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OfflineYthanA
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Psilocybin & migraine: First of its kind trial reports promising results
    #27054296 - 11/23/20 05:16 PM (3 years, 2 months ago)

Psilocybin & migraine: First of its kind trial reports promising results
newatlas.com

A first-of-its-kind exploratory study, led by researchers from Yale School of Medicine, has found a single dose of the psychedelic psilocybin can reduce migraine frequency by 50 percent for a least two weeks. The preliminary trial was small, with follow-up work necessary to validate the results, but the promising findings suggest great potential for psychedelics to treat migraines and cluster headaches.

Back in the 1960s, during the height of the first wave of psychedelic science, one of the more compelling research avenues was the potential for drugs such as LSD and psilocybin to treat headaches. Initial studies at the time seemed to suggest psychedelic drugs that activate 5-hydroxytryptamine 2A (5-HT2A) receptors could significantly reduce headache burden in chronic migraine sufferers.

Of course, all this research froze by the early 1970s as psychedelic drugs were criminalized and rendered taboo. It wasn’t really until the early years of the 21st century that the research restarted, and most modern psychedelic research has primarily focused on the drugs as adjuncts to psychotherapy, targeting conditions such as depression, addiction and PTSD.

Although official psychedelic investigations were in a state of deep freeze, out in the real world people continued to experiment with these drugs, self-treating for a number of conditions. Several surveys of these real-world applications revealed an abundance of cluster headache and migraine patients experimenting with LSD and psilocybin.

A new study, published in the journal Neurotherapeutics, is offering the first double-blind, placebo-controlled, cross-over study on the effects of a moderate psilocybin dose on migraine frequency and severity. The research is only preliminary and small but its results are deeply encouraging.

Ten migraine sufferers were recruited for the trial. Each subject completed two sessions, one with a placebo and one with a moderate psilocybin dose. Headache diaries were used to track headache frequency and severity in the two weeks leading up to, and following, each experimental session.

“Compared to placebo, a single administration of psilocybin reduced migraine frequency by about half over the two weeks measured,” explains corresponding author on the new study Emmanuelle Schindler, in an email to New Atlas. ”In addition, when migraine attacks did occur in those two weeks, pain intensity and functional impairment during attacks were reduced by approximately 30 percent each.”

Perhaps the most intriguing finding from this small study was the lack of any correlation between the subjective strength of the psychedelic experience and the therapeutic effect. Prior trials using psilocybin to treat depression or addiction have suggested the overwhelming magnitude of a psychedelic experience seems to be fundamentally entwined with its therapeutic efficacy. So essentially, the more powerful the experience the better the result.

But unexpectedly, this migraine/psilocybin trial did not detect that association. In fact, those subjects reporting the highest scores on a self-reported altered state of consciousness scale showed some of the smaller reductions in migraine burden.

What this intriguingly suggests is that, in the case of psilocybin for migraine, it may be possible to separate out the drug's psychotropic effects from its therapeutic effects. This could be achieved either by exploring microdoses and sub-hallucinogenic doses, or even homing in on the mechanism by which the drug is helping prevent migraines and finding a new way to pharmacologically target it.

“This is definitely a finding we’re interested in exploring further,” says Schindler. “If these outcomes are confirmed to be independent, it suggests that the migraine-suppressing effects do not involve the same systems that cause the acute changes in sensation and perception. Psilocybin has some chemical and pharmacological similarities to existing migraine medications that are not psychedelic, so we plan to investigate its therapeutic effect in this context.”

It is important to understand the limitations of these new findings. This is a small exploratory study, designed to uncover potential signals that are worthy of more robust investigation. The two-week follow up, for example, offers no indication as to the long-term efficacy of this kind of therapy. This is something Schindler suggests will be closely studied in future research.

Moving forward, Schindler is cautious not to overstate her team’s findings but she does say the results are exciting. Not only does this research offer signals psychedelic compounds could meaningfully help those suffering from debilitating migraines, but the study offers novel insights into the still-unexplained physiological causes of chronic headache disorders.

Lots of questions still need to be resolved before any kind of clinical treatment can come from this research but Schindler and colleagues are already working on the next steps, with longer follow-up periods and greater focus on different dose effects.

“I have a new migraine study starting soon and I’m also currently studying post-concussion headache, which often resembles migraine,” adds Schindler. “I’m not aware of any other groups investigating psilocybin or related compounds in migraine, though cluster headache is currently being studied, not only by my group, but also Swiss and Danish researchers.”

The new study was published in the journal Neurotherapeutics.


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Offlinepolaritymind
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: Ythan] * 1
    #27055151 - 11/24/20 09:15 AM (3 years, 2 months ago)

Yaaas what a year for drug science and legislature! I wonder what dose they used.
And how many patients.
But very nice that its such a well know uni as yale! Ivy league or whatever they call it right, whatever that means.


--------------------
"to affirm life is to also affirm death"
-Albert hofmann


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OfflineVP123
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: polaritymind]
    #27055310 - 11/24/20 10:39 AM (3 years, 2 months ago)

Quote:

polaritymind said:
Yaaas what a year for drug science and legislature! I wonder what dose they used.
And how many patients.
But very nice that its such a well know uni as yale! Ivy league or whatever they call it right, whatever that means.




The abstract of the paper is at https://link.springer.com/article/10.1007/s13311-020-00962-y

In the abstract it says 0.143 mg/Kg, which for a 70 Kg adult would translate in 10 mg. This seems like a large dose, at least not microdosing.


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OfflineFractal420
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: VP123]
    #27055503 - 11/24/20 01:04 PM (3 years, 2 months ago)

10mg is actually fairly small but enough for maybe level 1-2 if you don’t use them a lot

20- 25mg is where it gets intense And beyond like 12mg the response curve gets Steep

Psilocin more so than Psilocybin but for both of them, I’d imagine 10mg wouldn’t be Too different (in potency)

Or even vs 10mg 4aco


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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Offlinesuperreggie
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: Fractal420]
    #27056045 - 11/24/20 07:07 PM (3 years, 2 months ago)

This is just astounding. The fact that mushrooms is being found to have all these positive effects, and it's taken this long to figure this out?

My wife was having some crazy hormonal stuff happening, and some skin rashes and stuff. She went into the doctor. They offered her birth control pills or anti-depressants. It's just insane.

The system is broke.


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InvisibleAchuma
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: superreggie]
    #27056054 - 11/24/20 07:11 PM (3 years, 2 months ago)

From reading about people having migraine relief from psilocybin, LSD, and bromo-LSD, I decided to give it a go while I was feeling the onset of a hemiplegic migraine using psilocin tartrate that I extracted from mushrooms.  I dosed about 3-5mg, which is enough to make me feel a little psilly and get a mild body buzz.  I got zero psychedelic effect, but completely aborted the migraine attack.  I only had to lay down for about 20 minutes and then suddenly just felt perfectly normal.  Ever since then, I've used small doses, up to around 7mg, to abort migraine attacks and it works every time.  Glad to see studies backing this up.  Maybe this is the future of migraine treatments!


--------------------
Achuma's Psilocybe Extraction Pictorial


Pictured: crystalline extract derived from Psilocybe Cubensis.  See link for detailed instructions, as well as a lengthy discussion on the properties of light.


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OfflineFractal420
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Re: Psilocybin & migraine: First of its kind trial reports promising results [Re: Achuma]
    #27100279 - 12/21/20 04:32 AM (3 years, 1 month ago)

I can tell you that mushrooms are Amazing for even crippling migraines. My own research

To be more accurate I think what I am dealing with are Tension headaches, occasionally becoming migraines, and the very occasional cluster headache (or I assume, because I literally am in so much pain I can’t lay down, I have to keep walking around, I dunno why but it’s worse laying down)

But as we all know from clusterbusters, Psilo and L help with this a whole lot. And with this terrible (hard to even call it a headache) feeling I drank my Psilo tea and bam just relief almost immediately. I used a bit more than a microdose, something like 0.6g. Wasn’t trying to trip in pain

100x better than my migraine meds and I have several, some even are triptans which aren’t too different structurally from a tryptamine. However the triptans usually will help me with the migraine but then in a day or two itlll come back with fury, pretty much every time so I don’t even take those anymore. Sometimes fioricet but trying to stop using it, all these meds cause rebound headaches

I’d rather just use mushrooms and L. PS when I take L normally just to trip it is worth mentioning that I do sometimes get mild headaches. Typically on the way up. Usually it’ll subside but honestly it’s common enough that I would sometimes take L with an Advil


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



Edited by Fractal420 (12/21/20 04:43 AM)


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