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Offlinetregar
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New research: Morning glory contains 5 stimulating LSD-like drugs & receptorome binding data for LSH compared to LSD (post #4) * 2
    #27039370 - 11/14/20 07:13 PM (3 years, 3 months ago)

New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water.

It just so happens that the ancient Aztec and Mayan also added the fresh or dried pulverized morning glory seeds to a drink containing alcohol, they learned this would extract all the stimulating actives from the seeds:

Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally were added by the Aztec and Mayan to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."

New research from the 1975 and 2016 morning glory studies is shown in links and pics. 5 LSD-like drugs have been identified & tested on animals from the morning glory seeds (4 soluble only in alcohol & 1 which survives only in acidic medium like wine) that are just as stimulating as LSD, with one being more stimulating than LSD.

(1) Extraction & Identification of Clavine and Lysergic acid alkaloids from morning glories, Weldon L. Witters: 1975:
https://kb.osu.edu/bitstream/handle/1811/22310/V075N4_198.pdf;jsessionid=DF8F4FB54A2D36461CBC73314990F589?sequence=1
hxxps://kb.osu.edu/bitstream/handle/1811/22310/V075N4_198.pdf;jsessionid=DF8F4FB54A2D36461CBC73314990F589?sequence=1

(2) Identification and determination of ergot alkaloids in Morning Glory cultivars, Nowak, Wozniakiewicz, Klepacki, Sowa & Koscielniak, 2016:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830885/
hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830885/

The merck index shows that (1) elymoclavine, (2) agroclavine, (3) chanoclavine & (4) penniclavine are only soluble in alcohol (sparingly soluble in water). (5) Lysergic acid hydroxyethylamide (LSH) in the seeds was shown in the 2016 Polish morning glory study to only survive outside the seeds in an acidic environment (example: such as cold sherry wine which is already at ph=4). LSH decomposes in neutral water (plain water), when heated, or in alkaline environments.

Cold sherry cooking wine is recommended as the extraction solution since it is already at ph=4 and is 18% alcohol, and is also very cheap ($5 per bottle). It can be found in the wine isle of any grocery store, and is often on sale. A $9 wine preserver canister can be bought at Amazon which contains a gas mixture of argon, carbon dioxide & other inert gases which can be sprayed into an open bottle of sherry wine before sealing cork to preserve the wine indefinitely, otherwise the acetaldehyde in the wine converts to acetic acid over time, giving the wine a vinegar taste. The wine preserver contains enough gas to last for years of sealing many bottles.

It's a good idea to extract by hammering the (example: 400 to 500) "direct from grower" or "home-grown" seeds in-between a paper plate, then grind the resulting matter in a coffee grinder, then add the mush to a few shots (1 shot = 30ml) of cold sherry wine (already at ph=4) and let it sit in the fridge for 3 hours with occasional swirling, then filter solution thru a cotton ball stuffed into a funnel (this gets all the seed debris out but leaves the actives in solution), and consume the cold sherry wine which contains the actives. This is the method I use and has resulted in mind-blowing powerful visual trips, will post trip reports in part 2.

Not only does sherry wine extract the 5 LSD-like stimulating active drugs from the seeds (see below) without decomposition, but it also cuts down immensely on the amount of "snot" extracted from the seeds, which is quite high when a plain acidified cold water extraction (to preserve the LSH) is used, as alcohol will not extract the "stringy snot like material" from the seeds. 
------------------------------------------------
1) elymoclavine = approx 17% of heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected with elymoclavine, that they were stimulated MORE than when they were given LSD.

2) agroclavine = approx 25% of heavenly blue mg = 1958 paper from Yui Takeo showed than when animals were injected with agroclavine, that they were stimulated just as much as when they were give LSD.

3) chanoclavine = approx 7% of heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected wth chanoclavine, that they were stimulated just as much as when given LSD.

4) penniclavine = approx 25% plus of the heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected with penniclavine, that they were stimulated just as much as when given LSD.

5) D-Lysergic acid hydroxyethylamide (LSH) = approx 25% plus of the heavenly blue mg. Over time this converts to LSA (Lysergic acid amide). So the seeds may contain a makeup of 1/2 LSH to 1/2 LSA a long while later, like retail rack seeds as the LSH decomposes over time.

6) Ergometrine = approx 5% of the heavenly blue mg.

1.71 LSH detected in seeds direct from growers, only 0.54% LSH detected in seeds off retail racks (see 2016 Polish morning glory study). Best to freeze seeds fresh off vine or direct from growers to preserve their natural high LSH potency, as the longer they sit at room temp or in the heat after being picked (many months without freezing) the faster the LSH (very active at 1.5mg) decomposes to the minimally to non-active LSA.

From the 1958 paper:
"All members of the excitor group produced in all test animals a syndrome of central sympathetic excitation and elicited a stimulation of spontaneous activity. In this group, elymoclavine, was the most potent stimulant and next come agroclavine, triseclavine, penniclavine, and LSD which are almost equipotent, as judged by the degree of symptoms exhibited in the same dose. The arousal effect of elymoclavine or agroclavine on reserpine-sedation was superior to that of LSD."

Animal experiments have shown that elymoclavine, lysergol, LSD and several other ergot alkaloids such as agroclavine, triseclavine, penniclavine, lysergine and lysergene have excitory effects on the central nervous system (Note 1: Yui & Takeo, 1958) as well as lysergic acid hydroxyethylamide (LSH) which also excites the central nervous system in animals (Note 2: Glasser, 1961).

The effects of agroclavine are similar to those of elymoclavine and LSD on rabbits (Yui & Takeo, 1958), indicating that the effect of agroclavine may well be psychoactive in humans as well. It also seems likely that agroclavine, triseclavine, penniclavine, lysergine and lysergene and lysergic acid hydroxyethylamide (LSH) will be psychoactive in humans.

Agroclavine & Penniclavine (found in high amounts in the morning glory seeds & in claviceps paspali infected wild grass Paspalum distichum L, with the labile LSH a close second in both of them) binds to 5-ht1a, 5-ht2a, 5-ht6, 5-ht7, adrenal A2A, A2C, A2D, and most of the dopamine receptors. See "Agroclavine & Penniclavine radioligand (receptorome) data, Planta Med. 1996 Oct; 62(5): 387-92."

LSD binding data is shown below (compare to agroclavine/penniclavine above):

LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty, newness)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)

We don't have radioligand binding data for LSH (lysergic acid hydroxyethylamide in the seeds), we only know it is similar to LAE-32 in TIHKAL, in which human experiments were done, at 1.5mg it was stimulating & "LSD like".

It was Gröger who first discovered LSH in the seeds, published in his 1963 paper "Über das Vorkommen von Ergolinderivaten in Ipomoea-Arten". Later also Hofmann then extracted it from the seeds. It probably was in 1967, as Heim wrote in his work from August 1967 that Hofmann said he recently extracted it from the seeds (personal communication, as they knew each other very well).

LSD----------------------------------------CH2CH3-----CH2CH3.....chemical formula (C20 H25 N3 0)
LAE-32-----------------------------------------H------CH2CH3.....chemical formula (C18 H21 N3 0)
d-lysergic acid hydroxyethylamide-----------H---------CHOHCH3....chemical formula (C18 H21 N3 02)
Penniclavine-----------------------------------------------------chemical formula (C16 H18 N2 O2)

Glasser in 1961 noticed animals also became stimulated when injected with LSH. Dr. Glasser said some of the mice even stood on their hine legs and pressed on the noses of the mice in front of them, very peculiar.

Animal tests all point to LSH being an active psychedelic and it is indeed the closest thing to LSD found in nature, far closer than d-ergine. Owsley claims Hoffman himself told him that LAOH is very LSD-like.

Notes:

(1) The above experiments with mice, rabbits, cats and dogs who were injected with elymoclavine, agroclavine, chanoclavine alkaloids from morning glory can be found in "Neuropharmacological studies on a new series of ergot alkaloids" "Elymoclavine as a potent analeptic on reserpine-sedation" by tohoru Yui and Yuji Takeo, Hyg 911/LSD 494, Jap. J. Pharmacol. 7, 157 (1958). Jap. J. Pharmacol 7, 157-161 (1958).

(2) LSH experiments on animals: A. Glasser, Nature 189, 313 (1961)

(3) No high levels of stimulating LSH, agroclavine, elymoclavine, chanoclavine, penniclavine found in HBWR seeds, only in morning glory seeds. A 2014 forensics paper from Paulke found no LSH in HBWR seeds, but only found LSA & iso-LSA (83-84%) & ergometrine (10-17%) & rest minimal: lysergol, elymoclavine & chanoclavine. We know that MG has centuries of Shamanic use, while HBWR has no history of Shamanic use. HBWR only has history of medicinal use.

Sandgrease: "HBWR has more of a sedative effect compared to MG."

Nogal: "HBWR is more body related while MG seeds have effects more similar to LSD."

(4) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."

(5) Aum_Shanti, 2019, "In fresher seeds there's mainly LSH (in relation to LSA). Only in old seeds, the LSA is dominant. This is because the fungi on the plant can only biosynthesize LSH (not LSA), and LSA is then a decomposition product of LSH over time. The fungi on the vines biosynthesize:

From Tryptophan-->chanoclavine-->agroclavine-->elymoclavine-->lysergic acid-->ergometrine-->LSH, which then decomposes over time into LSA."

(6) Psychotomimetics of the Convolvulaceae pg 93: "This particular plant seems to have been more important to the Aztecs in divinity then Peyotl or Teonanacatl, two of their other classical sacred plants."

(7) Jonathan Ott "Pharmacotheon": "Ololiuhqui was far more prominent as an entheogen here in Mesoamerica than those mushrooms; the mushrooms are mentioned only here and there by a few competent chroniclers; yet almost an entire book was devoted to denouncing mainly the ololiuhqui idolatry. The annals of the Inquisition contain many times more autos de fe for ololiuhqui than for mushrooms."

(8) 2016 Polish morning glory study which finds 3x higher amounts of LSH in fresher MG seeds direct from grower/producer vs retail: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830885/ LSA is a decomposition product of LSH over time (see attached pics from study).

2016 Polish MG study: "Alkaloids abundance in all 3 HB cultivars is comparable, with most significant difference for LSH (Lysergic acid hydroxyethylamide), which varies from 0.54 to 1.71 compound to IS ratio. As has been demonstrated in this study, LSH is a labile compound, and therefore the variances in its concentration may be due to different age and storage conditions of the seeds rather than difference in plant metabolism. Indeed, seeds IT-HB2, which express highest concentration of LSH, were bought directly from the producer, whereas seeds IP-HB1 were purchased in retail stores."

(9) Researchers showed in 1961 that Claviceps paspali produces high amounts of LSH in culture: "Production of a new lysergic acid derivative (LSH or Lysergic acid hydroxyethylamide) by a strain of Claviceps paspali, Stevens & Hall". Likely entheogen used to serve hundreds of initiates at Eleusis in ancient Greece: see pic of Eleusian Mysteries & center for Eleusis Telesterion (initiation Hall for initiates...ALL men, women & even slave were invited) in ancient Greece, and pic of people who would attend in ancient Greece.

Chemist Peter Webster wrote that fresh Greek claviceps paspali infected paspalum grass which grows adjacent to Eleusis in the famous Rarian Plane contains the exact same alkaloids as found in the fresh Aztec morning glory. Albert Hofmann wrote that Claviceps paspali due to it's similar makeup to the Mexican morning glory could also have been the likely entheogen used at Eleusis to serve hundreds of people.

(10) Krystle Cole from the book "Lysergic":
Quote:

"Isn't Ergot what Socrates used to take at Eleusis?" I thought it was kind of cool to be taking something that the founders of our democracy used to take, but that our current democracy has made illegal.
   
LSD chemist Todd Skinner replied "Yes". Todd had prepared 6 jugs of ergot wine and stored them for many years.
   
Krystle Cole's "ergot wine" experience (several pages long) in the book "Lysergic", reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head.




(11) sample morning glory wine trip report from Erowid: Morning Glory & Alcohol by Psychopsilocybin:
https://erowid.org/experiences/exp.php?ID=95057
hxxps://erowid.org/experiences/exp.php?ID=95057





















Edited by tregar (11/20/20 07:22 AM)


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InvisibleAmanita86
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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27040085 - 11/15/20 08:13 AM (3 years, 3 months ago)

LC needs to pop in, I think he tried the sherry extraction method and it was too funky to drink.  Also I wonder what would be an equivalent non alcohol substitute for the sherry?


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Offlinetregar
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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: Amanita86]
    #27041035 - 11/15/20 06:11 PM (3 years, 2 months ago)

The clavine alkaloids & LSH in morning glory are just as stimulating as LSD according to animal tests, and should have psychoactive effects in humans accordingly the scientists speculated. No human trials have been performed with any of these clavine alkaloids. 2 of these alkaloids (elymoclavine & agroclavine) have been found to be even MORE stimulating than LSD.

1) elymoclavine = approx 17% of heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected with elymoclavine, that they were stimulated MORE than when they were given LSD.

2) agroclavine = approx 25% of heavenly blue mg = 1958 paper from Yui Takeo showed than when animals were injected with agroclavine, that they were stimulated MORE than when they were given LSD.

3) chanoclavine = approx 7% of heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected wth chanoclavine, that they were stimulated just as much as when given LSD.

4) penniclavine = approx 25% plus of the heavenly blue mg = 1958 paper from Yui Takeo showed that when animals were injected with penniclavine, that they were stimulated just as much as when given LSD.

5) D-Lysergic acid hydroxyethylamide (LSH) = approx 25% plus of the heavenly blue mg. Over time LSH decomposes to LSA unless the seeds are kept temp controlled in freezer/fridge. Glasser in 1961 noticed animals became stimulated when injected with LSH. Dr. Glasser said some of the mice even stood on their hine legs and pressed on the noses of the mice in front of them, very peculiar.

LSH decomposes in neutral water solutions, and quickly in alkaline solutions, and also if heated, but it is quite stable in acidic environments (example: cold sherry wine which is already at ph=4).

LSD----------------------------------------CH2CH3-----CH2CH3.....chemical formula (C20 H25 N3 0)
LAE-32-----------------------------------------H------CH2CH3.....chemical formula (C18 H21 N3 0)
d-lysergic acid hydroxyethylamide-----------H---------CHOHCH3....chemical formula (C18 H21 N3 02)

Animal tests all point to LSH being an active psychedelic and it is indeed the closest thing to LSD found in nature, far closer than d-ergine. Owsley claims Hoffman himself told him that LAOH is very LSD-like.

We don't have radioligand binding data for LSH (lysergic acid hydroxyethylamide in the seeds), we only know it is similar to LAE-32 in TIHKAL, in which human experiments were done, at 1.5mg it was stimulating & "LSD like".

1.71 LSH detected in seeds direct from growers, only 0.54% LSH detected in seeds off retail racks (see 2016 Polish morning glory study). Best to freeze seeds fresh off vine or direct from growers to preserve their natural high LSH potency indefinitely (prevent decomposition of the labile or unstable LSH to LSA).

6) Ergometrine = approx 5% of the heavenly blue mg.

Note: Agroclavine & Penniclavine (found in high amounts in the morning glory seeds & in claviceps paspali infected wild grass Paspalum distichum L, with the labile LSH a close second in both of them) binds to 5-ht1a (5-ht1a = 80% of brain 5-hta), 5-ht2a, 5-ht6, 5-ht7, adrenal A2A, A2C, A2D, and most of the dopamine receptors. These are many of the same receptors LSD binds to. See "Agroclavine & Penniclavine radioligand (receptorome) data, Planta Med. 1996 Oct; 62(5): 387-92."
------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------
additional notes:

(12) From "The Alkaloids: Chemistry and Physiology" page 32 "Agroclavine is readily soluble in organic acids, agroclavine is stable to acids", wine stands as one of the sources of organic acids. Page 33 "Elymoclavine is only somewhat soluble in water". Peter Webster states in "Sacred Mushrooms of the Goddess, the Secrets of Eleusis" in the morning glory chapter that Chanoclavine is soluble in alcohol.

(13) Sherry wine is also high in acetaldehyde (10mg per 30ml or shot glass). This may serve as an advantage...why is this possibly important? See: https://www.ncbi.nlm...icles/PMC49935/ or hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect.

Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed before (page 8439) and after (page 8441).

The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need water acidified to around ph=4 and around a 0.1% acetaldehyde solution, and around a 3 hour soak time for 100% conversion.

Sherry wine fits the bill perfectly with it's high acetaldehyde content, and low ph, which is already at ph=4, just like the study calls for. The researchers stated "the lower the PH, the faster the reaction (indole adduct formation at the NH group)." It contains the perfect amount of acetaldehyde as well, in an alcoholic medium no less.

Theoretically, soaking the seed solution in sherry wine in the fridge for several hours (around 3 hours with occasional swirling once per hour) will also create 1-acetaldehyde LSH from LSH in the seeds, 1-acetaldehyde LSA from LSA in the seeds, and 1-acetaldehyde penniclavine from the seeds. Acetaldehyde boils off at room temp, so best to leave the sherry wine/seed solution in the fridge at all times.

The acetaldehyde in sherry wine will according to the 1992 indole adducts study adduct onto the bottom NH group on the indole of LSH, LSA and penniclavine forming something more akin to looking like ALD-52, (at least bottom indole wise).

The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state.

It is quite possible that 1-acetaldehyde LSH and 1-acetaldehyde penniclavine produce stronger visual trips with zero anxiety. This has been my experience with the seed solution and also my experience when converting 3 x 100ug blotters of LSD to 1-acetaldehyde LSD (have done this over 10 times already spaced two weeks apart), also confirmed recently by Namaste at the Shroomery to work for him as well, now his preferred method of consuming LSD as well. Simply soak 3 LSD blotters in 1/2 shot sherry wine for 3 hours in fridge in a shot glass with swirling once per hour, then consume after 3 hours. Amazing visually strong trip, fantastic headspace with zero anxiety, and way more colorful than regular LSD: with out of this world neon colors -- very prominent with 1-acetaldehyde LSD or with ALD-52.

LSA (C16 H17 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSA
LSH (C18 H21 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSH
LSD (C20 H25 N3 O) + acetal (C2 H3 O) at bottom indole NH group = 1-acetal LSD (C22 H27 N3 O2) or ALD-52
LSD (C20 H25 N3 O) + acetaldehyde (C2 H4 0) at bottom indole NH group = 1-acetaldehyde LSD

Once you know your morning glory seeds are potent, you could also throw in a blotter or more of LSD into the sherry wine/morning glory seed solution soaking in the fridge for 3 hours, not only will this convert the LSD to the more colorful and anxiety free 1-acetaldehyde LSD but it can result in a trip way beyond normal LSD. Example below:

Dragonrider: "I have also experimented with morning glory seeds a lot. A couple of times the seeds came very close to LSD, but on other occasions they where nothing like LSD at all. But there is more. I have combined morning glory seeds with other psychedelics. And on some occasions they dulled the effects of them. But on a few occasions, they boosted the effects of psychedelics enormously and very few seeds where actually needed to create this effect.

Once a mere 30 seeds were enough to cause an overwhelming OBE on LSD, paired with the most insane visuals and a defragmentation of the mind like i have never experienced ever since. I am convinced that there is a substance in fresh morning glories, and maybe it is LSH or penniclavine, that modulates receptors that are being activated by psychedelics in such a way that it can boost the effects of other psychedelics."

Note (14) This is the paper that shows the alkaloid content of HBWR is vastly different from the alkaloid content of morning glory: Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs—ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62–71.


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Offlinetregar
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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar] * 1
    #27041039 - 11/15/20 06:11 PM (3 years, 2 months ago)

P.S. I also have met virtually no one else who has tried LSD in 1/2 shot of sherry wine soak for 3 hours in the fridge with stirring once per hour, then consuming besides myself and Namaste at the Shroomery. We both have taken regular LSD hundreds of times over 25 years, and both of us can tell a vastly different experience with the two. Most of the people I have run across can not source or do not have LSD. No one else seems to have tried this but us. Everyone seems to have access to 1p-LSD or something else, but few with real LSD.

Important new 2020 receptorome binding data just came out this year that is available for LSH or Lysergic acid hydroxyethylamide found in morning glory seeds! See below:

http://www.t3db.ca/toxins/T3D3687
hxxp://www.t3db.ca/toxins/T3D3687

5-ht2a
5-ht2b
5-ht2c
adrenal A1A
adrenal A1B
adrenal A1D
adrenal A2A
adrenal A2B
adrenal A2C

This is important as it shows LSH binds to just about all the adrenal receptors (more than any other entheogen so far), while LSD only binds to one of the adrenal receptors: A2A in comparison (as far as adrenal receptors are concerned). See chart below: DMT, mescaline & psilocin all bind to many of the adrenal receptors. The adrenal receptors are implicated in the perception of aesthetics, beauty, euphoria.

This may explain why the semi-synthetic man-made LSD has been perceived by many to have less aesthetic appreciation than the natural entheogens: LSH, mescaline, Ayahuasca (harmine + tetrahydroharmine + harmaline) with Caapi, dmt, psilocin. It's man-made quality may be more perceptable due to it's lack of significant adrenal agonism, which is prominent with the natural entheogens.

Example: Mescaline has a rating of 4.00 at adrenal A2C (see below), 4.00 = max = off the charts, and anyone who has ever consumed cactus knows the appreciation for beauty is "thru the roof" or "over the top".

Agroclavine and penniclavine in the seeds (metabolite of agroclavine) bind to 5-ht1a, 5-ht2a, 5-ht6, 5-ht7, adrenal A2A, A2C, A2D, and most of the dopamine receptors in comparison. See "Agroclavine & Penniclavine radioligand (receptorome) data, Planta Med. 1996 Oct; 62(5): 387-92."

in comparison to LSD:

LSD binding data is shown below (compare to LSH/agroclavine/penniclavine above):

Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max (off the charts), 0.00=min

LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty, newness)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)

In conclusion, it is apparent that there is significant teamwork taking place in the seeds between the alkaloids, with argoclavine/penniclavine/other clavines supplying the all important 5-ht1a agonism (which causes inhibitory shutdown of over 80% of brain 5-ht = the filtering & gate/door day to day survival serotonin filters built up since childhood) and agonism targeting of 5-ht2a, 5-ht6, 5-ht7, A2A, A2C, A2D, and the dopamine receptors...

...while LSH targets the 5-ht2a, 5-ht2b, 5-ht2c & SIX of the adrenal receptors, targeting 5 more adrenal receptors than even LSD hits. Wow, this is amazing! Who ever thought LSH was capable of targeting SIX ADRENAL RECEPTORS! Outstanding Nature.


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27042796 - 11/16/20 07:35 PM (3 years, 2 months ago)

Amanita86 said:
Quote:

LC needs to pop in, I think he tried the sherry extraction method and it was too funky to drink.  Also I wonder what would be an equivalent non alcohol substitute for the sherry?



As far as non-alcoholic Amanita86, I have in the past also used a cold water extraction acidified to ph=4 using a tiny pinch of DL tartaric acid ($7 ebay ph meter required) as you don't want to go below ph=4.

https://www.shroomery.org/forums/showflat.php/Number/26838327

Several trip reports on page 1 from myself, Hermes & Nogal (all of us used acidified water) to preserve the LSH in the seeds as it decomposes to LSA in neutral water.


Edited by tregar (11/16/20 07:37 PM)


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27043070 - 11/16/20 10:07 PM (3 years, 2 months ago)

Not surprised. Have they resarched HBWR too? I've believed for years that those raw seeds (when extractions are not used and the quality is high) must surely contain all kinds of interesting and not fully understood alkaloids (with different varieties containing different alkaloids as well). The raw seed experience is mindblowing! Far more to them than LSA I think.


--------------------
"I'm every nightmare you ever had. I am your worst dreams come true. I am everything you ever were afraid of."

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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: wolf8312]
    #27043206 - 11/17/20 01:52 AM (3 years, 2 months ago)

Thanks wolf8312 for your comments!

As I have shown in this thread, claviceps paspali infected pasplum grass grows in the famous Rarian plane adjacent to Eleusis
in ancient Greece where the ceremonies were held for hundreds of initiates and contains the exact same psychedelic alkaloid profile
as the Mexican Aztec morning glory seeds. It could have been used directly in powdered form...simply powder the ergot infected grass,
soak in wine, filter thru cloth to get rid of debris, then drink the resulting wine which contains all 5 of the stimulating
LSD like drugs.

Anyone who is into ergot or morning glory seeds, I highly recommend the following book which just came out last month,
what an incredible read!

...contains info on ancient ERGOTIZED BEER uncovered for the 1st time! Tons of info on Eleusis, psychedelic ergot, etc.

This incredible new book presents the hard archeological evidence substantiating the LSD-like chemical presence
in the Eleusinian and Dionysian Mysteries, which carried on for thousands of years, reappearing in democratized
form as the Eucharist in the mystery cult of early Christianity before its suppression under the Roman Empire.

https://www.amazon.com/gp/product/1250207142?pf_rd_r=9Q0J9HD60AQ9RK40C7FV&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee

The book is officially a New York Times Best Seller, and the author has interviews available to view here:

    The Joe Rogan Experience:

    CNN: https://edition.cnn.com/videos/tv/2020/10/10/did-hallucinogens-play-role-in-origin-of-religion.cnn
    goop: https://goop.com/the-goop-podcast/the-secret-history-of-religion/
    NPR: https://www.kcrw.com/culture/shows/life-examined/ancient-greece-psychedelics-mental-health-therapy
    Andrew Sullivan (just released this Friday, November 13): https://andrewsullivan.substack.com/p/brian-muraresku-on-psychedelics-and

All media available here: https://www.brianmuraresku.com/media.


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar] * 1
    #27043528 - 11/17/20 09:28 AM (3 years, 2 months ago)

Even LSD chemist Todd Skinner has prepared ergot wine, see above from the book "Lysergic", as I have done myself using high doses of fresh off the vine morning glory seeds. I recently harvested lots from my two planters. I use 15 plus grams of dark hard black fresh seeds, there are 30 to 35 seeds per gram. I see open eye geometric patterns on surface of everything...with closed eyes I have seen colored vectors which spin 360 degrees while traveling from left to right across visual plane. The euphoria and enhancement of beauty is strong. This has resulted in incredible visual and euphoric trips.

I use around 3 to 4 oz of cold sherry wine to soak the 500 plus pulverized and ground seeds fresh off the vine (I grow them every spring) in a 1/2 pint tall jar which sits in fridge for some time with occasional swirling, then strain thru a cotton ball in a funnel to get out the seed debris, changing out the cotton when or if it clogs, and drink the resulting nutty tasting solution which contains the actives. Extraction using wine also cuts down on the "stringy slimy snot material" extracted from the seeds, which the alcohol does not dissolve. This stringy snot however is readily soluble in plain water. Wine is also at ph=4 which keep the active LSH from decomposing to the inactive and sedating LSA. LSH only survives in acidic medium (like wine for example).

Fresh off the vine seeds (as I learned way before the 2016 Polish mg study came out) contain high amounts of LSH, (freeze seeds to preserve their high LSH potency indefinitely) way more than what is found in seeds off retail racks. Seeds direct from growers are also very good, I have two jars full of seeds from different growers that I keep in freezer. Search *mazon or *bay and look for those with hundreds of five star reviews. *ee* *eed* with reviews at *mazon is one I know of, *irt's garden is another, but they are gone from auction bay now. I miss them. The *irt's garden on *mazon is not the real *irt's garden but a different distributor of different seeds, and you can tell from the recent mediocre reviews, even wrong seeds being sold. Also notice from the 1975 study (1st post graph) that pearly gate seeds were found to contain even higher amounts of alkaloids.


Edited by tregar (11/17/20 10:17 AM)


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27043775 - 11/17/20 12:12 PM (3 years, 2 months ago)

As someone who has used LSD many times already, I have never tried LSA. Is it worth it? I heard there was unbearable nausea


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: skOsH]
    #27046065 - 11/18/20 06:19 PM (3 years, 2 months ago)

skOsH said:
Quote:

As someone who has used LSD many times already, I have never tried LSA. Is it worth it? I heard there was unbearable nausea


No, there is zero nausea if you extract like I explain above, and it's not the LSA that is active, it's the LSH...the LSH converts to the inactive LSA however if you extract into neutral water instead of wine, beer, or acidified water (all are acidic).


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27046552 - 11/18/20 10:24 PM (3 years, 2 months ago)

Where did you get the information that LSA is inactive? Not saying your wrong, but everything I see on erowid says it's a psychedelic in it's own right.


--------------------
LOVE


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: skOsH]
    #27046713 - 11/19/20 02:48 AM (3 years, 2 months ago)

Quote:

skOsH said:
Is it worth it?



No, not once you've tried LSD.


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: nooneman]
    #27047735 - 11/19/20 05:31 PM (3 years, 2 months ago)

Thank you for taking the time to compile all this detailed information, tregar.

For some weird reason, there is still much obscurity regarding "LSA"-containing seeds even though they have been an entheogen for who knows how long. It's hard to believe that a vine like Ipomoea Tricolor that grows so fast hasn't gathered more interest in those looking for psychedelic healing.

I hope that, with time, both scientists and users figure out the most effective ways of administration and the chemical makeup of the seeds. The wine extraction method sounds practical; I'll definitely give it a go when (and if) I finally get my own plants and they produce seeds. I can't wait to move to a house to plant Ipomoea Tricolor everywhere. :evil:

That book looks interesting as well, I think you've found my next read.

Peace!


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: jomanda1990]
    #27048476 - 11/20/20 07:32 AM (3 years, 2 months ago)

Thanks Jomanda1990.

Jesusfish, LSA is a schedule 3 sedative, even Albert Hofmann tried it at high dose and became tired and only noticed the emptiness of the outside world, it's a decomposition product of LSH over time if the seeds are not kept frozen or in fridge (temp controlled). It has only minimal psychedelic effects, none worth noting.

Nooneman, I have to disagree, I've had fresh off the vine seeds trips that have rivaled LSD in transcendence & visuals & euphoria.

Jamie: "Yeah that LSH can be very visually powerful..the only time I got morning glories to work was when they were fresh..and they blew away LSD for me. I had real visions..I am thinking there was more LSH in them than LSA..all the other times I just got some euphoria and nausea."

Below: 2 planters which gave me recent early winter (super late fall) harvest of two Lots of potent fresh black hard morning glory seeds, preserving seeds in freezer to retain their high LSH &  penniclavine/agroclavine & other clavines potency indefinitely.



Edited by tregar (11/20/20 07:35 AM)


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27049447 - 11/20/20 07:19 PM (3 years, 2 months ago)

Interesting read now if I can only get my hands on some fresh seeds to try this. Unfortunately I have no where to grow them inside a damn hotel.


--------------------


....Synthesized love story or is it just a crazy dream....


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27051758 - 11/22/20 09:00 AM (3 years, 2 months ago)

Quote:

tregar said:
Below: 2 planters which gave me recent early winter (super late fall) harvest of two Lots of potent fresh black hard morning glory seeds, preserving seeds in freezer to retain their high LSH &  penniclavine/agroclavine & other clavines potency indefinitely.





So that's how you grow a climbing plant in a pot, huh. Sorry, I'm just too new to any type of gardening and wouldn't have come up with that type of support for the plant.
Harvesting the seeds sound like a super relaxing activity, too.


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: Amanita86]
    #27053153 - 11/22/20 10:02 PM (3 years, 2 months ago)

Cold brew coffee work as a non-alcoholic substitute for sherry during the LSD or LSH conversion.


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27053281 - 11/23/20 01:55 AM (3 years, 2 months ago)

I'd always heard Heavenly Blue was the most potent morning glory, but that's an interesting graph...  I only wish they had included Rivea corymbosa and HBWR in the study!


Also a wonderful note about alcohol being needed for a complete extraction, thank you.  It aligns with most all my best trips having used alcohol: a sherry extraction, a cold-brewed coffee and rum extraction, and mixing homemade cumin vodka tincture in during the CWE (The cuminaldehyde adduct is just as worthy as the acetaldehyde one.  Holy Zen.)



For those unfamiliar with this topic, here are some personal thoughts in review:


My understanding of this reaction in a nutshell:


"LSA" + the aldehyde + low PH (4) + cold agitation = an adduct with modified effect.

Alcohol may facilitate the reaction.


Quick adduct differentiation:

Acetaldehyde adduct
Great euphoria, classical psychedelic mentally.  Offers light visual effects such as haloes, tracers, increased brightness and color saturation.

The Acetaldehyde adduct gives me vasoconstriction, but no bronchial constriction. 


----------------

Cinnamaldehyde adduct:
Short duration, high energy, occasional OEV's:  a rapidly expanding white "bubble-ring" (like the kind dolphins make and play with) shoots out from a Persian rug towards me.

*The Cinnamaldehyde adduct gave me bronchial constriction, so keep a bronchodilator like THC handy.*

This is the only adduct that has given me actual OEV; and with half my usual dose at that!  While it is the most stimulating adduct I've tried, it's the least uplifting.

More on the Cinnamaldehyde adduct: https://www.shroomery.org/forums/showflat.php/Number/22081081#22081081


--------------

Cuminaldehyde adduct
Good mood; centered.  Fair energy.  Long duration.  Presents visual effects from soft "breathing" to "rubber objects" (or seeing things how a video camera does after the lens is splash and water goes into streams across the lens). 

Thinking is unclouded, but not on overdrive.  Felt holy.
While the cuminaldehyde adduct may be slightly less euphoric than the acetaldehyde one, it is still very nice!


Here's my post on Cuminaldehyde written during and after trying it, "hbwr cumin mix kicks ass"*:  https://www.shroomery.org/forums/showflat.php/Number/21168265#21168265


^
*In that thread Achuma mentions that he also favors the cumin adduct over cinnamon one, saying "I preferred the one light cumin/ergine experience over my several cinnamon/ergine experiences."



~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~


There are a couple other aldehydes that have produced pleasant adducts (German chamomile contains one that is next on my list to try after the trip reports I read), while many more aldehydes will react to form inactive or even unpleasant ones.


Edited by flickedbic (11/23/20 02:10 AM)


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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: flickedbic] * 1
    #27058587 - 11/26/20 11:23 AM (3 years, 2 months ago)

Thanks for comments flickedbic, I've read many of your past remarkable posts!

I may even just grow Pearly Gates next spring, as the 1975 study found 3x times the amount of alkaloids in them compared to heavenly blue.

Lest we not forget that Norman also had remarkable seed extracts using wine:

Norman said on September 2019:
Quote:

Years ago I stumbled across a simple method for dosing HBWR.
Grind the seeds and cover them with white wine, let sit in the fridge for a day or so, shaking occasionally, decant, filter and drink.
No nausea no aches no vasoconstriction.
I am now off alcohol completely so I’m thinking of an alternative method short of a full on extraction.
I’m convinced that something in the wine besides water and alcohol is what makes the trip so clean. I’ve tried twelve percent water alcohol mixes in the past and still had the nasty side effects and at the same time the trip is not as strong.
I’m thinking acetaldehyde and or tartaric acid may be involved or at least a good place to start.
Any thought on what chemically may be going on?







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Re: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble i... [Re: tregar]
    #27064017 - 11/30/20 05:56 AM (3 years, 2 months ago)

Claviceps purpurea vs claviceps paspali:

The problem with Ergonovine (another name for ergometrine/ergobasin):

Have read all of the "The Immortality Key, the Secret History of the Religion with no Name" this past weekend, and highly recommend it.

There are two main water soluble alkaloids in the poisonous claviceps purpurea ergot: ergonovine and lysergic acid amide (LSA). These can be separated from the non-water soluble alkaloids which are poisonous.

The author cites Wasson's request for Albert Hofmann to track down and analyze the ergot of wheat and barley, "both of which would have been plentiful on the Rarian plain so explicitly showcased in the Hymn to Demeter". These cereal grains commonly become infected with claviceps purpurea ergot, and only rarely infected with claviceps paspali. I am thankful that he states "the search for the kykeon goes on", noting that ergonvine is only one of many alkaloids found in ergot.

Hofmann's letter to Gordon Wasson on page 205 (one of the colored pics) contain's Hofmann's trip report (which he recovered from the Wasson collection) with several milligrams of ergonovine which is another name for ergometrine or ergobasin, all names for the same water soluble alkaloid.

Note that this alkaloid is only found in very small amounts in morning glory and claviceps paspali, but is one of the main water soluble alkaloids in the poisonous claviceps purpurea. At the bottom of the page, Carl Ruck's experiment with the compound was noted as resulting instead with "mixed results" as opposed to Hoffman's findings.

My concerns with ergonovine stem from the follow-up experiments with it performed below by several experimenters...it resulted in heavy somatic symptoms (moderate vasoconstriction and cramping) while the psychedelic quality was mild, and contained none of the euphoria common with LSD, mushrooms, cactus, Ayahuasca, morning glory, and quite possibly the Greek claviceps paspali infected paspalum grass.

The claviceps paspali infected paspalum distichum grass, which as found in the 1961 paper by Stevens and Hall, contains same rich alkaloid profile as the Mexican morning glory (high levels of LSH or lysergic acid hydroxyethylamide along with a handful of other simulating LSD like alkaloids) which as show in this thread all work together (teamwork) to hit the same brain receptorome profile that LSD hits, and beyond. Note LSD only hits 1 of the adrenal receptors, while LSH hits 6 of the adrenal receptors, see brand new 2020 LSH receptorome data on post #7.

C. paspali submerged cultures have ergine, isoergine and lysergic acid N-1-hydroxyethylamide or LSH (Arcamone et al., 1960) while sclerotia from Australia contain up to 0.005% alkaloids composed of ergine and ergonovine along with chanoclavine and two unidentified ergoline alkaloids (Groger et al., 1961). Elymoclavine (Kobel et al., 1964) and agroclavine (Brar et al., 1968) have also been recorded.

We also know now that LSA is a schedule 3 sedative and is a breakdown (decomposition) product of LSH over time, or when LSH is heated, or when LSH is extracted into plain (neutral) water. LSH only survives intact in acidic environments, like those of acidified water or wine for example.

3 experimenter's effects when ingesting pure ergonovine, another name for ergometrine (found in HBWR), June 1979 Journal of Psychedelic Drugs:
Quote:

In the January-June 1979 issue of the Journal of Psychedelic Drugs, Jeremy Bigwood, Jonathan Ott, Catherine Thompson and Patricia Neely report on their attempt to replicate Hofmann's finding in three experiments with ergonovine maleate, each time in one pastoral setting. They were following up Wasson and Ruck, who tried the same amount as Hofmann but "did not experience distinct entheogenic effects."

    With Thompson acting as a guide, three of them took 3mg. of ergonovine maleate, which appeared as a slightly phosphorescent bluish solution in water. Fifteen minutes later they felt like lying down and looking at the sky; then there were "very mild visual alterations, characterized by perception of an 'alive' quality in inanimate objects." Most of this effect passed within an hour; walking along the beach, they experienced mild leg cramps. Bigwood saw eidetic imagery before going to bed, and the three "slept easily...awakening refreshed in the morning."
   
    The three experimenters were "convinced that ergonovine was psychoactive, but only J.B. was persuaded the drug was entheogenic." They decided to try it again two weeks later in an increased dosage of 5 mg., but Neely took only 3.75mg. "Again, we experienced lassitude and leg cramps, more pronounced than in the earlier experiment." The psychic effects were more intense than previously, particularly eidetic imagery.

"Now it was clear to all of us that ergonovine was entheogenic...The entheogenic effects, however, were very mild, while the somatic effects were quite strong. We had none of the euphoria characteristic of LSD and Psilocybin experiences."
   
    To determine if higher consciousness alteration was possible, they tried larger oral doses of ergonovine maleate a week later. This time, Neely took a dose of 7.5mg and the others took 10mg:
   
    "One of us (J.O.) described "flashes in periphery, ringing in ears, inner restlessness" 40 minutes after ingestion, and later noted "mild hallucinosis, cramps in legs and felt the cramping in the legs as painful and debilitating. The psychic effects did not increase with the same magnitude as the somatic effects...For what seemed like hours, we lay on our backs atop a small pumphouse, watching fluffy cumulus clouds pass silently above us. The effects were still quite intense six hours after ingestion. One of us experienced abundant eidetic imagery, rapidly-changing, colorful geometric patterns, undulating, never still. We all had a slight hangover the following morning."



Albert Hofmann even stated that Claviceps Paspali ergot which infects paspalum grass commonly all around the Mediterranean basin contains the same rich alkaloid profile as the Mexican morning glory long ago, and could have likely been a source of the Kykeon.

Albert Hofmann (page 10) of "The Road to Eleusis" by Wasson, Hofmann & Ruck: "Chapter 2, a challenging question and my answer":hxxps://maps.org/images/pdf/books/eleusis.pdf
Quote:

There is a further finding that may prove to be of utmost importance in considering Wasson's question. The main constituents of the Mexican morning glory seeds are (a) lysergic acid amide (=ergine), and (b) lysergic acid hydroxyethylamide (LSH), and these are also the main alkaloids in ergot growing on the wild grass Paspalum distichum L. This grass grows commonly all around the Mediterranean basin and is often infected with Claviceps paspali. F. Arcamone et al.3 were the first to discover these alkaloids in ergot of P. distichum, in 1960.



Professor Carl Ruck even states on page 161 of his book "Sacred Mushrooms of the Goddess, Secrets of Eleusis" that claviceps paspali was found in the 1961 study I cite at bottom to contain not only LSA, but LSH.
----------------------------------------------
Note (1) Researchers showed in 1961 that Claviceps paspali produces high amounts of LSH in culture: "Production of a new lysergic acid derivative (LSH or Lysergic acid hydroxyethylamide) by a strain of Claviceps paspali, Stevens & Hall". One of the studies I read indicated they picked the infected ergot from paspalum distichum grass in the vicinity of Rome.

Note (2) 2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail, hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830885/ LSA is a decomposition product of LSH over time.
   
Quote:


seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio




It is possible fresh black seeds from vine could likely be near 5.00 LSH to 5.00 penniclavine ratio, vacuum pack and freeze the freshly picked seeds to maintain their high LSH potency indefinitely.


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