuroPharm notes that eating magic mushrooms doesn’t give a person much control over what molecules they are ingesting and how much of each compound is entering their bloodstream. The company says, “Current methods for administering psilocybin [eating mushrooms] fail to provide reliable dosing, which makes the resulting effects both inconsistent and unreliable.” They go on to say, “Formulating the active components in ‘magic mushrooms’ into reliable dosage forms will allow users to know exactly what they are taking. Formulated products will provide the desired active ingredients without any undesired compounds…”

Mydecine’s Impact on Psychedelic Research

According to their website, Robert Roscow and his team at Mydecine/NeuroPharm are studying and applying what they understand as an entourage effect in magic mushrooms to their research and development efforts. It is too early to say what innovations may come from this work that could help people with medical conditions or those just wishing to improve their everyday lives. Based on press releases, Mydecine is currently making progress researching the single molecules psilocybin and psilocin.

NeuroPharm is conducting the first-of-its-kind clinical trial using psilocybin-assisted psychotherapy for treating PTSD (post-traumatic stress disorder) in Canadian Veterans. Also, Mydecine recently filed for a provisional patent for an ‘enhancer’ that reduces the enzymatic breakdown of psilocin in the body.


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InvisibleHolybullshit
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Registered: 01/06/19
Posts: 1,551
Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Study The CNS]
    #27066885 - 12/01/20 06:20 PM (3 years, 1 month ago)

Although it seems there motivation is standardization, I welcome their research as there's definitely more going on with mushrooms than just psilocybin/psilocin...like, why do MAOI's potentiate mushrooms so much? MAO is not the main elimination path of psilocin, if it were just MAO's effect on psilocin alone I figure you could expect modest potentiation and some lengthening of the experience. But instead MAOI's make mushrooms MUCH stronger.

I think MAOI's might be activating some of the more minor constituents that may be much more potent but normally are quickly deactivated. For example, Norpsilocin is pretty much a full agonist(99% iirc) but is deactivated by MAO under normal circumstances, along with any other secondary amines.


Edited by Holybullshit (12/02/20 03:00 PM)


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OfflineFractal420
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Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Holybullshit]
    #27067647 - 12/02/20 07:09 AM (3 years, 1 month ago)

Quote:

Holybullshit said:
Although it seems there motivation is standardization, I welcome their research as there's definitely more going on with mushrooms than just psilocybin/psilocin...like, why do MAOI's potentiate mushrooms so much? MAO is not the main elimination path of psilocin, if it were just MAO's effect on psilocin alone I figure you could expect modest potentiation and some lengthening of the experience. But instead MAOI's make mushrooms MUCH stronger.





I mean you’re adding maoi to at least 4 tryptamines. It would intensify synthetic Psilo or other tryptamines also

I don’t know of any tryptamine that isn’t strongly boosted by an Maoi. Plus, for what it’s worth mushrooms contain tiny traces of maois already


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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InvisibleHolybullshit
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Registered: 01/06/19
Posts: 1,551
Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Fractal420]
    #27068405 - 12/02/20 02:52 PM (3 years, 1 month ago)

That's pretty much my point, it was a rhetorical why, but generally people believe that psilo is wholly responsible for the affects of mushrooms. And because of this this other constituents have gotten very little attention.

If you were to add an MAOI to synthetic psilo I don't think you'd see anywhere near the type of potentiation you see when adding them to mushrooms...because my hypothesis is that compounds like norpsilocin, which are mostly inactive without MAOI(and I think varying levels of carbolines found in different strains/species of magic mushrooms may by allowing the entourage effect to come through) are coming to the forefront, not just potentiation of psilocin.

Like smoked DMT vs oral DMT+MAOI...the experiences aren't wholly different, yes depending on dose there can be different intensity levels but the biggest difference is duration. But if you add an MAOI to mushrooms its almost like a totally different drug, after all norpsilocin has an IA not seen with most commonly used DMT analogs.


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OfflineWhoManBeing
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Registered: 09/01/13
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Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Holybullshit]
    #27068907 - 12/02/20 07:52 PM (3 years, 1 month ago)

:smile:


--------------------
Hip, hip... WhoRAy!!!

Eye was thinking the other day...  ahh, thinking never done me no good.



Edited by WhoManBeing (12/03/20 04:32 PM)


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InvisibleBarnaby
Interesting lifetime
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Registered: 12/13/17
Posts: 9,136
Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Study The CNS]
    #27069140 - 12/02/20 11:36 PM (3 years, 1 month ago)

"Magic"?  So tired of the phrase magic mushrooms.  It is not a Blaine show or a mystery that science cannot solve.  But keep locking people up for it in some places. 

Been researching mycology and those people with degrees in it are amazing.  How it all works.  I eat culinary ones quite a bit and feel great.  When "magic" is brought up they just give a knowing smirk because they are actually educated.

It is amazing what mushrooms can do in life in so many ways with the ecosystem and also spiritually.  And for your body and mind.  Tired of it being illegal to cultivate it.  Manufacturing a controlled substance in some states like mine in Utah.  What a joke.

To eat though Shitake is my favorite.  Bought baby bellas today and soak some in terryaki sauce in rice dishes.  Tired of this heavy handed fuck your life over laws about growing what I really want and can't buy at a supermarket.  That would be great if one could.  Would change the world.


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InvisibleHolybullshit
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Registered: 01/06/19
Posts: 1,551
Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Barnaby]
    #27069333 - 12/03/20 05:49 AM (3 years, 1 month ago)

Are you sure they aren't magic? Fuck I gotta get that cow back before my mom finds out.


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InvisibleHolybullshit
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Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: WhoManBeing]
    #27069338 - 12/03/20 05:57 AM (3 years, 1 month ago)

Being against science because scientists make a living off it, that's a new one to me. Try to imagine a world where science is a hobby, only done for free after they put in their 40 hours elsewhere, it wouldn't be pretty.

You say it's none of your concern, but like it or not this is how progress happens, this is how nature becomes medicine. Yeah, it's slow as shit and this is one tiny brick and very large wall, and maybe it doesn't affect you personally, but if you've got any empathy in you then you should at least be cognizant of how many people could benefit from having these compounds being made available to them as medicine.

Then again, maybe you are a raving anti-vaxxer who has sworn off western medicine and think things like antibiotics and modern psychiatry are the devil incarnate.


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Invisibledurian_2008
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Registered: 04/02/08
Posts: 16,685
Loc: Raccoon City
Re: “Our researchers will isolate and study all of the potentially ‘magic’ molecules in mushrooms.” [Re: Holybullshit]
    #27071805 - 12/04/20 12:47 PM (3 years, 1 month ago)

I like the archaic version of psychedelics-use, which accomplishes a measurable result, and the archaic version of science, in which it is a parlor trick.


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