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OfflineLeningradCowboy
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New mutation of covid-19 in Denmark: The vaccines develobed may not work on this
    #27032373 - 11/10/20 09:59 PM (3 years, 3 months ago)

https://www.bbc.com/news/world-europe-54818615

New strain of covid-19 is passed to humans from minks in Denmark.

"Prime Minister Mette Frederiksen said the mutated virus posed a "risk to the effectiveness" of a future Covid-19 vaccine."

This can make the vaccine development take big leap backwards as it seems that there is not going to be single magic bullet against this one.

Known mutations of covid-19

https://nextstrain.org/ncov/global


Opinions please


Edited by LeningradCowboy (11/11/20 01:20 PM)


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy]
    #27032425 - 11/10/20 10:33 PM (3 years, 3 months ago)

https://www.bmj.com/content/371/bmj.m4338

"One strain of mutated SARS-CoV-2, found in 12 humans in Denmark, appeared in laboratory tests to exhibit “decreased susceptibility” to antibodies from previously infected people, the country’s State Serum Institute said in a preliminary report.1 This variant, if it spread, might be less easily controlled by covid-19 vaccines currently under development, the report warned."


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Offlinewhitecarnist
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Registered: 08/30/20
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy]
    #27032433 - 11/10/20 10:41 PM (3 years, 3 months ago)

Completely irrelevant.It's probably even weaker now.


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OfflineLoaded Shaman
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist] * 2
    #27032584 - 11/11/20 12:47 AM (3 years, 3 months ago)

Lol didn't McDonald's just make the news regarding something with minks?

Quote:

whitecarnist said:
Completely irrelevant.It's probably even weaker now.




Oh cool good to know the brand new guy 100% knows for fact the veracity and severity of these claims.


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"Real knowledge is to know the extent of one’s ignorance." — Confucius


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Offlinewhitecarnist
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Re: New mutation of covid-19 in Denmark [Re: Loaded Shaman]
    #27032593 - 11/11/20 12:53 AM (3 years, 3 months ago)

I'll be honest, I'm posting only because I need 10 posts.


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OfflineLoaded Shaman
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
    #27032598 - 11/11/20 12:55 AM (3 years, 3 months ago)

Quote:

whitecarnist said:
I'll be honest, I'm posting only because I need 10 posts.




Understandable just a heads up don't spam or try to be overly witty until you're here a bit; a lot of the top dogs will fuck with you and give you a low rating, even if it's not warranted, via an argument, from which you'll never recover, lol.

As such, for being honest, I started you off with a 5/5 shroom review (check under your name now!).

Welcome! :bongload: :sunny:

PM anytime.


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"Real knowledge is to know the extent of one’s ignorance." — Confucius


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist] * 1
    #27032660 - 11/11/20 02:00 AM (3 years, 3 months ago)

Quote:

whitecarnist said:
Completely irrelevant.It's probably even weaker now.




Who´s :puppet:  you are?
Kinda recognize that negative undertone though:lol:


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
    #27032671 - 11/11/20 02:12 AM (3 years, 3 months ago)

Quote:

whitecarnist said:
Completely irrelevant.It's probably even weaker now.




https://www.who.int/csr/don/06-november-2020-mink-associated-sars-cov2-denmark/en/

"Initial observations suggest that the clinical presentation, severity and transmission among those infected are similar to that of other circulating SARS-CoV-2 viruses. However, this variant, referred to as the "cluster 5" variant, had a combination of mutations, or changes that have not been previously observed. The implications of the identified changes in this variant are not yet well understood. Preliminary findings indicate that this particular mink-associated variant identified in both minks and the 12 human cases has moderately decreased sensitivity to neutralizing antibodies. Further scientific and laboratory-based studies are required to verify preliminary findings reported and to understand any potential implications of this finding in terms of diagnostics, therapeutics and vaccines in development. In the meantime, actions are being taken by Danish authorities to limit the further spread of this variant of the virus among mink and human populations."

Specialists of that are do not agree with you though:shrug:


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy]
    #27033111 - 11/11/20 09:52 AM (3 years, 3 months ago)

https://www.foreigner.fi/articulo/coronavirus/denmark-says-about-200-infected-with-mink-coronavirus-mutation/20201106172650008914.html

This is going to be bad for the vaccine.

"At least 214 people have been infected with a variant of the coronavirus that appeared in minks in June, said the Danish State Serum Institute (SSI) on Friday."


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InvisibleTexas Honey BadgerM
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Registered: 07/12/18
Posts: 58,687
Loc: Spicemaster Texas
Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
    #27033175 - 11/11/20 10:36 AM (3 years, 3 months ago)

Quote:

whitecarnist said:
I'll be honest, I'm posting only because I need 10 posts.



For what??


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InvisibleJokeshopbeard
Humble Student

Registered: 11/30/11
Posts: 26,088
Loc: Deep in the system Flag
Re: New mutation of covid-19 in Denmark [Re: Texas Honey Badger]
    #27033224 - 11/11/20 11:06 AM (3 years, 3 months ago)

You need 10 posts for ODD.


--------------------
Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not.
--Jac O'keeffe


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InvisibleTexas Honey BadgerM
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Registered: 07/12/18
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Re: New mutation of covid-19 in Denmark [Re: Jokeshopbeard] * 1
    #27033254 - 11/11/20 11:25 AM (3 years, 3 months ago)

That is pretty special:picard:


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: Texas Honey Badger]
    #27033443 - 11/11/20 01:19 PM (3 years, 3 months ago)

Explanation why one of these 5 different mutations is resistant to antibodies from normal covid-19. And speculation why the vaccines in development right now might not be effective against this strain of covid-19

https://www.theguardian.com/commentisfree/2020/nov/10/the-covid-carrying-danish-mink-are-a-warning-sign-but-is-anyone-heeding-it

"Mink ACE2 is slightly different from human ACE2, so mink-to-mink transmission may have favoured a mutated virus with a change to its spike protein key that better fits the mink ACE2 lock. As the antibodies that humans generate to fight off Covid-19 target the spike protein on the external surface of the virus, this mink-adapted virus, which has a mutation in its spike protein, may be better able to circumvent our defences.

Danish researchers report that one of the variants of the virus found in mink isn’t as easily defeated by the antibodies that humans produce against Covid-19. One risk is that people who have recovered from Covid-19 may have antibodies that are less able to fight off the mink strain of the virus, leaving them open to reinfection. And most of the vaccines under development, on which we are pinning so much hope, are intended to induce antibodies that target the spike protein in the virus that causes Covid-19 in humans. While it’s too early to say for certain, one possibility is that these vaccines could be less effective against the mink virus, because it has a different spike protein."


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Onlinekoods
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy]
    #27033944 - 11/11/20 06:09 PM (3 years, 3 months ago)

Immunity is not all or nothing. A virus can mutate away from immunity but very unlikely that it would drift so far the vaccine wouldn’t work.

Just like a flu vaccine, partial immunity may not prevent infection, but would limit the course of the infection and prevent serious illness. Partial immunity gives your immune system a head start.


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“if I believed she was 16 I would become unattracted to her”


Edited by koods (11/11/20 06:14 PM)


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: koods]
    #27034246 - 11/11/20 09:50 PM (3 years, 3 months ago)

Did you read that last article?
Antibodies from normal covid-19 do not react to proberly to 1 of the 5 strains founded in minks.


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy]
    #27034285 - 11/11/20 10:22 PM (3 years, 3 months ago)

And flu vaccine is new every season. The vaccine is made by educated guess how the virus is going to mutate from last season.

This is how flu vaccine development works, this is not my opinion how it works. This is how it works.

Some years they guess it right and the vaccine is effective, some years they dont and it is not.

https://www.fpca.net/flu-vaccine-the-educated-guess/


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Invisiblebreeg89
i'll tell ya hwhat

Registered: 05/04/11
Posts: 3,120
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Re: New mutation of covid-19 in Denmark [Re: LeningradCowboy] * 1
    #27034303 - 11/11/20 10:36 PM (3 years, 3 months ago)

Yeah, different spike protein sequence could be bad news. Hopefully Denmark can stay on top of this.

Vaccines designed to promote an immune response against the spike protein are inevitably going to select for resistant mutants with different spike protein sequences anyway. We just have to hope those mutations dramatically hinder fitness. Seems like we will probably be getting seasonal covid vaccines to fight the new strains as they emerge from selective pressure.


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OfflineSeriously_trippin
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
    #27034324 - 11/11/20 11:00 PM (3 years, 3 months ago)

Quote:

LeningradCowboy said:
https://www.bbc.com/news/world-europe-54818615

New strain of covid-19 is passed to humans from minks in Denmark.

"Prime Minister Mette Frederiksen said the mutated virus posed a "risk to the effectiveness" of a future Covid-19 vaccine."

This can make the vaccine development take big leap backwards as it seems that there is not going to be single magic bullet against this one.

Known mutations of covid-19

https://nextstrain.org/ncov/global


Opinions please



The Denmark government is in the process of exterminating all minks in the country and it better work


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Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many :heart:


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
    #27034347 - 11/11/20 11:29 PM (3 years, 3 months ago)

I really dont think it is going to stop this mutation of spreading.
Can stop new ones from forming though.

It has all ready been founded in 214 humans. And these are not todays numbers.

North Jutland is in isolation now. The area of most mink production on Denmark.

https://www.thelocal.dk/20201105/denmark-tightens-north-jutland-restrictions-in-response-to-coronavirus-mutation

https://coronasmitte.dk/en/restrictions-in-north-jutland


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
    #27035261 - 11/12/20 01:12 PM (3 years, 3 months ago)

Quote:

Seriously_trippin said:




The Denmark government is in the process of exterminating all minks in the country and it better work




https://www.theguardian.com/environment/2020/nov/09/denmark-drops-plans-for-mass-mink-cull-after-covid-mutation-fears

Denmark just announced that it cancelled the culling of minks.
Covid-19 has been founded on minks all so in Sweden and America.

"Frederik Waage, law professor at the University of Southern Denmark, told Danish national paper Berlingske the cull order was “illegal”."

"The American Veterinary Medical Association said at least 8,000 minks have died of infection with Sars-CoV-2 on farms in Utah. And nearly 3,400 mink are reported to have died from the coronavirus at a mink farm in Wisconsin. It added that the infection seems to be deadlier among older minks."

It looks like we are going to have A LOT of different strains soon.


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